Clinical trials: GERD
Gastro-esophageal Reflux
Safety & Initial Efficacy of the LunGuard PFT Sys. on Enteral-Fed, Sedated and Mechanically Ventilated Patients Peristaltic Feeding Tube
This study is designated to test the safety and initial efficacy of the LunGuard's PFT device for reduction of GER. Enterally-Fed, Sedated and Mechanically Ventilated Critically Ill Patients in the ICU will have the PFT…
- Trial name
- PFT (NCT02609620)
- Testing
- Peristaltic Feeding Tube, ConvaTec Levin Duodenal Tube
- Volunteers
- 20 people
- Sponsor
- LunGuard Ltd.
Gastroesophageal Reflux Disease
The Difference of Reflux Pattern Between the Patients Who Have Postprandial Reflux Symptoms
Gastroesophageal reflux disease is increasing worldwide. The causes of reflux symptoms are not found exactly. especially, the postprandial reflux symptoms are more common than the all day reflux symptoms.
- Trial name
- NCT02154659
- Testing
- 24hr pH monitoring
- Where
- South Korea
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- Yonsei University
Gastro Esophageal Reflux Disease
Endoscopic Treatment of Gastroesophageal Reflux Disease
Gastroesophageal reflux disease (GERD) occurs when stomach acid repeatedly flows back into the tube connecting your mouth and stomach (esophagus). This backwash (acid reflux) can irritate the inner lining of the esophagus.
- Trial name
- NCT05678491
- Testing
- Endoscopic mucosal band ligation
- Where
- Norway
- Volunteers
- 12 people
- Sponsor
- St. Olavs Hospital
Gastroesophageal Reflux Disease (GERD)
Endoscopic Fundoplication Versus Proton Pump Inhibitors for GERD Treatment
The study objective is to evaluate the relative merits, safety and effectiveness of Transoral Incisionless Fundoplication (TIF) in GERD patients currently treated with daily Proton Pump Inhibitors (PPIs).
- Trial name
- TvP (NCT00857597)
- Testing
- Transoral Incisionless Fundoplication, Proton Pump Inhibitors; active control
- Where
- Netherlands
- Volunteers
- 60 people
- Sponsor
- University of Pittsburgh
GERD
A Study to Compare PK, PD and Safety of CKD-381 in Healthy Subjects
A Study to compare Pharmacokinetics, Pharmacodynamics and safety of CKD-381 and D027 in healty subjects
- Trial name
- NCT03211143
- Testing
- CKD-381, Nexium
- Where
- South Korea
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Chong Kun Dang Pharmaceutical
Reflux Disease, Microbiome
Development of a Preparation for Supportive Supplementation of Probiotics in Patients With Reflux
A two-arm, double-blind, randomized, placebo-controlled study investigating the efficacy of a probiotic preparation developed as supportive supplementation of probiotics in patients with reflux.
- Conditions
- Reflux Disease, Microbiome, Probiotics Supplement
- Trial name
- NCT07600008
- Testing
- A probiotic dietary supplement
- Where
- Czechia
- Volunteers
- 50 people
- Sponsor
- University Hospital Olomouc
Gastroesophageal Reflux Disease
SThe Effects of Melatonin on GERD Symptoms
We hypothesize that melatonin as compared to PPI and to placebo, improves GERD symptoms by decreasing esophageal acid exposure and esophageal acid sensitivity in GERD.
- Trial name
- NCT00564590
- Testing
- Melatonin, omeprazole
- Where
- Israel
- Volunteers
- 150 people
- Sponsor
- Rabin Medical Center
Gastro-oesophageal Reflux Disease
Osteopathic Manipulative Treatment for Gastro-oesophageal Reflux Disease
To evaluate the effects of osteopathic manipulative treatment in patients affected by symptoms related to gastro-oesophageal reflux disease (GERD)
- Trial name
- NCT06317675
- Testing
- Osteopathic manipulative treatment (OMT)
- Where
- Italy
- Volunteers
- 26 people
- Sponsor
- Studio Osteopatico Busto Arsizio
Gastroesophageal Reflux Disease (GERD), Reflux, Gastroesophageal
An Investigation of the EndoStim® Lower Esophageal Sphincter (LES) Stimulation System for the Treatment of Reflux
The purpose of this investigation is to demonstrate the safety and effectiveness of Lower Esophageal Sphincter (LES) Stimulation System in treating gastroesophageal reflux disease (GERD).
- Conditions
- Gastroesophageal Reflux Disease (GERD), Reflux, Gastroesophageal, Gastroesophageal Reflux, Acid Reflux
- Trial name
- NCT02749071
- Testing
- Laparoscopic implantation surgery with or without crural repair, EndoStim stimulation for first six months of study, EndoStim stimulation from Month 6 thru end of study
- Where
- 21 sites in United States, Belgium and 2 more
- Volunteers
- 161 people
- Sponsor
- EndoStim Inc.
Gastroesophageal Reflux in Children
Study on the Efficacy and Tolerance of a New Anti-regurgitation Infant Formula (STELLAR)
The aim of the study is to assess the effectiveness of this new formula on regurgitations and secondarily its effect on digestive tolerance through a randomized, controlled, double-blind trial against a comparator.
- Trial name
- STELLAR (NCT04358146)
- Testing
- Experimental Infant formula, Infant formula thickened with locust bean gum
- Where
- 12 sites in Belgium, France and 2 more
- Volunteers
- 346 people
- Sponsor
- United Pharmaceuticals
GERD (Heartburn, Regurgitation, and Dyspepsia) Frequency, GERD (Heartburn, Regurgitation, and Dyspepsia) Severity
The Anti-gastroesophageal Reflux Effect of Anvitra Gastric Suspension on Outpatients With Gastroesophageal Reflux Disease
This is an open-label, single-center clinical trial evaluating the efficacy and safety of Anvitra Gastric Suspension health supplements in adult patients with gastroesophageal reflux.
- Trial name
- ANVITRA (NCT06889246)
- Testing
- Anvitra Gastric Suspension
- Where
- 2 sites in Vietnam
- Volunteers
- 27 people
- Sponsor
- Haiphong University of Medicine and Pharmacy
GERD
Study of the NDO Endoscopic Plication System For the Treatment of Symptomatic Gastroesophageal Reflux Disease
The purpose of this prospective, multicenter study was to evaluate the safety and efficacy of endoscopic full-thickness plication for the treatment of symptomatic gastroesophageal reflux.
- Trial name
- NCT00587522
- Testing
- NDO Full-thickness Plicator
- Where
- 7 sites in United States, Canada
- Volunteers
- 64 people
- Sponsor
- NDO Surgical, Inc.
Obesity
Evaluation of Omentopexy on Gastro-oesophageal Reflux Following Sleeve Gastrectomy
The aim of the study is to assess impact of omentopexy on de novo gastro-oesophageal reflux disease (GERD) after sleeve gastrectomy. This will be assess 2 years postoperatively.
- Trial name
- Sleevepexie (NCT04994665)
- Testing
- sleeve gastrectomy, sleeve gastrectomy with omentopexy
- Where
- 9 sites in France
- Volunteers
- 526 people
- Sponsor
- Centre Hospitalier Departemental Vendee
Gastroesophageal Reflux Disease
A Study to Evaluate the Effect of Lansoprazole on Hospitalized Neonates With Gastroesophageal Reflux Disease
The purpose of this study is to understand how quickly lansoprazole, once daily (QD), improves feeding in premature babies or babies less than 28 days of age.
- Trial name
- NCT00174928
- Testing
- Lansoprazole
- Volunteers
- 24 people
- Sponsor
- Takeda
GERD, Acid Reflux Disease
Validation of Patient-reported Outcomes Measures for the Assessment of Gastroesophageal Reflux Disease (GERD) Symptoms
This research study is being done to gather information about how to do further clinical studies using AZD3355 as an add-on treatment to proton pump inhibitors (PPI).
- Conditions
- GERD, Acid Reflux Disease, Heartburn, Regurgitation
- Trial name
- C27 (NCT00703534)
- Testing
- AZD3355, Gelusil®
- Where
- 84 sites in United States
- Volunteers
- 478 people
- Sponsor
- AstraZeneca
Gastroesophageal Reflux Disease
Efficacy And Safety Of PF-00885706 For The Relief Of Symptoms In Subjects With Gastro-esophageal Reflux Disease (GERD)
To understand the dose-response characteristics of PF-00885706 for efficacy in terms of symptomatic relief when used as add-on treatment to esomeprazole 20mg (standard proton pump inhibitor [PPI] treatment), in subjects with…
- Trial name
- NCT00730665
- Testing
- PF-00885706, Esomeprazole
- Where
- 38 sites in Belgium, Brazil and 5 more
- Volunteers
- 81 people
- Sponsor
- Pfizer
Gastro-esophageal Reflux, Reflux, Gastroesophageal
ARMA (Antireflux Mucosa Ablation) in Patients With Chronic Refractory Reflux Disease
Pilot study of the possible clinical response to anti reflux mucosal ablation in patients with chronic refractory reflux disease
- Trial name
- ARMA (NCT05425771)
- Testing
- Anti Reflux Mucosa Ablation
- Where
- Germany
- Volunteers
- 15 people
- Sponsor
- Klinikum Garmisch-Patenkirchen
Chronic Posterior Laryngitis (CPL)
Chronic Posterior Laryngitis With Suspected Laryngopharyngeal Reflux
This study looks at how effective acid suppression therapy is on symptoms associated with chronic posterior laryngitis (CPL) in patients with documented pharyngeal acid reflux.
- Trial name
- NCT00628667
- Testing
- Esomeprazole
- Volunteers
- 120 people
- Sponsor
- AstraZeneca
Gastroesophageal Reflux Disease
Role of Pain Modulation in GERD Patients Who Failed Standard Dose Proton Pump Inhibitors (PPI)
The main objective of this study is to evaluate the role of pain modulation in GERD patients who fail to obtain clinical relief with standard dose (once daily) PPI.
- Trial name
- NCT00251732
- Testing
- Standard dose (once daily) PPI plus low-dose antidepressant
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- University of Arizona
Gastroesophageal Reflux Disease, Obesity, Morbid
Determination of Change in Reflux Disease After Sleeve Gastrectomy by Intraluminal Impedance and pH-meter
710 / 5.000 Çeviri sonuçları Laparoscopic sleeve gastrectomy (LSG) has become the most common bariatric procedure in obesity. The overall relationship between sleeve gastrectomy and gastroesophageal reflux disease is still…
- Trial name
- NCT05405816
- Testing
- laparoscopic sleeve gastrectomy
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people
- Sponsor
- Fatih Sultan Mehmet Training and Research Hospital