Clinical trials: GastroIntestinal Bleeding
Gastrointestinal Hemorrhage
Video Capsule Endoscopy Versus Colonoscopy in Patients With Melena and Negative Upper Endoscopy
Acute gastrointestinal bleeding is a common medical problem. When patients with gastrointestinal bleeding present with melena (dark, tarry stool) the blood loss is usually originating in the upper gastrointestinal tract…
- Trial name
- NCT02609100
- Testing
- Video Capsule Endoscopy, Colonoscopy, 1.0 X 2.5 cm 'pill' containing a camera
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Washington University School of Medicine
Upper Gastrointestinal Bleeding
Detection of Upper Gastrointestinal (GI) Bleeding Using a Novel Bleeding Sensor Capsule -A Pilot Study
This is a multi-center, prospective, non-randomized, open-label, exploratory clinical investigation performed to evaluate safety and effectiveness of the PillSense System when used for detection of blood in the stomach of…
- Trial name
- NCT05631639
- Testing
- PillSense System
- Where
- 3 sites in Czechia
- Volunteers
- 30 people
- Sponsor
- EnteraSense Limited
Acute Coronary Syndrome, Acute Myocardial Infarction
Prevention of Gastrointestinal Bleeding in Patients With Severe Ischemic Heart Disease
Aspirin and clopidogrel +/- heparin or thrombolytic co-therapy is well established and effective treatment for unstable cardiac patients. However, the major complication was gastrointestinal bleeding (GIB) due to peptic ulcer.
- Trial name
- NCT00683111
- Testing
- esomeprazole 20 mg daily, famotidine 40 mg daily
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Ruttonjee Hospital
Bowel Cancer, Bowel Diseases, Inflammatory
LuCID - Investigating the Use of a Novel Digital Rectoscope for Community Examinations During COVID-19
The LumenEye scope and CHiP platform will be piloted in a number of clinical settings including remote colorectal clinics. The rationale is to perform an initial pilot study to determine the clinical utility of the LumenEye…
- Conditions
- Bowel Cancer, Bowel Diseases, Inflammatory, Rectal Bleeding
- Trial name
- LuCID (NCT05043363)
- Testing
- LumenEye X1 digital rectoscope
- Where
- United Kingdom
- Volunteers
- 114 people
- Sponsor
- Imperial College London
Iron Deficiency Anemia
Location of Lesions Responsible for Blood Loss in the Gastrointestinal (GI) Tract
The purpose of this study is to identify the prevalence, nature and location of lesions in the GI tract that may contribute to iron deficiency anaemia and compare diagnostic yied of the upper GI magnetic controlled capsule…
- Trial name
- A-MACE (NCT04840433)
- Testing
- MACE
- Where
- Hong Kong
- Volunteers
- 180 people
- Sponsor
- Chinese University of Hong Kong
Acute Upper Gastrointestinal Non Variceal Hemorrhage
Endoscopic Diagnosis and Treatment of Acute Nonvariceal Upper Gastrointestinal Bleeding
Acute nonvariceal upper gastrointestinal bleeding (ANVUGIB) is a common critical disease in gastroenterology. Due to the development of modern medical technology, the incidence rate of ANVUGIB has been decreasing in recent years…
- Trial name
- NCT04895904
- Testing
- No intervention
- Volunteers
- 3,200 people
- Sponsor
- The First Affiliated Hospital of Nanchang University
Gastric Varices
Secondary Prophylaxis of Gastric Variceal Bleed
The purpose of this study is to study the efficacy of endoscopic cyanoacrylate injection versus balloon-occluded retrograde transvenous obliteration in the prevention of gastric variceal rebleeding and improvement in survival.
- Trial name
- NCT02468206
- Testing
- Balloon-occluded retrograde transvenous obliteration, Endoscopic cyanoacrylate injection, N-butyl-2-cyanoacrylate
- Where
- China
- Volunteers
- 64 people
- Sponsor
- West China Hospital
Gastrointestinal Hemorrhage, Portal Hypertension
Secondary Prophylaxis After Variceal Bleeding in Non-Responders
Controlled and randomized study comparing combined treatment (nadolol and endoscopic ligation) versus nadolol associated with isosorbide mononitrate or prazosin according to hemodynamic response, in the prevention of esofagic…
- Conditions
- Gastrointestinal Hemorrhage, Portal Hypertension, Cirrhosis
- Trial name
- KT-2000 (NCT00450164)
- Testing
- esofagic varices ligation, Nadolol, Isosorbide mononitrate
- Where
- Spain
- Volunteers
- 50 people
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Acute Coronary Syndrome, Helicobacter Pylori Infection
The Effect of Dual Eradication Therapy vs PPI on Gastrointestinal Bleeding in ACS Patients
Patients with acute coronary syndrome (ACS) after Percutaneous Coronary Intervention (PCI) require routine treatment with dual antiplatelet (DAPT) treatment, but with the high risk of bleeding, gastrointestinal bleeding is the…
- Trial name
- NCT04728516
- Testing
- Vonoprazan-based dual eradication therapy for two weeks, amoxicillin, Pantoprazole
- Where
- 42 sites in China
- Volunteers
- 2,600 people
- Sponsor
- Qilu Hospital of Shandong University
Esophageal Varices, Portal Hypertension
Improve the Strategies of Endoscopic and Interventional Treatment of Gastroesophageal Hemorrhage in Portal Hypertension
Endoscopic esophageal variceal ligation combined with gastric variceal embolization using tissue glue is currently the first-choice method for preventing rebleeding in patients with cirrhosis and portal hypertension.
- Trial name
- NCT06970509
- Where
- 10 sites in China
- Volunteers
- 1,450 people
- Sponsor
- Shanghai Zhongshan Hospital
Melena, Gastrointestinal Bleeding
A Study to Evaluate the Performance of a Wireless Optical Sensor Capsule in Detection of UGIB
Upper gastrointestinal bleeding (UGIB) is a common and potentially lethal medical emergency, which requires hospitalization and healthcare resources.
- Conditions
- Melena, Gastrointestinal Bleeding, Hematemesis
- Trial name
- Hemopill-Pro (NCT06715293)
- Testing
- Hemopill, OGD
- Where
- Hong Kong
- Volunteers
- 193 people
- Sponsor
- Chinese University of Hong Kong
Gastrointestinal Hemorrhage
Artificial Intelligent Clinical Decision Support System Simulation Center Study for Technology Acceptance
The purpose of this research study is to measure the effect on of a large language model interface on the usability, attitudes, and provider trust when using a machine learning algorithm-based clinical decision support system in…
- Trial name
- NCT05816473
- Testing
- LLM
- Where
- United States
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- Yale University
Colorectal Cancer, Diverticulitis
Anastomotic Bleeding in Colorectal Anastomosis Relating to the Placement of the Stapler Spike to the Staple Line
Each colorectal anastomosis is routinely evaluated intraoperatively by sigmoidoscopy and, in the presence of signs of bleeding, also postoperatively (persistent rectal bleeding within 24 hours after surgery).
- Trial name
- NCT07506005
- Where
- Austria
- Volunteers
- 102 people
- Sponsor
- Kepler University Hospital
Obscure Gastrointestinal Bleeding (Occult or Overt)
Trial of Wireless Capsule Endoscopy in the Evaluation of Obscure Gastrointestinal Bleeding
This study compares wireless capsule endoscopy (patients swallow a pill-size camera that sends pictures of the intestine to a recorder worn on their belt) to an x-ray study (called dedicated small bowel contrast radiography) in…
- Trial name
- NCT01006824
- Testing
- Capsule endoscopy, Dedicated small bowel contrast radiography
- Where
- United States
- Volunteers
- 136 people
- Sponsor
- University of Southern California
Acute Necrotizing Pancreatitis, Portosplenomesenteric Venous Thrombosis
Acute Pancreatitis and Thrombosis (PATHRO)
Severe acute pancreatitis (AP) is a pathology with high morbidity and mortality. Portosplenomesenteric vein thrombosis is a well-known local complication of AP with a variable incidence, which can reach up to 50% in case of…
- Trial name
- PATHRO (NCT04642794)
- Testing
- observational study
- Where
- France
- Volunteers
- 51 people
- Sponsor
- Nantes University Hospital
GastroIntestinal Bleeding, Anticoagulant-induced Bleeding
Anticoagulation After GI Bleeding Pilot Study and Registry
PANTHER-GI Pilot Study will assess the feasibility of a full-scale multicentre cohort management study evaluating the safety of a standardized strategy for resuming direct oral anticoagulants (DOACs) after major DOAC-related…
- Trial name
- PANTHER-GI (NCT05290857)
- Testing
- Restart DOAC within 7 days of clinical hemostasis after GI bleeding, Restart DOAC between 7 to 14 days of clinical hemostasis after GI bleeding
- Where
- 2 sites in Canada
- Volunteers
- 100 people
- Sponsor
- Ottawa Hospital Research Institute
Laparoscopic Pancreatic Surgery, Pancreatic Fistula
Application and Optimization of the International Study Group of Pancreatic Surgery (ISGPS) Definition and Grading Criteria for Postoperative Complications of Pancreatic Surgery in Laparoscopic Pancreatic Surgery
In recent years, with the continuous development of minimally invasive techniques, laparoscopic pancreatic surgery has also been widely used.
- Conditions
- Laparoscopic Pancreatic Surgery, Pancreatic Fistula, Postoperative Bleeding, Delayed Gastric Emptying
- Trial name
- NCT05657327
- Volunteers
- 1,000 people
- Sponsor
- West China Hospital
Liver Cirrhosis
Terlipressin vs. Somatostatin in Cirrhotic Patients With Acute Variceal Bleeding and Renal Dysfunction
Acute upper gastrointestinal bleeding (AUGIB) is a common complication in the decompensated stage of liver cirrhosis, of which approximately 70% is acute variceal bleeding (AVB) caused by portal hypertension.
- Trial name
- NCT07252401
- Testing
- 2-4 mg of terlipressin, 3 mg of somatostatin
- Where
- China
- Volunteers
- 64 people
- Sponsor
- General Hospital of Shenyang Military Region
Anorectal Disorder
The Efficacy of Aescin in Combination With MPFF in the Early Control of Bleeding From Acute Internal Hemorrhoids, A Randomized Controlled Trial
Hemorrhoidal disease, characterized by symptomatic enlargement and distal displacement of anal cushions, has been a subject of recognition and management for centuries.
- Trial name
- NCT06363513
- Testing
- Aescin in Horse Chestnut, Flavonoid
- Where
- Thailand
- Volunteers
- 60 people
- Sponsor
- Chiang Mai University
Liver Surgery, Minimal Invasive Surgery
High Versus Low Pneumoperitoneum PressUre for Parenchymal Transection in Minimally Invasive Major Liver Surgery
Minimally invasive techniques in liver surgery gain popularity as they facilitate postoperative recovery while achieving comparable oncologic outcomes to the open approach.
- Conditions
- Liver Surgery, Minimal Invasive Surgery, Major Liver Resection
- Trial name
- PPULS (NCT06770803)
- Testing
- High Pressure Pneumoperitoneum, Low Pressure Pneumoperitoneum
- Volunteers
- 132 people
- Sponsor
- University Hospital Heidelberg