Clinical trials: Frailty
Atrial Fibrillation (AF), Stroke
Catheter Ablation Plus LAAO Versus Anticoagulation in Frail Elderly Patients With Atrial Fibrillation
Atrial fibrillation (AF) is the most common arrhythmia, significantly increasing the risk of stroke, heart failure, hospitalization and death in patients.
- Conditions
- Atrial Fibrillation (AF), Stroke, Hemorrhage, Frailty
- Trial name
- CLEAR-AF (NCT07441382)
- Testing
- catheter ablation combined with LAAO (Left Atrial Appendage Occlusion), Atrial Fibrillation Radiofrequency Ablation Only
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Guangdong Provincial People's Hospital
Chronic Kidney Diseases
Transitioning to Home or In-center Dialysis
For people with advanced kidney disease, deciding which type of dialysis is best can be challenging. Studies have shown that quality of life is very important to patients.
- Trial name
- TRANSIT-CARE (NCT05989659)
- Testing
- Exposure: Home dialysis or facility-hemodialysis
- Where
- Canada
- Volunteers
- 420 people
- Sponsor
- Ciusss de L'Est de l'Île de Montréal
Frail Elderly Syndrome
Effectiveness of a Socio-Community Health Intervention on Pre-Frailty in Older Adults
The objective of this study is: To evaluate the effectiveness of a health intervention with a socio-community approach on frailty in older adults with pre-frailty.
- Trial name
- NCT06663150
- Testing
- health intervention with a socio-community approach
- Where
- Colombia
- Volunteers
- 160 people
- Sponsor
- Keralty SAS. Colombia
Frailty, Aging
Open Label Study for the Use of Transcranial Ultrasound for Treatment of Age-Related Frailty
The purpose of this Phase I open label study is to evaluate longer term tolerability and potential effectiveness of transcranial ultrasound in people with age-related frailty.
- Trial name
- fUS-ARF (NCT04770350)
- Testing
- Focused Ultrasound
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Neurological Associates of West Los Angeles
Frail Elderly Syndrome
Management of Frailty in Older Adults With Turmeric and Tulsi Supplements
The aim of this study is to determine the efficacy of turmeric and tulsi polyherbal formulation in the management of frailty in the elderly population.
- Trial name
- NCT03365310
- Testing
- C. longa, curcuminoids , Z. officianale, O. sanctum along with 200 ml of Milk, Standard of Care
- Where
- India
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Composite Interceptive Med Science
Hiatus Hernia
Hiatus Hernia in Old
hiatus hernia in frail patient is common and requires suregry
- Trial name
- NCT06935617
- Testing
- nissein
- Volunteers
- 266 people
- Sponsor
- Zagazig University
Nursing Caries, Old Age; Debility
Multifactorial Study of the Relationship Between the Conditions of Life and the Incidence of Risk of Falling
HYPOTHESIS: The incidence of risk of falls is related to the living conditions of elderly people in the community. OBJECTIVES: To study the relationship between living conditions and the incidence of risk of falls in older adults…
- Conditions
- Nursing Caries, Old Age; Debility, Aging Disorder
- Trial name
- NCT04301713
- Testing
- Evaluation of rik of falls
- Where
- Spain
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- University of Salamanca
Frailty, Sarcopenia
Selenium, Sarcopenia, and Frailty in Hemodialysis
Chronic kidney disease (CKD) is a significant public health issue with an increasing prevalence worldwide. In patients undergoing hemodialysis (HD) in particular, various factors-such as chronic inflammation, oxidative stress…
- Conditions
- Frailty, Sarcopenia, Selenium
- Trial name
- NCT07896876
- Testing
- FRAIL scale, sarc-f, time up go test
- Where
- Turkey (Türkiye)
- Volunteers
- 78 people
- Sponsor
- Ankara City Hospital Bilkent
Pancreatic Cancer, Periampullary Cancer
Prehabilitation in Pancreatic Surgery
In patients with pancreatic cancer, older age, multiple comorbidities, frailty, malnutrition and poor functional status are common, especially in individuals receiving neoadjuvant chemotherapy.
- Conditions
- Pancreatic Cancer, Periampullary Cancer, Frailty Syndrome, Malnutrition
- Trial name
- PIPS (NCT06069297)
- Testing
- Multimodal Prehabilitation
- Where
- Italy
- Volunteers
- 238 people
- Sponsor
- IRCCS San Raffaele
Heart Failure
Effects of a Wed-based FRAIL-SM Program Among Patients With Heart Failure
This study aims to examine the effects of web-based FRAIL-SM (Family involvement, self-Regulation skills training, Autonomy, Information sharing and Linkage, Self-Management) on frailty, self-management behaviors and quality of…
- Trial name
- NCT07068308
- Testing
- web-based FRAIL-SM program
- Where
- Taiwan
- Volunteers
- 328 people
- Sponsor
- National Yang Ming Chiao Tung University
Frailty
Strength on Wheels: A Meal Delivery and Exercise Intervention for Homebound Older Adults
The purpose of this study is to implement a home-based exercise program, administered through Interfaith Ministries of Greater Houston Meals on Wheels (MOWGH), and evaluate its effects on frailty status and nutritional markers in…
- Trial name
- NCT04087343
- Testing
- Meals plus exercise, Meals only
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- The University of Texas Health Science Center, Houston
Frailty, Functional Recovery
Multi-Component Prehabilitation for Major Elective Surgery
The purpose of this pilot study is to assess the feasibility of delivering a multicomponent prehabilitation and measuring patient-centered outcomes in older adults undergoing major surgery.
- Conditions
- Frailty, Functional Recovery, Prehabilitation
- Trial name
- NCT05752474
- Testing
- Exercise, Nutrition, Meditation
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Beth Israel Deaconess Medical Center
Frailty, Resilience
Older Adults' Recovery Dynamics After Cardiac Surgery
Population aging has increased the number of older adults exposed to interventions with high physiological demand, which are associated with frequent adverse outcomes such as delirium, organ dysfunction, and delayed functional…
- Conditions
- Frailty, Resilience, Cardiac Surgery Recovery
- Trial name
- ODYSSEY (NCT07793708)
- Where
- Chile
- Volunteers
- 75 people
- Sponsor
- University of Chile
Sarcopenia
Exercise and Nutrition for Healthy AgeiNg
The aim of this randomized placebo-controlled 5-arm clinical trial is to evaluate the effect of combined anabolic interventions compared to single or placebo interventions on physical performance in community-dwelling…
- Trial name
- ENHANce (NCT03649698)
- Testing
- Home-based training program, High-quality protein supplement, Omega-3 fatty acid
- Where
- Belgium
- Volunteers
- 180 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Ovary Cancer, Fallopian Tube Cancer
KORE-INNOVATION: a Prospective, Multi-site Clinical Trial to Implement and Analyse the Effects of an Innovative Perioperative Care Pathway to Reduce Complications for Patients with Ovarian Cancer
KORE-INNOVATION is a multi-center clinical study aiming to implement and analyze an innovative care pathway to reduce perioperative complications for patients undergoing surgical treatment for ovarian cancer.
- Conditions
- Ovary Cancer, Fallopian Tube Cancer, Peritoneum Cancer, Frailty
- Trial name
- KORE (NCT05256576)
- Testing
- Implementation of an innovative multi-modal peri-operative care pathway
- Where
- 2 sites in Germany
- Volunteers
- 465 people
- Sponsor
- Charite University, Berlin, Germany
Fraility, Hypotension
The Effect of Frailty on Hypotension After Anesthesia Induction
Frailty is defined as a state of weakness resulting from a decrease in physiological reserves due to physiological changes, diseases, and/or malnutrition associated with advancing age.
- Trial name
- NCT07351552
- Volunteers
- 80 people
- Sponsor
- Selcuk University
Perioperative Risk Assessment
Frailty Assessment Reveals Cognitive Differences in ASA Classification: Anesthesiologists vs Large Language Models
The American Society of Anesthesiologists (ASA) Physical Status Classification System is widely used to assess perioperative risk, but it does not explicitly include frailty as a standardized variable.
- Trial name
- ASA-AI (NCT07399938)
- Testing
- Observational Assessment Only
- Where
- Turkey (Türkiye)
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Fatih Sultan Mehmet Training and Research Hospital
Cirrhosis, Frailty
Prehab and Creatine/Whey Supplementation in Frailty Among Patients With Cirrhosis
Frailty and muscle health are important for patients with chronic liver disease. This study looks at the use of a digital prehabilitation app (HEAL-ME) plus creatine and whey protein combination supplementation on maintaining…
- Conditions
- Cirrhosis, Frailty, Sarcopenia
- Trial name
- NCT07029243
- Testing
- HEAL-ME digital app, Creatine supplementation, Whey protein supplementation
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of California, San Francisco
Healthy Ageing, Frailty
An Intrinsic Capacity Identification and Management Programme for Older Adults in Singapore's Primary Care
The IMPACTFrail program is an intrinsic capacity (IC) identification and management program for mildly frail older adults. Specifically, it delivers the three-tier approach recommended in the National Frailty Strategy Policy…
- Trial name
- IMPACTFrail (NCT06753643)
- Testing
- The IMPACTFrail programme
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Geriatric Education and Research Institute
Cognition Disorders in Old Age, Cognitive Function
Impact of Nutrition, Sleep, and Physical Activity on Intellectual Function and Muscle Mass in Older Adults
The goal of this prospective, single site, interventional randomized control trial is to treat age related health conditions in adults older than 65 years and functional independence.
- Conditions
- Cognition Disorders in Old Age, Cognitive Function, Frailty/Sarcopenia, MCI
- Trial name
- INSPIOR (NCT06135740)
- Testing
- Fitbit wearing, with notification for sleep, activity and nutrition based fitbit data, Routine care
- Where
- Japan
- Volunteers
- 355 people, healthy volunteers welcome
- Sponsor
- Tokyo University