Clinical trials: Genito-Urinary Cancer
Metastatic Colorectal Cancer, Metastatic Pancreatic Cancer
Immunotherapy Using Tumor Infiltrating Lymphocytes for Patients With Metastatic Cancer
Background: The NCI Surgery Branch has developed an experimental therapy that involves taking white blood cells from patients' tumors, growing them in the laboratory in large numbers, and then giving the cells back to the…
- Conditions
- Metastatic Colorectal Cancer, Metastatic Pancreatic Cancer, Metastatic Ovarian Cancer, Metastatic Breast Carcinoma
- Trial name
- NCT01174121
- Testing
- Pembrolizumab (Keytruda), Fludarabine, Cyclophosphamide
- Where
- United States
- Volunteers
- 332 people
- Sponsor
- National Cancer Institute (NCI)
Urothelial Cancer, Bladder Cancer
A Multi-Center Natural History of Urothelial Cancer and Rare Genitourinary Tract Malignancies
Background: Tumors in the genitourinary tracts can occur in the kidney, bladder, prostate, and testicles and can have common and rare histologies. Some cancers that occur along the genitourinary (GU) tract are rare.
- Conditions
- Urothelial Cancer, Bladder Cancer, Genitourinary Cancer, Urogenital Neoplasms
- Trial name
- NCT04923178
- Where
- United States
- Volunteers
- 1,100 people
- Sponsor
- National Cancer Institute (NCI)
Fear of Cancer Recurrence, Prostate Cancer
Fear of Cancer Recurrence in Genitourinary Cancer
To perform an analysis of independent predictors of fear of cancer recurrence in patients with malignant genitourinary diseases and their impact on quality of life and survival
- Conditions
- Fear of Cancer Recurrence, Prostate Cancer, Renal Cell Cancer, Urothelial Carcinoma
- Trial name
- NCT04535921
- Testing
- FCR7 questionnaire
- Where
- Germany
- Volunteers
- 500 people
- Sponsor
- Ludwig-Maximilians - University of Munich
Genitourinary Cancer, Adrenocortical Carcinoma
Nivolumab Combined With Ipilimumab for Patients With Advanced Rare Genitourinary Tumors
This research study is studying a combination of drugs as a possible treatment for rare genitourinary malignancies among four cohorts, bladder or upper tract carcinoma with variant histology, adrenocortical carcinoma, other rare…
- Conditions
- Genitourinary Cancer, Adrenocortical Carcinoma, Non-urothelial Bladder, Non-urothelial Upper Tract
- Trial name
- NCT03333616
- Testing
- Ipilimumab, Nivolumab
- Where
- 6 sites in United States
- Volunteers
- 100 people
- Sponsor
- Dana-Farber Cancer Institute
Endocrine Tumors, Non-Small Cell Lung Cancer
Administration of Autologous T-Cells Genetically Engineered to Express T-Cell Receptors Reactive Against Neoantigens in People With Metastatic Cancer
Background: A person s tumor is studied for mutations. When cells are found that can attack the mutation in a person s tumor, the genes from those cells are studied to find the parts that make the attack possible.
- Conditions
- Endocrine Tumors, Non-Small Cell Lung Cancer, Ovarian Cancer, Breast Cancer
- Trial name
- NCT03412877
- Testing
- Cyclophosphamide, Fludarabine, Aldesleukin
- Where
- United States
- Volunteers
- 285 people
- Sponsor
- National Cancer Institute (NCI)
Genitourinary Cancers
Observational Study of the Effectiveness of Funded Drugs for Genitourinary Tumors.
SOGUG-PRINCIS is a retrospective (regarding patient inclusion) and prospective follow-up, epidemiological, non-interventional, non-blinded, non-randomized, multicenter, national observational study with drugs.
- Trial name
- SOGUG-PRINCIS (NCT06724159)
- Testing
- darolutamide, Nivolumab monotherapy, enfortumab vedotin
- Where
- 84 sites in Spain
- Volunteers
- 500 people
- Sponsor
- Spanish Oncology Genito-Urinary Group
Breast Cancer, Sarcoma
Riluzole For Preventing Cognitive Dysfunction in Ca Pts Receiving Chemo (REFOCUS): Pilot Trial
This is a phase II single-arm, Phase 2a, randomized, double-blinded, placebo-controlled pilot clinical trial determining efficacy of riluzole in preventing cognitive dysfunction in subjects with cancer, who are receiving…
- Conditions
- Breast Cancer, Sarcoma, Gastric (Stomach) Cancer, Lung Cancer
- Trial name
- NCT07447050
- Testing
- Riluzole
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- University of California, Irvine
Genitourinary Neoplasms, Neoplasms, Genitourinary
Malignant Genito-urinary Tumors in Children: South Egypt Cancer Institute Experience
The aim of this study is to identify demographic \& disease characteristics in pediatric oncology patients diagnosed with one of genitourinary tumors \& treatment outcomes in these patients.
- Trial name
- NCT02557230
- Where
- Egypt
- Volunteers
- 250 people
- Sponsor
- Assiut University
Metastatic Cancer, Locally Advanced Cancer
An Intervention to Help Patients and Caregivers Manage Stress and Improve Communication Skills When Talking About Cancer
This study will test an intervention to improve patients' and their caregivers' ability to manage difficult emotions and communicate about the patient's illness.
- Conditions
- Metastatic Cancer, Locally Advanced Cancer, Thoracic Cancer, Gynecologic Cancer
- Trial name
- NCT03794635
- Testing
- Weekly 45 minute Sessions
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Memorial Sloan Kettering Cancer Center
Gynecologic Cancer, Genitourinary Cancer
Compare Airway Pressure Release Ventilation (APRV) to Conventional Mechanical Ventila
This is a pilot study to determine if pulmonary function (lung compliance and ventilation/perfusion matching) is improved using APRV during general anesthesia, compared to the standard CMV.
- Trial name
- NCT07111039
- Testing
- Airway Pressure Release Ventilation, Conventional Mechanical Ventilation
- Where
- United States
- Sponsor
- H. Lee Moffitt Cancer Center and Research Institute
Melanoma, Colon Cancer
Messenger RNA (mRNA)-Based, Personalized Cancer Vaccine Against Neoantigens Expressed by the Autologous Cancer
Background: Exome sequencing can identify certain gene mutations in a person's tumor. This can then be used to create cancer treatments.
- Conditions
- Melanoma, Colon Cancer, Gastrointestinal Cancer, Genitourinary Cancer
- Trial name
- NCT03480152
- Testing
- National Cancer Institute (NCI)-4650, a messenger ribonucleic acid (mRNA)-based, Personalized Cancer Vaccine
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- National Cancer Institute (NCI)
Breast Cancer, Lung Cancer
Ontario-wide Cancer TArgeted Nucleic Acid Evaluation
Substantial progress has been made in the treatment of cancer through the use of targeted therapies, but what works for one patient might not work for another patient.
- Conditions
- Breast Cancer, Lung Cancer, Colorectal Cancer, Melanoma
- Trial name
- OCTANE (NCT02906943)
- Where
- 7 sites in Canada
- Volunteers
- 10,000 people
- Sponsor
- University Health Network, Toronto
Bladder Carcinoma, Genitourinary System Neoplasm
Light Therapy and Occupational Therapy Fatigue Management-Based Intervention for Patients With Genitourinary Cancers
This clinical trial evaluates light therapy and occupational therapy in improving cancer related fatigue (CRF) patients with genitourinary cancers.
- Conditions
- Bladder Carcinoma, Genitourinary System Neoplasm, Kidney Carcinoma, Prostate Carcinoma
- Trial name
- NCT05519878
- Testing
- Best Practice, Bright White Light Therapy, Occupational Therapy
- Where
- United States
- Volunteers
- 224 people
- Sponsor
- City of Hope Medical Center
Prostate Carcinoma, Erectile Function
Low-Intensity Extracorporeal Shockwave Therapy on Penile Rehabilitation After Robot-assisted Surgical Treatment of Genitourinary Cancers
This prospective randomized controlled trial (RCT) is designed to provide high level evidence on the efficacy of Low-intensity Extracorporeal Shock Wave Therapy (Li-ESWT) in the treatment of post-Robot-Assisted (RA) Radical…
- Conditions
- Prostate Carcinoma, Erectile Function, Genito Urinary Cancer
- Trial name
- RCT_LiESWT (NCT06717711)
- Testing
- Low-intensity Extracorporeal Shock Wave Therapy (LiESWT), PDE5 inhibitor (tadalafil)
- Where
- 2 sites in Italy
- Volunteers
- 158 people
- Sponsor
- Regina Elena Cancer Institute
Malignant Digestive System Neoplasm, Malignant Female Reproductive System Neoplasm
Surgical Thromboprophylaxis Practices in Oncology Patients Within the NCORP Network, STOP-VTE Study
This study evaluates the use of extended venous thromboembolism prophylaxis (ePPx) following abdominopelvic cancer surgery within the NCI Community Oncology Research Program (NCORP) network, targeting surgeons and surgical…
- Conditions
- Malignant Digestive System Neoplasm, Malignant Female Reproductive System Neoplasm, Malignant Genitourinary System Neoplasm
- Trial name
- STOP-VTE (NCT07215624)
- Testing
- Non-Interventional Study
- Where
- 103 sites in United States, Puerto Rico
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Cancer, Cancer Central Nervous System
Prospective Data Registry and Quality of Life Assessment of Patients Undergoing Radiotherapy With the RefleXion Medical Radiotherapy System
The purpose of this prospective cohort study is to assess clinical and quality of life measures as well as to define the severity of adverse effects for the use of the RefleXion system to deliver intensity-modulated radiotherapy…
- Conditions
- Cancer, Cancer Central Nervous System, Cancer Thoracic, Cancer, Gastrointestinal
- Trial name
- PREMIER (NCT05406167)
- Testing
- Registry - Observational
- Where
- 5 sites in United States
- Volunteers
- 500 people
- Sponsor
- RefleXion Medical
Breast Cancer, Lung Cancer
Study of High-Precision Evaluation of Molecular ResiduaL Disease Through a PlatfOrm for Cancer TracKing and Interception (SHERLOCK)
This study will collect, annotate, and sequence biospecimens (blood, tissue, urine, saliva and surgery drainage) from patients across different cancer types to detect molecular residual disease (MRD).
- Conditions
- Breast Cancer, Lung Cancer, Melanoma, Gynecologic Cancer
- Trial name
- SHERLOCK (NCT07524114)
- Where
- Canada
- Volunteers
- 7,000 people
- Sponsor
- University Health Network, Toronto
Metastatic Gastrointestinal Cancer, Genitourinary Cancer
Next Generation pErsonalized tX(Therapy) With Plasma DNA Trial-2 in Refractory Solid Tumors (The NEXT-2 Trial)
Analysis of cell free DNA(cfDNA), unlike tissue biopsy, presents a new tool for the monitoring and treatment of cancer. The investigators have developed a differentiated sequencing assay, Digital Sequencing Technology (DST) that…
- Trial name
- NCT02140463
- Where
- South Korea
- Volunteers
- 229 people
- Sponsor
- Samsung Medical Center
Bladder Adenocarcinoma, Bladder Clear Cell Adenocarcinoma
Testing the Effectiveness of Two Immunotherapy Drugs (Nivolumab and Ipilimumab) With One Anti-cancer Targeted Drug (Cabozantinib) for Rare Genitourinary Tumors
This phase II trial studies how well cabozantinib works in combination with nivolumab and ipilimumab in treating patients with rare genitourinary (GU) tumors that has spread from where it first started (primary site) to other…
- Conditions
- Bladder Adenocarcinoma, Bladder Clear Cell Adenocarcinoma, Bladder Mixed Adenocarcinoma, Bladder Neuroendocrine Carcinoma
- Trial name
- NCT03866382
- Testing
- Biospecimen Collection, Bone Scan, Cabozantinib S-malate
- Where
- 582 sites in United States, Puerto Rico
- Volunteers
- 314 people
- Sponsor
- National Cancer Institute (NCI)
Bladder Cancer, Genitourinary Cancer
A Validation Study of MR Lymphangiography Using SPIO, a New Lymphotropic Superparamagnetic Nanoparticle Contrast
The goal of this clinical research study is to evaluate how well ferumoxtran-10, a new Magnetic Resonance Imaging (MRI) contrast agent, can detect cancer in the pelvic lymph nodes or malignant pelvic lymph nodes.
- Conditions
- Bladder Cancer, Genitourinary Cancer, Prostate Cancer
- Trial name
- NCT00147238
- Testing
- Ferumoxtran-10 (USPIO), MR lymphangiography
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- M.D. Anderson Cancer Center