Clinical trials: Functional Decline
Age-related Hearing Loss, Age-related Cognitive Decline
Cognitive Function and EEG Brain Network Remodeling Among Users of Hearing Aids With ARHL
This study intends to retrospectively collect and analyze the case data of patients with age-related hearing loss who were admitted to the Otolaryngology Department of Sun Yat-sen Memorial Hospital from January 2020 to June 2024.
- Conditions
- Age-related Hearing Loss, Age-related Cognitive Decline, Depression, Sleep Disturbance
- Trial name
- EEG/ARHL (NCT06893432)
- Testing
- hearing aids
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
COPD, Lung Function
Lung Function Decline and Disease Risk From Young Adulthood to Middle Age
Chronic obstructive pulmonary disease (COPD) is the third leading cause of death in the United States, but markers that predict risk of developing disease outside of cigarette smoking have not been identified.
- Conditions
- COPD, Lung Function, Heart - Lung Interaction, Restrictive Lung Disease
- Trial name
- CARDIA Lung (NCT02245178)
- Testing
- Lung spirometry, CT scan analysis
- Volunteers
- 3,193 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Mild Cognitive Impairment (MCI), Self-Reported Memory Concerns
Transcranial Direct Current Stimulation Combined With Tai Chi for Dual-Task Mobility and Cognitive Function in Older Adults With Cognitive Decline
This randomized clinical trial evaluated the effects of transcranial direct current stimulation (tDCS) combined with Tai Chi on dual-task mobility, cognitive function, and physical function in older adults with mild cognitive…
- Trial name
- NCT07863518
- Testing
- Tai Chi, Transcranial Direct Current Stimulation
- Where
- 2 sites in China
- Volunteers
- 61 people
- Sponsor
- Shanghai University of Sport
Diminished Ovarian Reserve
A Randomized Controlled Trial of Combined Bu Shen Yi Qi Decoction and Dehydroepiandrosterone (DHEA) for the Treatment of Ovarian Function Decline
The purpose of this clinical trial is to evaluate the efficacy and safety of Bushen Yiqi formula combined with dehydroepiandrosterone (DHEA) in the treatment of women with diminished ovarian reserve (DOR).
- Trial name
- NCT07535983
- Testing
- Bushen formula combined with dehydroepiandrosterone
- Where
- China
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- Jiangxi University of Traditional Chinese Medicine
Physical Functional Performance, Psychological Health
Interactive Exergaming With Otago Exercise Program on Mobility in Community-Dwelling Older Adults
This clinical trial aims to evaluate the effectiveness of interactive exergaming combined with Otago Exercise Program on mobility among community-dwelling older adults aged 65 and above.
- Conditions
- Physical Functional Performance, Psychological Health, Physical Fitness, Mobility Limitation
- Trial name
- GAME-OEP (NCT06814678)
- Testing
- Interactive Exergaming with Otago Exercise Program, Control Group with Usual Care
- Where
- Taiwan
- Volunteers
- 100 people
- Sponsor
- National Taiwan University
Older People
The FINGER Model - Preventing Cognitive Decline and Promoting Health of Older People.
Cognitive impairment and dementia can cause considerable suffering, both for the person affected and for next of kin. They also pose major challenges for health and social care.
- Trial name
- NCT07661472
- Testing
- FINGER model
- Where
- Sweden
- Volunteers
- 180 people
- Sponsor
- University of Gavle
Resistance Exercise, Muscle Weakness
Effects of Elastic Band Resistance Exercise on Muscle Strength and Depression in Hospitalized Elderly.
With improved a five-day intensive, low-resistance elastic band exercise program to evaluate its effectiveness in improving total muscle mass, upper and lower extremity muscle strength, self-perceived fear of falling, and…
- Conditions
- Resistance Exercise, Muscle Weakness, Functional Decline
- Trial name
- NCT06205147
- Testing
- Elastic Band
- Where
- Taiwan
- Volunteers
- 62 people
- Sponsor
- National Taiwan University
Frailty, Disability Physical
Functional Decline and QoL in People Aging with HIV in Asia
This is a multi-center prospective cross-sectional study to determine the burden of decline in intrinsic capacity and functional ability, and the prevalence of geriatric syndromes, such as frailty, and disability in adult people…
- Conditions
- Frailty, Disability Physical, HIV/AIDS
- Trial name
- NCT04212884
- Where
- 2 sites in Hong Kong
- Volunteers
- 1,500 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Subjective Cognitive Decline
Polyamine-enriched Diet in Healthy Older Adults With Subjective Cognitive Decline
The overall objective of this study is to examine the effect of polyamine supplementation on cognitive performance of individuals with subjective cognitive decline.
- Trial name
- preSmartAge (NCT02755246)
- Testing
- Polyamine supplementation
- Where
- Germany
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Charite University, Berlin, Germany
Mild Cognitive Impairment
Spatial Memory Training and Cognitive Function
Mild cognitive impairment (MCI) is often considered a transitional stage between normal aging and dementia, particularly Alzheimer's disease (AD).
- Trial name
- NCT07002996
- Testing
- SMIP, No intervention
- Where
- Canada
- Volunteers
- 80 people
- Sponsor
- Douglas Mental Health University Institute
Alzheimer Disease
Comparative Efficacy, Safety, and Tolerability of Rivastigmine 10 and 15 cm^2 Patch in Patients With Alzheimer's Disease (AD) Showing Cognitive Decline
The purpose of this study was to support the optimal use of rivastigmine patch in long-term treatment of Alzheimer's Disease in patients demonstrating functional and cognitive decline at the target maintenance dose of…
- Trial name
- NCT00506415
- Testing
- Rivastigmine 5 cm^2, Rivastigmine 10 cm^2, Rivastigmine 15 cm^2
- Where
- 145 sites in United States, Canada and 5 more
- Volunteers
- 1,584 people
- Sponsor
- Novartis Pharmaceuticals
PARKINSON DISEASE (Disorder)
Multicontext Approach for Cognitive Function in Parkinson Disease
Mild cognitive decline is common in early Parkinson disease (PD) and is associated with disability, reduced quality of life (QOL), and increased risk for dementia.
- Trial name
- MC4PD R01 (NCT07190404)
- Testing
- A metacognitive strategy for cognitive rehabilitation called the Multicontext Approach., Cognitive (Process) Training, MC Approach Booster Session
- Where
- United States
- Volunteers
- 114 people
- Sponsor
- Washington University School of Medicine
Healthy Aging, Frailty
Characterisation of Functional and Cognitive Responses Following Olfactory Stimulation and/or Functional Training in Older Adults.
This randomized controlled trial will evaluate the effects of olfactory stimulation and/or multicomponent physical training in adults aged 60 years and older.
- Conditions
- Healthy Aging, Frailty, Cognitive Decline, Olfactory Dysfunction
- Trial name
- INNOLFACT 2 (NCT07623122)
- Testing
- Olfactory stimulation, Multicomponent physical training, Combined olfactory stimulation and multicomponent physical training
- Where
- Spain
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Fundacion Miguel Servet
Cognitive Impairment, Cognitive Decline
Neuromodulation Effects in Older Adults
The current study is a mechanistic study to evaluate working memory gains from application of transcranial direct current stimulation (tDCS) in older adults with mild cognitive impairments (MCI) compared to cognitively healthy…
- Trial name
- NCT06665022
- Testing
- Active tDCS
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Florida
Cognitive Decline, Motor Function Disorders
Effects of Task-Oriented Station Training on Cognitive Levels and Hand Functions in Geriatric Residents of Nursing Homes
This study explores the impact of task-oriented station training on the cognitive levels and hand functions of elderly residents in nursing homes.
- Conditions
- Cognitive Decline, Motor Function Disorders, Geriatric Health
- Trial name
- NCT06417073
- Testing
- Face-To-Face Task-orianted Training, Tele-Rehabilitation Task-orianted Training, Home-based Task-orianted Training
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 35 people
- Sponsor
- Çankırı Karatekin University
Health Behaviors, Functional Decline
Training Community Members to be Coaches to Deliver the HealthyLifetime Program
The goal of this randomized controlled study is to learn if, in addition to nurses, community members can be trained as health coaches to deliver the HealthyLifetime (HL) program to people without complex chronic health…
- Conditions
- Health Behaviors, Functional Decline, Chronic Disease, Risk Factors
- Trial name
- NCT06616246
- Testing
- HealthyLifetime
- Where
- 2 sites in United States
- Volunteers
- 300 people
- Sponsor
- University of Michigan
Cognitive Function Assessment, Mild Cognitive Impairment
Prediction of Cognitive Test Performance Using AI-Based Analysis of Narrative Speech
This study aims to evaluate a new artificial intelligence (AI)-based method for measuring cognitive function using speech recordings.
- Conditions
- Cognitive Function Assessment, Mild Cognitive Impairment, Subjective Cognitive Decline
- Trial name
- NCT07511270
- Testing
- AI-Based Storytelling Speech Assessment
- Where
- Taiwan
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Balance Impairment, Sarcopenia in Elderly
Multicomponent Exercise and Frailty in Nursing Home Residents
Frailty is common among older adults living in nursing homes and increases the risk of falls, disability, and loss of independence.
- Conditions
- Balance Impairment, Sarcopenia in Elderly, Frailty at Older Adults, Functional Decline
- Trial name
- BASE-Frail (NCT07686146)
- Testing
- Multicomponent Exercise Program (BASE), Usual Care
- Where
- Spain
- Volunteers
- 66 people
- Sponsor
- Escoles Universitaries Gimbernat