Clinical trials: Functional MRI
Atrial Fibrillation
Relationship Between Autonomic Central Nervous System Activation and Atrial Fibrillation Using Functional MRI (fMRI)
The fMRI study is a prospective study with the objective of evaluating the effects of the autonomic central nervous system on the regulation of heart rate in patients with atrial fibrillation (AF).
- Trial name
- fMRI (NCT02524028)
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- University of Utah
Hepatic Encephalopathy, Cirrhosis
Default Mode Network fMRI Maps as a Predictive Index of Hepatic Encephalopathy Outcome
Investigating the impact of hepatic encephalopathy on default mode networks within the brain to provide more clues with understanding the physiology of consciousness and predicting the reversibility of comatose states.
- Conditions
- Hepatic Encephalopathy, Cirrhosis, Nonalcoholic Steatohepatitis, Hepatitis C
- Trial name
- NCT02083367
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- OSF Healthcare System
Mild Traumatic Brain Injury
Functional MRI Study of Attention in Normal Controls and Traumatic Brain Injured Patients
The purpose of this study will be to assess the attentional ability of patients with mild to moderate traumatic brain injury (TBI) using the functional Magnetic Resonance Imaging (fMRI) technique.
- Trial name
- NCT00580918
- Testing
- functional magnetic resonance imaging fMRI
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of California, Irvine
Depression Disorder, fMRI Research
Modulatory Effects of Personalized Transcranial Magnetic Stimulation (TMS) on Heart-Brain Coupling in Individuals With Depressive Tendencies
This study focuses on individuals with depressive tendencies and investigates the regulatory effects of Transcranial Magnetic Stimulation (TMS)-guided by personalized functional connectivity mapping-on heart-brain coupling in…
- Conditions
- Depression Disorder, fMRI Research, Heart-Brain Coupling
- Trial name
- NCT07753473
- Testing
- DLPFC-insula TMS, DLPFC-sgACC TMS, 10-20 F3 TMS
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Xidian University
Parkinson's Disease
Superior Colliculus Activity in Parkinson Disease: a Potential Marker?
The ultimate goal of this project is to evaluate a possible new strategy to diagnose earlier Parkinson's disease, using the superior colliculus as a biomarker.
- Trial name
- AGIRPARK (NCT02488395)
- Testing
- fMRI, Ophthalmologic evaluation, visual psychophysics test
- Where
- 3 sites in France
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Female Sexual Dysfunction, Anorgasmia
Clitoral Location in Relation to Sexual Function Using Pelvic Imaging
Women who are unable to achieve orgasm compared to women who have normal orgasmic function may have different clitoral anatomy and different hormone levels.
- Trial name
- NCT01195701
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- TriHealth Inc.
Major Depressive Disorder
Impact of an Eight Week Exercise Intervention in Treating Major Depressive Disorder
To investigate the impact of a structured eight week exercise intervention as an add-on therapy in treating Major Depressive Disorder.
- Trial name
- NCT03191994
- Testing
- Exercise
- Where
- Canada
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Ontario Institute of Technology
Healthy Nutrition
DHA & Lutein and fMRI Brain Mapping in Healthy Children
Studies suggest that lutein and n-3 fatty acids may influence the development of a child's brain and may be related to how well children learn.
- Trial name
- NCT01789866
- Where
- Canada
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Healthy, Schizotypal Personality
Exceptional Experiences (EE), Salience & Dopaminergic Neurotransmission
The dopamine hypothesis of schizophrenia implies that alterations in the dopamine system cause functional abnormalities in the brain that may converge to aberrant salience attribution and eventually lead to psychosis.
- Trial name
- NCT03333369
- Testing
- 200 mg levodopa/50 mg benserazide, Dextrose
- Where
- Switzerland
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Larynx Disease, Laryngeal Stenosis
The Effectiveness of Reconstructive Microsurgery on the Clinical and Functional State of Laryngeal Stenosis
To improve diagnostic methods for patients with laryngeal stenosis for the optimal determination of the technique of surgical treatment.
- Trial name
- NCT04734483
- Testing
- spirometry, MRI and CT, Laryngoscopy
- Where
- 2 sites in Kazakhstan, Russia
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Astana Medical University
Perinatal Hypoxia, Dopamine
Measuring Brain Activity of School Age Children
This observational study will investigate whether differences in birth events and oxygen levels during the newborn period affects the brain activity of children during the middle childhood years.
- Conditions
- Perinatal Hypoxia, Dopamine, Neurobehavioral Manifestations
- Trial name
- NCT03407729
- Testing
- Magnetic Resonance Imaging, Cognitive Performance Testing
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Case Western Reserve University
Healthy
Neurofeedback to Reduce Spontaneous Recovery of Threat Expectancy
This study tests the efficacy of a new behavioral intervention with the goal of reducing spontaneous recovery of threat expectancy in healthy adults.
- Trial name
- NCT07122739
- Testing
- Active Real-time fMRI Neurofeedback
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Trustees of Princeton University
Anterior Cruciate Ligament Reconstruction;Resting State Functional Magnetic Resonance;Three-dimensional Gait Analysis;Return to Sports
The Establishment of Advanced Brain Function Evaluation Model for Anterior Cruciate Ligament Reconstruction
It is difficult to establish the standard of return to sports post anterior cruciate ligament (ACL) reconstruction. The amplitude of low frequency fluctuation (ALFF) and functional connectivity (FC) of resting state functional…
- Trial name
- NCT04715672
- Where
- China
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Healthy Volunteers
Healthy Lung Study- Development of 3T MRI Hardware and Software for 3He Gas Imaging of the Lung: Healthy Volunteer Development Study
Healthy volunteers aged 18-75 will undergo hyperpolarized 3-Helium MRI and pulmonary function testing for the development of tools to assess image signal to noise and reproducibility of spin-density and diffusion-weighted imaging.
- Trial name
- NCT03169673
- Testing
- Hyperpolarized Helium 3 Magnetic Resonance Imaging
- Where
- Canada
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Western University, Canada
Prostate Cancer, Adverse Effects Surgery
TRANBERG® Transperineal MR/US Fusion Laser--Induced Thermal Therapy for Men With Prostate Cancer
This study is set up as a phase I prospective, single center, device interventional pilot study carried in office setting under local anesthesia.
- Conditions
- Prostate Cancer, Adverse Effects Surgery, MRI, Ultrasound
- Trial name
- TPF-LITT (NCT05698576)
- Testing
- TRANBERG® Transperineal Fusion Laser--Induced Thermal Therapy of Prostate Cancer (TPF-LITT)
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Urological Research Network, LLC
Parkinson
Impact of Exercise on Muscle Metabolism and Function for Persons With Parkinsons
This investigation assesses the impact of a strengthening program on muscle metabolism in the gastrocnemius muscle (GM) and is an essential step in the establishment of future clinical intervention for the GM in people with…
- Trial name
- NCT07720713
- Testing
- Home Exercise Program
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Amputation, Congenital, Upper Limb; Amelia
CNS Changes Following Upper Limb Loss
The objective of this study is to better understand the structural and functional changes that the central nervous system (CNS) undergoes following congenital upper limb loss.
- Trial name
- NCT06043518
- Testing
- MRI
- Where
- Switzerland
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Repetitive Negative Thinking, Neurofeedback
Effect of Mindfulness-based Neurofeedback for Adolescents With Elevated Repetitive Negative Thinking
This study will test the hypotheses that adolescent with repetitive negative thinking who at at-risk for serious mental illness will show greater default mode network (DMN) connectivity than healthy controls, at-risk adolescents…
- Trial name
- CHARMS (NCT07055217)
- Testing
- Mindfulness Training, Mindfulness-based Neurofeedback (Real mbNF)
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Alzheimer's Disease
The Role of Mid-Life Adiposity in Functional Brain Connectivity
The purpose of the study is to use functional MRI (fMRI) to measure brain connectivity in middle-aged individuals with different levels of body fat.
- Trial name
- NCT01777789
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Medical College of Wisconsin
Attention-Deficit/Hyperactivity Disorder (ADHD)
Investigation of the Association of Multimodal Neuroimaging and Peripheral Biomarkers With Executive Functions and Emotional Regulation in Adolescents With Attention-Deficit/Hyperactivity Disorder
The purpose of this observational study is to investigate the relationships among resting-state brain connectivity, peripheral blood biomarkers, executive functions, and emotional regulation in adolescents with…
- Trial name
- NCT07800117
- Testing
- No Intervention
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Akdeniz University
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