Clinical trials: GENE EXPRESSION
Breast Cancer Metastatic
HER2-PET: Predicting T-DXd Efficacy and HER2 Heterogeneity
The study will be conducted as an open-label, single-center, Phase II clinical study, with a planned enrollment of 86 patients with locally advanced or metastatic HER2-positive and HER2-low breast cancer who are intended to…
- Trial name
- PREDICT-HER (NCT07586215)
- Testing
- PET
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Fudan University
Parkinson
The Effect of Deep Brain Stimulation on Facial Expressions.
Whether Subthalamic Nucleus (STN) Deep Brain Stimulation (DBS), a treatment commonly used to ameliorate the motor symptoms of Parkinson's disease (PD), affects on facial expressions is unclear.
- Trial name
- STN-DBS (NCT03558568)
- Testing
- Deep Brain Stimulation
- Where
- Turkey (Türkiye)
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Mustafa Kemal University
Exposure to Pollution, Inhalation of Ozone
Epigenetic Effects of Diesel Exhaust and Ozone Exposure
Purpose: The purpose of this protocol is to compare the genetic and epigenetic effects between diesel exhaust and ozone exposure in healthy individuals and in mild/moderate asthmatics.
- Trial name
- Lamarck (NCT01492517)
- Testing
- Ozone exposure, Diesel exhaust, Ozone18
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Environmental Protection Agency (EPA)
Cognitive Decline
Analysis of Inflammatory Predictors and Gene Expression in Patients With Mild Cognitive Impairment
A randomized, double-blind, placebo-controlled clinical trial will be conducted, using data from participants who met the diagnostic criteria for mild cognitive impairment and who participated in a primary clinical trial that…
- Trial name
- NCT04934423
- Testing
- Direct Current Transcranial Stimulation - tDCS
- Volunteers
- 40 people
- Sponsor
- Federal University of Paraíba
Triple-Negative Breast Cancer
T-DXd in the First-Line Treatment of Locally Advanced or Metastatic TNBC-LAR HER2-low Patients
This is an open-label, single-arm phase II trial of first-line treatment with trastuzumab deruxtecan (T-DXd) for patients with locally advanced or metastatic triple-negative breast cancer, luminal androgen receptor subtype…
- Trial name
- NCT05953168
- Testing
- Trastuzumab Deruxtecan
- Where
- China
- Volunteers
- 69 people
- Sponsor
- Fudan University
Follicular Thyroid Cancer
Aberrant Helix Pomatia Agglutinin Binding Glycan Expression in Follicular Thyroid Tumours
Aberration of glycosylation is a hallmark of cancer cells, and plays an important role in oncogenesis and cancer progression, including metastasis.
- Trial name
- NCT05052359
- Testing
- Lectin-histochemistry retrospectively performed
- Where
- Singapore
- Volunteers
- 37 people
- Sponsor
- National University Health System, Singapore
Barrett's Esophagus
Barrett's Esophagus - 315 - 3 Way Cross Over
This study evaluates PGE2 production, COX-2 enzyme activity and PCNA expression in Barrett's metaplastic tissue. All patients will have a baseline endoscopy with multiple biopsies.
- Trial name
- NCT00637988
- Testing
- Esomeprazole, Aspirin, Rofecoxib
- Volunteers
- 32 people
- Sponsor
- AstraZeneca
Neoplasms
Differential Expression of CD200 in B-chronic Lymphoproliferative Disorders by Multicolour Flow Cytometry
The investigator's goals in this study are to assess : 1. Differential expression of CD200 by using flow cytometric immune-phenotyping in broad range of patients with B-chronic lymphoproliferative disorders (B-CLPD) 2.
- Trial name
- NCT03712488
- Testing
- flowcytometry
- Volunteers
- 50 people
- Sponsor
- Assiut University
Prostate Cancer, Resistance, Disease
Search for Predictive Factors of Resistance to Treatment for Metastatic Castration-resistant Prostate Cancer by Studying the Expression of microRNAs
Several drugs are available for metastatic castration resistant prostate cancer such as chemotherapy (docetaxel, cabazitaxel) and novel hormonal agents (abiraterone, enzalutamide), in France.
- Conditions
- Prostate Cancer, Resistance, Disease, MicroRNAs
- Trial name
- MiR_CPMRC (NCT04662996)
- Testing
- Blood sample
- Where
- France
- Volunteers
- 33 people
- Sponsor
- University Hospital, Tours
Colorectal Cancer
Role of IMP3 Expression in Colorectal Carcinoma: An Immunohistochemical Study
Colorectal carcinoma (CRC) is the third most common malignancy worldwide. In Egypt, the relative frequency of CRC is about 9-12% with high male predominance 3:1.
- Trial name
- NCT05601388
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Sohag University
Ventricular Tachycardia, Cardiovascular Diseases
Genetic Substudy of the Alternans Before Cardioverter Defibrillator (ABCD) Trial
The ABCD clinical study (ClinicalTrials.gov Identifier NCT00187291) was designed to determine if a T-Wave Alternans (TWA) test is equivalent to an Electrophysiology Study (EPS) in predicting life-threatening heart rhythms in…
- Conditions
- Ventricular Tachycardia, Cardiovascular Diseases, Arrythmia, CVD
- Trial name
- ABCD (NCT00583297)
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- CardioDx
Inflammation
Effect of Glucose Load on Expression of Advanced Glycation End Products in Women Screened for Gestational Diabetes
The investigator's main objective is to analyze the effects of a routine prenatal care screening tool (glucola test for gestational diabetes) on maternal inflammation through assessment of maternal circulatory biomarkers and…
- Trial name
- NCT03029546
- Where
- United States
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Ohio State University
Urinary Bladder Cancer
An Epidemiologic Study on PD-L1 Expression Combined With Clinical Observation in the Chinese MIUBC Patients.
The Primary Objective of this observational study is to investigate the prevalence of high PD-L1 expression in Chinese MIUBC patients.
- Trial name
- POLARIS (NCT03433924)
- Where
- 17 sites in China
- Volunteers
- 248 people
- Sponsor
- AstraZeneca
Systemic Lupus Erythematosus
Evaluation of Janus Kinase_3 in Juvenile Onset Systemic Lupus Erythematosus
One of the best understood mechanisms by which cytokines activate signals, thus eliciting specific responses in target cells, involves enzymes such as Janus kinases (JAKs) and transcriptional factors such as signal transducers…
- Trial name
- NCT04293510
- Testing
- renal biopsy and blood sampling
- Volunteers
- 67 people
- Sponsor
- Assiut University
Cutaneous Melanoma
Expression of IL4 Induced Gene 1 in Patients With Cutaneous Melanoma: Value in Prognosis and/or in Predictive Response to Immune Checkpoint Inhibitors
To characterize and quantify immune cells expressing the Interleukine 4 induced gene 1 (IL4I1) immunosuppressive enzyme in the blood and in tissue of melanoma patients (primary tumor, sentinel lymph nodes and cutaneous…
- Trial name
- ENZYMELA (NCT04253080)
- Testing
- Blood sample, Cutaneous melanoma biopsy
- Where
- France
- Volunteers
- 127 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Feeding; Difficult, Newborn
An Exploration of Antenatal Hand Expression.
The study is an exploration of mother's experiences of antenatal hand expression of colostrum, and the effects upon breastfeeding continuation and maternal emotional health
- Trial name
- NCT05307497
- Where
- United Kingdom
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- University of Liverpool
Autism Spectrum Disorder, High-functioning Autism
Neuralized1 and RGS14 Genes
Autism is a broad spectrum neurodevelopmental disease. Some individuals with ADS by high cognitive functions are diagnosed with High Functioning Autism (HFA).
- Conditions
- Autism Spectrum Disorder, High-functioning Autism, Healthy
- Trial name
- NCT04865198
- Testing
- Neurl1 gene expression, RGS14 gene expression
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- TC Erciyes University
Chronic Obstructive Pulmonary Disease
Expression of SLC25A48 in Chronic Obstructive Pulmonary Disease
This study aims to investigate the expression level of SLC25A48, a mitochondrial choline transporter, in peripheral blood mononuclear cells of patients with chronic obstructive pulmonary disease, and to analyze its correlation…
- Trial name
- NCT07474220
- Where
- 2 sites in Taiwan
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Fu Jen Catholic University
Healthy
Changes in mRNA Expression Following Exposure to Naproxen
Using tissue samples obtained from a previous study, the effect of naproxen on the gene expression profiles of antral mucosal tissue will be assessed.
- Trial name
- Lesions3 (NCT01090596)
- Testing
- Naproxen
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Research Associates of New York, LLP
Neonatal Disease
Intestinal Genes Expression Associated With Necrotizing Enterocolitis
In recent days, necrotizing enterocolitis is one of the most common and devastating problem in preterm infants. Therefore, it became a high growing research topic in the last decade.
- Trial name
- NCT04073342
- Testing
- Gene expression of inflammatory mediator (Interleukin 8) and recognition receptor of Toll like receptor (TLR4).
- Volunteers
- 1 people
- Sponsor
- Assiut University