Clinical trials: Functional; Anesthesia
Anesthesia; Functional
Neuromuscular Blockade Reversal Agent Effect on Postoperative Cognitive Function and Behaviour in Children
The aim of this prospective randomized study is to investigate comparatively the effect of neostigmine-atropine versus sugammadex on speed and quality of recovery and on postoperative cognitive function \& behavior in children…
- Trial name
- NCT02455921
- Testing
- neostigmine - atropine, Sugammadex
- Where
- Greece
- Volunteers
- 200 people
- Sponsor
- Attikon Hospital
Liver Function After Partial Liver Resection
Xenon-anesthesia on Patients Undergoing Major Liver-resection
The aim of this study is to compare the postoperative outcome of patients undergoing major liver resection under xenon- compared to desflurane-anesthesia.
- Trial name
- XeLiv (NCT03504033)
- Testing
- Xenon, Desflurane
- Where
- Germany
- Sponsor
- RWTH Aachen University
Anesthesia, Anesthesia; Functional
IANB Success Rate With and Without Panoramic Help
Since it is difficult to achieve anesthesia in lower jaw and the success rate of IANB is low and there are a lot of anatomic variations for the location of inferior alveolar nerve in different races, investigators decided to…
- Trial name
- NCT03786211
- Testing
- IANB by the guide of Panoramic, IANB without the guide of Panoramic
- Where
- Iran
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Hormozgan University of Medical Sciences
Postoperative Complications
4-choice Reaction Time Test for the Measurement of Psychomotor Recovery After General Anaesthesia
The recovery of patients after general anaesthesia is usually estimated by using clinical signs and scores. Since there is a lack of the agreed objective methods for assessing cognitive and psychomotor recovery after general…
- Trial name
- 4CRT_Ane (NCT03697057)
- Testing
- General anaesthesia
- Where
- Germany
- Volunteers
- 166 people, healthy volunteers welcome
- Sponsor
- University Medicine Greifswald
Cardiac Surgery
Ropivacaine Though Laterosternal Catheters After Cardiac Surgery
This is a prospective double-blinded and randomised study involving patients undergoing cardiac surgery with median sternotomy, the effects on postoperative analgesia of a 48-hr continuous infusion of ropivacaine 2 mg.mL-1, at…
- Trial name
- NCT01196767
- Testing
- Ropivacaine (in one arm); catheterization (in both).
- Where
- France
- Volunteers
- 40 people
- Sponsor
- University Hospital, Clermont-Ferrand
Intravenous Lidocaine and Immunity
Impact of Intravenous Lidocaine During Colorectal Surgery on Pain and Immune Functions
This study evaluates the impact of intraoperative intravenous lidocaine administered during laparoscopic colorectal surgery on the intraoperative remifentanil consumption as well as postoperative pain and opioid requirements.
- Trial name
- NCT03410836
- Testing
- intravenous lidocaine (IVL)
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- Ciusss de L'Est de l'Île de Montréal
Thyroid Surgery Intraoperative Nerve Monitoring (IONM) Recurrent Laryngeal Nerve Function Dexmedetomidine vs Midazolam (Anesthetic Agents)
EFFECT OF DEXMEDETOMİDİNE ON RECURRENT LARYNGEAL NERVE MONİTORİNG: A COMPARATİVE STUDY WİTH MİDAZOLAM
This prospective observational study evaluated the effect of dexmedetomidine compared with midazolam on intraoperative monitoring of the recurrent laryngeal nerve during thyroid surgery.
- Trial name
- DEX-RLN (NCT07195214)
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Amasya University
Complication of Anesthesia, Ischaemia-reperfusion Injury
Dexmedetomidine Effect on Mitochondrial Function
The investigators hypothesize that in addition to a known sympatholytic effect, intraoperative dexmedetomidine reduces adverse changes in mitochondrial function and structure attenuating ischaemia-reperfusion and end-organ injury…
- Trial name
- NCT02299063
- Testing
- Dexmedetomidine, 0.9% NaCl
- Where
- Canada
- Volunteers
- 36 people
- Sponsor
- The Hospital for Sick Children
Aminophylline, Dexmedetomidine
Aminophylline on Recovery in Functional Endoscopic Sinus Surgery Under Dexmedetomidine Hypotensive Anesthesia
This study will be conducted to evaluate the effect of intravenous aminophylline on hemodynamics and recovery of patients receiving dexmedetomidine infusion during functional endoscopic sinus surgery.
- Conditions
- Aminophylline, Dexmedetomidine, Functional Endoscopic Sinus Surgery
- Trial name
- NCT05738135
- Testing
- Aminophylline group, normal saline
- Where
- Egypt
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Tanta University
Chronic Kidney Diseases, General Anesthesia
Effect of N-acetylcysteine on Renal Functioning of Chronic Kidney Diseases(CKD) Patients After General Anesthesia
Acute kidney injury (AKI) is one of the most serious and frequent complication of general anesthesia. Patients suffer from chronic kidney diseases (CKD) predispose to develop AKI.
- Trial name
- NCT01251029
- Testing
- N-acetylcysteine, Siran (N-acetylcysteine)
- Where
- Israel
- Sponsor
- Assaf-Harofeh Medical Center
Diastolic Dysfunction, Coronary Artery Disease
Study of the Effect of Inhaled Anesthetics on Diastolic Heart Function Using a Doppler-derived Efficiency Index
The purpose of this study is to determine the effect of inhaled anesthetic drugs upon diastolic heart function (heart suction and filling performance) in patients who are undergoing coronary bypass surgery.
- Conditions
- Diastolic Dysfunction, Coronary Artery Disease, General Anesthesia
- Trial name
- NCT00907439
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Washington University School of Medicine
Hepatectomy
Effect of Epidural Anesthesia and Analgesia on Patients' Outcomes After Liver Resection
The purpose of this study is to analyze the effects of epidural anesthesia and analgesia on intraoperative clinical outcome, postoperative recovery, metabolic changes, and immune functions of the patients receiving open liver…
- Trial name
- NCT01617811
- Testing
- epidural anesthesia and analgesia
- Where
- China
- Volunteers
- 26 people
- Sponsor
- Sir Run Run Shaw Hospital
Regional Anaesthesia, Functional Magnetic Resonance Imaging
Assessment of Brain Activity During Complex Fine Hand Movements: an fMRI Study
Brain cortex controls movement but the influence of peripheral component of movement on the cortex is not known. Functional Magnetic Resonance Imaging(fMRI) studies in stroke and fantom limb patients investigate cortex areas…
- Trial name
- NCT03965338
- Testing
- fMRI
- Where
- Turkey (Türkiye)
- Volunteers
- 15 people
- Sponsor
- Akdeniz University
Postoperative Residual Curarization
Algorithm of Muscle Function Tests to Detect Residual Neuromuscular Blockade.
Objective neuromuscular monitoring is the gold standard to detect postoperative residual curarization (PORC). Many anesthesiologist just use qualitative neuromuscular monitoring or unreliable, clinical tests.
- Trial name
- NCT03219138
- Testing
- Acceleromyography
- Where
- 5 sites in Germany
- Volunteers
- 265 people
- Sponsor
- University of Regensburg
Bowel Disease, Liver Diseases
The Impact of an Epidural Anesthetic on the Consumption of Sevoflurane in Major Abdominal Surgery
Major abdominal surgery - like non-laparoscopic bowel resection, liver, gastric, or pancreas surgery - is performed under general anesthesia.
- Conditions
- Bowel Disease, Liver Diseases, Pancreas Disease, Anesthesia; Functional
- Trial name
- NCT04021264
- Testing
- Ropivacaine-Sufentanil, Dextrose 5
- Where
- Canada
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Alberta
Anesthesia; Functional, Anesthesia Awareness
The Effect of Minimal Flow Sevoflurane Anesthesia
Our aim is to investigate the effect of minimal flow anesthesia with sevoflurane on hemodynamics and arterial blood gas parameters in laparoscopic cholecystectomy operations.
- Trial name
- NCT04813952
- Testing
- Sevoflurane inhalant product
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people
- Sponsor
- Sisli Hamidiye Etfal Training and Research Hospital
Obesity, Abdominal, Anesthesia Morbidity
CPAP in Patients With Severe Obesity After Anesthesia
The goal of this study is to compare two continuous positive airway pressure (CPAP) settings on heart and lung function in patients with severe obesity after anesthesia. The main questions it aims to answer are: 1.
- Conditions
- Obesity, Abdominal, Anesthesia Morbidity, Apnea, Obstructive Sleep, Atelectases, Postoperative Pulmonary
- Trial name
- NCT06287632
- Testing
- Recruitment/ITP-CPAP (Intervention A), Standard CPAP (Intervention B), Atmospheric Pressure
- Volunteers
- 60 people
- Sponsor
- Massachusetts General Hospital
Magnesium Sulfate, Remifentanil
Anesthesia Techniques, Neuroprotection and Surgical Field in FESS Under Controlled Hypotension
This prospective, randomized controlled trial investigates the effect of four different anesthetic maintenance techniques on surgical field conditions, hemodynamic stability, and neuroprotection during functional endoscopic sinus…
- Conditions
- Magnesium Sulfate, Remifentanil, S 100beta, S100 Beta Protein, Human
- Trial name
- NCT07181564
- Testing
- Propofol / Remifentanil, Ketamine + Magnesium sulfate (drug combination), Sevoflurane and Remifentanil
- Where
- Greece
- Volunteers
- 150 people
- Sponsor
- University General Hospital of Patras
Chronic Pain, Anaesthesia
Comprehensive Pain Programme to Determine Mechanism of Transition of Acute to Chronic Postsurgical Pain
To determine whether central sensitization is a mechanism of CPSP (chronic postsurgical pain) in women who will develop CPSP compared to women with no CPSP after hysterectomy.
- Conditions
- Chronic Pain, Anaesthesia, Genetics Predisposition
- Trial name
- TAHP (NCT02025153)
- Testing
- pain testing
- Where
- Singapore
- Volunteers
- 216 people
- Sponsor
- KK Women's and Children's Hospital
Delayed Recovery From Anaesthesia
Measurement of Psychomotor Recovery After Anesthesia Using 4CRT
The aim of the investigation is to validate the SmartPhone-based 4-Reaction Choice Time Test (4CRT) as a measure for recovery of the psychomotor function in patients after general anesthesia.
- Trial name
- 4CRT (NCT02232139)
- Testing
- Midazolam
- Where
- Germany
- Volunteers
- 124 people
- Sponsor
- University Medicine Greifswald