Clinical trials: Frailty
Frailty, Disability Physical
Viability of an Educational Program for Lifestyle Changes and an Algorithm for the Derivation of Exercise Programs in Older People at Risk of Dependency at Primary Care.
According to the INE in 2021, more than 9 million people are currently over 65 years of age. This means that more than 1 million are frail and almost 4 million are pre-fragile only in Spain.
- Conditions
- Frailty, Disability Physical, Old Age; Atrophy
- Trial name
- PRICA-POWFRAIL (NCT05772910)
- Testing
- EDUcation, EXERcise, EDU-EXER
- Volunteers
- 110 people
- Sponsor
- University of Cadiz
Frailty, Comorbidities and Coexisting Conditions
Frailty in Outpatient Digestive Endoscopy
The increase in our society of the proportion of frail people who suffer from disability and dependency forces us to detect modifiable factors and therefore subject to intervention that can adapt health care for frail patients in…
- Conditions
- Frailty, Comorbidities and Coexisting Conditions, Complication
- Trial name
- FRIEND (NCT06507527)
- Testing
- Collection of variables
- Where
- Spain
- Volunteers
- 1,474 people
- Sponsor
- Parc de Salut Mar
Frailty
Effects of Preoperative Frailty on Postoperative Recovery
This study aims to evaluate frailty using Short Physical Performance Battery (SPPB) before surgery and find out how frailty affects short-term postoperative recovery after surgery using Quality of Recovery-15 (QOR-15)…
- Trial name
- NCT06185270
- Testing
- SPPB
- Volunteers
- 139 people
- Sponsor
- Seoul National University Hospital
Fall Injury, Frailty
A Personalized Video-based Exercise Program for Fall Prevention in Frail and Pre-frail Older Adult
This is a randomized interventional clinical trial, whereby 100 participants will be randomized to either follow the SAFE exercise program (experimental group) or not (control group).
- Conditions
- Fall Injury, Frailty, Old Age; Atrophy, Age-Related Atrophy
- Trial name
- NCT06363942
- Testing
- SAFE program (exercise intervention)
- Where
- Canada
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
COVID-19
Clinical and Biological Predictors of COVID-19 Disease in Older Patients
The project is an observational, prospective study. Its aim is to deepen our understanding of COVID-19 in older patients hospitalized and diagnosed with COVID-19.
- Trial name
- NCT04348396
- Where
- 3 sites in Italy
- Volunteers
- 300 people
- Sponsor
- Istituto Nazionale di Ricovero e Cura per Anziani
Aging, Frailty
Metabolic Dysregulation as Biomarker of Frailty: Role of the Mitochondrial Dysfunction
The goal of this observational study is to evaluate the presence of mitochondrial dysfunction related to oxidative stress and its possible role in frailty, with and without multimorbidity, and to identify possible frailty…
- Conditions
- Aging, Frailty, Mitochondrial Dysfunction, Chronic Disease
- Trial name
- FRAMITO (NCT06433427)
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- University Hospital of Ferrara
Frailty
Longitudinal Study of Frailty in Shanghai Older People
To investigate the prevalence of Frailty in community older residents.
- Trial name
- NCT04650789
- Where
- China
- Volunteers
- 6,000 people, healthy volunteers welcome
- Sponsor
- Shanghai University of Traditional Chinese Medicine
Delirium, Cognitive Decline
Dexmedetomidine or Clonidine Infusion for Prevention of Delirium After Open Heart Surgery
A parallel-group treatment, five-centre, participant and investigator masked, three-arm study to assess the safety and effectiveness of dexmedetomidine or clonidine infusion compared to placebo for the prevention of delirium and…
- Conditions
- Delirium, Cognitive Decline, Frailty
- Trial name
- ALPHA2PREVENT (NCT05029050)
- Testing
- Dexmedetomidine, Clonidine, Natriumchlorid
- Where
- 5 sites in Norway
- Volunteers
- 900 people
- Sponsor
- Oslo University Hospital
Sarcopenia, Nicotinamide Adenine Dinucleotide Concentration
Impacts of Nicotinamide Riboside on Functional Capacity and Muscle Physiology in Older Veterans
Frailty is an age-associated clinical condition of poor physiological reserve that increases risks for falls, hospitalization and mortality.
- Conditions
- Sarcopenia, Nicotinamide Adenine Dinucleotide Concentration, Muscle Quality and NAD+ Content
- Trial name
- NR-VET (NCT04691986)
- Testing
- Nicotinamide Riboside
- Where
- United States
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
End Stage Liver Disease
Evaluation of Frailty and Functional Capacity in End-Stage Liver Disease
Development of fibrosis plays a main role in the pathophysiology of liver diseases. The rate of progression in fibrogenesis varies according to the type of underlying liver disease and varies with the environment and host-related…
- Trial name
- NCT04220723
- Testing
- Frailty Assessment, Functional Capacity Assessment
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Hacettepe University
Frailty, Functional Recovery
Multi-Component Prehabilitation for Major Elective Surgery
The purpose of this pilot study is to assess the feasibility of delivering a multicomponent prehabilitation and measuring patient-centered outcomes in older adults undergoing major surgery.
- Conditions
- Frailty, Functional Recovery, Prehabilitation
- Trial name
- NCT05752474
- Testing
- Exercise, Nutrition, Meditation
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Beth Israel Deaconess Medical Center
Mental Health Issue, Frailty
Brief Health Promotion Intervention for Older People in Mental Health
The goal of this observational study is to test the delivery of brief health promotion advice with supporting information leaflets as part of standard clinical consultation for older people attending a community mental health…
- Trial name
- NCT06127680
- Testing
- Brief Health Promotion Advice
- Where
- Ireland
- Volunteers
- 20 people
- Sponsor
- University College Cork
Frailty, Well-Being, Psychological
Home-based Psychoeducation for Older Adults With Frailty: A Feasibility Trial
This study aims to test the feasibility and acceptability of home-based psychoeducation in older adults with frailty in the community. The main questions it aims to answer are 1.
- Trial name
- NCT06415617
- Testing
- Psychoeducation, Attention control
- Where
- Hong Kong
- Volunteers
- 24 people
- Sponsor
- TAO An
Endovascular Aneurysm Repair (EVAR)
Evaluating the Impact of Psoas Muscle Size, Composition, and Clinical Frailty on Long-term Outcomes Following Elective Endovascular Aneurysm Repair
Sarcopenia, which is characterized by the progressive loss of skeletal muscle mass and strength, has emerged as a significant prognostic biomarker in the field of vascular surgery, particularly regarding endovascular aneurysm…
- Trial name
- NCT06864247
- Testing
- No Intervention: Observational Cohort
- Where
- Taiwan
- Volunteers
- 525 people
- Sponsor
- National Taiwan University Hospital
Cardiovascular Diseases+Liver Transplantation
Usefulness of Cardiopulmonary Exercise Testing for Cardiovascular Risk Estimation and Frailty Assessment in Liver Transplant Candidates
Patients undergoing liver transplantation (LT) have a high risk for cardiovascular disease (CVD). Frailty is a frequent condition among LT candidates.
- Trial name
- NCT04543825
- Testing
- Cardiopulmonary exercise testing
- Where
- 2 sites in United States
- Volunteers
- 54 people
- Sponsor
- Andres Duarte-Rojo
Frailty, Physical Inactivity
Effectiveness of Graded Training in the Vivifrail Exercise Program Among Long-Term Care Residents
This study evaluates the effectiveness of the Vivifrail multicomponent physical exercise program among elderly residents with different levels of frailty in long-term care centers.
- Conditions
- Frailty, Physical Inactivity, Aging
- Trial name
- NCT06975449
- Testing
- Multicomponent Physical Exercise Program (Vivifrail)
- Where
- Taiwan
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- China Medical University Hospital
Sarcopenia
Multicomponent Intervention for Physical Frailty and Sarcopenia
The SPRINTT study will evaluate the efficacy of a multicomponent intervention programme (physical activity, nutritional counselling/dietary intervention, and information and communications technology intervention) compared with a…
- Trial name
- SPRINTT (NCT02582138)
- Testing
- Multicomponent intervention (MCI), Healthy Aging Lifestyle Education (HALE)
- Where
- Italy
- Volunteers
- 1,500 people, healthy volunteers welcome
- Sponsor
- Catholic University of the Sacred Heart
Frailty, Sarcopenia
The SHAPE Project (Hospital System for Physical Activity and Active Participation) After Hospitalized Decompensation of Respiratory Chronic Diseases
It is widely established that a lack of adapted physical activity (APA) and sedentary behaviors increase the prevalence of frailty, which exacerbates chronic diseases.
- Conditions
- Frailty, Sarcopenia, Hospital Discharge, Physical Activity
- Trial name
- SHAPE (NCT07663955)
- Testing
- Hospital System for Physical Activity and Active Participation
- Where
- Spain
- Volunteers
- 90 people
- Sponsor
- Hospital Universitari de Bellvitge
Frailty, Kidney Transplant; Complications
Frailty Assessment Among Kidney Transplant Candidates
Frailty is common among chronic kidney disease patients who are on the kidney transplant (KT) waiting list. The aim of this study is to assess frailty according to different frailty tools among KT candidates and to establish…
- Trial name
- Mar-Kid (NCT04811417)
- Volunteers
- 500 people
- Sponsor
- Parc de Salut Mar
Frailty, Aging
MItochondrial Intervention for Resilience in Older Adults With Coenzyme Q10
This randomized, double-blind, placebo-controlled clinical trial will investigate whether 10 weeks of CoQ10 supplementation can improve biological resilience and functional health in community-dwelling adults aged 65 years or…
- Conditions
- Frailty, Aging, Mitochondria Health, Skin Aging
- Trial name
- MIRO-Q (NCT07772336)
- Testing
- Q10Vital® (CoQ10, ubiquinone)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University Medical Centre Ljubljana