Clinical trials: GastroIntestinal Bleeding
Peptic Ulcer Bleeding
Risk Factors of Rebleeding After Peptic Ulcer Bleeding: a Nationwide Cohort Study
The purpose of the investigators study is to investigate the factors associated with rebleeding in patients with peptic ulcer bleeding.
- Trial name
- KPUB (NCT02152904)
- Where
- South Korea
- Volunteers
- 892 people
- Sponsor
- Joon Sung Kim
Upper GI Bleeding, Point of Care Ultrasound
Bedside Ultrasonic Assessment for Gastric Content in Patients With Upper GI Bleeding Undergoing Endoscopy
Emerging studies have evaluated POCUS (Point of Care Ultrasound) for assessing of gastric content prior to anesthesia to reduce the risk of aspiration and demonstrated that POCUS can accurately identify presence of gastric food…
- Conditions
- Upper GI Bleeding, Point of Care Ultrasound, Upper Endoscopy, Gastric Content
- Trial name
- NCT05763745
- Testing
- Point of Care Ultrasound
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Loma Linda University
Intra Cerebral Hemorrhage, Hypertension
Proper Timing of Control of Hypertension and Outcome in Acute Spontaneous Intracerebral Hemorrhage.
The ideal management of blood pressure in BP after acute intracerebral haemorrhage is still debated and whether a higher intensive reduction of blood pressure after acute intracerebral haemorrhage may be better or not is still…
- Trial name
- NCT04167644
- Testing
- Modified Rankin Scale (mRS)
- Where
- Egypt
- Volunteers
- 150 people
- Sponsor
- Mansoura University Hospital
Esophageal and Gastric Varices, Child, Only
HEMOCC Study. Hemostasis in Cirrhotic Children.
Prospective investigations into the role of hemostatic factors in the risk of variceal bleeding among children with chronic liver disease (thromboelastometry e.g) is still required.
- Trial name
- HEMOCC (NCT03244332)
- Testing
- Collecting Clinical Data, Collecting laboratory data
- Where
- Belgium
- Volunteers
- 30 people
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Liver Cirrhosis
Terlipressin vs. Somatostatin in Cirrhotic Patients With Acute Variceal Bleeding and Renal Dysfunction
Acute upper gastrointestinal bleeding (AUGIB) is a common complication in the decompensated stage of liver cirrhosis, of which approximately 70% is acute variceal bleeding (AVB) caused by portal hypertension.
- Trial name
- NCT07252401
- Testing
- 2-4 mg of terlipressin, 3 mg of somatostatin
- Where
- China
- Volunteers
- 64 people
- Sponsor
- General Hospital of Shenyang Military Region
Venous Thromboembolism, Esophagus Cancer
Venous Thromboembolism and Bleeding Risk in Patients With Esophageal Cancer
This study aims to assess the 6- and 12-month venous thromboembolism (VTE) and bleeding incidence from the start of cancer diagnosis in a retrospective cohort of patients with esophageal cancer.
- Conditions
- Venous Thromboembolism, Esophagus Cancer, Bleeding, Chemotherapy Effect
- Trial name
- VENETIA (NCT03646409)
- Testing
- Venous thromboembolic event, arterial thromboembolic event, bleeding events
- Where
- Netherlands
- Volunteers
- 542 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Portal Hypertension
Austrian Registry on Transjugular Intrahepatic Portosystemic Shunts
Patients with TIPS will be recruited in this prospective registry study. The clinical course will be documented and biomarkers for prediction of complicatiosn will be assessed.
- Trial name
- AUTIPS (NCT03409263)
- Testing
- Observational study
- Where
- Austria
- Volunteers
- 400 people
- Sponsor
- Thomas Reiberger
Gastrointestinal Hemorrhage
Video Capsule Endoscopy Versus Colonoscopy in Patients With Melena and Negative Upper Endoscopy
Acute gastrointestinal bleeding is a common medical problem. When patients with gastrointestinal bleeding present with melena (dark, tarry stool) the blood loss is usually originating in the upper gastrointestinal tract…
- Trial name
- NCT02609100
- Testing
- Video Capsule Endoscopy, Colonoscopy, 1.0 X 2.5 cm 'pill' containing a camera
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Washington University School of Medicine
Venous Thrombosis, Pulmonary Embolism
Study of Rivaroxaban Use and Potential Adverse Outcomes in Routine Clinical Pratice (UK)
This prospective cohort study will provide information about: characteristics of Rivaroxaban use in patients who are prescribed Rivaroxaban for the first time compared to patients who are prescribed Warfarin for the first time…
- Conditions
- Venous Thrombosis, Pulmonary Embolism, Atrial Fibrillation, Acute Coronary Syndrome
- Trial name
- NCT01947998
- Testing
- Rivaroxaban (Xarelto, Bay59-7939), Warfarin, Antiplatelet drugs
- Where
- United Kingdom
- Volunteers
- 50,299 people
- Sponsor
- Bayer
Hereditary Hemorrhagic Telangiectasia, Ectasia
Phase II Pilot Study of Octreotide, a Somatostatin Octapeptide Analog, for Gastrointestinal Hemorrhage in Hormone-Refractory Hereditary Hemorrhagic Telangiectasia and Senile Ectasia
OBJECTIVES: I. Evaluate the efficacy of octreotide, a somatostatin octapeptide analog, in decreasing gastrointestinal bleeding in patients with hormone-refractory hereditary hemorrhagic telangiectasia or senile ectasia.
- Trial name
- NCT00004327
- Testing
- octreotide
- Volunteers
- 8 people
- Sponsor
- National Center for Research Resources (NCRR)
Intracerebral Hemorrhage
Clinical Outcomes Following Parafascicular Surgical Evacuation of Intracerebral Hemorrhage: A Pilot Study
This study is determining the clinical outcomes, based on neurological testing, for the parafascicular minimally invasive clot evacuation technique. We will collect data from the time of surgery up until 90 days post procedure.
- Trial name
- MISPACE (NCT01971359)
- Where
- United States
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- OSF Healthcare System
Gastroduodenal Ulcer, Marginal Ulcer
Efficacy of Low Dose of Proton Pump Inhibitor in Treatment Bleeding Ulcers
Determining the efficacy of low dose of PPI in management acute peptic ulcer bleeding
- Conditions
- Gastroduodenal Ulcer, Marginal Ulcer, Peptic Ulcer Hemorrhage
- Trial name
- NCT03163680
- Testing
- Omeprazole 40 MG
- Where
- Syria
- Volunteers
- 295 people
- Sponsor
- Damascus Hospital
Liver Cancer, Hemorrhage Liver
Standard of Care Versus Hemopatch® During Liver Resection
This multicentre prospective and randomized study aims to compare the sealant effect after surgical liver resection of a new collagen - polyethylene glycol hemostatic / sealant patch (Hemopatch) vs standard of care.
- Conditions
- Liver Cancer, Hemorrhage Liver, Bile Leak, Surgery
- Trial name
- IBERLIVER (NCT03166683)
- Testing
- Hemopatch, Standard of care
- Volunteers
- 284 people
- Sponsor
- Fundación Pública Andaluza para la gestión de la Investigación en Sevilla
Gastric Ulcer, Duodenal Ulcer
Comparison of Ulcer Healing in Patients Taking Rabeprazole With Different Antiplatelets
Clopidogrel causes significantly less peptic ulcer disease (PUD) and ulcer bleeding than low-dose aspirin in general population.
- Trial name
- NCT01037491
- Testing
- rabeprazole plus aspirin versus rabeprazole plus clopidogrel
- Where
- Taiwan
- Volunteers
- 200 people
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Advanced Colorectal Cancer in Elderly Patient
The Management of Complicated Colo-rectal Cancer in Older Patients in the Emergency Setting: the CO-OLDER Study
This is a multicenter observational study aimed to investigate the management of older patients aged 75 years old and over admitted to the emergency department with complicated colorectal cancer.
- Trial name
- CO-OLDER (NCT05788224)
- Where
- France
- Volunteers
- 200 people
- Sponsor
- Poissy-Saint Germain Hospital
Haemorrhoid, Haemorrhoidal Bleeding
Hemorrhoid Suture Mucopexy Combined With Laser Hemorrhoidoplasty
This prospective cohort study evaluates whether combining "suture mucopexy" (a simple stitch-based lift of prolapsed tissue) with Laser Hemorrhoidoplasty (LHP) can effectively relieve pain, bleeding and prolapse in adults with…
- Conditions
- Haemorrhoid, Haemorrhoidal Bleeding, Anorectal Surgeries, Anorectal Diseases
- Trial name
- HeMuLa (NCT07404774)
- Testing
- Laser Haemorrhoidoplasty and Suture Mucopexy
- Where
- Greece
- Volunteers
- 100 people
- Sponsor
- National and Kapodistrian University of Athens
Diverticular Disease
Prophylactic Elective Clipping of Colonic Diverticula
Diverticular bleeding is the most common cause of acute lower gastrointestinal bleeding (LGIB) in Western populations. Although self-limited in 85% of cases, some patients may require hospitalization with blood transfusion and…
- Trial name
- NCT02094456
- Testing
- Endoscopic clipping of diverticula, Follow-up colonoscopy
- Where
- United Kingdom
- Volunteers
- 9 people
- Sponsor
- King's College Hospital NHS Trust
Gastrointestinal Bleeding
Uninterrupted Clopidogrel Therapy Before Elective Colonoscopy Will Increase the Risk of Post-polypectomy Bleeding
This double-blind, randomized trial aims to evaluate whether uninterrupted anti-platelet therapy (clopidogrel) will increase the risk of bleeding associated with removal of polyp during colonoscopy in patients with coronary…
- Trial name
- NCT01806090
- Testing
- clopidogrel
- Where
- China
- Volunteers
- 216 people
- Sponsor
- Chinese University of Hong Kong
Gastrointestinal Hemorrhage, Tranexamic Acid
Local Administration of Tranexamic Acid in Upper Gastrointestinal Hemorrhage
Upper gastrointestinal hemorrhage is a frequently diagnosis in emergency departments. Although new drugs and endoscopic techniques were easily applied in various settings in this condition, the role of local administered…
- Conditions
- Gastrointestinal Hemorrhage, Tranexamic Acid, Emergency Department, Antifibrinolytic Agents
- Trial name
- NCT02903017
- Testing
- Tranexamic acid 5%
- Where
- Turkey (Türkiye)
- Volunteers
- 114 people
- Sponsor
- Kocaeli University
Colorectal Cancer
Community Based Screening for Colorectal Cancer in an Underserved High Risk Population in Nigeria
Patient age 45 year old and above who presented with rectal bleeding at three tertiary hospitals in South West Nigeria were invited for colonoscopy. The clinical information of the patients and the colonoscopy data were analyzed
- Trial name
- NCT03032874
- Testing
- Colonoscopy
- Where
- Nigeria
- Volunteers
- 100 people
- Sponsor
- Obafemi Awolowo University Teaching Hospital