Clinical trials: Frailty
Frailty, Quality of Life
Family-based Frailty Self Management Model and the Effects of the FRAIL-SM Program Among Patients With Heart Failure
This randomized controlled trial study aims to develop a frailty self-management model for heart failure patients, and to examine the effect of family-based frailty self-management program (FRAIL-SM) including Family involvement…
- Conditions
- Frailty, Quality of Life, Self-management
- Trial name
- FRAIL-SM (NCT05765721)
- Testing
- FRAIL-SM Program
- Where
- 2 sites in Taiwan
- Volunteers
- 232 people
- Sponsor
- National Yang Ming Chiao Tung University
Dependency
Comprehensive Geriatric Assessment for Frail Older People
The study "Comprehensive Geriatric Assessment for frail older people in Swedish acute care settings - a randomized controlled study" comprised two study arms: one intervention and one control group.
- Trial name
- NCT02773914
- Testing
- Comprehensive Geriatric Assessment
- Where
- Sweden
- Volunteers
- 155 people
- Sponsor
- Göteborg University
CKD Stage 4, CKD Stage 5
Frailty, Cognitive Function and Health-related Quality of Life in Older Adults With Advanced Chronic Kidney Disease.
This observational study explores the impact of cognitive impairment and frailty in older adults with advanced chronic kidney disease ].
- Conditions
- CKD Stage 4, CKD Stage 5, Frailty, Cognitive Impairment
- Trial name
- NCT05705011
- Where
- Romania
- Volunteers
- 240 people
- Sponsor
- Grigore T. Popa University of Medicine and Pharmacy
Frailty
Enhancing Functional Capacity in Older Adults With Short Session High Intensity Interval Training
Frailty is a clinical condition of poor physiological reserve that increases risks for adverse health outcomes including falls, hospitalization and mortality.
- Trial name
- HIIT-VA (NCT03750006)
- Testing
- Short session HIIT
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Frailty, Frail Older Adults
Cognitive Groove (Brought to You by GERAS DANCE)
The goal of this clinical trial is to determine the effect of a community-based rehabilitation intervention (Cognitive Groove, Brought to you by GERAS DANCE), compared to usual care, on clinical outcomes in community-dwelling…
- Conditions
- Frailty, Frail Older Adults, Frailty in Aging, Frailty Syndrome
- Trial name
- GERAS DANCE (NCT06870149)
- Testing
- Dance Rehabilitation Intervention
- Where
- Canada
- Volunteers
- 250 people
- Sponsor
- McMaster University
Frail Elderly Persons
SUPPORT FOR FRAIL ELDERLY PERSONS - From Prevention to Palliation
The present study "Elderly person in the risk zone" form part of the research programme "Support for frail elderly persons - from prevention to palliation" (www.
- Trial name
- NCT00877058
- Testing
- preventive home visit, senior meetings
- Where
- Sweden
- Volunteers
- 459 people
- Sponsor
- Vardalinstitutet The Swedish Institute for Health Sciences
Frailty, Anesthesia Induction
ED50 of Remimazolam for Anesthesia Induction in Frail Elderly Patients
This study aimed to determine the median effective dose (ED50) of remimazolam for loss of consciousness (LOC) in elderly and frail elderly patients using the Dixon up-and-down method, while utilizing a novel Respiratory Volume…
- Trial name
- NCT07467603
- Testing
- Remimazolam Tosilate
- Where
- China
- Volunteers
- 58 people
- Sponsor
- The First Hospital of Hebei Medical University
Sarcopenia in Elderly
The Study, Conducted With 54 Individuals Over the Age of 65, Aimed to Reveal the Advantages and Disadvantages of a Combined Exercise Program Compared to Otago Exercise Alone.
Falls are a leading cause of morbidity and mortality in older adults. Approximately one-third of individuals over 65 years of age fall each year, and 10-15% of these falls result in serious injury.
- Trial name
- OPEP-SARCOBAL (NCT07689903)
- Testing
- Proprioception Exercise, Exercise Intervention
- Where
- Turkey (Türkiye)
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Hacettepe University
Frailty, Frail Elderly Syndrome
The NADage Study: Nicotinamide Riboside Replenishment Therapy Against Functional Decline in Aging
This clinical study, designed as a double-blind, randomized, placebo-controlled trial, aims to investigate the potential of nicotinamide riboside (NR) to decelerate functional decline in the elderly frail population.
- Conditions
- Frailty, Frail Elderly Syndrome, Frailty Syndrome, Aging
- Trial name
- NADage (NCT06208527)
- Testing
- Nicotinamide Riboside (NR)
- Where
- 2 sites in Norway
- Volunteers
- 100 people
- Sponsor
- Haukeland University Hospital
Chronic Kidney Disease Stage 5, Chronic Kidney Disease Stage 4B
Prognostic Value of a Multidimensional Assessment for Survival in Elderly Patients With CKD 4B/5
The aim of this study is to determine a multidimensional signature (integrating frailty and patient-reported outcomes measures (PROMs) at entry into stage 4B/5 CKD) to improve prediction of renal death (dialysis, transplantation…
- Trial name
- PROFILER (NCT06825234)
- Where
- 2 sites in France
- Volunteers
- 390 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Frailty, Osteoporosis
An Interventional Study of Geriatric Frailty, Osteoporosis, and Depression
Frailty, osteoporosis, and depression are three highly prevalent geriatric syndromes. Having these conditions are associated with adverse outcome in physical health, mental health, quality of life, and daily functioning.
- Conditions
- Frailty, Osteoporosis, Depression
- Trial name
- NCT00718432
- Testing
- Exercise and nutritional integrated care, Usual care with education, Problem solving therapy (PST) integrated care
- Where
- Taiwan
- Volunteers
- 406 people
- Sponsor
- National Health Research Institutes, Taiwan
Frailty, Intensive Care Unit Syndrome
Ultrasound of the Quadriceps Femoris Compared With the Clinical Frailty Scale
This is a single-centre prospective diagnostic study. When a patient is admitted to the inclusion centre, the clinician responsible for the patient checks the inclusion and exclusion criteria.
- Trial name
- QUADRI-REA (NCT06523348)
- Testing
- quadricipital muscle ultrasound
- Where
- France
- Volunteers
- 70 people
- Sponsor
- University Hospital, Toulouse
Frailty in Older Adults
A Biopsychosocial Approach to Improving Multidimensional Frailty Status in Community-Dwelling Older Adults
Frailty is a common clinical syndrome that is becoming increasingly important as populations age worldwide. Individuals who are frail are at a higher risk for negative outcomes, such as falls, disability, hospitalizations, and…
- Trial name
- NCT06741878
- Testing
- Exercise, Psychosocial, Nutritional
- Volunteers
- 308 people, healthy volunteers welcome
- Sponsor
- Hong Kong Baptist University
Frailty in Aging
Ghrelin Repeated Dose Study
Frailty is a geriatric syndrome leading to physical deterioration including muscle wasting (sarcopenia) and unintentional weight loss. There are currently no approved therapies for frailty.
- Trial name
- GRD (NCT01833078)
- Testing
- ghrelin
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- University of Pennsylvania
Vascular Diseases
Clinical Frailty Scale Validation in Patients Scheduled for Vascular Surgery
Major vascular operations put the body under stress. We are trying to find out if the general health of a patient and the stress resulting from surgery can lead to the development of complications after surgery as well as…
- Trial name
- NCT03403673
- Testing
- Frailty assessment tools
- Where
- United Kingdom
- Volunteers
- 100 people
- Sponsor
- South Tees Hospitals NHS Foundation Trust
Type 2 Diabetes Mellitus
Multi-Modal Intervention In Frail And Prefrail Older People With Type 2 Diabetes
The MID-Frail STUDY project focuses on the use of interventions designed to improve functional status and enhance quality of life (rather than traditional treatments such as glucose- and blood pressure- lowering) by acting on the…
- Trial name
- MID-Frail (NCT01654341)
- Testing
- Exercise, dietary and educational program
- Where
- Spain
- Volunteers
- 986 people
- Sponsor
- Hospital Universitario Getafe
Elderly (People Aged 65 or More), Swallowing Training on Muscle Strength
Efficacy of Oral Exercise Training in Oral Frailty
As the elderly grow older, the quality and function of skeletal muscle are affected. Sarcopenia is commonly seen in the elderly, due to the loss of skeletal muscle mass and function, often resulting in loss of activity and…
- Conditions
- Elderly (People Aged 65 or More), Swallowing Training on Muscle Strength, Dysphagia
- Trial name
- NCT06926426
- Testing
- oral function training
- Where
- Taiwan
- Volunteers
- 58 people
- Sponsor
- China Medical University Hospital
Frailty in Older Adults, Intrinsic Capacity
Optimizing INtrinsic Capacity for Functional INdependence and to Impede FrailTY in Older Adults: Adaptation of the WHO-ICOPE for Healthy Ageing in Singapore
The goal of this intervention study is to screen and identify frailty and decline in intrinsic capacity (physical and mental capacities) in community-dwelling older adults in Singapore, and to evaluate whether early…
- Conditions
- Frailty in Older Adults, Intrinsic Capacity, Age-related Functional Decline, Healthy Ageing
- Trial name
- INFINITY-ICOPE (NCT07477561)
- Testing
- INFINITY-ICOPE programme
- Where
- Singapore
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Sengkang General Hospital
Chronic Kidney Diseases, Diabetes Mellitus
Inflammation and Stem Cells in Diabetic and Chronic Kidney Disease
The proposed studies will examine the effect of fisetin on adipose tissue-derived mesenchymal stem/stromal cell function, kidney function, markers of inflammation, and physical function in individuals with advanced chronic kidney…
- Conditions
- Chronic Kidney Diseases, Diabetes Mellitus, Diabetic Nephropathies
- Trial name
- NCT03325322
- Testing
- Fisetin
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Mayo Clinic
Chronic Liver Disease and Cirrhosis
Impact of Home-Based Aerobic and Resistance Training in Chronic Liver Disease: a Randomized Control Trial
The goal of this clinical trial is to evaluate whether home-based exercise interventions, including aerobic exercise (AE) and a combination of aerobic and resistance exercise (ARE), can improve physical and health-related…
- Trial name
- NCT06892366
- Testing
- Home-Based Aerobic Exercise Program, Home-Based Aerobic and Resistance Exercise (ARE) Group
- Where
- Turkey (Türkiye)
- Volunteers
- 39 people
- Sponsor
- Hacettepe University