Clinical trials: Genotype
DRUG REACTIONS
Clinical Trial to Evaluate the Influence of Genotype and DDIs of Aspirin on the PK/PD of Clopidogrel and PK of Digoxin
Clinical trial to evaluate the influence of multiple aspirin administration on PK and PD of co-administered drugs
- Trial name
- NCT01775839
- Testing
- Aspirin+Clopidogrel/Digoxin(oral), Aspirin+Clopidogrel/Digoxin(IV)
- Where
- South Korea
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
CYP1A2 Polymorphism
Personalized Nutrition Caffeine Intake in Healthy Adults.
Personalized nutrition is one of the most up to date trends in human nutrition and gains much interest of general public and scientists as well.
- Trial name
- NCT04122053
- Testing
- Intervention group with genotype information, Control group without genotype information
- Where
- Poland
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- Poznan University of Life Sciences
Venous Thromboembolism
Effect of the Genotype on Postoperative DVT
Postoperative Venous Thromboembolism Events (VTE) constitute a major source of morbidity and mortality after surgery. The aim of this study was to investigate whether commonly occurring Single Nucleotide Polymorphisms (SNPs) are…
- Trial name
- NCT04940377
- Where
- Denmark
- Volunteers
- 502,505 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
HCV Infection
Safety, Tolerability and PK Study of Single Doses of ABT-450 With and Without Ritonavir to Treat Hepatitis C Virus (HCV) Genotype 1
The purpose of this study is to determine the pharmacokinetic and safety profiles of an experimental HCV protease inhibitor with and without ritonavir in healthy volunteers.
- Trial name
- NCT00850044
- Testing
- ABT-450, ritonavir
- Where
- United States
- Volunteers
- 87 people, healthy volunteers welcome
- Sponsor
- AbbVie
Depression, Depressive Disorder
Metformin as Adjunct Therapy in Depression-obesity Comorbidity: Clinical and Genetic Evaluation
The patients with depression and obesity will receive add-on metformin with antidepressant therapy, which may result in greater improvement in depressive symptoms and BMI reduction compared to antidepressant monotherapy.
- Conditions
- Depression, Depressive Disorder, Overweight or Obesity, Depressive Symptoms
- Trial name
- NCT07654179
- Testing
- Metformin, Antidepressant Therapy
- Where
- 2 sites in Pakistan
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Riphah International University
Genotype
AI-Driven Genotype Prediction Using EHR and Multimodal Data
The goal of this clinical study is to explore the potential of using electronic health records (EHR) and multimodal data (such as imaging, lab results, and clinical history) to predict a patient's genotype.
- Trial name
- NCT06791421
- Testing
- AI-Predictng Model
- Where
- 4 sites in China
- Volunteers
- 100,000 people, healthy volunteers welcome
- Sponsor
- The Eye Hospital of Wenzhou Medical University
ICD, Arrythmia
Genome-Wide Association Study With the Aim of Implantable Cardioverter Defibrillator Implantation Genophenotypic Risk Stratification
This clinical study will be conducted with funding from European Innovation Council(EIC) after approval of the fund grant and is part of our organization's European Pathfinder Project(Ref…
- Conditions
- ICD, Arrythmia, Sudden Cardiac Death
- Trial name
- ICDGPSS (NCT05582252)
- Testing
- Non-Invasive saliva sampling
- Where
- Turkey (Türkiye)
- Volunteers
- 2,500 people, healthy volunteers welcome
- Sponsor
- Selcuk University
Primary Immune-Deficiency (PID) Common Variable Immune Deficiency (CVID)
Severe PID With Lymphoproliferation and Neutropenia
The purpose of this study is to analyse the phenotype in a sub-population of adults with severe primary immunodeficiency with lymphoproliferation and neutropenia and to decipher the possible pathways involved, especially under…
- Trial name
- DICEP (NCT03427593)
- Testing
- FACS analyses, Target Sequencing by NGS ( Next-generation sequencing), Whole Exome Sequencing
- Where
- France
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- University Hospital, Strasbourg, France
Glucose Metabolism Disorders
Interaction of MTNR1B Genotype and Type of Breakfast (Protein-enriched v Carbohydrate-rich) on Postprandial Glucose Response.
The risk version of the MTNR1B gene (which codes for a melatonin receptor) has been associated with type II diabetes (T2D) and associated physiological markers.
- Trial name
- NCT06821620
- Testing
- Breakfast
- Where
- United Kingdom
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- St. Mary's University, Twickenham
Validation, Biosensors
Validation of New G6PD Point of Care Tests Against Gold Standard Quantitative
This is a laboratory research to evaluate performances of quantitative POC G6PD tests (Biosensors) against gold standard quantitative laboratory based tests and genotyping.
- Conditions
- Validation, Biosensors, Genotyping
- Trial name
- Biosensors (NCT02625285)
- Where
- Thailand
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Healthy Volunteers, Modeling Psychosis
Gene-Environment-Interaction: Influence of the COMT Genotype on the Effects of Different Cannabinoids - a PET Study
The study evaluates the gene-environment interaction of the COMT-genotype on the effects of the phytocannabinoids delta-9-tetrahydrocannabinol, cannabidiol or a combination of both on induction of psychotic symptoms…
- Trial name
- NCT02492074
- Testing
- Delta-9-tetrahydrocannabinol, Cannabidiol
- Where
- Germany
- Volunteers
- healthy volunteers welcome
- Sponsor
- Central Institute of Mental Health, Mannheim
Healthy
Does Incorporation of EPA and DHA in Lipoproteins Differ According to Apolipoprotein E Genotype?
Genetics and nutrition both clearly affect the risk of Alzheimer's disease (AD) in the elderly. Apolipoprotein E (APOE4) is the most important known genetic risk for AD and is prevalent in 20-25% of Canadians, but at present…
- Trial name
- NCT01544855
- Testing
- omega-3 fatty acids
- Where
- Canada
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Université de Sherbrooke
Amyotrophic Lateral Sclerosis, Hereditary Spastic Paraplegia
Phenotype, Genotype and Biomarkers 2
The purpose of this study is to learn more about amyotrophic lateral sclerosis (ALS) and other related neurodegenerative diseases, including frontotemporal dementia (FTD), primary lateral sclerosis (PLS), hereditary spastic…
- Conditions
- Amyotrophic Lateral Sclerosis, Hereditary Spastic Paraplegia, Primary Lateral Sclerosis, Progressive Muscular Atrophy
- Trial name
- PGB2 (NCT04875416)
- Where
- 4 sites in United States, South Africa
- Volunteers
- 217 people, healthy volunteers welcome
- Sponsor
- University of Miami
Age-Related Macular Degeneration, Diabetic Retinopathy
National Eye Institute Biorepository for Retinal Diseases
Background: To understand diseases of the retina and the eye, information is needed about people with and without such diseases. Researchers want to study these people and follow them over time.
- Conditions
- Age-Related Macular Degeneration, Diabetic Retinopathy, Von Hippel-Lindau Syndrome, Retinal Disease
- Trial name
- NCT01496625
- Where
- United States
- Volunteers
- 650 people, healthy volunteers welcome
- Sponsor
- National Eye Institute (NEI)
HCV Infection
Study of ABT-333 in Both Healthy Volunteers and Hepatitis C Virus (HCV) + Genotype 1 Infected Subjects
The purpose of this study is to assess the safety, tolerability, pharmacokinetics of ABT-333 in healthy volunteers and the antiviral activity in HCV infected subjects.
- Trial name
- NCT00696904
- Testing
- ABT-333
- Volunteers
- 133 people, healthy volunteers welcome
- Sponsor
- AbbVie
Conotruncal Cardiac Defects
Conotruncal Cardiac Defects and Nutrigenetic Etiopathogeny
The investigators planned to study the etiopathogenic factors of conotruncal cardiac defects regarding the relations between the metabolic, the genetic and the environmental factors which lead to these cardiopathy.
- Trial name
- CCOMET (NCT01460316)
- Testing
- Bood sampling for biochemicals and genetic analysis
- Where
- France
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Central Hospital, Nancy, France
Acute Myelogenous Leukemia
Selecting a Favorable KIR Donor in Unrelated HCT for AML
Donors with favorable KIR B haplotype gene content have yielded reduced relapse risk and improved leukemia free survival (LFS) in retrospective analyses of unrelated donor (URD) hematopoietic cell transplantation (HCT) for acute…
- Trial name
- NCT01288222
- Testing
- KIR genotype
- Where
- 19 sites in United States
- Volunteers
- 506 people, healthy volunteers welcome
- Sponsor
- Masonic Cancer Center, University of Minnesota
Hepatitis C, Chronic
Randomized Clinical Trial of Sofosbuvir in Combination With Daclatasvir or Simeprevir for 12 Weeks in Non-cirrhotic Subjects Infected With Chronic Hepatitis C Virus Genotype 1 (TNT)
The purpose of the study is to study the combination of Sofosbuvir in Combination With Daclatasvir or Simeprevir for 12 Weeks in Non-cirrhotic Subjects Infected With Chronic Hepatitis C Virus (HCV) Genotype 1.
- Trial name
- NCT02624063
- Testing
- Daclatasvir + Sofosbuvir, Simeprevir + Sofosbuvir
- Where
- Brazil
- Volunteers
- 121 people, healthy volunteers welcome
- Sponsor
- Federal University of São Paulo
Heart Failure, Sudden Cardiac Death
Marathon, Genetics, Inflammation and the Cardiovascular System: MAGIC-Trial
The purpose of the study is to determine the myocardial function and vascular adaptation after strenuous exercise in association with genotype/polymorphisms.
- Trial name
- MAGIC (NCT00845286)
- Testing
- Munich Marathon
- Where
- Germany
- Volunteers
- 162 people, healthy volunteers welcome
- Sponsor
- Technical University of Munich
Alzheimer's Disease
Study of Uptake, Break Down and Elimination of an Investigational Drug in Healthy Volunteers
This study is being performed in order to learn more about a new drug (possible as treatment for people with Alzheimer's Disease and other conditions with cognitive dysfunction (memory and attention problems)) and how it is…
- Trial name
- MB (NCT00777361)
- Testing
- AZD3480
- Where
- United Kingdom
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- AstraZeneca