Clinical trials: Gastrointestinal Endoscopy
Crohn's Disease
Mucosal Healing Study in Crohn's Disease (CD)
The aim of the study will be to investigate the effect of certolizumab pegol on the intestinal mucosa in active Crohn's disease.
- Trial name
- MUSIC (NCT00297648)
- Testing
- Certolizumab pegol
- Where
- 19 sites in Belgium, France and 1 more
- Volunteers
- 89 people
- Sponsor
- UCB Pharma
Nasal Polyps
Efficacy and Safety of Depemokimab (GSK3511294) in Participants With Chronic Rhinosinusitis With Nasal Polyps
This study will evaluate the efficacy and safety of depemokimab (GSK3511294) in participants with Chronic rhinosinusitis with nasal polyps (CRSwNP).
- Trial name
- ANCHOR-1 (NCT05274750)
- Testing
- Depemokimab (GSK3511294)
- Where
- 105 sites in United States, Argentina and 9 more
- Volunteers
- 276 people
- Sponsor
- GlaxoSmithKline
Gastric Cancer, Colon Nos Polypectomy Tubular Adenoma
Phase III Open-labeled Study of NPO-11 in Patients Undergoing Therapeutic Upper Gastrointestinal Endoscopy
Patients who require therapeutic upper gastrointestinal endoscopy, such as polypectomy, endoscopic hemostasis, percutaneous endoscopic gastrostomy (PEG), endoscopic mucosal resection (EMR) and endoscopic submucosal dissection…
- Conditions
- Gastric Cancer, Colon Nos Polypectomy Tubular Adenoma, Gastric Adenoma
- Trial name
- NCT01411189
- Testing
- Menthol
- Where
- Japan
- Volunteers
- 33 people
- Sponsor
- Nihon Pharmaceutical Co., Ltd
Diagnostic, Procedures and Surgeries on or Through Accessible Mucous Membranes
Topical Application of Cocaine HCl 4% and 10% on Safety and Efficacy in Local (Topical) Anesthesia
This study aims to evaluate topical application of Cocaine HCl 4% and 10% on safety and efficacy in local (topical) anesthesia for diagnostic procedures and surgeries on or through accessible mucous membranes of the nasal…
- Conditions
- Diagnostic, Procedures and Surgeries on or Through Accessible Mucous Membranes, of the Nasal Cavities
- Trial name
- NCT01746940
- Testing
- Cocaine HCl 4% Topical Solution, Cocaine HCl 10% Topical Solution
- Where
- 2 sites in United States
- Volunteers
- 159 people, healthy volunteers welcome
- Sponsor
- Lannett Company, Inc.
Upper Gastrointestinal Bleeding
UI-EWD for Endoscopic Hemostasis of Bleeding Peptic Ulcers and Bleeding After EMR/ESD
UI-EWD (NextBiomedical Co, Incheon, South Korea), a new hemostatic powder for endoscopic treatment of high-risk bleeding peptic ulcers and bleeding after ESD/EMR.
- Trial name
- NCT02978391
- Testing
- UI-EWD Hemostatic system, epinephrine endoscopic injection (conventional therapy)
- Where
- 2 sites in South Korea
- Volunteers
- 76 people
- Sponsor
- Next Biomedical Co., Ltd.
Sedation
Study of Remimazolam Tosilate in Patients Undergoing Diagnostic Upper GI Endoscopy
The purpose of this study is to evaluate the safety and efficacy of the sedation for Remimazolam or Propofol in patients undergoing diagnostic upper GI endoscopy.
- Trial name
- NCT03425474
- Testing
- Remimazolam Tosilate, Propofol
- Where
- China
- Volunteers
- 378 people
- Sponsor
- Jiangsu HengRui Medicine Co., Ltd.
Colonoscopy, Endoscopy, Digestive System
Safety and Effectiveness of a Computer-Assisted Personalized Sedation (CAPS) Device for Propofol Delivery During Endoscopy
Patients routinely receive sedation during a colonoscopy or upper endoscopy (esophagogastroduodenoscopy; EGD) procedure. Propofol is a sedative that can be used during these procedures.
- Conditions
- Colonoscopy, Endoscopy, Digestive System, Conscious Sedation
- Trial name
- NCT00452426
- Testing
- Computer-Assisted Personalized Sedation (CAPS) Device (SEDASYS® System), benzodiazepines and opioid sedation
- Where
- 7 sites in United States
- Volunteers
- 1,000 people
- Sponsor
- Ethicon Endo-Surgery
Colonoscopy, Bowel Preparation
BLI800-480: A Safety and Efficacy Evaluation of 2 Different Bowel Cleansing Preparations in Adult Subjects
To compare the safety, tolerance and efficacy of SUPREP Bowel Prep Kit to an FDA approved control as bowel preparations prior to colonoscopy in adult patients.
- Conditions
- Colonoscopy, Bowel Preparation, Endoscopy
- Trial name
- NCT01786629
- Testing
- SUPREP Bowel Prep Kit, FDA approved bowel preparation containing electrolytes
- Where
- 10 sites in United States
- Volunteers
- 338 people
- Sponsor
- Braintree Laboratories
Pancreatic Pseudocyst(s)
AXIOS Stent & Delivery System Study
The Xlumena AXIOS Stent and Delivery System is an investigational device in the USA, and this study is being conducted under an Investigational Device Exemption (IDE) granted by the US Food and Drug Administration (FDA).
- Trial name
- NCT01419769
- Testing
- AXIOS Stent & Delivery System
- Where
- 7 sites in United States, Spain
- Volunteers
- 30 people
- Sponsor
- Xlumena, Inc.
Diabetes, Diabetes Type 2
Safety and Feasibility of Novel Therapy for Duodenal Mucosal Regeneration for Type II Diabetes
This is a multi-center, open-label study to assess the feasibility and preliminary safety of the Endogenex Device for endoscopic duodenal mucosal regeneration in patients with type 2 Diabetes inadequately controlled on 2-3…
- Conditions
- Diabetes, Diabetes Type 2, Diabetes Mellitus, Type 2, Glucose Metabolism Disorders
- Trial name
- REGENT-1-US (NCT05014204)
- Testing
- The Endogenex Device
- Where
- 3 sites in United States
- Volunteers
- 20 people
- Sponsor
- Endogenex, Inc.
Gastrointestinal Endoscopy, Gastrointestinal Polypectomy
Dose Rate Range Finding Study of Propofol for minimal-to Moderate Sedation on Upper & Lower Endoscopic Tests
Phase IIB study to find the optimal dose rate range of propofol to maintain minimal-to-moderate sedation for diagnostic gastrointestinal endoscopy and gastrointestinal polypectomy.
- Trial name
- NCT01189604
- Testing
- ICI35,868 (propofol)
- Where
- 2 sites in Japan
- Volunteers
- 123 people
- Sponsor
- AstraZeneca
Gastroesophageal Reflux Disease
Efficacy Study of AGSPT201 Tablet to Treat Gastroesophageal Reflux Disease
The purpose of this study is to evaluate treatment in Gastroesophageal Reflux Disease (GERD) patients (aged 18~75) with endoscopically proven GERD treated with AGSPT201 Tablet.
- Trial name
- AGSPT (NCT01400945)
- Testing
- AGSPT201 Tab contains S-pantoprazole
- Where
- South Korea
- Volunteers
- 154 people
- Sponsor
- Ahn-Gook Pharmaceuticals Co.,Ltd
Bowel Cleanliness
Monitoring of Safety and Tolerance of PICOPREP in Clinical Practice
A Confirmation of Safety, Tolerance and Efficacy of PICOPREP in Clinical Practice.
- Trial name
- NCT01748591
- Where
- 22 sites in Czechia
- Volunteers
- 3,324 people
- Sponsor
- Ferring Pharmaceuticals
Colonoscopy
Evaluating the Effectiveness of Colon Preparation for Endoscopy Using Specialized Clinical Nutrition
This study is an open, prospective, comparative diagnostic studies aimed at improving the colonoscopy results, by optimizing the way of preparation for endoscopy
- Trial name
- NCT02714296
- Testing
- Nutridrink 200 ml, Nutridrink compact protein
- Where
- Russia
- Volunteers
- 150 people
- Sponsor
- Nutricia Advanced
Sinusitis
Safety and Effectiveness Evaluation of the Sinusway Device for Endoscopy of the Nasal Cavity and Paranasal Sinuses
3NT flexible endoscope is a single-use disposable handheld endoscope that provides a means to visualize the nasal cavity and paranasal sinus space and deliver irrigation to treat the sinus ostia and spaces within the paranasal…
- Trial name
- NCT02502084
- Testing
- 3NT flexible endoscope
- Where
- 2 sites in Belgium, Israel
- Volunteers
- 17 people
- Sponsor
- 3NT Medical Ltd.
Colorectal Cancer
CB-17-08 Augmented Endoscopy System for Mucosal Lesion Detection During Colonoscopy for Colon Rectal Cancer.
The aim of this study is to assess the performance of the CB-17-08 to help endoscopists find potential mucosal polyps during the colonoscopy procedure, without significant noise disturbing the endoscopist attention, nor negative…
- Trial name
- NCT03954548
- Testing
- CB-17-08 CADe
- Where
- 10 sites in United States, Italy and 1 more
- Volunteers
- 249 people, healthy volunteers welcome
- Sponsor
- Cosmo Artificial Intelligence-AI Ltd
Esophageal Varices, Portal Hypertension
Use of Sanvar® With Endoscopic Treatment for the Control of Acute Variceal Bleeding
The main objective of this study is to determine the efficacy of early administration of Sanvar® in combination with endoscopic treatment for the control of acute variceal bleeding.
- Conditions
- Esophageal Varices, Portal Hypertension, Gastric Varices, Esophageal Bleeding
- Trial name
- NCT00331188
- Testing
- Sanvar® (vapreotide)
- Where
- 19 sites in United States
- Volunteers
- 70 people
- Sponsor
- Debiovision
Colorectal Polyps
Clinical Trial to Evaluate the Efficacy and Safety of SUBMO® as a Submucosal Injection Agent in Endoscopic Resection of Superficial Gastrointestinal Lesions.
The SUBMO-PIC01-2025 study evaluates whether SUBMO®, a submucosal injection hydrogel composed of high-molecular weight hyaluronic acid and methylene blue, is as effective and safe as normal saline for endoscopic resection of…
- Trial name
- NCT07448129
- Testing
- SUBMO® Submucosal Injection, Normal Saline (0.9% Sodium Chloride) with Surface Dye Injection
- Where
- 4 sites in Spain
- Volunteers
- 300 people
- Sponsor
- i+Med S.Coop.
Feeding Tube, Dysphagia
Safety and Usability Evaluation of the Fidmi Low-Profile Enteral Feeding Device
A First In Human Usability Open Label trial will be performed using the Fidmi Feeding device on 20 adult patients with a need for enteral feeding.
- Trial name
- Fidmi (NCT03007511)
- Testing
- Fidmi enhanced enteral feeding device
- Where
- 2 sites in Israel
- Volunteers
- 20 people
- Sponsor
- Fidmi Medical
Anastomotic Leaks
Study of Eso-SPONGE for Treating Leaks After Upper Gastrointestinal Surgery
To evaluate the safety and effectiveness of sponge-based Endoscopic Vacuum Therapy (EVT) using Eso-SPONGE for the treatment of anastomotic leaks in the upper gastrointestinal tract in a prospective multi-center study.
- Trial name
- DRAIN Upper (NCT07711093)
- Testing
- sponge-based Endoscopic Vacuum Therapy (EVT) using Eso-SPONGE
- Where
- United States
- Volunteers
- 74 people
- Sponsor
- Boston Scientific Corporation