Clinical trials: Gastroenteritis
Eosinophilic Esophagitis
Comparison of Histology From a Mesh Sponge and Traditional Esophageal Biopsies in Children and Adolescents With EoE
The aim of the present study is determining the accuracy, safety and tolerance of the CytospongeTM (expandable sponge within a gelatin capsule attached to a string) relative to traditional upper endoscopy and esophageal biopsies…
- Trial name
- NCT05342168
- Testing
- Using a swallowed expanding sponge (Cytosponge TM) to obtain sampling of the esophageal musosa
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- The Hospital for Sick Children
Gastroenteritis
Clinical Trial to Investigate the Efficacy and Safety of Ondansetron (Danset - Adwia) Versus Placebo Plus the Standard of Care in the Treatment of Nausea and Vomiting in Adult Patients With Acute Gastroenteritis
A Randomized, Open-label, Active-Controlled Clinical Trial to Investigate the Efficacy and Safety of Ondansetron compared to Metoclopramide in the management of Nausea and Vomiting in Adult Patients with Acute Gastroenteritis.
- Trial name
- NCT05876585
- Testing
- Ondansetron 8 mg ampoule, Metoclopramide 10 mg ampoule
- Volunteers
- 126 people
- Sponsor
- Genuine Research Center, Egypt
Sepsis, Gastroenteritis
Utility of Ultrasound Assessment of the Inferior Vena Cava in Patients With Sepsis and Dehydration
Conduct a randomized, controlled trial looking at how the use of ultrasound analyzing the inferior vena cava impacts the management and outcomes of pediatric emergency department patients undergoing evaluation and treatment of…
- Conditions
- Sepsis, Gastroenteritis, Dehydration
- Trial name
- NCT02568189
- Testing
- SonoSite Maxx Series Ultrasound System
- Where
- United States
- Volunteers
- 112 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Crohn's Disease, Crohn Disease
High-dose Cyclophosphamide for Severe Refractory Crohn Disease
This research is being done to see if people with Crohn's disease who receive high-dose cyclophosphamide have an improvement of their disease, how long the benefit may last, and how safe cyclophosphamide is.
- Trial name
- NCT01836289
- Testing
- High-dose Cyclophosphamide
- Sponsor
- Johns Hopkins University
Inflammatory Bowel Diseases (IBD), Crohn's Disease (CD)
Fecal Microbiota Transplantation in Pediatric Patients
A disturbance in the diversity of gut bacterial composition could be linked to several immune mediated diseases including inflammatory bowel diseases (IBD).
- Conditions
- Inflammatory Bowel Diseases (IBD), Crohn's Disease (CD), Ulcerative Colitis (UC)
- Trial name
- FMT (NCT02108821)
- Testing
- Fecal Microbiota Transplantation (FMT)
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Children's Mercy Hospital Kansas City
Refractory Multiple Myeloma, Stage I Multiple Myeloma
Randomized Trial of Cryotherapy Duration Prior to High Dose Melphalan in Myeloma Patients
The purpose of this study is to compare the effect of short-term (2 hours/120 minutes) and long-term (6 hours/360 minutes) schedules of crushed ice therapy (cryotherapy).
- Conditions
- Refractory Multiple Myeloma, Stage I Multiple Myeloma, Stage II Multiple Myeloma, Stage III Multiple Myeloma
- Trial name
- NCT01653106
- Testing
- cryotherapy, questionnaire administration, pharmacological study
- Where
- United States
- Volunteers
- 148 people
- Sponsor
- Ohio State University Comprehensive Cancer Center
Mucositis
Comparing Triamcinolone Acetonide Mucoadhesive Films With Licorice Mucoadhesive Films
Abstract: Background: Complementary and alternative medicine (CAM) had proven efficacy in pain relief, correction of nutritional status and improving the performance status.
- Trial name
- NCT02075749
- Testing
- Triamcinolone Acetonide, licorice mucoadhesive films
- Where
- Iran
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Isfahan University of Medical Sciences
Infections, Rotavirus
Effectiveness of Rotarix™ Against Rotavirus Severe Gastroenteritis (RV SGE) in Infants in Panama
This study aims to estimate the effectiveness of Rotarix™ vaccine which is used nationwide as a part of the expanded program on immunization (EPI), in preventing RV SGE among hospitalised children born after 1 March 2006, which…
- Trial name
- NCT00653198
- Testing
- No intervention
- Where
- Panama
- Volunteers
- 885 people
- Sponsor
- GlaxoSmithKline
Shigellosis
A Phase 1, Dose Escalation Study, to Evaluate a New Shigella Sonnei Vaccine in Healthy Adults.
This Phase 1 clinical trial is aimed to evaluate the safety and immunogenicity of 3 doses of 5 sequentially escalating dosages of a candidate vaccine against Shigella sonnei (1790GAHB vaccine) administered by intramuscular route…
- Trial name
- NCT02017899
- Testing
- S. sonnei 1790GAHB
- Where
- France
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- GSK Vaccines Institute For Global Health S.r.l.
Crohn's Disease
High Dose Oral 4-Aminosalicylic Acid (PASER®) to Control Acute Flares of Mild to Moderate Crohn's Disease in Children
The purpose of this 4 week study is to determine whether PASER®, an approved delayed-release oral formulation of 4-aminosalicylic acid, in doses of 50 milligrams per kilogram three times daily for 2 weeks followed by 50…
- Trial name
- NCT00495521
- Testing
- 4-Aminosalicylic acid extended release granules
- Where
- 5 sites in United States
- Volunteers
- 2 people
- Sponsor
- Jacobus Pharmaceutical
Inflammatory Bowel Diseases, Colitis, Ulcerative
Protein and Magnesium in Ulcerative Colitis
The aim of the study is to improve the quality of nutritional therapy for patients admitted with Acute Severe Ulcerative Colitis (ASUC) treated with high-dose steroids.
- Conditions
- Inflammatory Bowel Diseases, Colitis, Ulcerative, Magnesium Deficiency, Nutritional Deficiency
- Trial name
- PAMUC (NCT05271838)
- Testing
- Magnesium acetate mixture (30 mmol/ml), High-protein diet (2 g/kg/day)
- Where
- Denmark
- Volunteers
- 36 people
- Sponsor
- University of Aarhus
Crohn's Disease
SECURE, the Cimzia ® Crohn's Disease Post-Marketing Registry
The purpose of this study is to monitor safety outcomes of patients who have taken Cimzia® as compared to a non- Cimzia® control population.
- Trial name
- SECURE (NCT00844285)
- Testing
- Cimzia
- Where
- 197 sites in United States
- Volunteers
- 3,072 people
- Sponsor
- UCB BIOSCIENCES, Inc.
Crohn's Disease
Crohn's Disease Stem Cell Transplantation
Crohn's disease (CD) is a chronic illness, immunologically mediated, probably induced by the exposure of the intestine to an antigen or antigens similar to the intestine, to which immunologic tolerance is lost or a dysregulated…
- Trial name
- NCT00271947
- Testing
- Autologous Stem Cell Transplantation
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Northwestern University
Ulcerative Colitis
Fecal Transplantation Using a Diet for Donor and Recipient in Refractory Colitis
Changing the microbiota has become the most intriguing target for intervention in inflammatory bowel disease (IBD). Dietary therapy is successful in mild to moderate Crohn's disease and may be effective in mild to moderate…
- Trial name
- NCT02734589
- Testing
- Fecal transplantation, Unique novel Diet for UC and Unique novel Diet for the donor + FMT, Unique novel Diet for UC
- Where
- 5 sites in France, Israel and 1 more
- Volunteers
- 54 people
- Sponsor
- Wolfson Medical Center
Crohns Disease, Pregnancy
Pregnant Women With and Without Crohns Disease to Explore the Role of Plastics and Toxins in Intestinal Inflammation
The PLANET Study aims to determine the impact of microplastics on intestinal inflammation and gut microbiome in order to understand the role of this pollutant on the risk of developing inflammatory bowel disease (IBD) as well as…
- Conditions
- Crohns Disease, Pregnancy, Inflammatory Bowel Disease
- Trial name
- PLANET (NCT06001450)
- Where
- United States
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai
Crohn's Disease, Ulcerative Colitis
Protein Metabolism in Newly Diagnosed Pediatric Inflammatory Bowel Disease
Inflammatory bowel disease, which includes both Crohn's disease and ulcerative colitis, is a disease of the gastrointestinal tract leading to symptoms of abdominal pain, diarrhea, and growth disturbance.
- Conditions
- Crohn's Disease, Ulcerative Colitis, Protein Metabolism
- Trial name
- NCT00586352
- Testing
- stable isotope infusions
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- Indiana University
Crohn Disease, Ulcerative Colitis
National Observational Study On The Use Of Inflectra™ An Infliximab Biosimilar In Real Life
National, prospective, multicentre observational study designed for eligible patients treated with Inflectra. Its objectives are to describe under real conditions of use, the profile of patients treated with Inflectra and the…
- Conditions
- Crohn Disease, Ulcerative Colitis, Rheumatoid Arthritis, Ankylosing Spondylitis
- Trial name
- ReFLECT (NCT02925338)
- Testing
- QOL questionaire
- Where
- 67 sites in France
- Volunteers
- 1,431 people
- Sponsor
- Pfizer
Crohn's Disease (CD)
The Impact of Time Restricted Feeding in Crohn's Disease
Time-restricted feeding (TRF) is a dietary regimen involving the consumption of food and liquids within a defined time window with or without additional restriction on dietary composition.
- Trial name
- TRF-CD (NCT04271748)
- Testing
- Time Restricted Feeding
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Weill Medical College of Cornell University
Colitis, Ulcerative
Phase II Dose-Ranging Study in Subjects With Mild to Moderate Ulcerative Colitis Treated With SPD476
Evaluate the percentage of subjects in remission at the end of an 8-week treatment period for three dose groups (SPD476 1.2 g/day, 2.4 g/day or 4.8 g/day, administered once daily).
- Trial name
- NCT00545389
- Testing
- SPD476 is a polymeric matrix formulation that displays both delayed- and extended-release of mesalazine
- Where
- Belgium
- Volunteers
- 38 people
- Sponsor
- Shire
Colitis, Ulcerative
A Protocol of Icotrokinra Therapy in Adult and Adolescent Participants With Moderately to Severely Active Ulcerative Colitis
The purpose of this protocol is to evaluate the efficacy (how well it works), safety and tolerability of oral icotrokinra as therapy in adult and adolescent participants with moderately to severely active ulcerative colitis (UC…
- Trial name
- ICONIC-UC (NCT07196748)
- Testing
- Icotrokinra
- Where
- 402 sites in United States, Argentina and 26 more
- Volunteers
- 882 people
- Sponsor
- Janssen Research & Development, LLC