Clinical trials: Frozen Sections
Rectal Cancer
Optical Biopsy for Distal Margin in Low Rectal Cancer
This is a multi-center prospective randomized controlled study. In this study, the investigators will use confocal laser endomicroscopy to make real-time in vivo optical biopsy of distal margin in rectal cancer surgery and help…
- Trial name
- NCT04016948
- Testing
- Probe-based confocal laser endomicroscopy optical biopsy, Intra-operative frozen section
- Where
- China
- Volunteers
- 146 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Vulvar Neoplasm, Dysplasia Vulvar
A Study Evaluating the Effect of Frozen-Section Directed Excision Surgery on Vulvar Dysplasia
The purpose of this study is to compare "Frozen-Section Directed Excision", which has been a proven method of surgery used in dermatology, versus the current, standard method called "Wide Local Excision" to treat high-grade…
- Trial name
- NCT05934851
- Testing
- Frozen-Section Directed Excision, Wide Local Excision
- Where
- United States
- Volunteers
- 112 people
- Sponsor
- Wake Forest University Health Sciences
Lung Adenocarcinoma
Radiomics Combined With Frozen Section Prediction Model for Spread Through Air Space in Lung Adenocarcinoma
a multifactorial model combining radiomics with frozen section analysis is a potential biomarker for assessing Spread Through Air Space during surgery, which can provide decision-making support to therapeutic planning for…
- Trial name
- NCT05400304
- Testing
- radiomics
- Volunteers
- 900 people
- Sponsor
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Breast Neoplasms, Breast Diseases
Clinical Evaluation of OSNA Breast Cancer System to Extensive Frozen Section Histopathology
The study will determine the sensitivity, specificity, negative predictive value and positive predictive value of the OSNA Breast Cancer System by comparing its performance to an extensive intraoperative frozen section protocol…
- Trial name
- NCT01368744
- Testing
- OSNA Breast Cancer System
- Where
- Italy
- Volunteers
- 150 people
- Sponsor
- Sysmex America, Inc.
Early Stage Breast Cancer
Shaving as an Safe Alternative to Frozen Section Analysis
Evaluation of Tumor Bed Cavity Shaving as an Oncologically Safe Alternative to Frozen Section Analysis in Breast-Conserving Surgery and aim of study To assess the oncological safety and practicality of tumor bed cavity shaving…
- Trial name
- NCT07244588
- Testing
- Tumor bed cavity shaving
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Mark Ezzat Gerges
Lung Adenocarcinoma
Segmentectomy Versus Lobectomy for Lung Adenocarcinoma ≤ 2cm
This study aims to evaluate the non-inferiority in recurrence-free survival and overall survival of segmentectomy compared with lobectomy in patients with lung adenocarcinoma ≤ 2 cm with micropapillary and solid subtype negative…
- Trial name
- NCT04937283
- Testing
- Segmentectomy, Lobectomy
- Where
- 14 sites in China
- Volunteers
- 690 people
- Sponsor
- Shanghai Pulmonary Hospital, Shanghai, China
Rectal Cancer Patients
Selective Total Mesorectal Excision Based on Intra-Operative Frozen Section From Local Excision in Rectal Cancer Undergoing Neoadjuvant Chemoradiotherapy
This study is a prospective, single-arm, phase II superiority trial to determine whether a selective organ-preserving strategy based on immediate intra-operative frozen-section results can achieve favorable 2-year local control…
- Trial name
- NCT07337811
- Testing
- Selective Total Mesorectal Excision Based on Intra-Operative Frozen Section From Local Excision
- Where
- China
- Volunteers
- 27 people
- Sponsor
- Sun Yat-sen University
Gallbladder Cancer
Evaluation of the Effectiveness of Intraoperative Frozen Section on the Treatment of Suspected Gallbladder Cancer
Evaluate the effectiveness of intra-operative frozen section in the treatment of gallbladder cancer. The study will be looking in to identify if intraoperative frozen section is a viable method to intraoperatively evaluate the…
- Trial name
- NCT06189664
- Testing
- Frozen section
- Volunteers
- 37 people
- Sponsor
- Imperial College London
Lung Adenocarcinoma
Comparison of Segmentectomy Versus Lobectomy for Lung Adenocarcinoma ≤ 2cm
This study aims to evaluate the superiority in recurrence-free survival of lobectomy compared with segmentectomy in patients with lung adenocarcinoma ≤ 2 cm with micropapillary and solid subtype positive by intraoperative frozen…
- Trial name
- NCT05838053
- Testing
- Lobectomy with systemic lymph node dissection, Segmentectomy with systemic lymph node dissection
- Where
- China
- Volunteers
- 446 people, healthy volunteers welcome
- Sponsor
- Shanghai Pulmonary Hospital, Shanghai, China
Cancer, Intraoperative Pathology
Development and Validation of an AI Foundation Model for Frozen-Section Pathology
This multicenter observational study aims to develop and validate an artificial intelligence foundation model for frozen-section pathology. The study includes a retrospective phase and a prospective validation phase.
- Conditions
- Cancer, Intraoperative Pathology, Artificial Intelligence (AI)
- Trial name
- NCT07708207
- Where
- China
- Volunteers
- 33,000 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Rectal Cancer
Intraoperative Assessment of Distal Resection Margins Using Frozen Section in Mid and Low Rectal Cancer Surgery
This study aims to improve the safety of distal surgical margins in patients with middle and low rectal cancer who receive neoadjuvant radiotherapy.
- Trial name
- NCT07398716
- Testing
- Intraoperative Frozen Section Assessment, Standard Surgery Without Frozen Section
- Where
- Turkey (Türkiye)
- Volunteers
- 99 people
- Sponsor
- Bakirkoy Dr. Sadi Konuk Research and Training Hospital
Basal Cell Carcinoma
Periocular Basal Cell Carcinoma (BCC): Permanent vs. Frozen Section Pathological Control
This study is an equivalency study designed as a randomized clinical trial. Patients with a biopsy proven nodular periocular basal cell carcinoma (BCC) who have agreed to have surgical excision will be eligible.
- Trial name
- NCT00663650
- Testing
- Permanent Section Control, Frozen Section Control
- Where
- Canada
- Volunteers
- 290 people
- Sponsor
- Queen's University
Oral Cavity Cancer
Gross Examinations Versus Frozen Section for Assessment of Surgical Margins in Oral Cancers
Surgical margin is a significant prognostic factor in oral cavity squamous cell carcinoma (OCSCC)[1,2,3]. Intra-operative frozen section (FS) has been routinely used by the surgeons to achieve adequate surgical margins.
- Trial name
- NCT04809324
- Testing
- Gross examination of the resection specimen, Frozen section
- Where
- 3 sites in India
- Volunteers
- 1,206 people
- Sponsor
- Dr.Pankaj Chaturvedi
Lung Adenocarcinoma, Surgical Procedure, Unspecified
Intraoperative Frozen Section Pathology to Guide Surgical Treatment for Lung Adenocarcinoma (ECTOP-1016)
This study is one of Eastern Cooperative Thoracic Oncology Projects (ECTOP-1016). The goal of this clinical trial is to confirm the concordance rate between intra-operative frozen section pathological diagnosis and post-operative…
- Conditions
- Lung Adenocarcinoma, Surgical Procedure, Unspecified, Pathology
- Trial name
- NCT05794724
- Testing
- Surgical resection
- Where
- China
- Volunteers
- 1,063 people
- Sponsor
- Fudan University
Role of Frozen Section in Categorization of Thyroid Follicular Neoplasm
Role of Frozen Section in Categorization of Thyroid Follicular Neoplasm
The goal of this prospective study is to assess the effectiveness of frozen section in distinguishing between benign and malignant tumors in the category of follicular thyroid neoplasm to prevent over-surgery for benign…
- Trial name
- NCT06947629
- Testing
- Intraoperative Frozen Section
- Where
- Egypt
- Volunteers
- 48 people
- Sponsor
- Assiut University
Lung Adenocarcinoma, Surgical Procedure, Unspecified
Intraoperative Frozen Section Pathology to Diagnose the IASLC Grades for Lung Adenocarcinoma (ECTOP-1014)
This study is one of Eastern Cooperative Thoracic Oncology Projects (ECTOP-1014). The goal of this clinical trial is to confirm the concordance rate between intra-operative frozen section pathological diagnosis and post-operative…
- Conditions
- Lung Adenocarcinoma, Surgical Procedure, Unspecified, Pathology
- Trial name
- NCT05794698
- Testing
- Surgical resection
- Where
- China
- Volunteers
- 827 people
- Sponsor
- Fudan University
Breast Cancer, Sentinel Lymph Node
Application of EndoScell Intraoperative Cellular Probing Technology for Early-Stage Breast Cancer
Sentinel Lymph Node Biopsy (SLNB) is a common surgical treatment for breast cancer and a primary method for assessing the pathological status of axillary lymph nodes.
- Conditions
- Breast Cancer, Sentinel Lymph Node, Frozen Section, Cytology
- Trial name
- EDGE (NCT06911528)
- Testing
- EndoScell Scaner (ES) novel intraoperative cellular probing technology
- Where
- China
- Volunteers
- 709 people
- Sponsor
- Fudan University
Prostate Cancer
Evaluating the Effects of Frozen Section Technology on Oncological and Functional Outcomes at Radical Prostatectomy.
In summary this trial will test whether this new surgical technique can be used to make surgery safer and more effective whilst allowing improved quality of life for patients having surgery for prostate cancer.
- Trial name
- NeuroSAFEPROOF (NCT03317990)
- Testing
- NeuroSAFE procedure, Standard RARP
- Where
- 5 sites in United Kingdom
- Volunteers
- 407 people
- Sponsor
- University College, London
Frozen Sections
Assessment of Tele-expertise for Frozen Section Diagnosis
The purpose of the study is to assess whether performing a frozen section diagnosis off site with virtual slides would be as quick and accurate as usual technique.
- Trial name
- Télé-extempo (NCT02368769)
- Testing
- During Tele-expertise
- Where
- 6 sites in France
- Volunteers
- 253 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Prostate Cancer
Infrared Fluorescence Staining Versus Frozen Section for Prostate Cancer Surgery
This study aims to validate the accuracy of the infrared fluorescence rapid detection technique for the diagnosis of prostate biopsy specimens, and to compare it with intraoperative frozen section and conventional paraffin…
- Trial name
- NCT07690462
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Xiangya Hospital of Central South University