Clinical trials: General Anesthesia With Propofol
Opioids, Clinical Trial
The Comparative Efficacy and Safety of Two General Anesthesia Protocols Consisting of Fentanyl Plus Propofol Plus Rococuronium Plus Isoflurane Versus Ketamime Plus Magnesium Sulphate Plus Lidocaine Plus Clonidine Plus Propofol Plus Rococuronium Plus Isoflurane for Gynaecology Surgery in Cameroon
Recently, a lot of side effects have been identified from the perioperative use of opioids. To remedy this, anesthesia research has recently focused on providing safe general anesthesia without opioids in a new concept or…
- Conditions
- Opioids, Clinical Trial, Anesthesia, Gynecology
- Trial name
- OFA-AFRO (NCT04737473)
- Testing
- Opiod Free Anesthesia
- Where
- Cameroon
- Volunteers
- 36 people
- Sponsor
- University of Yaounde 1
Anesthesia
Prediction of Propofol Effect-Site Concentration Associated With Deep Anesthesia
The goal of this observational study is to explore the variability of the concentration at the effect site (Ce) of propofol to reach deep anesthesia (DA) during induction of general anesthesia in adults.
- Trial name
- PRESCOD-AI (NCT06346158)
- Testing
- Cognitive testing, electroencephalogram, High density electroencephalogram
- Where
- Canada
- Volunteers
- 110 people
- Sponsor
- Ciusss de L'Est de l'Île de Montréal
General Surgery With Endotracheal Intubation
The Effect Site Concentration of Remifentanil for Preventing QTc Interval Prolongation During Intubation Under Propofol-remifentanil Anesthesia in Elderly Patients
To find out the effect site concentration of remifentanil for preventing QTc interval prolongation during intubation under propofol-remifentanil anesthesia in elderly patients
- Trial name
- NCT01720498
- Testing
- remifentanil
- Where
- South Korea
- Volunteers
- 50 people
- Sponsor
- Severance Hospital
Etomidate is Mixed With Propofol
Etomidate/Propofol Mixture or Propofol Monotherapy Use in Patients Undergoing General Anesthesia
The purpose of this study was to investigate the effects of different proportions of etomidate/propofol mixture and propofol alone intravenous anesthesia on intraoperative and postoperative physiological indicators and…
- Trial name
- NCT03855267
- Testing
- Propofol 20 MG/ML, Propofol 20 mg/ml , etomidate 2 mg/ml
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Guolin Wang
Anesthesia, Intravenous
Comparison of Recovery Profile After TIVA Between Remimazolam With Flumazenil and Propofol
This prospective, randomized, single-blinded study is designed to compare the recovery profile between propofol-based total intravenous anesthesia (TIVA) and remimazolam-based TIVA in patients undergoing thyroidectomy.
- Trial name
- NCT05047939
- Testing
- remimazolam-based TIVA, propofol-based TIVA
- Where
- South Korea
- Volunteers
- 58 people
- Sponsor
- Seoul National University Hospital
Recovery
Comparison of Recovery From General Anesthesia in Remimazolam With Flumazenil vs. Propofol
This prospective randomized trial aims to compare recovery time from discontinuation of remimazolam followed by flumazenil administration vs.
- Trial name
- NCT05435911
- Testing
- REMIMAZOLAM BESYLATE 2.5 Mg in 1 mL INTRAVENOUS INJECTION, POWDER, LYOPHILIZED, for SOLUTION [BYFAVO], Flumazenil, Propofol
- Where
- South Korea
- Volunteers
- 66 people
- Sponsor
- Seoul National University Hospital
General Anesthesia
The Optimal Time to Put Laryngeal Mask Airway in the Mouth Under General Anesthesia
Laryngeal mask airway (LMA) is routinely used for some patients who have surgery under general anesthesia. LMA is placed in the mouth and allow the anesthesia to be given without having to put a breathing tube in the throat.
- Trial name
- LMA (NCT00972491)
- Testing
- Insertion of Laryngeal Mask Airway
- Where
- United States
- Volunteers
- 198 people
- Sponsor
- Tufts Medical Center
Cognitive Functioning, Propofol
The Effect of General Anesthesia with Remimazolam and Propofol on Rhythmic State and Cognitive Function
This study want to observe the effects of remimazolam and propofol for general anesthesia on postoperative rhythm and cognitive function.
- Conditions
- Cognitive Functioning, Propofol, Remimazolam, Circadian Rhythm
- Trial name
- NCT06775366
- Testing
- Remimazolam, propofol
- Where
- China
- Volunteers
- 174 people, healthy volunteers welcome
- Sponsor
- The Second Affiliated Hospital of Chongqing Medical University
Elective Surgery Requiring Laryngeal Mask Airway General Anesthesia
ED90 of Tegileridine Combined With Propofol for LMA Insertion
This is a prospective two-group dose-finding trial using biased-coin sequential up-and-down design. We plan to enroll 108 patients who need general anesthesia with laryngeal mask airway placement, divided into young group (18-64…
- Trial name
- NCT07665151
- Testing
- Tegileridine combined with Propofol for anesthesia induction
- Where
- China
- Volunteers
- 109 people
- Sponsor
- Shiyou Wei
General Anaesthesia, Depth of Anaesthesia
Epileptiform EEG Patterns During Induction of General Anaesthesia With Sevoflurane Compared to Those With Propofol
The aim of the study was to assess the influence of volatile induction of general anaesthesia with sevoflurane using two different techniques and intravenous anaesthesia with propofol on the possible presence of epileptiform…
- Conditions
- General Anaesthesia, Depth of Anaesthesia, Intraoperative Awareness, Seizures
- Trial name
- EEG (NCT03209323)
- Testing
- electroencephalography (EEG), bispectral index (BIS), response and state entropy (RE and SE)
- Where
- Poland
- Volunteers
- 60 people
- Sponsor
- Medical University of Silesia
Anesthesia
The PROTECT Trial: PROpofol Titration to Enhance haemodynamiC sTability
The aim of this multicentre, single-blinded, expertise-based randomised controlled trial is evaluate whether slowly increasing the dose of the anaesthetic drug propofol based on a patient's needs leads to more stable blood…
- Trial name
- NCT06980688
- Testing
- Propofol titration, Conventional propofol induction
- Where
- 4 sites in Switzerland
- Volunteers
- 320 people
- Sponsor
- University Hospital, Basel, Switzerland
General Anesthesia With Propofol, Closed-Loop
Feasibility of Closed-loop TCI Based on New EEG Baseline in the Presence of Low Dose of Esketamine
The propofol-remifentanil closed-loop TCI system based on EEG guidance has been clinically verified, which enables more precise anesthetic dosing.
- Trial name
- NCT06729892
- Testing
- Esketamine at low dose, new BIS baseline, an equivalent dose of saline
- Volunteers
- 120 people
- Sponsor
- bo xu
Cerebral Hypoxia, Postoperative Delirium
Sevoflurane Decreases the Risk of Postoperative Delirium After Cerebral Hypoxemia During Surgery
The aim of this study is to distinguish possible differences in frequency of delirium after Volatile Induction and Maintenance of Anesthesia and Total Intravenous Anesthesia in case of undeliberate cerebral desaturation during…
- Trial name
- NCT02133638
- Testing
- Sevoflurane, Propofol
- Where
- Russia
- Volunteers
- 130 people
- Sponsor
- Negovsky Reanimatology Research Institute
Patients Undergoing Robotic Surgery
Quality of Recovery After Robotic Surgery
Robotic approach to laparoscopic surgery has greatly facilitated undertaking complex surgery inside the abdominal cavity with ease.
- Trial name
- NCT03659539
- Testing
- PROPOFOL, Desflurane
- Where
- India
- Volunteers
- 120 people
- Sponsor
- Nitin Sethi, DNB
Rotator Cuff Tears, Rotator Cuff Injuries
Total Intravenous Anesthesia With Propofol vs. General Anesthesia in Outpatient Shoulder Arthroscopic Surgeries
This study is comparing total intravenous anesthesia with propofol with a regional nerve block against general anesthesia with a regional nerve block on the primary endpoint of time to meet discharge criteria.
- Conditions
- Rotator Cuff Tears, Rotator Cuff Injuries, Orthopedic Disorder, Sports Injury
- Trial name
- TIVA (NCT04793022)
- Testing
- TIVA with Propofol, Inhaled Anesthesia
- Where
- United States
- Volunteers
- 192 people, healthy volunteers welcome
- Sponsor
- Carilion Clinic
General Anesthesia With Propofol
Comparison Between Ondansetron 8 mg and Lidocain 40 mg in Preventing Pain Due to Propofol Injection
This study aims to compare the effectivity between ondansetron 8 mg and lidocain 40 mg in preventing pain due to propofol injection
- Trial name
- NCT03134612
- Testing
- Ondansetron 8 mg, Lidocain 40 mg
- Where
- Indonesia
- Volunteers
- 104 people
- Sponsor
- Universitas Indonesia
Hypnotic Effect
Monitoring of Hypnosis State During General Anesthesia With Propofol by Patient State Index From SEDLine®
The purpose of this study is the evaluation of possible relationships and correlation between PSI values obtained from the SEDLine® monitor and the infusion rate of propofol during general anesthesia.
- Trial name
- NCT02706665
- Testing
- SEDline monitor
- Where
- Spain
- Volunteers
- 12 people
- Sponsor
- Hospital Universitario de Canarias
General Anesthesia
Safety and Efficacy of HSK3486 Compared to Propofol for Induction of General Anesthesia in Adults With Elective Surgery
To demonstrate HSK3486 0.4/0.2 mg/kg (0.4 mg/kg intravenous [IV] slow injection over 30 [±5] seconds for the first dose, an additional 0.2 mg/kg if needed) is non-inferior to Propofol 2.0/1.0 mg/kg (2.0 mg/kg IV slow injection…
- Trial name
- NCT05486416
- Testing
- HSK3486, Propofol
- Where
- 28 sites in United States, Poland and 1 more
- Volunteers
- 465 people, healthy volunteers welcome
- Sponsor
- Haisco-USA Pharmaceuticals, Inc.
Patients Requiring Ambulatory Surgery Under General Anesthesia
Propofol for Supreme LMA Insertion With and Without Remifentanil
The aims of this study were to determine the clinically required concentration of propofol for LMA Supreme insertion, and to examine to what extent remifentanil reduces the dose of propofol and improves conditions for it's…
- Trial name
- SC50 (NCT01974648)
- Testing
- propofol, propofol and remifentanil
- Where
- Spain
- Volunteers
- 59 people
- Sponsor
- Hospital General Universitario Gregorio Marañon
Anaesthesia
General Anesthesia With Xenon in Inspiratory Concentrations of 50% and 70% and Total I.V. Anaesthesia.
The purpose of this study is to evaluate the quantity of propofol administered with Xenon in two inspiratory concentrations, to maintain comparable depth of anaesthesia during the maintenance period of general anaesthesia.
- Trial name
- NCT00919126
- Testing
- Xenon, Medical Air in Oxygen
- Where
- 6 sites in France, Germany and 1 more
- Volunteers
- 102 people
- Sponsor
- Air Liquide SA