Clinical trials: Geriatric Disorder
Cognition Disorders in Old Age, Dementia
The "Motoric Cognitive Risk" Syndrome in the Quebec Population
The overall objective of the proposal is to examine the epidemiology of the newly reported "motoric cognitive risk" (MCR) syndrome, which is a pre-dementia syndrome combining subjective cognitive complaint (i.e.; memory…
- Trial name
- NCT03633253
- Testing
- Summarize of participants' characteristics using means and standard deviations or frequencies and percentages
- Where
- Canada
- Volunteers
- 1,741 people, healthy volunteers welcome
- Sponsor
- Jewish General Hospital
Coronary Artery Disease, Diabetes Mellitus, Type 2
PIPAF Platelets in the Pathogenesis of Ageing Associated Frailty
This is a prospective observational study aimed at testing the existence of an association between frailty, inflammatory status, and degree of platelet activation and reactivity in elderly subjects with type 2 diabetes or…
- Conditions
- Coronary Artery Disease, Diabetes Mellitus, Type 2, Alzheimer Disease
- Trial name
- PIPAF (NCT05798637)
- Testing
- Standard of care
- Where
- 2 sites in Italy
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Azienda Ospedaliera di Perugia
Hand, Foot, and Mouth Disease (HFMD), Enterovirus 71 Infection
Bridging Clinical Trial of EV71 Vaccine in Vietnamese Children
The purpose of this study is to evaluate the immunogenicity and safety of an inactivated Enterovirus Type 71 (EV71) vaccine, manufactured by Sinovac, in healthy Vietnamese children aged 6 to 71 months.
- Trial name
- NCT07793175
- Testing
- EV71 vaccine
- Where
- Vietnam
- Volunteers
- 320 people, healthy volunteers welcome
- Sponsor
- Sinovac Biotech Co., Ltd
Neoplasms, Aged
Silent Threat: Impact of Preoperative Albumin Levels on Outcomes in Geriatric Cancer Surgery
This retrospective, single-center study aims to evaluate the impact of preoperative albumin levels on postoperative outcomes in geriatric patients (aged 65 and above) undergoing cancer surgery.
- Conditions
- Neoplasms, Aged, Hypoalbuminemia, Postoperative Complications
- Trial name
- NCT06998030
- Where
- Turkey (Türkiye)
- Volunteers
- 330 people, healthy volunteers welcome
- Sponsor
- Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital
Influenza
Study of Sanofi Pasteur's Intradermal Influenza Vaccine (IDflu™) in Adults and Elderly in Korea
This study is designed to assess the immunogenicity and safety of the 2010-2011 NH season formulation of intradermal (ID) influenza vaccine as part of a post registration commitment.
- Trial name
- NCT01215669
- Testing
- IDflu™: Split virion inactivated influenza vaccine, Vaxigrip®: Split virion inactivated influenza vaccine
- Where
- 2 sites in South Korea
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Sanofi Pasteur, a Sanofi Company
Alzheimer's Disease, Dementia
Safety and Efficacy of Divalproex and Quetiapine in Elderly Alzheimer's Dementia Patients
The primary aim is to determine whether Divalproex ER or one of the atypical antipsychotics is more effective improving dementia related behavioral symptoms in patients with dementia, and evaluate the impact of such improvements…
- Conditions
- Alzheimer's Disease, Dementia, Behavioral Symptoms
- Trial name
- NCT00375557
- Testing
- Divalproex ER, Quetiapine
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Cincinnati
Pain, Pulmonary Nodules
Effect of CYP2D6*10 Gene Mutation on Perioperative Precision Analgesia of Oxycodone in Elderly Patients
The purpose of this prospective study was to determine the effect of CYP2D6 gene polymorphism on perioperative analgesia of oxycodone in elderly patients, and to assign the CYP2D6 phenotype according to the genotype, and to use…
- Conditions
- Pain, Pulmonary Nodules, Oxycodone
- Trial name
- NCT07484867
- Testing
- oxycodone
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Henan Provincial People's Hospital
Vasomotor Symptoms as a Sex Hormone-dependent Disorder in Women and Men
A Study to Learn What Happens to Elinzanetant in the Body When Taken With or Without Carbamazepine, and How Safe it is in Healthy Men and Women Aged 18 to 60 Years.
Researchers are looking for a better way to treat people who have symptoms caused by hormonal changes, such as hot flashes. Before a treatment can be approved for patients to take, researchers do clinical studies to better…
- Trial name
- NCT05028608
- Testing
- Elinzanetant (BAY3427080), Midazolam, Carbamazepine
- Where
- Germany
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Bayer
Mild Cognitive Impairment
The Effect of Daily Consumption of Eggs on Cognitive Function in the Elderly
Cognitive impairment is also a major risk factor for development of dementia later in life. Findings from our studies suggest that the carotenoids, lutein and zeaxanthin may be important in cognitive function in the elderly.
- Trial name
- NCT01621646
- Testing
- eggs or egg whites
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Tufts University
Meningitis, Meningococcal Meningitis
Safety of a Meningococcal (Groups A, C, Y and W-135) Polysaccharide Diphtheria Toxoid Conjugate Vaccine in Healthy Subjects in Vietnam
The aim of the study is to assess the safety of Menactra vaccine in infants, toddlers, children, adolescents, and adults Objective: To describe the safety profile after each and any dose (when applicable) of Menactra vaccine in…
- Conditions
- Meningitis, Meningococcal Meningitis, Meningococcal Infections
- Trial name
- NCT02640404
- Testing
- Meningococcal (Groups A, C, Y and W-135) Polysaccharide Diphtheria Toxoid Conjugate Vaccine
- Where
- Vietnam
- Volunteers
- 224 people, healthy volunteers welcome
- Sponsor
- Sanofi Pasteur, a Sanofi Company
Obesity
Effects of Grapefruit or Grapefruit Juice on Anthropometry, Dietary Intakes, Appetite, and Metabolic Profile in Overweight and Obese Young and Middle-Aged Adults
This trial examines the effects of grapefruit or grapefruit juice on anthropometry, dietary intakes, appetite, and metabolic profile in overweight and obese young and middle-aged adults.
- Trial name
- GJW (NCT00581074)
- Testing
- diet (grapefruit or grapefruit juice)
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University
Influenza
Tolerability and Immunogenicity Study of Fluval AB Influenza Vaccine in Adults and Elderly Persons
The purpose of this study is to determine the immunogenicity and tolerability of Fluval AB trivalent influenza vaccine in adults and elderly people.
- Trial name
- NCT01404182
- Testing
- Vaccination with Fluval AB influenza vaccine
- Where
- 2 sites in Hungary
- Volunteers
- 121 people, healthy volunteers welcome
- Sponsor
- Fluart Innovative Vaccine Ltd, Hungary
Knee Osteoarthritis
The Effect of Motivational Messages by "WhatsApp" on Adherence to Home Exercise Program
This study aims to examine the effect of the text message platform (WhatsApp) on the adherence to home exercise programs, pain and physical function among middle age and older adults with knee OA in two public hospitals in Riyadh…
- Trial name
- NCT05453123
- Testing
- telerehabilitation
- Where
- Saudi Arabia
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- King Saud University
Influenza
Immunogenicity and Safety of PrepandrixTM in Korean Subjects Aged 18 to 60 Years Old
This study will evaluate the immunogenicity and the safety of PrepandrixTM in Korean subjects. A second group of subjects will receive FluarixTM vaccine as control.
- Trial name
- NCT01730378
- Testing
- Prepandrix™, Fluarix™
- Where
- 4 sites in South Korea
- Volunteers
- 131 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Meningitis, Meningococcal
Safety Study of Meningococcal ACYW135 Polysaccharide Conjugate Vaccine in Healthy Volunteers Aged Above 3 Months
The purpose of this study is to evaluate safety of meningococcal ACYW135 polysaccharide conjugate vaccine in healthy volunteers aged above 3 Months
- Trial name
- NCT02878291
- Testing
- Meningococcal ACYW135 Polysaccharide Conjugate Vaccine
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Beijing Zhifei Lvzhu Biopharmaceutical Co., Ltd
Generalized Anxiety Disorder
Computerized Cognitive Training in Middle-Aged Adults With Generalized Anxiety Disorder: A Pilot Study
The purpose of this research is to look at the effects of computerized cognitive training on anxiety, sleep, mental abilities (cognition), and other aspects of daytime functioning, such as arousal.
- Trial name
- COGMA (NCT04421690)
- Testing
- Cognitive Training, Trivia Training
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Missouri-Columbia
Caregiver, Lobectomy Patient
Physical Activity Intervention Before and After Surgery in Older Adults With Lung Cancer and Their Family Caregivers
This trial studies whether a telephone-based physical activity intervention before and after lung cancer surgery can be provided to older patients and their caregivers.
- Conditions
- Caregiver, Lobectomy Patient, Lung Carcinoid Tumor, Lung Non-Small Cell Carcinoma
- Trial name
- NCT04085081
- Testing
- E-mail, Exercise Intervention, Quality-of-Life Assessment
- Volunteers
- healthy volunteers welcome
- Sponsor
- City of Hope Medical Center
Sarcopenia, Osteoporosis
Ibuprofen Supplementation After Resistance Training and Its Effects on Bone in Older Women
Inflammation increases with aging and is implicated in the reduction of bone mass, muscle mass, and strength. Resistance training is safe and effective for increasing muscle mass and strength in older adults,however resistance…
- Trial name
- NCT01886196
- Testing
- Non-steroidal anti-inflammatory drug (Ibuprofen), Resistance exercise, Flexibility training
- Where
- Canada
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of Saskatchewan
Influenza
Comparison of Immune Responses to Influenza Vaccine In Adults of Different Ages (SLVP015 2007-2017)
In this study the investigators are trying to understand how immune function declines in the elderly using annual influenza vaccinations as a model system. The longitudinal study began in 2007 and continued through early 2017.
- Trial name
- NCT01827462
- Testing
- Trivalent, inactivated influenza vaccine (TIV), Quadrivalent, inactivated influenza vaccine (IIV4), High-Dose Trivalent, inactivated influenza vaccine (TIV High-Dose)
- Where
- United States
- Volunteers
- 136 people, healthy volunteers welcome
- Sponsor
- Stanford University
COVID-19, Immunologic Factors
Study of the Immunogenicity, Safety and Tolerability of the Convacell Vaccine.
A two-stage trial will involve healthy volunteers. The first stage is open trial, and the second stage is a double-blind trial with randomization of volunteers into three groups.
- Conditions
- COVID-19, Immunologic Factors, Coronavirus Infections, Respiratory Tract Infections
- Trial name
- NCT05156723
- Testing
- Subunit recombinant vaccine for the prevention of coronavirus infection
- Where
- 3 sites in Russia
- Volunteers
- 155 people, healthy volunteers welcome
- Sponsor
- St. Petersburg Research Institute of Vaccines and Sera