Clinical trials: Genital Diseases, Female
Genital Neoplasms, Female
Intra-tumor Injection of Oncolytic Viruses H101 Combined With or Without Radiotherapy in Refractory/Recurrent Gynecological Malignancies
The purpose of this clinical trial is to evaluate the effectiveness and safety of oncolytic viruses H101 intra-tumor injection combined with or without radiotherapy in refractory or recurrent gynecological malignancies.
- Trial name
- NCT05051696
- Testing
- H101
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Liu Zi
Endometrial Cancer
Carboplatin, Paclitaxel With or Without Avelumab in Advanced or Recurrent Endometrial Cancer
This study aims to evaluate the safety and activity of the Avelumab in combination with Carboplatin-Paclitaxel in advanced or recurrent endometrial cancer
- Trial name
- MITO END-3 (NCT03503786)
- Testing
- Carboplatin, Paclitaxel, Avelumab
- Where
- 11 sites in Italy
- Volunteers
- 125 people
- Sponsor
- National Cancer Institute, Naples
Polycystic Ovary Syndrome, Glucose Profile
Glucose Profiles in Women With Polycystic Ovary Syndrome
Polycystic ovary syndrome is a very common condition that is associated with metabolic complications. Patients with polycystic ovary syndrome exhibit insulin resistance and are at greater risk to develop type 2 diabetes.
- Conditions
- Polycystic Ovary Syndrome, Glucose Profile, Insulin Resistance, Continuous Glucose Monitoring
- Trial name
- PROGLYSOPK (NCT07483723)
- Testing
- sensor, Age reader
- Where
- France
- Volunteers
- 80 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
HPV16 Positive, Cervical Intraepithelial Neoplasia (CIN 2/3)
Therapeutic Vaccination for Patients With HPV16+ Cervical Intraepithelial Neoplasia (CIN2/3)
This study will test the efficacy and safety of different routes of administration of a DNA vaccine in patients with HPV16+ CIN2/3. Subjects will be enrolled in one of six treatment groups.
- Trial name
- NCT00988559
- Testing
- DNA vaccination, Gene gun vaccine, intramuscular vaccination
- Where
- 3 sites in United States
- Volunteers
- 132 people
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Sexual Dysfunction
Erbium Laser for Treatment of Vaginal Looseness and Sexual Dysfunction.
Patients with a primary complaint of vaginal looseness and sexual dysfunction, visiting a sexual dysfunction clinic at a tertiary medical center will undergo randomization to either a series of 3 laser treatments or 3 sham…
- Trial name
- NCT04228679
- Testing
- Erbium laser
- Where
- Israel
- Volunteers
- 106 people
- Sponsor
- Rambam Health Care Campus
Ovarian Cancer
Establishing the Incidences of BRCA1 and BRCA2 Mutation by Combining DHPLC and Direct Sequencing in Ovarian Cancer
Ovarian cancer is the first mortality rate of gynecologic malignancies. The incidence of ovarian cancer increased in recent 10 years.
- Trial name
- NCT00155896
- Where
- Taiwan
- Volunteers
- 100 people
- Sponsor
- National Taiwan University Hospital
Ovarian Cancer
Efficacy and Safety Study of AVB-S6-500 in Patients With Platinum-Resistant Recurrent Ovarian Cancer
This is a Phase 1b/2 study of AVB-S6-500 in combination with pegylated liposomal doxorubicin (PLD) or paclitaxel (Pac) in patients with platinum resistant recurrent ovarian cancer.
- Trial name
- NCT03639246
- Testing
- AVB-S6-500, Paclitaxel (Pac), Pegylated liposomal doxorubicin (PLD)
- Where
- 16 sites in United States
- Volunteers
- 53 people
- Sponsor
- Aravive, Inc.
GYN Disorders
GENERATE - Next GENERATion of GynEcological Surgery - Robotic Assisted Surgery in Gynecological Indications
GENERATE - Next GENERATion of GynEcological Surgery - Robotic Assisted Surgery in Gynecological Indications Generate real-world evidence in the use of the da Vinci Surgical Systems for gynecological indications within the German…
- Trial name
- GENERATE (NCT05867927)
- Testing
- Robotic-assisted surgery (da Vinci), Non-da Vinci Surgery
- Where
- 15 sites in Germany
- Volunteers
- 1,250 people
- Sponsor
- Intuitive Surgical
Cervical Cancers
Phase II Trial Comparison of 3 vs 4 Fractions (BRACHY-FIT).
This is a prospective non-randomized clinical trial to evaluate the feasibility of 3 fraction versus a standard 4 fraction high dose rate brachytherapy regimen in patients with locally advanced cervical cancer.
- Trial name
- NCT07022470
- Testing
- 3-Fraction HDR Brachytherapy, 4-Fraction HDR Brachytherapy
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- Stanford University
Endometrial Cancer
Preoperative Risk Stratification in Endometrial Cancer for Tailoring Lymph Node Staging
The goal of this observational study is to evaluaty the accuracy of current risk stratification of patients with endometrial cancer and to redefine lymph node staging recommendations based on real-world clinical data.
- Trial name
- PRSTEC_multipr (NCT07368205)
- Testing
- No Intervention: Observational Cohort
- Where
- Czechia
- Volunteers
- 350 people
- Sponsor
- University Hospital Hradec Kralove
Ovarian Neoplasms
MRI in Ovarian Tumors
Role of multi paramrtric MRI and MRI perfusion in indetermint ovarian lesions by using ORADS MRI
- Trial name
- NCT05769205
- Testing
- MRI
- Volunteers
- 25 people
- Sponsor
- Assiut University
Ovarian Cancer, Fallopian Tube Cancer
DCVAC/OvCa and Standard of Care (SoC) in Relapsed Ovarian, Fallopian Tube, and Primary Peritoneal Carcinoma
Multi-center, phase III trial of DCVAC/OvCa added to standard of care treatments for relapsed ovarian cancer. Patients will receive study treatment until all doses are administered, or other criteria are met.
- Conditions
- Ovarian Cancer, Fallopian Tube Cancer, Peritoneal Carcinoma
- Trial name
- VITALIA (NCT03905902)
- Testing
- DCVAC/OvCa
- Sponsor
- SOTIO a.s.
Uterine Adenomyosis
Efficacy of Uterine Artery Embolization (UAE) in Management of Symptomatic Uterine Adenomyosis
Aim of the work: Evaluating the efficiency of uterine artery embolization as a minimally invasive method of treatment in management of symptomatic women with uterine adenomyosis
- Trial name
- NCT06652945
- Testing
- Uterine artery embolization
- Volunteers
- 30 people
- Sponsor
- Assiut University
Ovarian Cancer
Imatinib Mesylate in Combination With Docetaxel for Advanced, Platinum-Refractory Ovarian Cancer
Imatinib mesylate is an inhibitor of the receptor tyrosine kinases for platelet-derived growth factor (PDGF) and stem cell factor (SCF), c-Kit, and inhibits PDGF- and SCF-mediated cellular events.
- Trial name
- NCT00216112
- Testing
- Imatinib Mesylate, Docetaxel
- Where
- 9 sites in United States
- Volunteers
- 23 people
- Sponsor
- Daniela Matei, MD
Endometriosis
Evaluation of the Long-term Therapeutic Effect of High-Intensity Focused Ultrasound (HIFU) Treatment in Patients With Rectal Endometriosis
Evaluate the long-term effects of HIFU treatment for rectal endometriosis.
- Trial name
- ENDO HIFU FU (NCT07179419)
- Where
- France
- Volunteers
- 140 people
- Sponsor
- EDAP TMS S.A.
Endometrial Cancer, Extreme Obesity
Transvaginal Natural Orifice Endoscopic Surgery for Extremely Obese Patients With Early-stage Endometrial Cancer
The aim of this study is to investigate the feasibility and efficacy of the v-NOTES approach for extremely obese patients with early-stage type 1 endometrial cancer.
- Trial name
- NCT04240730
- Testing
- Transvaginal natural orifice endoscopic surgery for endometrial cancer staging
- Where
- Turkey (Türkiye)
- Volunteers
- 6 people
- Sponsor
- Dr. Lutfi Kirdar Kartal Training and Research Hospital
Ovarian Cancer
Determine if Either of 2 Doses of Study Drug Given With a Low-dose of Cyclophosphamide After a Complete or Partial Response to a Platinum-based Second-line Therapy in Women With Recurrent Ovarian Carcinoma Results in a Longer Time to Progression When Compared to the First Time to Progression.
The purpose of this study is to determine if either of two doses of EMD 273066 when given with a low dose of cyclophosphamide will result in a second time to progression that is as long or longer than the first time to progression
- Trial name
- NCT00408967
- Testing
- Tucotuzumab celmoleukin (EMD 273066)
- Sponsor
- EMD Serono
Infertility, Anovulation
A Phase III Clinical Study to Compare the Efficacy and Safety of DA-3801 and That of Gonal-F®
open label, active-controlled, randomized, parallel group, comparative study.
- Trial name
- NCT01820728
- Testing
- DA-3801 Injection, Gonal-F®
- Where
- South Korea
- Volunteers
- 93 people
- Sponsor
- Dong-A ST Co., Ltd.
Cervical Cancer
Testing an Implementation Science Tool to Increase Cervical Cancer Screening in Mombasa, Kenya
Cervical cancer is the most common cancer in women in sub-Saharan Africa, and the majority of cervical cancer mortality occur in low and middle income countries (LMICs).
- Trial name
- NCT03514459
- Testing
- Systems Analysis and Improvement Approach
- Where
- Kenya
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Washington
Endometrial Cancer, Squamous Non-Small Cell Lung Cancer
A Study to Assess the Efficacy and Safety of ABTL0812
A phase I/ II, open label study to assess the efficacy and safety of ABTL0812 in combination with paclitaxel and carboplatin in patients with advanced endometrial cancer or squamous NSCLC.
- Trial name
- Endolung (NCT03366480)
- Testing
- ABTL0812 in combination with paclitaxel and carboplatin
- Where
- Spain
- Volunteers
- 103 people
- Sponsor
- Ability Pharmaceuticals SL
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