Clinical trials: Gastrointestinal Bleeding
GastroIntestinal Bleeding
Video Capsule Endoscopy for Detection of Gastrointestinal Bleeding in the Small Bowel
Small bowel capsule endoscopy is the main diagnostic standard for small bowel bleeding. This study investigates the detection rate of small bowel bleeding in capsule endoscopy and further endoscopic treatment in a prospective and…
- Trial name
- NCT05949268
- Testing
- Small bowel capsule endoscopy
- Where
- Germany
- Volunteers
- 1,300 people, healthy volunteers welcome
- Sponsor
- University Hospital Freiburg
Occult Gastrointestinal Bleeding, Upper Gastrointestinal Bleeding (UGIB)
PillSense Use in Anemia and Hemoccult
In this study, participants will be offered a PillSense™ capsule, a small capsule to swallow, which can detect the presence of blood in the upper digestive tract within about 10 minutes.
- Trial name
- PillSense™ (NCT06951490)
- Testing
- PillSense™
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- AdventHealth
Melena, Gastrointestinal Bleeding
A Study to Evaluate the Performance of a Wireless Optical Sensor Capsule in Detection of UGIB
Upper gastrointestinal bleeding (UGIB) is a common and potentially lethal medical emergency, which requires hospitalization and healthcare resources.
- Conditions
- Melena, Gastrointestinal Bleeding, Hematemesis
- Trial name
- Hemopill-Pro (NCT06715293)
- Testing
- Hemopill, OGD
- Where
- Hong Kong
- Volunteers
- 193 people
- Sponsor
- Chinese University of Hong Kong
Gastrointestinal Endoscopy, Upper Gastrointestinal Hemorrhage
TEAS for Variceal Bleeding Endoscopy in Cirrhosis
This randomized controlled trial evaluates whether transcutaneous electrical acupoint stimulation (TEAS) improves procedural success and patient tolerance in cirrhotic patients undergoing urgent unsedated endoscopy for suspected…
- Conditions
- Gastrointestinal Endoscopy, Upper Gastrointestinal Hemorrhage, Variceal Bleeding, Cirrhosis
- Trial name
- TEAS-VBE-C (NCT07106658)
- Testing
- TEAS + Urgent Endoscopy, Urgent Endoscopy Only
- Where
- China
- Volunteers
- 180 people
- Sponsor
- Beijing 302 Hospital
Gastrointestinal Bleeding
Tranexamic Acid for The Treatment of Gastrointestinal Bleeding
Studies showed that in cases of gastrointestinal bleeding, injection tranexamic acid decreasing the risk of death and the need of surgical intervention.
- Trial name
- NCT03540368
- Testing
- Tranexamic acid injection
- Where
- Indonesia
- Volunteers
- 48 people
- Sponsor
- Universitas Indonesia
Atrial Fibrillation (AF), Upper Gastrointestinal Bleeding (UGIB)
FENOX Trial (Comparative Effectiveness of Fexuprazan Co-therapy in Patients Receiving Non-Vitamin K Antagonist Oral Anticoagulants)
Background Non-vitamin K antagonist oral anticoagulants (NOACs) are recommended for stroke prevention in non-valvular atrial fibrillation (AF).
- Conditions
- Atrial Fibrillation (AF), Upper Gastrointestinal Bleeding (UGIB), Gastrointestinal Hemorrhage (Clinically Important, Upper), Drug-Related Side Effects and Adverse Reactions
- Trial name
- FENOX (NCT07497893)
- Testing
- Fexuprazan, NOAC therapy
- Where
- South Korea
- Volunteers
- 1,000 people
- Sponsor
- Ewha Womans University Mokdong Hospital
Gastrointestinal Bleeding
Capsule Endoscopy in GI Bleeding: A Retrospective Study
The goal of this observational study is to evaluate the diagnostic value and safety of capsule endoscopy in patients with gastrointestinal bleeding.
- Trial name
- NCT07481591
- Testing
- capsule endoscopy
- Volunteers
- 350 people
- Sponsor
- Changhai Hospital
Upper GI Bleeding, Proton Pump Inhibitors
PPI Infusion Versus Oral Acid Pump Inhibitors for Bleeding Peptic Ulcers
Vonoprazan (VPZ), an oral potassium-competitive acid blocker (P-CAB) has emerged as an alternative potent acid-suppressant.It has a faster onset of action in 1 day (3-5 days in PPI), and is more stable in acidic condition than…
- Trial name
- NCT05582174
- Testing
- Vonoprazan, esomeprazole
- Where
- 8 sites in China
- Volunteers
- 594 people
- Sponsor
- Chinese University of Hong Kong
Liver Cirrhosis, Gastrointestinal Bleeding
Utilizing of Physiological Parameters Predict the Prognosis of Cirrhotic Patients With Gastrointestinal Bleeding
Can physiological indicators such as quick Sequential Organ Failure Assessment , Shock Index, and its derived indicators such as Modified Shock Index , Age Shock Index and Respiratory Adjusted Shock Index accurately predict the…
- Trial name
- SI (NCT06680583)
- Testing
- physical indicators such as shock index relatives
- Where
- Taiwan
- Volunteers
- 150 people
- Sponsor
- St. Martin De Porress Hospital
Upper Gastrointestinal Bleeding (UGIB), High Risk Bleeding
A New Scoring System to Predict High-Risk Groups in Upper Gastrointestinal Bleeding
Upper gastrointestinal bleeding (UGIB) remains a common and potentially life-threatening emergency condition requiring early risk stratification to guide clinical management.
- Trial name
- UGIS (NCT07458178)
- Where
- Turkey (Türkiye)
- Volunteers
- 312 people
- Sponsor
- Izmir Katip Celebi University
Hemorrhage, Trauma
RE-BLEED: A Digital Platform for Identifying Bleeding Patients - a Feasibility Study
The RE-BLEED feasibility study aims to develop and test a real-time digital platform, whereby bleeding patients in-hospital can be identified and approached for their consent to participate in future research studies.
- Conditions
- Hemorrhage, Trauma, Gastro Intestinal Bleeding
- Trial name
- RE-BLEED (NCT05608577)
- Where
- United Kingdom
- Volunteers
- 40 people
- Sponsor
- University of Oxford
Gastrointestinal Bleeding
Yiwei Jiaohuang Ointment for Gastrointestinal Bleeding Associated With Oral Antithrombotic Agents
The goal of this clinical trial is to evaluate the clinical efficacy and safety of YiWei Jiaohuang Ointment in treating gastrointestinal bleeding associated with oral antithrombotic therapy.
- Trial name
- NCT07339956
- Testing
- A Chinese herb formula--Yiwei Jiaohuang Onitment, Rabeprazole Enteric-Coated Tablets
- Where
- China
- Volunteers
- 60 people
- Sponsor
- China-Japan Friendship Hospital
Upper Gastrointestinal Bleeding
Gastric CLEANsing by Intravenous AZithromycin in Urgent Endoscopy
This study will test the hypothesis that azythromycin is efficient and safe in cleansing the upper gastrointestinal tract for endoscopic examination in the case of acute bleeding.
- Trial name
- CLEAN-AZ (NCT06077916)
- Testing
- Azithromycin, Saline solution
- Where
- Romania
- Volunteers
- 224 people
- Sponsor
- Clinical Hospital Colentina
Gastrointestinal Bleeding
Management of Gastrointestinal Bleeding Under Direct Oral Anticoagulants
Gastrointestinal bleeding (GIB) is a common emergency in hepatology and gastroenterology, with an overall mortality rate ranging from 5% to 10% depending on the study.
- Trial name
- HEMOD-AOD (NCT07333144)
- Where
- France
- Volunteers
- 250 people
- Sponsor
- University Hospital, Strasbourg, France
Gastrointestinal Bleeding, Antiplatelet Agents
How Often Does the Fecal Test for Occult Blood Turn Positive After Using Blood Thinners?
Blood thinner medications used for cardiovascular disease can cause gastrointestinal bleeding. Early detection of invisible bleeding by performing occult fecal blood test (called fecal immunochemical test, or FIT) can uncover…
- Conditions
- Gastrointestinal Bleeding, Antiplatelet Agents, Oral Anticoagulant Therapy
- Trial name
- NCT07327853
- Testing
- Fecal Immunochemical Test (FIT)
- Where
- Jordan
- Volunteers
- 200 people
- Sponsor
- Jordan Collaborating Cardiology Group
Infection Wound, Gastrointestinal Complication
Tranexamic Acid to Reduce Infection After Gastrointestinal Surgery
This international, multicentre, pragmatic, double-blind, placebo-controlled, randomised trial of TxA versus placebo will enrol 3,300 patients throughout Australia and internationally.
- Conditions
- Infection Wound, Gastrointestinal Complication, Anesthesia, Bleeding
- Trial name
- TRIGS (NCT04192435)
- Testing
- Tranexamic Acid
- Where
- Australia
- Volunteers
- 3,300 people
- Sponsor
- Bayside Health
GastroIntestinal Bleeding
Acute Gastrointestinal Bleeding Peripheral Pulse Volume Changes
The purpose and aim of this study are to compare changes in pulse volume to non-invasively predict active bleeding or high-risk stigmata in patients undergoing a gastrointestinal endoscopy to assess feasibility of the flow meter…
- Trial name
- NCT06441201
- Testing
- Pulse flowmeter
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Mayo Clinic
Cap-assisted Endoscopy, Upper Gastro Intestinal Bleeding
Is Cap Assisted Endoscopy Useful in Acute Upper Gastrointestinal Bleeding ?
High digestive bleeding (HDH) is a medical emergency associated with high morbidity and mortality rates and significant healthcare costs. Upper endoscopy can locate the bleeding and treat it.
- Conditions
- Cap-assisted Endoscopy, Upper Gastro Intestinal Bleeding, Endoscopy
- Trial name
- CAP (NCT07268365)
- Testing
- upper endoscopy, CAP
- Where
- France
- Volunteers
- 72 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Carbon Footprint in Upper GI Endoscopy, Dyspepsia
The Difference in Carbon Footprint Between Diagnostic Upper GI Endoscopy in Dyspeptic Patients Versus Therapeutic Upper GI Bleeding
The goal of this observational study is to learn about the carbon footprint produced from diagnostic upper GI endoscopy in patients with dyspepsia and therapeutic upper GI endoscopy in patients with non-variceal upper GI…
- Conditions
- Carbon Footprint in Upper GI Endoscopy, Dyspepsia, Non-variceal Upper Gastrointestinal Bleeding
- Trial name
- NCT07261228
- Where
- 2 sites in Thailand
- Volunteers
- 75 people
- Sponsor
- King Chulalongkorn Memorial Hospital
Esophageal Varices, Liver Cirrhoses
Comparison of 24-hours Versus 72-hours of Octreotide Infusion in Preventing Early Rebleed From Esophageal Varices
This study evaluates the safety and efficacy of 24-hour vs 72-hour octreotide infusion after variceal banding in cirrhotic patients with bleeding esophageal varices.
- Conditions
- Esophageal Varices, Liver Cirrhoses, Bleeding Esophageal Varices, Upper Gastrointestinal Bleeding
- Trial name
- LOVARB (NCT03624517)
- Testing
- Octreotide
- Where
- 8 sites in United States
- Volunteers
- 34 people
- Sponsor
- Medical University of South Carolina