Clinical trials: GENE EXPRESSION
Asthma, Inflammation
Mucins and Toll-like Receptors in Asthma
This study raises two main hypotheses: 1) Asthmatics patients who present with bronchial hypersecretion differ phenotypically from asthmatic patients without hypersecretion and 2) mucins in asthmatic patients with hypersecretion…
- Trial name
- MUCITOLL (NCT02948153)
- Testing
- clinical study
- Where
- Spain
- Volunteers
- 43 people
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Type 1 Diabetes Mellitus
Gene Expression Profiling in Type 1 Diabetes
One of the goals of the Kansas City Diabetes Consortium is to identify and characterize genes and their products that are associated with T1DM.
- Trial name
- NCT00330954
- Where
- United States
- Volunteers
- 64 people
- Sponsor
- Children's Mercy Hospital Kansas City
Cluster Headache
Role of Specific microRNAs in Cluster Headache
Cluster headache (CH) is a primary headache included in the trigeminal autonomic cephalalgias (TACs) according to the International Calssification of Headache Disorder, Third Edition.
- Trial name
- 5*1000 (NCT06503328)
- Where
- Italy
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- IRCCS National Neurological Institute "C. Mondino" Foundation
Multiple Myeloma in Relapse, Multiple Myeloma, Refractory
Cyclosporine in Combination With Carfilzomib and Dexamethasone in Relapsed Multiple Myeloma Refractory to Carfilzomib and High Expression of PPIA Gene in Myeloma Cells
This phase 1, open-label, single-arm, prospective, single center study will evaluate the safety, tolerability and efficacy of cyclosporine in combination with carfilzomib and dexamethasone in patients with relapsed and refractory…
- Trial name
- NCT04813653
- Testing
- cyclosporine in combination with carfilzomib and dexamethasone
- Where
- Israel
- Volunteers
- 3 people
- Sponsor
- Tel-Aviv Sourasky Medical Center
Stem Cells
Isolation and Characterization of Mammary Stem Cells
Background: Cancer stem cells in breast cancer have been identified as a small population of tumor cells whose self-renewal mechanism is highly deregulated. This deregulation seems to be necessary for cancer to develop.
- Trial name
- NCT00340392
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- National Cancer Institute (NCI)
Head and Neck (HNSCC)
Matching Primary Tumor and Blood Gene Expression Analysis of HPV-negative Squamous Head and Neck Cancers
The goal of this observational study is to learn whether a blood test can show the same biological features as the tumor in people with head and neck cancer that is not caused by HPV.
- Trial name
- BIOMATCH (NCT07512921)
- Testing
- Standard of Care (Investigator Choice)
- Where
- 2 sites in Italy
- Volunteers
- 300 people
- Sponsor
- Fondazione IRCCS Istituto Nazionale dei Tumori, Milano
Lung Cancer
Construction and Use of Lung Tumor Microarray for the Analysis of Gene Expression in Lung Cancer
The proposed research intends to construct a set of tissue microarrays containing different types of normal and lung cancer tissues for the study of genes associated with lung cancer.
- Trial name
- NCT00340847
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- National Cancer Institute (NCI)
Delirium, Artificial Intelligence (AI)
Development and Validation of Delirium Recognition Using Computer Vision in Neuro-critical Patients
This research project employs machine learning algorithms integrated with computer vision, image processing, and pattern recognition technologies to perform digital analysis of facial expression behaviors in neurocritical care…
- Trial name
- NCT07136207
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- Beijing Tiantan Hospital
Type 2 Diabetes
Gene Expression Profiles and Metformin Efficacy in Type 2 Diabetes
Our general aim is to investigate whether messenger RNA (mRNA) and/or microRNA (miRNA) expression profiles in white blood cells, predict metformin monotherapy efficacy in patients with type 2 diabetes.
- Trial name
- NCT01334684
- Testing
- Metformin
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- Casa Sollievo della Sofferenza IRCCS
Chronic Low Back Pain, Self-Management
Physical Activity on Neurophysiologic Gene Expression Profiles of Chronic Low Back Pain
This pilot project will provide an understanding of the contextual variables responsible for chronic low back pain. These variables include, genetic variation, pain sensitivity, reactivity, pain catastrophizing, perceived stress…
- Trial name
- PROPEL (NCT03637998)
- Testing
- Problem-solving Pain to Enhance Living Well (PROPEL)
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Connecticut
Breast Cancer
MammaPrint, BluePrint, and Full-genome Data Linked With Clinical Data to Evaluate New Gene EXpression Profiles
The FLEX Registry will be implemented to operate as a large-scale, population based, prospective registry. All patients with stage I to III breast cancer who receive MammaPrint® and BluePrint testing on a primary breast tumor are…
- Trial name
- FLEX (NCT03053193)
- Testing
- MammaPrint, BluePrint, and Full-Genome Testing
- Where
- 134 sites in United States, Canada and 2 more
- Volunteers
- 30,000 people
- Sponsor
- Agendia
Breast Cancer
A Study Of Changes In PD-L1 Expression During Preoperative Treatment With Nab-Paclitaxel And Pembrolizumab In Hormone Receptor-Positive Breast Cancer
This research study is exploring chemotherapy in combination with immunotherapy (a therapy that uses the body's own immune system to control cancer) as a possible treatment for hormone receptor positive breast cancer.
- Trial name
- NCT02999477
- Testing
- Pembrolizumab, Nab-Paclitaxel, Biopsy
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Adrienne G. Waks
Vulvar Lichen Sclerosus
To Compare Inflammatory Biomarkers Before and After Treatment With Clobetasol or Fractional CO2 Laser, in Women With Histologically Confirmed Vulvar Lichen Sclerosus, Without Prior Corticosteroid Treatment.
The present study is a Clinical trial that compares clobetasol ointment versus Fractional CO2 laser for vulvar lichen sclerosus (VLE) treatment confirmed by histology, with no previous treatment.
- Trial name
- LASER (NCT07240519)
- Testing
- Fractional microablative CO2 Laser
- Where
- Brazil
- Volunteers
- 40 people
- Sponsor
- Universidade Federal do Rio de Janeiro
Acute Lymphoblastic Leukemia, BCR-ABL1 Fusion Protein Expression
Combination Chemotherapy and Dasatinib in Treating Participants With Philadelphia Positive or BCR-ABL Positive Acute Lymphoblastic Leukemia.
This phase II trial studies how well combination chemotherapy and dasatinib works in treating participants with Philadelphia-positive or B-cell receptor-ABL positive acute lymphoblastic leukemia.
- Conditions
- Acute Lymphoblastic Leukemia, BCR-ABL1 Fusion Protein Expression, Blast Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive, Philadelphia Chromosome Positive
- Trial name
- NCT00390793
- Testing
- Cyclophosphamide, Cytarabine, Dasatinib
- Where
- United States
- Volunteers
- 107 people
- Sponsor
- M.D. Anderson Cancer Center
Breastmilk Expression, Collection, Breastmilk
Antenatal Breastmilk Expression From Week 34 of Gestation
In this pilot study, the investigators aim to examine if antenatal breastmilk expression from week 34 of pregnancy is a safe and feasible procedure for the mother and fetus.
- Conditions
- Breastmilk Expression, Collection, Breastmilk, Breastfeeding, Healthy
- Trial name
- EXPRESS-MOM (NCT05516199)
- Testing
- Antenatal breastmilk expression, Breastfeeding consultation
- Where
- Denmark
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Odense University Hospital
Solid Tumors, Neoplasms (Cancer / Tumors)
Exploratory Study on the Efficacy and Safety of Trastuzumab Rezetecan in the Treatment of HER2-Expressiong Advanced Solid Tumor
The goal of this clinical trial is to learn if Trastuzumab Rezetecan can treat advanced solid tumors with HER-2 expression in adult participants.
- Conditions
- Solid Tumors, Neoplasms (Cancer / Tumors), Advanced Malignant Solid Neoplasm, Locally Advanced Malignant Solid Neoplasm
- Trial name
- NCT07631884
- Testing
- Trastuzumab Rezetecan
- Volunteers
- 15 people
- Sponsor
- Haihua Yuan
Breast Cancer
Investigation of the Prognostic Value of Patterns of Genomic Alterations or Protein Expression in Patients With Operated Early Breast Cancer
This study retrospectively analyze tumor samples and clinical data from Greek women with operable breast cancer of intermediate or high-risk of relapse who participated in HeCOG adjuvant studies.
- Trial name
- NCT07630558
- Where
- Greece
- Volunteers
- 1,891 people
- Sponsor
- Hellenic Cooperative Oncology Group
Prostate Cancer
Expression of Tumor Markers in Circulating Tumor Cells of Metastatic Hormone-sensitive Prostate Cancer
As prostate cancer progresses, tumor cells dissociate and enter the bloodstream. Considered a "liquid biopsy," these circulating tumor cells (CTC) can show how a patient's cancer evolves and responds to treatments.
- Trial name
- NCT02723526
- Testing
- Blood drawing
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Fudan University
Non-Small Cell Lung Cancer
Saliva mRNA Expression Profiling for Early Stage Non-Small Cell Lung Cancer Screening
This is a pilot study to test the feasibility of using gene expression from saliva to identify patients with early-stage non-small cell lung cancer (NSCLC).
- Trial name
- SPIT-LC (NCT00607425)
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Scottsdale Healthcare
Alveolar Childhood Rhabdomyosarcoma, Childhood Rhabdomyosarcoma
Biomarkers in Tumor Tissue Samples From Younger Patients With Rhabdomyosarcoma
This research trial studies biomarkers in tumor tissue samples from younger patients with rhabdomyosarcoma. Studying samples of tumor tissue from patients with cancer in the laboratory may help doctors learn more about changes…
- Conditions
- Alveolar Childhood Rhabdomyosarcoma, Childhood Rhabdomyosarcoma, Embryonal Childhood Rhabdomyosarcoma
- Trial name
- NCT01496573
- Testing
- laboratory biomarker analysis
- Where
- United States
- Volunteers
- 77 people
- Sponsor
- Children's Oncology Group