Clinical trials: Functional Decline
Alzheimer Disease
A Donanemab (LY3002813) Study in Participants With Preclinical Alzheimer's Disease (TRAILBLAZER-ALZ 3)
The main purpose of this study is to evaluate the safety and efficacy of donanemab in participants with preclinical Alzheimer's Disease (AD) over up to 332 weeks.
- Trial name
- NCT05026866
- Testing
- Donanemab
- Where
- 216 sites in United States, Japan and 1 more
- Volunteers
- 2,996 people
- Sponsor
- Eli Lilly and Company
Cognitive Decline
Manipulating Cognitive Intensity During Aerobic Exercise
The purpose of this study is to investigate the performance effects of manipulating the properties of a cognitively engaging aerobic task.
- Trial name
- NCT06479265
- Testing
- Phyical/Cognitve Exercise
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Southern California
Idiopathic Pulmonary Fibrosis(IPF)
Jin-shui Huan-xian Formula for Retarding the Decline of Pulmonary Function in IPF
This study is to evaluate the clinical efficacy and safety of Jin-shui Huan-xian Formula in retarding the decline of pulmonary function in IPF, generate high - quality clinical evidence, and establish a treatment plan of Jin-shui…
- Trial name
- NCT06914713
- Testing
- Jin-shui Huan-xian granule
- Where
- China
- Volunteers
- 384 people
- Sponsor
- Henan University of Traditional Chinese Medicine
Healthy
Effects of Dietary Interventions on the Aging Brain
The researchers will investigate whether caloric restriction or dietary supplementation could provide positive effects on general brain functions in healthy elderly people.
- Trial name
- NCT00996229
- Testing
- Caloric restriction, Omega-3 (fish oil capsules), Resveratrol
- Where
- Germany
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- University Hospital Muenster
Cognitive Decline, Heart Diseases
The Effect of Intranasal Insulin Administration on Cognitive Function After Cardiac Surgery.
Decline in cognitive function after surgery occurs most commonly in older patients and patients undergoing major surgeries, such as heart surgery.
- Conditions
- Cognitive Decline, Heart Diseases, Delirium
- Trial name
- NCT03324867
- Testing
- Regular insulin, Normal Saline Flush, 0.9% Injectable Solution
- Volunteers
- 316 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Knee Osteoarthritis, Chronic Knee Pain
Selective Nerve Ablation for Chronic Knee Pain: A Retrospective Study
SAVE-KNEE is a single-center retrospective observational cohort study evaluating outcomes of ultrasound-guided cryoneurolysis, radiofrequency ablation and chemical neurolysis for chronic knee pain in routine clinical care.
- Trial name
- SAVE-KNEE (NCT07835672)
- Testing
- Ultrasound-Guided Cryoneurolysis, Ultrasound-Guided Radiofrequency Ablation, Ultrasound-Guided Chemical Neurolysis
- Where
- Poland
- Volunteers
- 746 people
- Sponsor
- Michał Bartoszewicz
Subjective Cognitive Decline (SCD)
Polyamine-enriched Diet in Elderly Individuals With Subjective Cognitive Decline
The overall objective of this study is to examine the effect of polyamine supplementation on cognitive performance and further characterization of individuals with subjective cognitive decline.
- Trial name
- SmartAge (NCT03094546)
- Testing
- Polyamine
- Where
- Germany
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Charite University, Berlin, Germany
Insulin Resistance, Mild Cognitive Impairment
Effects of Sabroxy® Supplementation on Insulin Resistance and Cognitive Function in Adults With Mild Cognitive Impairment and Insulin Resistance
This randomized, double-blind, placebo-controlled, 8-week clinical trial is designed to evaluate the effects of Sabroxy®, a standardized extract of Oroxylum indicum bark, on insulin resistance and cognitive function in adults…
- Conditions
- Insulin Resistance, Mild Cognitive Impairment, Cognitive Decline, Neurodegenerative Disorders
- Trial name
- NCT07220694
- Testing
- Sabroxy®
- Where
- United States
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- SF Research Institute, Inc.
Age-Related Cognitive Decline, Age-Related Memory Disorders
Memory Improvement With Docosahexaenoic Acid Study (MIDAS)
The purpose of this study is to investigate the effect of docosahexaenoic acid (DHA, 22:6n-3) in improving cognitive functions in subjects with age-related cognitive decline.
- Trial name
- MIDAS (NCT00278135)
- Where
- 14 sites in United States
- Volunteers
- 485 people
- Sponsor
- dsm-firmenich Switzerland AG
Life Style, Risk Reduction
The Effects of a Multidomain Lifestyle Intervention on Brain Functioning and Its Relation With Immunometabolic Markers in Ageing
HELI is a multicenter, randomised controlled trial in two Dutch research centres (Donders Centre for Cognitive Neuroimaging, Nijmegen, and the department of Human Nutrition \& Health at Wageningen University) among 104 older…
- Conditions
- Life Style, Risk Reduction, Cognitive Decline, Aging
- Trial name
- HELI (NCT05777863)
- Testing
- Multidomain lifestyle intervention
- Where
- 2 sites in Netherlands
- Volunteers
- 102 people
- Sponsor
- Donders Centre for Cognitive Neuroimaging
Frail Elderly Subjects
Omega-3 Fatty Acids and/or Multi-domain Intervention in the Prevention of Age-related Cognitive Decline
Epidemiological and fundamental research carried out in recent years has highlighted the role played by omega-3 fatty acids in the process of cognitive decline that accompanies advancing age and Alzheimer's disease.
- Trial name
- MAPT (NCT00672685)
- Testing
- omega-3, multi-domain intervention
- Where
- 13 sites in France, Monaco
- Volunteers
- 1,680 people
- Sponsor
- University Hospital, Toulouse
Age-related Functional Decline, Mild Cognitive Impairment
Health Benefits of Nutraceutical Supplementation in Older Adults.
This study examines a multi-ingredient nutraceutical designed to support several areas of health in older adults, including muscle strength, cognitive function, immune response, and inflammation.
- Trial name
- NCT07534878
- Testing
- Powder containing whey isolate and herbal extracts (30g sachet)
- Where
- India
- Volunteers
- 23 people
- Sponsor
- GPLIFE HEALTHCARE PRIVATE LIMITED
Middle-aged Adults, Major Depressive Disorder
Daily Stress and Vascular Function in Midlife as a Risk Factor for Cognitive Decline
The goal of this pilot clinical trial is to begin to understand how day-to-day stress affects cardiovascular health and brain function in middle-aged adults.
- Trial name
- NCT06466655
- Testing
- MitoTempol, Lactated Ringer's (control)
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- University of Delaware
Memory, Cognitive Function Decline
Cognitive Effects of Bioavailable Curcumin
An estimated 50% of older adults complain of memory changes that worsen as they age. Although numerous commercially available dietary supplements claim cognitive benefits, relatively few well-designed, longitudinal…
- Trial name
- NCT07251985
- Testing
- Curcumin
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Hypertension, Systolic, Cerebrovascular Disease
Intensive Versus Standard Blood Pressure Lowering to Prevent Functional Decline in Older People
This randomized clinical trial examines if lowering and maintaining 24-hour ambulatory systolic blood pressure to <130 mmHg (intensive control) versus <145 mmHg (standard control) slows/halts the progression of deterioration of…
- Trial name
- NCT01650402
- Testing
- Anti-hypertensive therapy to SBP 130 mm Hg, Anti-hypertensive therapy to SBP 145 mm Hg
- Where
- United States
- Volunteers
- 199 people
- Sponsor
- UConn Health
Geriatric Assessment, Geriatric Oncology
Geriatric Oncology Care in Brazil: Remote Geriatric Assessment-Driven Interventions With Supportive Care
The goal of this clinical trial is to determine whether a telehealth-delivered, geriatric assessment-guided supportive care program (GAIN-S) can improve health outcomes in older adults (age 65 and above) with solid tumors who are…
- Conditions
- Geriatric Assessment, Geriatric Oncology, Quality of Life, Functional Decline
- Trial name
- GAIN-S (NCT07084454)
- Testing
- GAIN-S Multidisciplinary Telehealth Intervention, Standard Oncology Care
- Where
- Brazil
- Volunteers
- 350 people
- Sponsor
- Cristiane Decat Bergerot, PhD
Subjective Cognitive Decline (SCD)
Cog-Fun Ageing Participation-centered, Health Promotion for Older Adults
The goal of this feasibility study is to test the feasibility of a group intervention program based on health management principles for older adults with Subjective Cognitive Decline (SCD).
- Trial name
- NCT06632145
- Testing
- Cog Fun Ageing intervention
- Where
- Israel
- Volunteers
- 11 people
- Sponsor
- Hebrew University of Jerusalem
Cognitive Ability, General, Brain Health
Investigating the Combined Effects of Intermittent Hypoxia and Exercise on Cognitive and Cerebral Function in Middle-Aged Adults
This study investigates whether intermittent hypoxia (IH) and physical activity (PA), either alone or in combination (simultaneously or sequentially), can improve cognitive function and brain health in middle-aged adults (50-65…
- Conditions
- Cognitive Ability, General, Brain Health, Cerebral Oxygenation
- Trial name
- HYPOX-AGE (NCT06874387)
- Testing
- Hypoxia, intermittent, physical exercise
- Volunteers
- 176 people, healthy volunteers welcome
- Sponsor
- Ayoub Boulares
Funcional Status, Return to Work
Machine Learning Model for Predicting Recovery After Critical Illness
This study aims to develop and test an artificial intelligence (AI) model to predict long-term functional status and return to work after critical illness.
- Conditions
- Funcional Status, Return to Work, Predictive Learning Models
- Trial name
- NCT07616388
- Testing
- No interventions were performed.
- Where
- Brazil
- Volunteers
- 2,016 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
Cognitive Decline, Cerebrovascular Function
Resistance Training and Neuroimaging
Aging tends to compromise the ability to solve problems, remember details, and process information. At the extreme level, this normal cognitive decline can interfere with independent living.
- Trial name
- RTNI (NCT03982550)
- Testing
- Periodized Resistance Training
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Todd Schroeder