Clinical trials: Gastrointestinal Disease
Pancreatic Cancer
Evaluation of GEMCITEST in Patients With Pancreatic Cancer and Treated by Chemotherapy
Pancreatic cancer has a 5-year overall survival rate around 5%. It is the 6th most common cancer in France (11 600 new annual cases in 2012) and the 4th leading cause of cancer deaths in France and Europe.
- Trial name
- GEMCIPANC (NCT03599154)
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Centre Georges Francois Leclerc
Resectable Esophageal Cancer
Circulating Tumor Cells as a Biomarker for Preoperative Prognostic Staging in Patients With Esophageal Cancer
Despite the availability of several preoperative diagnostic techniques, accurate pretreatment staging of esophageal cancer (EC) remains challenging.
- Trial name
- NCT01858805
- Testing
- esophagectomy
- Where
- Germany
- Volunteers
- 123 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Anal Cancer
ASSESSING THE GAY MALE EXPERIENCE WITH ANAL CANCER PREVENTION STRATEGIES
The purpose of this study is to describe current knowledge and opinions about anal cancer screening among men who have sex with men (MSM), as well as their experience receiving guideline-compliant care aimed at anal cancer risk…
- Trial name
- NCT05628194
- Testing
- Observational/Survery
- Where
- United States
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Hepatocellular Carcinoma
Role of CEUS as a Secondary Diagnostic Modality
To determine the role of contrast-enhanced ultrasound (CEUS) as a second-line imaging modality after gadoxetate-enhanced MRI (Gd-EOB-MRI) for identifying hepatocellular carcinoma (HCC) among at-risks observations.
- Trial name
- NCT04494022
- Testing
- contrast enhanced ultrasound
- Where
- South Korea
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
Inflammatory Bowel Diseases, Crohn's Disease
Transition of Inflammatory Bowel Disease (IBD) Patients From Pediatric to Adult Gastroenterologist (GI)
The purpose of this study is to determine if the program that has been made to ease the transition of care for adolescent patients with IBD from pediatric gastroenterology to adult gastroenterology is effective to reduce the risk…
- Conditions
- Inflammatory Bowel Diseases, Crohn's Disease, Ulcerative Colitis
- Trial name
- NCT00360022
- Testing
- Joint visits
- Where
- 2 sites in United States
- Volunteers
- 28 people
- Sponsor
- Vanderbilt University Medical Center
Intestinal Diseases, Ulcerative Colitis
Anti-Inflammatory Effects of Mango Polyphenolics in Inflammatory Bowel Disease
Bioactive compounds from mango are bioavailable and their anti-inflammatory efficacy has been demonstrated in animals and humans.
- Conditions
- Intestinal Diseases, Ulcerative Colitis, Crohn Disease
- Trial name
- NCT02227602
- Testing
- Mango polyphenolics
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Texas A&M University
Abdominal Pain
Effect of tDCS on Chronic Abdominal Visceral Pain in HCC Patients
To evaluate the effect of transcranial direct current stimulation (tDCS) applied to the motor cortex to reduce chronic abdominal visceral pain in a group of participants with hepatocellular carcinoma
- Trial name
- NCT02928237
- Testing
- transcranial direct current stimulation tDCS
- Volunteers
- 40 people
- Sponsor
- Assiut University
Pancreatic Cancer
CAR-NK Cells (CL-NK-001) in Pancreatic Cancer
This is a single-center, open-label, first-in-human, dose-escalation study in patients with pancreatic cancer.
- Trial name
- NCT06816823
- Testing
- CL-NK-001
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Changhai Hospital
Hepatitis C, Chronic, Heart Failure
Hepatitis C Virus(HCV) Heart and Lung Study
This is a multicenter study in Hepatitis C Virus (HCV) infected adult patients who also have advanced cardiac disease or advanced lung disease.
- Conditions
- Hepatitis C, Chronic, Heart Failure, Pulmonary Disease, Chronic Obstructive, Lung Diseases, Interstitial
- Trial name
- NCT02858180
- Testing
- Sofosbuvir/ledipasvir fixed dose combination(SOF/LDV FDC)
- Where
- 4 sites in United States
- Volunteers
- 15 people
- Sponsor
- Duke University
Gastrointestinal Hemorrhage, Volatile Organic Compounds
Volatile Organic Compounds (VOCs) of Exhaled Breath in Patients With GI Bleeding
Cross sectional case-control study investigating the difference of volatile organic compound in the exhaled breath of the patients with GI bleeding and normal population.
- Trial name
- NCT04226079
- Testing
- Collection of exhaled breath
- Where
- South Korea
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
Colitis, Ulcerative
A Study of LY3471851 in Adult Participants With Moderately to Severely Active Ulcerative Colitis (UC)
The reason for this study is to determine if the study drug LY3471851 is safe and effective in adult participants with active ulcerative colitis (UC). The study treatment will last about 52 weeks.
- Trial name
- INSTRUCT-UC (NCT04677179)
- Testing
- LY3471851
- Where
- 116 sites in United States, Argentina and 20 more
- Volunteers
- 81 people
- Sponsor
- Nektar Therapeutics
Crohn's Disease
PDA001 for the Treatment of Adults With Moderate-to-Severe Crohn's Disease
This Phase 2a study evaluated the efficacy, safety, and tolerability of intravenous human placenta-derived cells (PDA001) compared with placebo in adults with moderate-to-severe Crohn's disease.
- Trial name
- NCT01155362
- Testing
- Human Placenta-Derived Cells PDA001 Intravenous Infusion, Vehicle Control
- Where
- 13 sites in United States
- Volunteers
- 50 people
- Sponsor
- Celularity Incorporated
Hepatocellular Carcinoma
A Study to Evaluate the Safety, Tolerability and Efficacy of Cabozantinib in Patients With Hepatocellular Carcinoma and Impaired Liver Function
This is an prospective, interventional, non-randomized multicenter phase II study to evaluate the safety, tolerability and efficacy of Cabozantinib as a second-line therapy (after one prior systemic therapy) in patients with…
- Trial name
- CaboCHILD (NCT04454762)
- Testing
- Cabozantinib
- Where
- Germany
- Volunteers
- 20 people
- Sponsor
- Johannes Gutenberg University Mainz
Lymph Node Metastasis, Cancer of Rectum and Anus
A Prospective, Multicenter Randomized Controlled Study of the Application of Preoperative FOLFOXIRI Chemotherapy Combined With Lateral Lymph Node Dissection in Low- and Medium-lying Rectal Cancer With Lateral Lymph Node Metastasis
The goal of this clinical trial is to compare in newly diagnosed patients with resectable rectal cancer with lateral lymph node metastasis.
- Conditions
- Lymph Node Metastasis, Cancer of Rectum and Anus, Oxaliplatin, Intestinal Neoplasms
- Trial name
- NCT06048146
- Testing
- Experimental: FOLFOXIRI and Lateral lymph node dissection, Preoperative long-term concurrent chemoradiotherapy and Lateral lymph node dissection
- Where
- China
- Volunteers
- 180 people
- Sponsor
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences
Hepatolenticular Degeneration; Wilson
Performance and Safety of MEX-CD1 Low-volume Continuous Veno-venous Haemodialysis Medical Device for Copper-extraction in Patients With Wilson's Disease
The goal of this clinical trial is to test the MEX-CD1 hemodialysis medical device in patients suffering from Wilson's Disease. The main questions it aims to answer are: Does the device work as expected by removing the excess of…
- Trial name
- MEXWILS (NCT05917327)
- Testing
- Low-volume continuous veno-venous haemodialysis
- Where
- 4 sites in France, Spain
- Volunteers
- 1 people
- Sponsor
- Mexbrain
Cancer, Hepatocellular, Radiotherapy Side Effect
A Pilot Study For Patients Receiving Radiation Therapy for Liver Cancer
The purpose of this study is to evaluate the role of quantitative MR imaging and blood-based biomarkers to measure liver function in patients receiving radiation therapy for liver cancer or cancer that has spread to the liver.
- Trial name
- HepQuant (NCT06144827)
- Testing
- Multiparametric MRI scans, Multiparametric MRI scans + HepQuantShunt Test
- Sponsor
- Montefiore Medical Center
Insomnia Disorder
Investigating Racing Thoughts in Patients With Insomnia Disorder
Cognitive arousal has been identified as playing a key role in the inability to fall asleep or stay asleep. However, although people with insomnia frequently complain about racing thoughts appearing as soon as they get into bed…
- Trial name
- TIP (NCT04752254)
- Where
- France
- Volunteers
- 150 people
- Sponsor
- University Hospital, Strasbourg, France
Hepatocellular Carcinoma
Study of Anlotinib After Lenvatinib in Patients With Hepatocellular Carcinoma
This clinical study evaluates the efficacy and safety of anlotinib in patients with hepatocellular carcinoma who have progressed on lenvatinib treatment.
- Trial name
- ALTER-H-002 (NCT04080154)
- Testing
- Anlotinib
- Where
- China
- Volunteers
- 28 people
- Sponsor
- Shanghai Zhongshan Hospital
Crohn's Disease, Inflammatory Bowel Disease
GI Symptoms and Sleep Disturbances in Patients With Quiescent Crohns Disease
In this study we would like to clarify the effect of long lasting Crohn's Disease on motility of the gastrointestinal system in patient and the effect regarding sleep disturbances.
- Conditions
- Crohn's Disease, Inflammatory Bowel Disease, Sleep Disturbances
- Trial name
- NCT02245594
- Where
- Denmark
- Volunteers
- 20 people
- Sponsor
- University of Aarhus
Hepatocellular Carcinoma
Transarterial Chemoembolization Prior to Transplantation for Hepatocellular Carcinoma
The hope to treat more patients with hepatocellular carcinoma successfully is however tempered by the shortage of donors leading to an increasing waiting time for liver transplantation (LT).
- Trial name
- CATCH (NCT01676194)
- Testing
- Intra-arterial administration of DC BeadsR
- Where
- 7 sites in France
- Volunteers
- 7 people
- Sponsor
- Rennes University Hospital
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