Clinical trials: Genito-Urinary Cancer
Genito Urinary Cancer, Bladder Cancer
Reconstitution of a Human Immune System in a Patient Derived Xenograft (PDX) Model of Genitourinary (GU) Cancers
The objective of this study is to obtain human blood CD34+ hematopoietic stem/progenitor cells (HSPCs) to reconstitute a match human immune system in our PDX model.
- Conditions
- Genito Urinary Cancer, Bladder Cancer, Kidney Cancer, Prostate Cancer
- Trial name
- Immune PDX (NCT03134027)
- Testing
- Bone marrow biopsy, Tumor biopsy
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Duke University
Lower Limb Lymphedema, Urogenital Cancer
Lymphoedema and Nocturia/ Nocturnal Polyuria After Pelvic Lymph Node Dissection for Urogenital Cancer
After the treatment of urogenital cancer, a person may develop lymphoedema of the leg(s) and/ or midline region. Lymphoedema is the result of a dysfunction in the lymphatic system and is characterized by excessive retention of…
- Trial name
- UroLymph (NCT05266157)
- Testing
- Manual lymph drainage, Usual care
- Where
- Belgium
- Volunteers
- 30 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Renal Cell Carcinoma
Study Comparing Bevacizumab + Temsirolimus vs. Bevacizumab + Interferon-Alfa In Advanced Renal Cell Carcinoma Subjects
Primary objective: Comparison of independently assessed progression free survival (PFS) in subjects administered Bevacizumab + Temsirolimus vs. those administered Bevacizumab + Interferon-Alfa.
- Trial name
- INTORACT (NCT00631371)
- Testing
- Bevacizumab, Temsirolimus, Interferon-Alfa 9MU
- Where
- 172 sites in United States, Argentina and 28 more
- Volunteers
- 791 people
- Sponsor
- Pfizer
Bladder Cancer Requiring Cystectomy, Ureteral Stents
STENT X: a Randomized Trial to Assess Stent-free Radical Cystectomy
Radical Cystectomy (RC) remains the gold standard for localized muscle-invasive bladder cancer (MIBC); however, use of ureteral stents at time of surgery remains controversial without level 1 evidence to comment on risks or…
- Trial name
- NCT07655284
- Testing
- ureteral stents, no ureteral stent
- Where
- 2 sites in United States, Brazil
- Sponsor
- Brigham and Women's Hospital
Breast Cancer, Gastrointestinal Cancer
A Feasibility Trial of Geriatric Assessment and Management for Older Cancer Patients
The purpose of this study is to determine the feasibility of implementing a randomized controlled study of the intervention (Geriatric Assessment followed by an integrated care plan carried out by the multidisciplinary geriatric…
- Conditions
- Breast Cancer, Gastrointestinal Cancer, Genitourinary Cancer
- Trial name
- NCT02222259
- Testing
- GA and Integrated Care Plan
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- University of Toronto
Metastatic Renal Cell Carcinoma, Metastatic Urothelial Carcinoma
A Phase II Randomized Trial of Immunotherapy Plus Radiotherapy in Metastatic Genitourinary Cancers
The trial is open to patients who have metastatic renal cell carcinoma/urothelial (bladder) carcinoma with at least 2 measurable sites of disease.
- Trial name
- NCT03115801
- Testing
- Nivolumab, Atezolizumab, Radiation & immunotherapy
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Weill Medical College of Cornell University
Breast Carcinoma, Prostate Cancer Surgery
High-resolution PET-CT Specimen Imaging for the Perioperative Visualization of Resection Margins
These are patients in whom a benign or malignant tumor was recorded requiring surgery. During that surgery, the surgeon will cut away the tumor as part of the treatment of the disease.
- Conditions
- Breast Carcinoma, Prostate Cancer Surgery, Thyroid Cancer, Parathyroid Adenomas
- Trial name
- NCT06835426
- Testing
- Single intravenous injection of the radiotracer, Imaging resected specimen using the high-resolution PET-CT specimen imager
- Where
- Belgium
- Volunteers
- 150 people
- Sponsor
- Algemeen Ziekenhuis Maria Middelares
Venous Thromboembolism, Urologic Cancer
VTE Prevention With Rivaroxaban in Genitourinary Cancer Patients Receiving Systemic Therapy
Patients with genitourinary cancers (ex: bladder, testicular, kidney) are at high risk of developing blood clots if they receive systemic therapy (ex: chemotherapy, immunotherapy).
- Trial name
- PREVENT-GU (NCT05920343)
- Testing
- Rivaroxaban 10 MG
- Where
- Canada
- Volunteers
- 120 people
- Sponsor
- Ottawa Hospital Research Institute
Genitourinary Cancer
Discharge Medication Use Post-Operatively in GU Cancer Patients
The main purpose of this research study is to determine the amount of opioids that are taken after discharge following a cystectomy, nephrectomy (partial or total), or prostatectomy surgeries via a 30-day post- discharge opioid…
- Trial name
- NCT06795087
- Testing
- Opioid Medication Disposal Education
- Where
- United States
- Volunteers
- 684 people
- Sponsor
- Wake Forest University Health Sciences
Microbial Disease
Personalized Treatment of Urogenital Cancers Depends on the Microbiome
This is a randomized controlled trial where patients undergoing surgical treatment for urogenital cancers will be randomized in a two arms study: surgical treatment + antibiotics OR surgical treatment + placebo.
- Trial name
- NCT03962920
- Testing
- Tigecycline 50 MG
- Where
- Denmark
- Volunteers
- 28 people
- Sponsor
- Zealand University Hospital
COVID-19 Infection, Genitourinary Cancer
Impact of COVID-19 on GU Disease
The purpose of this research study is to identify patients with GU disease with active or past COVID-19 infection. Participants will be asked to: Complete an Online COVID-19 Questionnaire.
- Conditions
- COVID-19 Infection, Genitourinary Cancer, Benign Urologic Conditions
- Trial name
- NCT04761107
- Where
- United States
- Volunteers
- 15,240 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Infiltrating Bladder Urothelial Carcinoma, Recurrent Bladder Carcinoma
sEphB4-HSA Before Surgery in Treating Patients With Bladder Cancer, Prostate Cancer, or Kidney Cancer
This pilot clinical trial studies the side effects of recombinant EphB4-HSA fusion protein before surgery in treating patients with transitional cell carcinoma of the bladder, prostate cancer, or kidney cancer.
- Conditions
- Infiltrating Bladder Urothelial Carcinoma, Recurrent Bladder Carcinoma, Stage I Prostate Cancer, Stage I Renal Cell Cancer
- Trial name
- NCT02767921
- Testing
- Cytology Specimen Collection Procedure, Laboratory Biomarker Analysis, Radical Cystectomy
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- University of Southern California
Breast Cancer, Lung Cancer
Using an End-of-life Conversation Game to Engage Patients With Cancer in Advance Care Planning
The goal of this clinical trial is to explore feasibility, acceptability, and effectiveness of end-of-life conversation game "Hello" as a tool to help individuals with breast, lung, and/or genito-urinary cancers treated at Penn…
- Conditions
- Breast Cancer, Lung Cancer, Genito Urinary Cancer
- Trial name
- NCT06028152
- Testing
- End-of-life conversation game called "Hello"
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Milton S. Hershey Medical Center
Healthy Volunteer, Prostate Cancer
Circulating Tumor DNA (ctDNA) for Early Treatment Response Assessment of Solid Tumors
Earlier detection of disease recurrence will enable greater treatment options and has strong potential to improve patient outcomes.
- Conditions
- Healthy Volunteer, Prostate Cancer, Head and Neck Cancer, Esophageal Cancer
- Trial name
- NCT04354064
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Metastatic Castration Resistant Prostate Cancer Patients
Prostate Cancer Evaluation of TaRgets in Genito Urinary Screening Program
Toward personalised treatment in early metastatic prostate cancer based on the assessment of biomarkers in cancer tissue samples and circulating tumour cells.
- Trial name
- PETRUS (NCT01786031)
- Testing
- metastasis biopsy
- Where
- France
- Volunteers
- 55 people
- Sponsor
- Gustave Roussy, Cancer Campus, Grand Paris
Cancer, Breast Cancer
Genomic Investigation of Unusual Responders
Studies have shown that tumors from the same patient may respond very differently to the same therapeutic agents. This study aims to investigate the genetic basis of tumors that respond abnormally well or poorly to therapeutic…
- Conditions
- Cancer, Breast Cancer, Non-small Cell Lung Cancer, Colorectal Cancer
- Trial name
- GENIUS (NCT03740503)
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- University Health Network, Toronto
Breast Cancer, Gastrointestinal Cancer
Pathways to Advance Targeted and Helpful Serious Illness Conversations (PATH-SIC)
The purpose of this study is to increase serious illness conversations (SICs) about patients goals and preferences regarding their healthcare between patients with cancer and their oncology clinicians and improved care provided…
- Conditions
- Breast Cancer, Gastrointestinal Cancer, Gynecologic Cancer, Thoracic Cancer
- Trial name
- (PATH-SIC) (NCT05629065)
- Testing
- Clinician Nudge Email, Patient Nudge Letter and Share questionaire
- Where
- United States
- Volunteers
- 800 people
- Sponsor
- Dana-Farber Cancer Institute
Bladder Small Cell Neuroendocrine Carcinoma, Bladder Squamous Cell Carcinoma
Cabozantinib S-malate and Nivolumab With or Without Ipilimumab in Treating Patients With Metastatic Genitourinary Tumors
This phase I trial studies the side effects and best doses of cabozantinib s-malate and nivolumab with or without ipilimumab in treating patients with genitourinary (genital and urinary organ) tumors that have spread from where…
- Conditions
- Bladder Small Cell Neuroendocrine Carcinoma, Bladder Squamous Cell Carcinoma, Bladder Urothelial Carcinoma, Clear Cell Renal Cell Carcinoma
- Trial name
- NCT02496208
- Testing
- Biopsy Procedure, Biospecimen Collection, Cabozantinib S-malate
- Where
- 8 sites in United States
- Volunteers
- 152 people
- Sponsor
- National Cancer Institute (NCI)
Prostate Cancer, Kidney Cancer
Personal Web Page In Clinical Trial Participant Education
This research study is evaluating the effectiveness of video and web-based communication in clinical research compared to standard practices.
- Conditions
- Prostate Cancer, Kidney Cancer, Genitourinary Cancer
- Trial name
- NCT03887091
- Testing
- Postwire
- Where
- United States
- Volunteers
- 99 people
- Sponsor
- Dana-Farber Cancer Institute
Cancer, Severe Major Depression
Adapting the Tumor Board Model for Mental Illness and Cancer
This study examines the feasibility and acceptability of a virtual tumor board for cancer and mental illness for patients with serious mental illness and a new cancer diagnosis.
- Conditions
- Cancer, Severe Major Depression, Schizophrenia, Bipolar Disorder
- Trial name
- NCT05837598
- Testing
- Virtual Cancer and Mental Health Tumor Board
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Massachusetts General Hospital