Clinical trials: General Anesthesia With Propofol
Vitrectomy Operation Under General Anesthesia
Comparison Between Propofol-remifentanil Total Intravenous Anesthesia and Desflurane-remifentanil Balanced Anesthesia With Regard to Post-anesthetic Functional Recovery Measured With QoR-40 in Vitrectomy
Total intravenous anesthesia (TIVA) and inhalation anesthesia are both widely and safely used, and there are many clinical trials comparing these on various aspects of anesthesia.
- Trial name
- NCT02212340
- Testing
- fresofol and remifentanil, desflurane and remifentanil
- Where
- South Korea
- Volunteers
- 84 people
- Sponsor
- Yonsei University
General Anesthesia
Design of a Closed-loop Controller Based on the Bispectral Index (BIS) Effectiveness of the Smith Predictor
The action of anesthetics such as propofol is not immediate after intravenous administration. Delay in pharmacodynamic effect of intravenous drugs is a commonly observed phenomenon in total intravenous anesthesia (TIVA).
- Trial name
- NCT03073408
- Testing
- Propofol
- Where
- Spain
- Volunteers
- 50 people
- Sponsor
- José Antonio Reboso Morales
Carotid Artery Stenosis, Endarterectomy, Carotid
CAROTID ENDATORECTOMY AND GENERAL ANESTHESIA: Assessment and Evaluation of Cerebral Ischemic Damage With Clinical, Laboratory and Imaging Parameters
This study is aiming to provide us with information about the neuroprotective effect of two commonly used anesthetic drugs, during carotid endarterectomy.
- Conditions
- Carotid Artery Stenosis, Endarterectomy, Carotid, Ischemic Cerebrovascular Accident
- Trial name
- NCT07602400
- Testing
- MRI, Propofol (Astra-Zeneca), biomarkers
- Volunteers
- 160 people
- Sponsor
- University Hospital of Patras
Target Controlled Infusion, General Anesthesia
The Application of Target Controlled Infusion of Etomidate Combined With Propofol in the Maintenance of Anesthesia During Brain Surgeries
To explore the application of target controlled infusion of etomidate combined with propofol in the maintenance of anesthesia during brain surgeries.
- Trial name
- NCT02174120
- Testing
- propofol, etomidate
- Volunteers
- 120 people
- Sponsor
- Henan Provincial People's Hospital
Postoperative Delirium, Elderly Patient
Automated Administration of Intravenous Compared With Inhalatory Anesthesia on the Occurrence of Postoperative Delirium
The intravenous administration of anesthetic agents by a controller automatically-guided by an index of cerebral activity (i.e. the bispectral index) decreases the incidence of postoperative delirium, compared with an…
- Conditions
- Postoperative Delirium, Elderly Patient, General Anesthetic Drug Adverse Reaction
- Trial name
- AG-DPO (NCT03705728)
- Testing
- Propofol, Sevoflurane, Remifentanil automatic
- Where
- France
- Volunteers
- 1,000 people
- Sponsor
- Centre Clinical, France
Intravenous Anesthesia, Cholelithiasis
Time to Loss of Consciousness With Remimazolam Versus Propofol for Anesthetic Induction in Laparoscopic Cholecystectomy
The goal of this clinical trial is to compare two medicines used to induce general anesthesia in adults undergoing elective laparoscopic cholecystectomy.
- Trial name
- REMIPROP-LOC (NCT07717684)
- Testing
- Remimazolam, Propofol
- Where
- Brazil
- Volunteers
- 66 people
- Sponsor
- Universidade Federal de Sergipe
Anesthesia, Surgery
Frontal Electroencephalography of Neonatal Patients Under Sedation With Opioids and General Anesthesia With Propofol.
Frequently, neonates hospitalized in neonatology units require anesthesia for surgery. The drugs used for this purpose are opioids and other anesthetics, such as propofol.
- Conditions
- Anesthesia, Surgery, Neonate, Depth of Anesthesia
- Trial name
- NCT04904965
- Testing
- Propofol Group 1, Propofol Group 2, Propofol Group 3
- Where
- Chile
- Volunteers
- 20 people
- Sponsor
- Pontificia Universidad Catolica de Chile
General Anesthesia
Efficacy and Safety of HSK3486 Compared to Propofol for Adults Undergoing Elective Surgery With General Anesthesia
To demonstrate HSK3486 0.4/0.2 mg/kg (0.4 mg/kg intravenous [IV] slow injection over 30 [±5] seconds for the first dose, an additional 0.2 mg/kg if needed) is non-inferior to propofol 2.0/1.0 mg/kg (2.0 mg/kg IV slow injection…
- Trial name
- NCT05478174
- Testing
- HSK3486, Propofol
- Where
- 23 sites in United States
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Haisco-USA Pharmaceuticals, Inc.
Hemodynamic Instability, Anesthesia, General
Hemodynamics During Induction of General Anesthesia After Prophylactic Ephedrine, Phenylephrine or Norepinephrine.
In this trial the investigators want to examine if there is any difference in hemodynamic stability when giving equipotent prophylactic injections of ephedrine 0,1 mg/kg, phenylephrine 1 microg/kg, norepinephrine 0,1 microg/kg or…
- Conditions
- Hemodynamic Instability, Anesthesia, General, Anesthesia, Intravenous
- Trial name
- VH (NCT03864094)
- Testing
- Ephedrine, Phenylephrine, Norepinephrine
- Where
- Norway
- Volunteers
- 128 people
- Sponsor
- Helse Fonna
Anesthesia Recovery Period
Postoperative Quality of Recovery After General Anesthesia With Remimazolam
126 patients undergoing general anesthesia for elective surgery in Beijing Chaoyang Hospital were selected. In the intervention group, anesthesia was induced with remimazolam besylate at a rate of 6mg/min; Anesthesia was…
- Trial name
- NCT06332157
- Testing
- Remimazolam besylate, Propofol Injection Emulsion
- Volunteers
- 126 people
- Sponsor
- Beijing Chao Yang Hospital
Anesthesia, Intravenous, Hemodynamic Stability
Hemodynamic Effects of Remimazolam vs Propofol During Robot-assisted Gynecologic Surgery
This single-center study at CHA Ilsan Medical Center compares intraoperative hemodynamics between remimazolam- and propofol-based total intravenous anesthesia (TIVA) in patients undergoing robot-assisted gynecologic surgery…
- Conditions
- Anesthesia, Intravenous, Hemodynamic Stability, Gynecologic Surgery
- Trial name
- By_HD (NCT07251101)
- Testing
- Remimazolam, Propofol
- Where
- 2 sites in South Korea
- Volunteers
- 58 people
- Sponsor
- Ilsan Cha hospital
E03.155.253, Bispectral Index Monitor
The Use of Sedation Score and Bispectral Index for Induction in Geriatric Patients
The main objective of this clinical study is to determine the effectiveness of BIS-guided propofol administration in avoiding hypotension during propofol induction in geriatric patients.
- Conditions
- E03.155.253, Bispectral Index Monitor, Hypotension
- Trial name
- NCT06232980
- Testing
- urological surgical intervention
- Where
- Turkey (Türkiye)
- Volunteers
- 134 people
- Sponsor
- Ankara City Hospital Bilkent
Propofol, Anesthesia Brain Monitoring
Effect of Midazolam Bolus on Eleveld and Schnider TCI (Target Controlled Infusion) Models
No trials have evaluated the effect of a Midazolam bolus (routinely used for premedication before general anesthesia) on the Concnetration at the effector site of Propofol (CeP) of Eleveld and Schnider TCI models, routinely used…
- Trial name
- TCI (NCT05800288)
- Testing
- Propofol
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- University of Padova
Ischemic Stroke, Acute, Thrombectomy
Total Intravenous Anesthesia Versus Sevoflurane Anesthesia for Endovascular Thrombectomy in Acute Ischemic Stroke
The present clinical trial compares the effect of two general anesthesia (GA) modalities, the one with volatile anesthetic sevoflurane (endotracheal-intubated) and the other integrating total intravenous anesthesia (TIVA) with…
- Conditions
- Ischemic Stroke, Acute, Thrombectomy, General Anesthesia, Total Intravenous Anesthesia
- Trial name
- NCT05493813
- Testing
- Cognitive function and delirium evaluation, Neurological functional assessment
- Where
- Taiwan
- Volunteers
- 298 people
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Pregnancy Complications, Anesthesia
Propofol Anesthesia and Perinatal Outcome
The effects of intravenous propofol administration for general anesthesia in cesarean deliveries on maternal and infant health will be evaluated in relation to maternal and umbilical cord blood propofol levels.
- Trial name
- PA-Perinatal-O (NCT07035899)
- Testing
- Caesarean Section
- Where
- Turkey (Türkiye)
- Volunteers
- 102 people
- Sponsor
- Haseki Training and Research Hospital
Major Depression
Study of Psilocybin Under Anesthesia Controlled by EEG
Major depressive disorder (MDD) affects millions of Americans and remains difficult to treat. Psilocybin, a psychedelic compound, has shown promise for reducing depression symptoms, but a key challenge in psychedelic research is…
- Trial name
- SPACE (NCT07479550)
- Testing
- Psilocybin (Usona Institute), Propofol
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Stanford University
Deep Sedation, Anesthesia, General
Addition of Nitrous Oxide and Its Effects on Depth of Anesthesia
The study hypothesizes that adding 60% nitrous oxide to a steady state sevoflurance or propofol anesthetic will lead to a decrease in both BIS and Entropy indices during a constant level of surgical stimulus
- Trial name
- N20 (NCT00717574)
- Testing
- Sevoflurane group, Propofol group
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- University of Oklahoma