Clinical trials: Gastrointestinal Cancers
Liver Cancer
Interventional X-ray and Scintigraphy Imaging of 99mTc-MAA During the Radioembolisation Pretreatment Procedure
To establish the safety and feasibility of interventional x-ray and scintigraphy imaging during the pre-treatment procedure of hepatic radioembolization
- Trial name
- IXSI (NCT06013774)
- Testing
- IXSI
- Where
- Netherlands
- Volunteers
- 12 people
- Sponsor
- UMC Utrecht
Metastatic Renal Cell Carcinoma, Advanced Urothelial Carcinoma
Study to Evaluate Ibrutinib Combination Therapy in Patients With Selected Gastrointestinal and Genitourinary Tumors
The purpose of this study is to evaluate the safety, tolerability, and efficacy of single agent ibrutinib or the combination treatments of ibrutinib with everolimus, paclitaxel, docetaxel, pembrolizumab or cetuximab in selected…
- Conditions
- Metastatic Renal Cell Carcinoma, Advanced Urothelial Carcinoma, Advanced Gastric Adenocarcinoma, Metastatic Colorectal Adenocarcinoma
- Trial name
- NCT02599324
- Testing
- ibrutinib, everolimus, paclitaxel
- Where
- 65 sites in United States, South Korea and 2 more
- Volunteers
- 263 people
- Sponsor
- Pharmacyclics LLC.
Hepatocellular Carcinoma
TACE Combined With Lenvatinib Versus TACE Sequential Lenvatinib in the Treatment of Intermediate/Advanced Liver Cancer
TACE(transcatheter arterial chemoembolization) has been recommended by domestic and international guidelines as the standard treatment for a subset of HCC patients with very high heterogeneity, including BCLC stage…
- Trial name
- NCT05220020
- Testing
- TACE(Transcatheter arterial chemoembolization), Lenvatinib
- Where
- China
- Volunteers
- 299 people
- Sponsor
- Sun Yat-sen University
Carcinoma, Hepatocellular
Comparison Study of Sorafenib and 5-fluorouracil/Mitomycin for Metastatic Hepatocellular Carcinoma
The aim of this study is to compare the efficacy of sorafenib to 5-fluorouracil/mitomycin in HCC patients with pulmonary metastasis whose intrahepatic tumors has been controlled with locoregional therapies.
- Trial name
- NCT01171482
- Testing
- 5-FU, Mitomycin, sorafenib
- Where
- South Korea
- Volunteers
- 5 people
- Sponsor
- Seoul National University Hospital
Colorectal Cancer
Adherence to Minimally Invasive Testing
Colorectal cancer (CRC) screening has been demonstrated to reduce long term disease burden and costs. Unfortunately, less than 65 % of age-eligible persons in the US are actually screened for CRC.
- Trial name
- ADMIT (NCT02251782)
- Testing
- Epi proColon Test, Fecal Immunochemical Test (FIT)
- Where
- 2 sites in United States
- Volunteers
- 490 people, healthy volunteers welcome
- Sponsor
- Epigenomics, Inc
Esophageal Squamous Cell Carcinoma
Endostar Combined With IP Second-line Treatment of Advanced Esophageal Squamous Cell Carcinomas
The aim of this study is to explore whether endostar combined with IP as treatment could improve progression-free surial time (PFS) and to evaluate the safety of the chemotherapy regimens
- Trial name
- NCT03797625
- Testing
- Irinotecan, DDP, Endostar
- Where
- China
- Volunteers
- 52 people
- Sponsor
- Fudan University
Gastric Cancer, Metaplasia
Reversal of Preneoplastic Metaplasia in the Stomach With MEK Inhibitor
This is a study of the safety and effectiveness of Trametinib treatment in patients who have received successful endoscopic submucosal resection of a Stage I gastric cancer.
- Conditions
- Gastric Cancer, Metaplasia, Stage I Gastric Cancer, Initial-onset Gastric Cancer
- Trial name
- NCT04454476
- Testing
- Trametinib treatment, Endoscopy
- Where
- 3 sites in Japan
- Volunteers
- 15 people
- Sponsor
- Vanderbilt-Ingram Cancer Center
Colorectal Cancer
Cetuximab Plus Combination Chemotherapy in Treating Patients With Stage IV Colorectal Cancer
RATIONALE: Monoclonal antibodies such as cetuximab can locate tumor cells and either kill them or deliver tumor-killing substances to them without harming normal cells.
- Trial name
- NCT00020917
- Testing
- cetuximab, fluorouracil, irinotecan hydrochloride
- Where
- United States
- Sponsor
- Memorial Sloan Kettering Cancer Center
Circulating Tumor Cell;, Hepatocellular Carcinoma
Decrease in Circulating Tumour Cell Count Reflects the Effectiveness of Postoperative Adjuvant Transarterial Chemoembolization (TACE) in Preventing Hepatocellular Carcinoma Recurrence
Circulating tumour cell (CTC) count could reflect the effect of postoperative transarterial chemoembolization (TACE) on hepatocellular carcinoma (HCC) recurrence.
- Trial name
- NCT02032368
- Testing
- transarterial chemoembolization (TACE)
- Where
- China
- Volunteers
- 57 people
- Sponsor
- Guangdong Provincial People's Hospital
Gastric Cancer
Phase III Study of Docetaxel + S-1 vs. S-1 for Advanced Gastric Cancer
The primary objective of this study is to compare median overall survival of the test arm (docetaxel and S-1) to the control arm (S-1 only) in subjects with advanced or recurrent gastric cancer.
- Trial name
- NCT00287768
- Testing
- docetaxel + S-1, S-1
- Where
- 116 sites in Japan
- Volunteers
- 628 people
- Sponsor
- Japan Clinical Cancer Research Organization
Metastatic Colorectal Cancer
Phase II Study of Anti-PD-1/VEGF Bispecific Antibody Ivonescimab in Patients With Previously Treated Metastatic Colorectal Cancer
The goal of this clinical research study is to learn if ivonescimab can help to control previously treated, metastatic colorectal cancer.
- Trial name
- NCT06959550
- Testing
- Ivonescimab
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- M.D. Anderson Cancer Center
Gastric Cancer
Neoadjuvant TACiE in Locally Advanced Gastric Cancer
This is a prospective, single-center, single-arm, phase 2 trial to evaluate the feasibility and safety of neoadjuvant transcatheter infusion and embolism (TACiE) in patients with locally advanced adenocarcinoma of stomach and…
- Trial name
- NCT05346874
- Testing
- Oxaliplatin, Teysuno, Transarterial chemoembolization (TACE)
- Where
- China
- Volunteers
- 37 people
- Sponsor
- Shanghai Zhongshan Hospital
Colorectal Surgery
Comparision of Air Versus CO2 for Distention During Sigmoidoscopy
Intra-operative colonoscopy (inserting a flexible endoscope with a camera at its tip through the anus and up into the rectum and colon) is most often indicated to locate or verify the location of small cancer, polyp, bleeding…
- Trial name
- NCT00771290
- Testing
- Air insufflation with standard endoscopy unit, CO2 insufflation for colonoscopy (special CO2 insufflation unit)
- Where
- United States
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Columbia University
Depression, Anxiety
Effects of CBT-Based Intervention Among Patients With Liver Cancer
This study investigates the effects of a CBT- based intervention on depression, anxiety, immune function, quality of life, and overall survival.
- Conditions
- Depression, Anxiety, Liver Cancer, CBT
- Trial name
- NCT05942560
- Testing
- Cognitive behavioural therapy-based intervention, Educational group
- Where
- China
- Volunteers
- 160 people
- Sponsor
- The Nethersole School of Nursing
Metastatic Colorectal Cancer
Real-World Effectiveness of Regorafenib in the Treatment of Patients With Metastatic Colorectal Cancer
Real-World Effectiveness of Regorafenib in the Treatment of Patients with Metastatic Colorectal Cancer- A Retrospective, Observational Study
- Trial name
- NCT05023720
- Testing
- nonintervention
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Henan Cancer Hospital
Hepatocellular Carcinoma
Prognosis Stratification for Advanced HCC Receiving TACE with PD-1/PD-L1 Inhibitors and Molecular Target Therapies
The purpose of this study is to establish a personalized model of prognosis stratification for patients with advanced-stage hepatocellular carcinoma (HCC) receiving transarterial chemoembolization (TACE) in combination with…
- Trial name
- NCT06607120
- Where
- China
- Volunteers
- 950 people
- Sponsor
- Zhongda Hospital
Stomach Neoplasms
Tumor Markers Study in Gastric Cancer for Cancer Immunotherapy (ONCO-RD 010 CRT)
Gastric cancer is one of the leading causes of cancer-related deaths worldwide. Despite advances in therapeutic intervention, the mortality from this disease remains high.
- Trial name
- ONCO-RD010CRT (NCT02686424)
- Volunteers
- 250 people
- Sponsor
- Seoul National University Hospital
Colon Cancer, Rectal Cancer
Clinical Study-evaluate Performance&Safety "Aer-O-Scope" in Colon of Low Risk Patients
A double center study to evaluate the safety and efficacy of the Aer-O-Scope in traveling through the colon in low risk subjects.
- Trial name
- NCT00867724
- Testing
- Aer-O-Scope Colonoscopy
- Where
- Israel
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- GI View Ltd.
Gastrointestinal Cancer, Frailty
Preoperative Frailty and Postoperative Outcomes in Older Patients Undergoing Surgery for Gastrointestinal Cancer
This prospective observational cohort study will evaluate whether preoperative frailty, assessed using the Fried Frailty Index and the Clinical Frailty Scale, is associated with postoperative outcomes in patients aged 60 years or…
- Trial name
- NCT07815392
- Testing
- Fried Frailty Index, Clinical Frailty Scale
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Van Training and Research Hospital
Stage III Colorectal Cancer
Genetic and Epigenetic Determinants of Response to Fluorouracil-based Adjuvant Chemotherapy in Patients With Stage III Colorectal Cancer
The goal of this laboratory research is to look for genetic and epigenetic markers that can predict which patients with stage III colorectal cancer will benefit from fluorouracil-based adjuvant chemotherapy.
- Trial name
- NCT03127111
- Testing
- Gene mutations analysis, Gene methylation analysis, Gene expression analysis
- Where
- China
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Renmin Hospital of Wuhan University
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