Clinical trials: Gastrointestinal Hemorrhage
Lower GI Bleeding
Safe Discharge in Lower Gastrointestinal Bleeding
The increasing incidence in lower gastrointestinal bleeding (LGIB) leads to a rise in hospital admission. Many LGBI are self-limiting thus the several scores to identify low risk patients suited to outpatient care have been…
- Trial name
- NCT06409988
- Testing
- Safe discharge
- Where
- Spain
- Volunteers
- 398 people
- Sponsor
- Germans Trias i Pujol Hospital
Peptic Ulcer Hemorrhage
Effect of High-dose Oral Rabeprazole on Recurrent Bleeding After the Endoscopic Treatment of Bleeding Peptic Ulcers
This study is conducted to compare and evaluate the effect of administering a high-dose intravenous proton pump inhibitors or high-dose oral Rabeprazole in preventing recurrent bleeding after the endoscopic treatment of bleeding…
- Trial name
- NCT00838682
- Testing
- omeprazole sodium IV, Rabeprazole
- Where
- 2 sites in South Korea
- Volunteers
- 106 people
- Sponsor
- The Catholic University of Korea
Acute Upper Gastrointestinal Bleeding
To Compare a Hemostatic Powder TC-325 and Standard Treatment in the Control of Acute Upper Gastrointestinal Bleeding From Nonvariceal Causes
Acute upper gastrointestinal bleeding is a common medical emergency. Bleeding peptic ulcers and other non-variceal causes constitute to about 95% of all cases of bleeding.
- Trial name
- TC325 (NCT02534571)
- Testing
- Endoscopic Application of a Hemostatic Powder TC-325, Hemo-clipping, Epinephrine
- Where
- China
- Volunteers
- 224 people
- Sponsor
- Chinese University of Hong Kong
Gastrointestinal Hemorrhage
Assessment of Combined Bowel Preparation for Capsule Endoscopy Study
The investigators are conducting a study to see if taking a bowel preparation before having a capsule endoscopy is more helpful than the standard preparation of not eating after 7 PM the night before a capsule endoscopy in making…
- Trial name
- CEPREP (NCT01243736)
- Testing
- Combination Prep
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Mayo Clinic
Upper Gastrointestinal Bleeding
Awareness of Iron Status Evaluation in UGIB
BACKGROUND: Data on the awareness of the need to evaluate iron status and IDA prevalence in acute UGIB are limited. OBJECTIVES: This study aimed to investigate the rate of evaluation of iron status and prevalence of iron…
- Trial name
- AISE (NCT06299007)
- Where
- Thailand
- Volunteers
- 867 people
- Sponsor
- Hat Yai Medical Education Center
Cirrhosis, Portal Hypertension
A Study Evaluating the Utility of Ambrisentan in Lowering Portal Pressure in Patients With Liver Cirrhosis
Endothelin is a human hormone which has been associated with increased portal pressure in patients with liver cirrhosis (also called portal hypertension). Ambrisentan blocks the effects of endothelin.
- Conditions
- Cirrhosis, Portal Hypertension, Ascites
- Trial name
- NCT03827200
- Testing
- Ambrisentan
- Where
- 6 sites in Spain
- Volunteers
- 19 people
- Sponsor
- Noorik Biopharmaceuticals AG
Gastrointestinal Vascular Malformation
the Efficiency of Thalidomide for Recurrent Small Intestinal Bleeding Due to Gastrointestinal Vascular Malformation
Gastrointestinal vascular malformation (GIVM), which is an important cause of acute or chronic gastrointestinal bleeding, currently lacks of effective treatment.
- Trial name
- NCT02707484
- Testing
- Thalidomide (100mg), Thalidomide (50mg)
- Where
- 10 sites in China
- Volunteers
- 150 people
- Sponsor
- Shanghai Jiao Tong University School of Medicine
Venous Thromboembolism, Esophagus Cancer
Venous Thromboembolism and Bleeding Risk in Patients With Esophageal Cancer
This study aims to assess the 6- and 12-month venous thromboembolism (VTE) and bleeding incidence from the start of cancer diagnosis in a retrospective cohort of patients with esophageal cancer.
- Conditions
- Venous Thromboembolism, Esophagus Cancer, Bleeding, Chemotherapy Effect
- Trial name
- VENETIA (NCT03646409)
- Testing
- Venous thromboembolic event, arterial thromboembolic event, bleeding events
- Where
- Netherlands
- Volunteers
- 542 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Gastrointestinal Hemorrhage
Pediatric Intensive Care Ulcer Prophylaxis Pilot Trial
This study tests the feasibility of a large study of stress ulcer prophylaxis in critically ill children. Children admitted to the Pediatric Intensive Care Unit who are expected to require mechanical ventilation for more than 48…
- Trial name
- PIC-UP (NCT02929563)
- Testing
- Pantoprazole
- Where
- 7 sites in Canada
- Volunteers
- 116 people
- Sponsor
- McMaster University
Variceal Hemorrhage, TIPS
TIPS vs. NSBB Plus Endotherapy for the Prevention of Variceal Rebleeding in NSBB Non-responders of Primary Prophylaxis
Variceal bleeding (VB) is a life-threatening complication of cirrhosis with a 6-week mortality of approximately 15%-20%. The 1-year rate of recurrent VB is approximately 60% in patients without prophylaxis treatment.
- Conditions
- Variceal Hemorrhage, TIPS, NSBB, Liver Cirrhosis
- Trial name
- NCT04207398
- Testing
- Transjugular intrahepatic portosystemic shunts, Nonselective β-blocker (NSBB)+ endoscopic band ligation (EBL)
- Volunteers
- 114 people
- Sponsor
- Air Force Military Medical University, China
Upper Gastrointestinal Bleeding, Hexacapron
The Use of Hexacapron in Upper Gastrointestinal Bleeding
The purpose of this study is to conduct a randomized control trial, double-blind study to compare Hexacapron with standard of care treatment to standard of care alone to evaluate the efficacy of adding effect of Hexacapron to…
- Conditions
- Upper Gastrointestinal Bleeding, Hexacapron, Hemostasis, Rebleeding
- Trial name
- HEXUGI (NCT02071316)
- Testing
- Hexacapron( Tranexamic acid), esomeprazole
- Where
- Israel
- Volunteers
- 300 people
- Sponsor
- Shaare Zedek Medical Center
Colorectal Cancer
An Observational Study to Learn About the Medicine - BEVACIZUMAB BS [Pfizer] in Colorectal Cancer Patients From Japan.
The purpose of this study is to look at the safety of BEVACIZUMAB BS [Pfizer] when it was used to colorectal cancer patients in real-world clinical setting in Japan.
- Trial name
- NCT07527832
- Testing
- Bevacizumab-Pfizer Biosimilar, Avastin
- Where
- Japan
- Volunteers
- 1,000 people
- Sponsor
- Pfizer
Decompensated Liver Cirrhosis
TIPS in Patients With Decompensated Liver Cirrhosis
This is a single center patient registry of patients receiving a transjugular intrahepatic portosystemic shunt (TIPS) at Hannover Medical School.
- Trial name
- NCT04801290
- Testing
- TIPS insertion
- Where
- Germany
- Volunteers
- 250 people
- Sponsor
- Hannover Medical School
Bleeding After GI Endoscopy
Endoscopic Application of Tranexamic Acid and Sucralfate in Gastrointestinal Tumor Bleeding: A Randomized Controlled Trial
Background Gastrointestinal bleeding is a common disease among the population in Taiwan, with gastrointestinal tumor bleeding accounting for 3-5% of cases.
- Trial name
- NCT07540026
- Testing
- 3g of sucralfate powder and 1.5g of tranexamic acid powder, Standard Treatment
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- National Cheng-Kung University Hospital
Gastroduodenal Ulcer, Marginal Ulcer
Comparison of Low Against High Regimen of Proton Pump Inhibitors for Treatment of Acute Peptic Ulcer Bleeding
Evaluate the efficacy of Two different regimens of proton pump inhibitors High against Low in the management of acute peptic ulcer bleeding
- Conditions
- Gastroduodenal Ulcer, Marginal Ulcer, Peptic Ulcer Hemorrhage
- Trial name
- NCT02724150
- Testing
- Omeprazole High dose, Omeprazole Low dose
- Where
- Syria
- Sponsor
- Damascus Hospital
Liver Cirrhosis, Portal Hypertension
Anticoagulation Therapy After Splenectomy in Cirrhosis Patient
1. Inclusion and Exclusion Criteria Inclusion criteria: Inpatients who received laparotomy or laparoscopic splenectomy according to clinical, B-ultrasound scan, CT or MRI diagnosis of cirrhosis and portal hypertension.
- Conditions
- Liver Cirrhosis, Portal Hypertension, Anticoagulant-induced Bleeding, Thrombosis
- Trial name
- ATASICP (NCT04397289)
- Testing
- Heparin and Rivaroxaban
- Where
- China
- Volunteers
- 70 people
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
LVAD, Frailty
Human/Machine Interface: What the HeartMate 3 ® Device Tells Us About the Future
Durable left ventricular assist devices (dLVAD) have been increasingly utilized since the mid to late 1990s, with an uptick of utility starting in 2010 following expanded indications for therapy to not only include a bridge to…
- Conditions
- LVAD, Frailty, GI Bleed, Right Heart Failure
- Trial name
- NCT06039176
- Testing
- HeartMate 3 (R) left ventricular assist device
- Where
- 7 sites in United States
- Volunteers
- 150 people
- Sponsor
- International Consortium of Circulatory Assist Clinicians
Hemorrhage, Gastrointestinal, Myocardial Infarction
A Study of Channeling in the Use of Nonprescription Paracetamol and Ibuprofen in an Electronic Medical Records Database: Evidence and Implications
The Purpose of this study is to examine whether evidence of channeling exists by analyzing within a cohort of participants with first prescriptions of single-ingredient paracetamol or ibuprofen (or both) whether participants with…
- Conditions
- Hemorrhage, Gastrointestinal, Myocardial Infarction, Stroke, Kidney Diseases
- Trial name
- NCT02830178
- Where
- United States
- Volunteers
- 144,337 people
- Sponsor
- Janssen Research & Development, LLC
Upper GI Bleeding
Clinical Risk Scores in Prediction Outcome of Acute UGIT Bleeding in Non Cirrhotic Patients
To compare the ability of 4 bleeding risk scoring systems (Glasgow -Blatchford score, MAP, H3B2 and ABC scores ) in prediction of: Need of intervention, Re bleeding, Thirty-day mortality, length of hospital stay
- Trial name
- NCT06254352
- Testing
- scoring system
- Volunteers
- 100 people
- Sponsor
- Assiut University
Portal Hypertension Related to Cirrhosis
Small Diameter TIPS in Patients with Severe Liver Atrophy and Variceal Bleeding
Portal hypertension is the most common complication in patients with end-stage liver cirrhosis. Portal hypertension-related complications, such as variceal bleeding, often lead to a poor prognosis.
- Trial name
- NCT06589531
- Testing
- During TIPS operation, shunt diameter or diameter of covered stent
- Volunteers
- 120 people
- Sponsor
- Huang Mingsheng