Clinical trials: Gastro Intestinal Cancers
Colorectal Cancer (CRC), Gastric Cancer
A Study of SC-007 in Subjects With Advanced Cancer
This is a multicenter, open-label, Phase 1 study in participants with colorectal cancer (CRC) or gastric cancer to study the safety and tolerability of SC-007 and consists of Part A (dose regimen finding) in participants with CRC…
- Trial name
- NCT03253185
- Testing
- SC-007
- Where
- 7 sites in United States
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- AbbVie
Colorectal Cancer
Point of Care Test to Diagnosed Colorectal Cancer and Polyps in Low Middle Income Countries
This is a-two phase study. Phase 1 will adapt a 3-metabolite biosensor that identifies patients with colorectal cancer (CRC) and precancerous polyps to Nigerian patients.
- Trial name
- NCT03173729
- Testing
- Biosensor Point of Care Device
- Where
- 5 sites in Nigeria
- Volunteers
- 926 people, healthy volunteers welcome
- Sponsor
- Obafemi Awolowo University Teaching Hospital
Cancer, Lung, Cancer, Breast
Early Detection of Five Common Cancers Using the ctDNA Analysing Test
This is a multi-centre, prospective cohort study, aiming to evaluate a blood test in early detection of the four common cancers, based on the investigation of the circulating tumour DNA (ctDNA).
- Conditions
- Cancer, Lung, Cancer, Breast, Cancer Liver, Cancer, Colorectal
- Trial name
- K-DETEK (NCT05227261)
- Where
- Vietnam
- Volunteers
- 9,057 people, healthy volunteers welcome
- Sponsor
- Gene Solutions
Radiation Disease
Pelvic Radiation Disease in Childhood Cancer Survivors
This study aims to characterise the impact of radiotherapy on physical symptoms and quality of life in childhood and young adult cancer survivors.
- Trial name
- NCT05533541
- Where
- United Kingdom
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Royal Marsden NHS Foundation Trust
Esophageal Neoplasms, Stomach Neoplasms
Food Intake and Gut Hormones in Patients Who Have Undergone Upper Gastrointestinal Surgery for Cancer
Improvements to treatment strategies for patients upper gastrointestinal cancers have produced an increasing population of people who remain free from disease recurrence in the long term.
- Conditions
- Esophageal Neoplasms, Stomach Neoplasms, Weight Loss, Malnutrition
- Trial name
- NCT02385617
- Testing
- Octreotide
- Where
- 2 sites in Ireland, Sweden
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- St. James's Hospital, Ireland
Obesity, Colon Cancer
Proteomic Analysis of Patients Undergoing Bariatric Surgery
The expression of proteins in the blood of obese individuals is different from the expression of proteins in healthy individuals, and is also different in individuals after bariatric surgery.
- Conditions
- Obesity, Colon Cancer, Thyroid Cancer, Esophageal Cancer
- Trial name
- NCT06787807
- Testing
- bariatric surgery
- Where
- Brazil
- Volunteers
- 103 people, healthy volunteers welcome
- Sponsor
- Universidade Federal de Pernambuco
Gastric Cancer, Pancreatic Cancer
Chemoradiation-Induced Nausea and Emesis: Quality of Life
The primary objectives of this study are: 1. To assess the preferences of cancer patients scheduled to receive chemoradiation and caregiver controls for side-effects of chemoradiation. 1.
- Conditions
- Gastric Cancer, Pancreatic Cancer, Cervical Cancer, Vulvar Cancer
- Trial name
- NCT00394602
- Testing
- Interview, Questionnaire
- Where
- United States
- Volunteers
- 207 people, healthy volunteers welcome
- Sponsor
- M.D. Anderson Cancer Center
Stage IV Melanoma, Advanced Lung Cancer
Improving Patient and Caregiver Understanding of Risks and Benefits of Immunotherapy for Advanced Cancer
The purpose of this study is to refine and pilot test educational material developed to educate and support patients receiving immunotherapy for advanced cancer.
- Conditions
- Stage IV Melanoma, Advanced Lung Cancer, Stage IV Non-Small Cell Lung Cancer, Unresectable Non-Small Cell Lung Carcinoma
- Trial name
- UPLIFT (NCT04670445)
- Testing
- Educational Video and QPL List, Usual Care
- Where
- United States
- Volunteers
- 199 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Gastric Atrophy, Gastric Intestinal Metaplasia
A Study Collecting Health Information to Understand and Prevent Gastric Cancer
The purpose of this study is to create a registry of participants with precursor lesions for gastric cancer, including gastric atrophy, intestinal metaplasia, and dysplasia.
- Conditions
- Gastric Atrophy, Gastric Intestinal Metaplasia, Dysplasia, Gastric Adenocarcinoma
- Trial name
- NCT06370143
- Testing
- Questionnaire
- Where
- 7 sites in United States
- Volunteers
- 3,200 people, healthy volunteers welcome
- Sponsor
- Memorial Sloan Kettering Cancer Center
Lynch Syndrome, Li Fraumeni Syndrome
Video Capsule Examination in Patients With Lynch Syndrome
Surveillance for colorectal cancer (CRC) in patients predisposed to develop CRC during their lifetime has been impacted by access to colonoscopy suites and endoscopy specialists in the past couple of years.
- Conditions
- Lynch Syndrome, Li Fraumeni Syndrome, PTEN Hamartoma Syndrome, FAP
- Trial name
- PILLCAM (NCT06712095)
- Testing
- Video capsule investigation
- Where
- United Kingdom
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Royal Marsden NHS Foundation Trust
Colorectal Cancer
Detection of Colorectal Cancer in Peripheral Blood by Septin 9 DNA Methylation Assay
Epigenomics is developing a colon cancer screening assay based on differential methylation of specific CpG sites for the detection of early stage disease.
- Trial name
- NCT00696345
- Where
- 5 sites in Germany, Hungary
- Volunteers
- 700 people, healthy volunteers welcome
- Sponsor
- Epigenomics, Inc
Colorectal Cancer, Gastric Cancer (GC)
Clinical Application of PET Imaging Targeting GPA33 in Malignant Tumors
This study is a diagnostic study. Patients and healthy volunteers with clinically suspected or confirmed colorectal cancer, gastric cancer, pancreatic cancer and other malignant tumors with high expression of GPA33 will be…
- Conditions
- Colorectal Cancer, Gastric Cancer (GC), Pancreatic Cancer
- Trial name
- NCT07172503
- Testing
- 68Ga-NOTA-GPA33 nanobody
- Where
- China
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Stomach Neoplasms, Gut Microbiota
Gut Microbiota and Metabonomics
To evaluate the correlation between gut microbiota and metabolites in Borrmann type IV gastric cancer; To find the effects of microflora and metabolites on target organs; To detect the mechanism of key flora and metabolite by in…
- Conditions
- Stomach Neoplasms, Gut Microbiota, Metabolomics
- Trial name
- MBS (NCT05205187)
- Testing
- Healthy control specimen collection, Non-Borrmann IV patient specimen collection, Borrmann IV patient specimen collection
- Where
- 6 sites in China
- Volunteers
- 450 people, healthy volunteers welcome
- Sponsor
- First Hospital of China Medical University
Gastric Microbiota, Non-atrophic Gastritis
Difference of Gastric Microbiota in the Process of Correa's Model.
Helicobater pylori plays an important role in the development of gastric cancer. Eradication therapy can reducing the morbidity of gastric cancer, but can't totally prevent it especially when atrophy and more serious precancerous…
- Conditions
- Gastric Microbiota, Non-atrophic Gastritis, Atrophic Gastritis, Intestinal Metaplasia
- Trial name
- NCT02833363
- Where
- China
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Shandong University
Cancer, Pregnancy Related
Distribution of Biospecimens From Biorepositories/Biobanks for Research Use
This protocol seeks to assist biorepositories/biobanks in distributing their stored specimens and data to researchers that will actually utilize them to advance medicine and technology.
- Conditions
- Cancer, Pregnancy Related, Gastro-Intestinal Disorder, Cardio-Respiratory Distress
- Trial name
- NCT03884400
- Testing
- Specimens obtained from surgical, phlebotomy or other non-invasive procedure
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- iSpecimen Inc
Healthy
Using Magnetic Resonance (MR) to Understand the Effect of Erythromycin on Bowel Motility
Magnetic Resonance Imaging (MRI) has proven to be a valuable imaging technique for suspected small bowel disease. This technique depends, in part, on adequate distension of the small bowel.
- Trial name
- NCT01379183
- Testing
- Erythromycin, Magnetic Resonance Imaging, Barium Sulfate Solution
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Lung Cancers, Liver Cancer
AI-Assisted Non-Contrast CT for Multi-Cancer Screening
Cancer poses a major public health challenge in China. Early detection can improve treatment outcomes and survival rates. In this study, we will conduct a large-scale, prospective, multi-center cohort study to evaluate the…
- Conditions
- Lung Cancers, Liver Cancer, Gastric Cancers, Colorectal, Cancer
- Trial name
- NCT06632886
- Testing
- AI-Assisted Non-Contrast CT for Multi-Cancer Screening
- Where
- China
- Volunteers
- 1,000,000 people, healthy volunteers welcome
- Sponsor
- Guo ShiWei
Liver Cancer, Pancreatic Cancer
Xenotransplantation of Primary Cancer Samples in Zebrafish Embryos
The study consists in a co-clinical trial by using zebrafish embryos. Specifically, an observational prospective clinical trial on patients operated of epato-biliar-pancreatic cancers and gastro-intestinal cancers undergoing a…
- Conditions
- Liver Cancer, Pancreatic Cancer, Gastric Cancer, Esophageal Cancer
- Trial name
- xenoZ (NCT03668418)
- Testing
- Fluorouracil, Lederfolin, Oxaliplatin
- Where
- Italy
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Pisa
Gastric Cancer, Esophagus Cancer
Exosome-based Liquid Biopsies for Upper Gastrointestinal Cancers Diagnosis
This study constitutes a case-control investigation employing a retrospective approach. Plasma samples from individuals with esophageal cancer, benign esophageal diseases, gastric cancer, benign gastric diseases, and a healthy…
- Trial name
- NCT06278064
- Testing
- Gastric Cancer, Esophagus Cancer
- Where
- 3 sites in China
- Volunteers
- 562 people, healthy volunteers welcome
- Sponsor
- Beijing Friendship Hospital
Acute Myelogenous Leukemia, Ovarian Cancer
Galinpepimut-S in Combination With Pembrolizumab in Patients With Selected Advanced Cancers
To evaluate the safety, tolerability, and anti-tumor activity of galinpepimut-S in combination with pembrolizumab in patients with selected advanced cancers.
- Conditions
- Acute Myelogenous Leukemia, Ovarian Cancer, Colorectal Cancer, Triple-negative Breast Cancer
- Trial name
- NCT03761914
- Testing
- galinpepimut-S, pembrolizumab, Montanide
- Where
- 12 sites in United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Sellas Life Sciences Group