Clinical trials: Frailty Syndrome, open to volunteers
Post Intensive Care Syndrome
Impact of Frailty and ICU-AW on Post-ICU Fatigue Self-reported
After a prolonged stay in Intensive Care Unit (ICU), fatigue is the most common symptom reported by patients in the Post Intensive Care Syndrome (PICS).
- Trial name
- FICUF (NCT05984069)
- Testing
- observational prospective data collection
- Where
- 2 sites in France
- Volunteers
- 150 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Frailty, Frail Elderly Syndrome
The NADage Study: Nicotinamide Riboside Replenishment Therapy Against Functional Decline in Aging
This clinical study, designed as a double-blind, randomized, placebo-controlled trial, aims to investigate the potential of nicotinamide riboside (NR) to decelerate functional decline in the elderly frail population.
- Conditions
- Frailty, Frail Elderly Syndrome, Frailty Syndrome, Aging
- Trial name
- NADage (NCT06208527)
- Testing
- Nicotinamide Riboside (NR)
- Where
- 2 sites in Norway
- Volunteers
- 100 people
- Sponsor
- Haukeland University Hospital
Acute Coronary Syndromes (ACS), Iron Deficiencies
Effect of Intravenous Iron on Quality of Life in Older Patients With Acute Coronary Syndrome
The goal of this phase IV, open-label, randomized clinical trial is to evaluate whether intravenous iron improves quality of life in adults aged 65 years and older with iron deficiency after an acute coronary syndrome (ACS).
- Conditions
- Acute Coronary Syndromes (ACS), Iron Deficiencies, Elderly (People Aged 65 or More)
- Trial name
- HI-COR-65 (NCT07476859)
- Testing
- Ferric Carboxymaltose Injection [Ferinject]
- Where
- 9 sites in Spain
- Volunteers
- 538 people
- Sponsor
- Fundación para la Investigación del Hospital Clínico de Valencia
Frailty Syndrome, Older Adults, Balance
Effectiveness of Immersive Virtual Reality Combined With Occupational Therapy in Reducing Fall Risk and Frailty Among Older Adults
Population aging is a growing global phenomenon that poses significant challenges to healthcare systems, particularly in preventing falls and managing frailty among older adults.
- Conditions
- Frailty Syndrome, Older Adults, Balance, Fall Prevention in Healthy Aging
- Trial name
- VIRTO-FRAIL (NCT07060677)
- Testing
- Inmersive Virtual Reality, Conventional occupational therapy sessions
- Where
- 2 sites in Spain
- Volunteers
- 30 people
- Sponsor
- Universidad Rey Juan Carlos
Geriatric Assessment
Frailty Syndrome and Its Associated Factors Among Elderly Patients
This is a cross-sectional analytical study conducted among elderly patients attending Assiut university hospital. 2.4. 2- Study Setting:The study will be conducted in Assiut University hospital, including outpatients and…
- Trial name
- Frailty (NCT07727811)
- Volunteers
- 175 people
- Sponsor
- Assiut University
Frail Elderly Syndrome, Coronary Heart Disease
Frailty Syndrome in Daily Practice of Interventional Cardiology Ward
The impact of frailty on immediate and long term outcomes of invasive treatment of coronary artery disease is not fully characterized.
- Conditions
- Frail Elderly Syndrome, Coronary Heart Disease, Acute Coronary Syndrome, Coronary Artery Bypass Grafting
- Trial name
- FRAPICA (NCT03209414)
- Where
- Poland
- Volunteers
- 1,000 people
- Sponsor
- Medical University of Silesia
Acute Coronary Syndromes (ACS)
Prognostic Value of Functional-Nutritional Status in Older Adults With Acute Coronary Syndrome
This study aims to find out whether reduced everyday functioning before the acute illness and malnutrition help predict health outcomes in adults aged 65 years and older hospitalized with acute coronary syndrome (heart attack or…
- Trial name
- FNS-ACS65 (NCT07898345)
- Testing
- Functional-Nutritional Burden
- Where
- 2 sites in Russia
- Volunteers
- 270 people
- Sponsor
- Samara State Medical University
Frailty in Adult Surgery, Frailty Syndrome
Modified Essential Frailty Toolset in Older Adults Undergoing Major Elective Surgery
Frailty is a common geriatric syndrome associated with reduced physiological reserve and increased vulnerability to surgical stress.
- Conditions
- Frailty in Adult Surgery, Frailty Syndrome, Elective Surgeries, Readmission Rates
- Trial name
- NCT07452263
- Testing
- Major elective surgery
- Where
- Iceland
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- University of Iceland
Frailty, Delirium Confusional State
Patients With Long-stay at ICU: Factors and Evaluation - Feasibility Study
Every year, many critically ill patients are admitted to an intensive care unit (ICU). Most stay only a few days, but a smaller group stays much longer.
- Conditions
- Frailty, Delirium Confusional State, Persistent Critical Illness, Post-Intensive Care Syndrome
- Trial name
- LIFE-ICU (NCT07851974)
- Where
- 4 sites in Sweden
- Volunteers
- 300 people
- Sponsor
- Uppsala University
Older Adults
Frailty, Geriatric Syndromes and Care Pathways of Older Adults Living With HIV in West Africa
With currently available antiretroviral therapy, people living with HIV (PLWHIV) are living longer. This exposure to HIV and combination antiretroviral therapy may accelerate the aging of this population, thus increasing the…
- Trial name
- NCT07355413
- Where
- 6 sites in Burkina Faso, Côte d’Ivoire and 1 more
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- ANRS, Emerging Infectious Diseases
Frailty Syndrome, Older Adults
Feasibility and Effects of Inspiratory Muscle Training Combined With Blood Flow Restriction for Frail Older Adults
This randomized controlled trial study aims to evaluate the feasibility and preliminary efficacy of a combined inspiratory muscle training (IMT) and blood flow restriction (BFR) intervention in frail older adults.
- Conditions
- Frailty Syndrome, Older Adults, Blood Flow Restriction (BFR) Training Effects, Inspiratory Muscle Training
- Trial name
- NCT07573995
- Testing
- Exercise
- Where
- Taiwan
- Volunteers
- 30 people
- Sponsor
- Taipei Medical University
Frailty
Safety Study of Intravenous MiraMSC in Older Adults With Mild to Moderate Frailty Syndrome
The purpose of this Phase I, open-label study is to evaluate the safety and tolerability of intravenous MiraMSC-FS-001 in older adults with mild to moderate frailty syndrome.
- Trial name
- NCT07705464
- Testing
- MiraMSC-FS-001
- Volunteers
- 12 people
- Sponsor
- Miracle Biomedical Co., Ltd.
Frailty in Adult Surgery, Frailty Syndrome
Validity of Frailty Screening Tools as a Measure for Postoperative Outcomes
Frailty is a common geriatric syndrome defined as a clinical state of decreased physiologic reserve resulting in increased vulnerability to stressors.
- Conditions
- Frailty in Adult Surgery, Frailty Syndrome, Elective Surgery
- Trial name
- NCT07367828
- Testing
- Intermediate/major elective surgery
- Where
- Iceland
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- University of Iceland
Aging, Mortality
Longevity Metrics AI/ML Development Study
This study builds AI models that score diagnostic screening tests, and that predict screening results, clinical judgment, and life expectancy.
- Conditions
- Aging, Mortality, Cardiovascular Disease Prevention, Metabolic Syndrome
- Trial name
- NCT07808619
- Testing
- AIML scored health screening battery
- Where
- United States
- Volunteers
- 1,000,000 people, healthy volunteers welcome
- Sponsor
- Longevity Metrics, Inc.
Chronic Disease, Immunocompromised
Integrating Vaccination Into Hospital Care Pathways for Vulnerable Patients
AMBU-VAX is a prospective, single-center observational study designed to develop and implement an organizational model for delivering recommended vaccinations within a hospital setting.
- Conditions
- Chronic Disease, Immunocompromised, HIV Infection, Chronic Kidney Disease
- Trial name
- AMBU-VAX (NCT07391046)
- Testing
- Hospital-Based Vaccination Pathway
- Volunteers
- 1,500 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Frailty, ACS (Acute Coronary Syndrome)
Prospective Observational Cohort Study on Impact of Frailty on Risk Prediction, Treatment Strategies, and Short-Term Outcomes in Patients With Acute Coronary Syndrome
we aim : To evaluate how frailty influences acute management decisions (invasive vs conservative strategy) in ACS patients and whether it independently affects short-term outcomes.
- Conditions
- Frailty, ACS (Acute Coronary Syndrome), MACE, GRACE Score
- Trial name
- NCT07190274
- Volunteers
- 645 people
- Sponsor
- Assiut University
Kidney Transplant; Complications, Dialysis; Complications
Structured Program of Exercise for Recipients of Kidney Transplantation
Older patients with end- stage kidney disease (ESKD) are at very high risk for functional impairment. Kidney transplantation (KT) has the potential to ameliorate the detrimental effects of ESKD on physical activity and functional…
- Conditions
- Kidney Transplant; Complications, Dialysis; Complications, Physical Disability, Frailty Syndrome
- Trial name
- SPaRKT (NCT04954690)
- Testing
- Structured Program of exercise for Recipients of Kidney Transplantation (WC), Structured Program of exercise for Recipients of Kidney Transplantation (WC + CG), Usual Care
- Where
- United States
- Volunteers
- 136 people
- Sponsor
- University of California, San Francisco
Frailty, Aging
Comprehensive Geriatric Assessment in Primary Care
This study evaluates the feasibility and acceptability of implementing the electronic Comprehensive Geriatric Assessment (eCGA) in primary care for adults aged 65 years and older.
- Conditions
- Frailty, Aging, Geriatric Syndromes, Mobility Limitation
- Trial name
- PC-CGA (NCT07341061)
- Testing
- Personalized Approach for Healthy Aging (PAHA)
- Volunteers
- 120 people
- Sponsor
- Nova Scotia Health Authority
OSA - Obstructive Sleep Apnea, Dysphagia
Effects of Surgery on Oral Frailty and Dysphagia in Patients With Obstructive Sleep Apnea
Dysphagia is a commonly reported complaint among patients with obstructive sleep apnea (OSA), particularly those who have undergone upper-airway (oropharyngeal) surgery.
- Conditions
- OSA - Obstructive Sleep Apnea, Dysphagia, Oral Frailty
- Trial name
- NCT07880067
- Testing
- Upper airway surgery for OSA, Non-surgical management
- Where
- Taiwan
- Volunteers
- 450 people
- Sponsor
- National Sun Yat-sen University
Frail Elderly Syndrome, Primary Prevention
Non-pharmacological Prevention of POD in Frailty Elderly Undergoing Elective Surgery Applied by Nursing Teams
The increase in the population over 60 years of age who could receive surgery due to changes in life expectancy and advances in surgical and anesthetic techniques.
- Conditions
- Frail Elderly Syndrome, Primary Prevention, Postoperative Delirium, Frailty
- Trial name
- NPPOD (NCT05993754)
- Testing
- Non-pharmacological intervention
- Where
- Chile
- Volunteers
- 400 people
- Sponsor
- Pontificia Universidad Catolica de Chile