Clinical trials: Functional MRI
Chronic Pain, Intractable Pain
Multi-center Prospective Study Determining the Sustainability of Pain Relief and Psychosocial and Functional Responses When Utilizing a Multiple Waveform Enabled Neurostimulator
The TRIUMPH study is a post-market, international, multicenter, interventional, prospective, single-arm study intended to evaluate the sustainability of pain control and psychosocial and functional responses utilizing a…
- Trial name
- TRIUMPH (NCT03082261)
- Testing
- Prodigy, Prodigy MRI or Proclaim Elite IPG
- Where
- 22 sites in United States, Canada and 5 more
- Volunteers
- 269 people, healthy volunteers welcome
- Sponsor
- Abbott Medical Devices
Healthy
Chatbot Intervention Effects on Social and Monetary Incentive Processing in Anhedonia
The main aim of the present study is to investigate the effects of a Motivational Interviewing-based artificial intelligence chatbot on social incentive processing in college students with elevated levels of depression and…
- Trial name
- NCT07665242
- Testing
- MI Chatbot Interaction, Active Control Chatbot Interaction
- Where
- China
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Electronic Science and Technology of China
Healthy
tDCS of the Left dlPFC: Effects on Information Processing
This study investigates how a non-invasive form of brain stimulation, called transcranial direct current stimulation (tDCS), affects brain activity and information processing in younger and older adults.
- Trial name
- NCT07168031
- Testing
- Active Transcranial Direct Current Stimulation (tDCS)
- Where
- Switzerland
- Volunteers
- 196 people, healthy volunteers welcome
- Sponsor
- University of Bern
Healthy
Biological Basis of Individual Variation in Social Cooperation
The project has three overall objectives. The first is to determine whether and how administration of intranasal oxytocin (OT) and intranasal vasopressin (AVP) influence cooperative decision-making and neural responses to…
- Trial name
- NCT01566539
- Testing
- Intranasal Oxytocin (OT) 24 IU, Intranasal Vasopressin (AVP), Intranasal Vasopressin (AVP) 40 IU
- Where
- 2 sites in United States
- Volunteers
- 707 people, healthy volunteers welcome
- Sponsor
- Emory University
Healthy
Cardiac Magnetic Resonance Imaging (MRI) Normal Reference Control Group Testing
The purpose of this research is to understand how to apply cardiac magnetic resonance imaging (CMR) to women with small artery heart disease by looking at the CMRs of women without heart disease.
- Trial name
- NCT00573339
- Testing
- Cardiac MRI
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Cedars-Sinai Medical Center
Anxiety Disorders
PharmacofMRI (Functional Magnetic Resonance Imaging) of Anxiolytic Medications (Alprazolam)
The purpose of this study is to use functional magnetic resonance imaging (fMRI) in healthy controls to examine the acute effects of certain anxiolytic medications on brain function.
- Trial name
- NCT00703885
- Testing
- 0.25 mg alprazolam, 1.0 mg alprazolam
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Bipolar Disorder, Alcohol Drinking
Acute Alcohol Response In Bipolar Disorder: a fMRI Study
Alcohol use disorders (AUDs) affect up to 60% of individuals with bipolar disorder during their lifetime-a rate 3 to 5 times higher than what occurs in the general population.
- Conditions
- Bipolar Disorder, Alcohol Drinking, Alcohol Use Disorder
- Trial name
- BACS (NCT04063384)
- Testing
- alcohol beverage
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Texas at Austin
Coronavirus Disease 2019
Olfactory and Neurosensory Rehabilitation in COVID-19-related Olfactory Dysfunction
A combination of oral vitamin A (VitA) and intense aromatic chemosensory smell training (ST) by pulse aromatic stimulation will expedite the neurosensory recovery of olfaction in patients suffering from prolonged COVID-19-related…
- Trial name
- NCT04900415
- Testing
- Vitamin A, Electronic portable aromatic rehabilitation (EPAR) diffuser
- Where
- 2 sites in Hong Kong
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Ivan FN Hung MD
PTSD, Post-traumatic Stress Disorder
Network-based Neurofeedback in PTSD
This project will examine the use of real-time fMRI (rt-fMRI) neurofeedback in the regulation of neural networks underlying symptoms experienced by individuals with posttraumatic stress disorder (PTSD).
- Trial name
- NCT04875221
- Testing
- Connectivity-based neurofeedback
- Where
- Canada
- Volunteers
- healthy volunteers welcome
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Menstrual Cycle, Hormonal Contraception
Oxytocin and Reward Processing in Women
Oxytocin is a hypothalamic neuropeptide that is best known for its peripheral physiological effects in the female organism i.e., uterine contractions during birth.
- Trial name
- NCT06222749
- Testing
- Intranasal oxytocin administration
- Where
- Germany
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- International Research Training Group 2804
Tinnitus
Exploration of Cortical Neural Network in Patients With Bothersome Tinnitus
This will be an experimental task-based functional MRI pilot study involving the neuroimaging assessment of patients with severely bothersome tinnitus, defined by a global bothersome scale.
- Trial name
- NCT01385540
- Testing
- Task-Based Functional Magnetic Resonance Imaging (fMRI)
- Where
- United States
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Bipolar Disorder
FMRI Study of Brain Response Before and After Lithium Treatment in People With Bipolar Disorder
This study will assess the effects of bipolar disorder on brain activity and will determine if medication changes the brain activity in people with bipolar disorder.
- Trial name
- NCT00596622
- Testing
- Lithium
- Where
- United States
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Indiana University
Healthy
Use of a Functional Neuroimaging Battery for the Evaluation of a Meditation Retreat
Over 2 decades scientists have been studying the effect on brain function from meditation practices. The purpose of this study is to measure the effect of a meditation retreat program on serotonin and dopamine transporter binding…
- Trial name
- FETZER (NCT02443766)
- Testing
- Meditation Retreat
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Thomas Jefferson University
Healthy Volunteers
Insulin Modulation of fMRI Connectivity in Healthy Adults
This study evaluates the effects of changing insulin levels on brain activity. Participants will complete functional magnetic resonance imaging (fMRI) scans during fasting conditions, then during an insulin infusion.
- Trial name
- NCT02982551
- Testing
- Insulin, Taste Task, Magnetic Resonance Imaging
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Pittsburgh
AUD
Title: Effect of Opioid Receptor Modulation on Alcohol Self-Administration and Neural Response to Alcohol Cues in Heavy Drinkers: Role of OPRM1 Gene Variation
Background: Drugs like nalmefene interfere with opioid receptors. This might reduce drinking. The gene OPRM1 determines opioid receptor functions. Researchers want to see if nalmefene affects people s responses to alcohol cues.
- Trial name
- NCT02639273
- Testing
- Nalmefene
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Aging
Arlington Aging Study
The goal of this observational study is to learn about the mechanisms causing functional decline with age, using magnetic resonance imaging, exercise science, integrative physiology, neuroscience, and remote monitoring.
- Trial name
- NCT06857877
- Where
- United States
- Volunteers
- 770 people, healthy volunteers welcome
- Sponsor
- The University of Texas at Arlington
Healthy Volunteers
Investigating the Analgesic Potential of (2R,6R)-HNK in Acute Pain in Healthy Volunteers
Background: Opioid drugs are often prescribed for acute and chronic pain. But these drugs are addictive, and they lead to more than 14,000 overdose deaths in the United States each year.
- Trial name
- NCT07504601
- Testing
- (2R,6R)-Hydroxynorketamine
- Where
- United States
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- National Center for Complementary and Integrative Health (NCCIH)
Bilingualism
Neural Correlates of Language Control in Bilinguals. Functional MRI and Stimulation Mapping Data in Awake Surgery.
For bilingual and multilingual patients, brain activation and Electric Stimulation Mapping studies have shown that different languages may be localized, at least partially, in distinct microanatomical systems located within the…
- Trial name
- NEUROSWITCH (NCT02391493)
- Testing
- functional magnetic resonance imaging
- Where
- France
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University Hospital, Toulouse
Group 1: Healthy Controls, Group 2: Stable CF
Assessment of CFTR-Modulator Treatment in Cystic Fibrosis Lung Disease Using Novel Structural and Functional MRI
This is a prospective, longitudinal observational study conducted at The Hospital for Sick Children (SickKids). The purpose of this study is to evaluate the ability of MRI to detect changes in lung structure and function in CF…
- Conditions
- Group 1: Healthy Controls, Group 2: Stable CF, Group 3: CF Participants Anticipated to Receive CFTR-modulator Therapy, Group 4: 4-8 yo CF Participants Starting Triple Combination Modulator Therapy
- Trial name
- NCT04391322
- Where
- Canada
- Volunteers
- 86 people, healthy volunteers welcome
- Sponsor
- The Hospital for Sick Children
Depression
Functional Neuroanatomy and Regional Metabolism Before and After Treatment With Duloxetine
The findings may guide future investigations on novel therapeutic targets in depressive subjects. Based on the depicted link between personality traits and altered brain metabolism and function, the latter might be used as…
- Trial name
- NCT02658617
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Heinz Boeker
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