Clinical trials: Gastric Submucosal Tumors, open to volunteers
Small Size Gastrointestinal Stromal Tumors, GIST
RCT of EFTR Versus STER for GIST Treatment
Endoscopic resection has been increasing utilized as the treatment for small size gastrointestinal stromal tumors (GIST), of which the best resection method has not been identified.
- Trial name
- NCT07411118
- Testing
- Endoscopic full thickness resection (EFTR) / Exposed non-tunneling EFTR, Submucosal Tunneling Endoscopic Resection (STER) / Exposed tunneling EFTR
- Where
- 4 sites in China, Hong Kong and 2 more
- Volunteers
- 136 people
- Sponsor
- Chinese University of Hong Kong
Gastrointestinal Stromal Tumor of Stomach, Submucosal Tumor of Stomach
MCB vs EUS-FNA for Preoperative Pathological Evaluation of Gastric SMT
Gastrointestinal stromal tumors (GISTs) are the most common submucosal tumors (SMTs) of the stomach. The 2022 European Society of Oncology ESMO Diagnosis and Treatment Guidelines recommend that GISTs undergo biopsy with a clear…
- Trial name
- NCT06748690
- Testing
- mucosal cutting biopsy, endoscopic ultrasound-guided-fine needle aspiration
- Where
- China
- Volunteers
- 96 people
- Sponsor
- Peking University People's Hospital
Early Gastric Cancer, Endoscopic Submucosal Dissection
Safety and Efficacy of Traction Robot-assisted Endoscopic Submucosal Dissection for Early Gastric Cancer
The goal of this clinical trial is to investigate whether the flexible auxiliary single-arm transluminal endoscopic robot (FASTER) system can improve the safety of the endoscopic submucosal dissection (ESD).
- Conditions
- Early Gastric Cancer, Endoscopic Submucosal Dissection, Robot Surgery
- Trial name
- NCT06748352
- Testing
- FASTER-assisted ESD, Conventional ESD
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Shandong University
Interstitialoma, Endoscopic Surgery
A Study on the Safety and Effectiveness of Endoscopic Intracavitary Submucosal Dissection for Gastric Extracavitary-Type Submucosal Tumors
The aim of this study is to explore the safety and efficacy of endoscopic surgery in the treatment of extraluminal growing stromal tumors
- Trial name
- NCT07337980
- Testing
- Extraluminal growing stromal tumors treated endoscopically
- Volunteers
- 20 people
- Sponsor
- Zhongda Hospital
Aspirin, Gastric Cancer
Aspirin Use for Gastric Cancer Prevention in the Early Gastric Cancer Patients
This study aimed to investigate the effect of low-dose (100 mg) asprin on the prevention of gastric cancer in the early gastric cancer patients with negative H. pylori status who underwent endoscopic submucosal dissection.
- Trial name
- EASTERN (NCT04214990)
- Testing
- Aspirin 100mg
- Where
- 10 sites in South Korea
- Volunteers
- 1,700 people
- Sponsor
- National Cancer Center, Korea
Early Gastric Cancer
Comparison of the Sensitivity of pCLE and Pathological Biopsy for Gastric Mucosal Lesions
The pathological biopsy of gastric lesions, performed prior to endoscopic submucosal dissection (ESD), is crucial for differentiating the pathological nature of the lesions and guiding treatment decisions.
- Trial name
- pCLE (NCT07507071)
- Testing
- Probe-based Confocal Laser Endomicroscopy, Pathological biopsy
- Where
- China
- Volunteers
- 169 people
- Sponsor
- Changhai Hospital
Gastric Cancer (Diagnosis), Gastric High-grade Intraepithelial Neoplasia
Comparison of the Sensitivity of pCLE and Pathological Biopsy Before ESD
Pathological biopsy before endoscopic submucosal dissection (ESD) the gastric lesion plays an important role in differentiating the pathological nature of the lesion and guiding treatment decisions.
- Conditions
- Gastric Cancer (Diagnosis), Gastric High-grade Intraepithelial Neoplasia, Gastric Low-grade Intraepithelial Neoplasia, Gastritis
- Trial name
- NCT07088744
- Testing
- Probe-based Confocal Laser Endomicroscopy, Pathological biopsy
- Where
- 4 sites in China
- Volunteers
- 169 people
- Sponsor
- Changhai Hospital
Early Gastric Cancer
Endoscopic Submucosal Dissection Versus Surgery in the Treatment of Early Gastric Cancer
In this study, patients who are going to undergo endoscopic submucosal dissection (ESD) or surgery for early gastric cancer will be enrolled and divided into ESD group and Surgery group according to the procedure they go through.
- Trial name
- NCT03857737
- Testing
- endoscopic submucosal dissection, Surgery
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Peking University Third Hospital
Gastric Submucosal Tumors
Endofaster Robot for Gastroesophageal Submucosal Tumors: A Randomized Controlled Study
In endoscopic treatment for gastric submucosal tumors arising from the muscularis propria, does robot-assisted surgery yield a higher serosa preservation rate, shorter operative time and lower complication rates than conventional…
- Trial name
- NCT07655674
- Testing
- Robot system, Non-robotic conventional endoscopy
- Volunteers
- 110 people
- Sponsor
- The First Affiliated Hospital of Soochow University
Neoplasm, Stomach, Neoplasm, Colorectal
Endoscopic Submucosal Dissection Registry
This is a patient registry for all cases of pre-neoplastic or early neoplastic digestive tract lesions treated with curative intention by endoscopic submucosal dissection (ESD) technique.
- Conditions
- Neoplasm, Stomach, Neoplasm, Colorectal, Neoplasm, Esophagus, Neoplasm, Duodenal
- Trial name
- ESDREG (NCT06033976)
- Testing
- Endoscopic submucosal dissection (ESD)
- Where
- Romania
- Volunteers
- 200 people
- Sponsor
- Carol Davila University of Medicine and Pharmacy
Early Gastric Cancer, Endoscopic Submucosal Dissection
The Relationship Between Scar Formation and ESD Depth in Therapy for Gastric Carcinoma
This study is a single-center, prospective, group-controlled clinical trial, aiming to clarify the relationship between the depth of dissection and scar formation in the treatment of early gastric cancer by ESD, and to provide…
- Trial name
- NCT05323929
- Testing
- ESD
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Submucosal Tumor, Gastrointestinal Stromal Tumor (GIST)
Multicenter Observational Study of Multimodal AI for Upper GI Mesenchymal Tumor Diagnosis
This study develops a multimodal AI model using endoscopic ultrasound, white-light endoscopy, and clinical information to support the diagnosis of upper GI mesenchymal tumors and the risk stratification of gastric GISTs.
- Conditions
- Submucosal Tumor, Gastrointestinal Stromal Tumor (GIST), Leiomyoma, Schwannoma
- Trial name
- NCT07078136
- Testing
- Multimodal AI Model, Expert Endoscopist Assessment
- Where
- China
- Volunteers
- 130 people
- Sponsor
- Huazhong University of Science and Technology
Gastric Cancer
Evaluation of the Efficacy and Safety of Indocyanine Green Tracing in 3D Fluorescent Laparoscopic Lymph Node Dissection for Gastric Cancer
Purpose of the study To evaluate whether the clinical efficacy of submucosal injection of indocyanine green tracer laparoscopic gastric cancer lymph node dissection is superior to that of laparoscopic gastric cancer lymph node…
- Trial name
- NCT06421220
- Testing
- Preoperative injection of indocyanine green
- Where
- China
- Volunteers
- 484 people
- Sponsor
- Qilu Hospital of Shandong University
Gastric Neoplasms, Gastric Dysplasia
Epinephrine 1:100,000 Versus 1:500,000 During Gastric Endoscopic Submucosal Dissection
This prospective, randomized, single-center trial compares two epinephrine concentrations (1:100,000 and 1:500,000) in the submucosal injection solution used during gastric endoscopic submucosal dissection.
- Trial name
- EPI-DILUTE (NCT07920068)
- Testing
- Epinephrine 1:100,000, Epinephrine 1:500,000
- Where
- Portugal
- Volunteers
- 100 people
- Sponsor
- Unidade Local de Saúde do Alto Ave, EPE
Helicobacter Pylori, Early Gastric Cancer
Helicobacter Pylori Infection Status and Pathological Features for Predicting Gastric Cancer Biological Behavior and Prognosis: A Real-World Observational Study
This multicenter retrospective and prospective real-world observational study will evaluate the relationship of Helicobacter pylori (H.
- Trial name
- NCT07724496
- Testing
- 13C-Urea Breath Test, Serum Helicobacter pylori Antibody Testing, Pathological Assessment of Gastric Tissue
- Where
- 3 sites in China
- Volunteers
- 1,500 people
- Sponsor
- Chinese PLA General Hospital
Gastric Cancer
Efficacy and Safety of ESD for the Treatment of Superficial Gastric Neoplasms
Endoscopic submucosal dissection (ESD) is the technique that has replaced surgery in the treatment of early neoplastic lesions of the stomach (LNPS).
- Trial name
- NCT05930860
- Testing
- Endoscopic Submucosal Dissection
- Where
- Italy
- Volunteers
- 200 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Early Gastric Cancer, Colon Neoplasia
Magnetic Guided Counetrtraction During Endoscopic Submucosal Dissection
Endoscopic submucosal dissection (ESD) is a technique that allows curative treatment of early gastrointestinal neoplasia with organ preservation. However, it is a technically demanding procedure.
- Trial name
- NCT06962293
- Testing
- MAG-ESD assisted ESD
- Where
- Hong Kong
- Volunteers
- 20 people
- Sponsor
- Chinese University of Hong Kong
Early Gastric Cancer or Gastric Adenoma
Full-time RDI for ESD: Impact on Major Adverse Events and Procedure Time
Gastric cancer remains a major global health burden, ranking fifth in incidence worldwide and disproportionately affecting Asia, with China accounting for a significant share of cases and deaths.
- Trial name
- NCT07401303
- Testing
- ESD
- Where
- China
- Volunteers
- 640 people
- Sponsor
- Xijing Hospital of Digestive Diseases
Endoscopic Mucosal Resection, Endoscopic Submucosal Dissection
Endoscopic Resection of Gastrointestinal Neoplasms
The study aims to retrospectively investigate the endoscopic resection procedures of cancerous and precancerous lesions of the upper and lower digestive tract in order to evaluate the efficacy and safety outcomes and to compare…
- Conditions
- Endoscopic Mucosal Resection, Endoscopic Submucosal Dissection, Gastric Neoplasm, Colonic Neoplasms
- Trial name
- NCT04780256
- Testing
- Endoscopic resection
- Where
- Italy
- Volunteers
- 2,000 people
- Sponsor
- Azienda USL Reggio Emilia - IRCCS
Esophageal Carcinoma, Gastric Carcinoma
Detection of Upper Gastrointestinal Tumour Depth and Demarcation Using Systemic Administration of Indocyanine Green During Endoscopic Submucosal Dissection
Endoscopic submucosal dissection (ESD) is a relatively new technique to treat superficial cancers in the upper gastrointestinal (GI) tract. Previous studies reported high en bloc resection rates (95%-97%).
- Trial name
- BRIGHT (NCT07108855)
- Testing
- Indocyanine Green (IC-Green), Fluorescence guided identification using indocyanine green
- Where
- Netherlands
- Volunteers
- 10 people
- Sponsor
- University Medical Center Groningen