Clinical trials: Frailty, injection or injectable or infusion or IV or syringe or subcutaneous, open to volunteers
- Condition Frailty
- Drug or intervention injection OR injectable OR infusion OR IV OR syringe OR subcutaneous
- Status Open to volunteers
Acute Coronary Syndromes (ACS), Iron Deficiencies
Effect of Intravenous Iron on Quality of Life in Older Patients With Acute Coronary Syndrome
The goal of this phase IV, open-label, randomized clinical trial is to evaluate whether intravenous iron improves quality of life in adults aged 65 years and older with iron deficiency after an acute coronary syndrome (ACS).
- Conditions
- Acute Coronary Syndromes (ACS), Iron Deficiencies, Elderly (People Aged 65 or More)
- Trial name
- HI-COR-65 (NCT07476859)
- Testing
- Ferric Carboxymaltose Injection [Ferinject]
- Where
- 9 sites in Spain
- Volunteers
- 538 people
- Sponsor
- Fundación para la Investigación del Hospital Clínico de Valencia
Frail Elderly Patients, Hypogonadal Males
Effect of Testosterone on Elderly Frail Men With Testosterone Deficiency
The purpose of this study is to increase the functional level of the elderly to thereby reduce fall risk, improve motor skills, and increase psychological well-being, as well as to assess whether the restoration of a normal…
- Conditions
- Frail Elderly Patients, Hypogonadal Males, Testosterone Replacement Therapy, Falls (Accidents) in Old Age
- Trial name
- NCT07512323
- Testing
- Nebido (Testosterone Undecanoate)
- Where
- Denmark
- Volunteers
- 96 people
- Sponsor
- Rune Skovgaard Rasmussen
Frailty
Safety Study of Intravenous MiraMSC in Older Adults With Mild to Moderate Frailty Syndrome
The purpose of this Phase I, open-label study is to evaluate the safety and tolerability of intravenous MiraMSC-FS-001 in older adults with mild to moderate frailty syndrome.
- Trial name
- NCT07705464
- Testing
- MiraMSC-FS-001
- Volunteers
- 12 people
- Sponsor
- Miracle Biomedical Co., Ltd.
Fragility, Cirrhosis
Impact of Nutritional Management on the Frailty of Patients Waiting for Liver Transplantation (Via the LFI Tool)
Cirrhosis is a major public health issue responsible for about 15000 deaths each year. Liver transplantation (LT) remains the only curative treatment for decompensated cirrhosis.
- Conditions
- Fragility, Cirrhosis, Hepatic Transplantation, Undernutrition
- Trial name
- LFI-PATH (NCT06911619)
- Testing
- Dietary management, No dietary management
- Where
- France
- Volunteers
- 210 people
- Sponsor
- Hospices Civils de Lyon
Frailty, Plasma Exchange
Human Albumin Combined With Plasma Exchange for Frailty Intervention
Background Frailty is an age-related syndrome characterized by reduced physiological reserve, decreased stress tolerance and multisystem functional decline in the elderly, which markedly increases the risks of falls…
- Trial name
- NCT07836127
- Testing
- Plasma Exchange, 5% human albumin, Intravenous immunoglobulin (IVIG)
- Where
- China
- Volunteers
- 34 people
- Sponsor
- Institute of Hematology & Blood Diseases Hospital, China
Frailty
Safety of Cultured Allogeneic Adult Umbilical Cord or Placental Derived Mesenchymal Stem Cell Intravenous Infusion for Aging Frailty
This trial will study the safety and efficacy of intravenous infusion of cultured allogeneic adult umbilical cord or placental derived mesenchymal stem cells for the treatment of Aging Frailty
- Trial name
- NCT05018767
- Testing
- cultured allogeneic adult umbilical cord or placental derived mesenchymal stem cells
- Where
- 2 sites in United States, Greece
- Volunteers
- 86 people
- Sponsor
- The Foundation for Orthopaedics and Regenerative Medicine
Frailty, Suboptimal Mask Ventilation
Preoperative Frailty and Suboptimal Mask Ventilation in Cardiac Surgery Patients
This study aims to investigate whether frailty before surgery is associated with difficulty providing adequate breathing support through a face mask after the start of general anesthesia in patients aged 60 years and older…
- Trial name
- FRAILSMV (NCT07916675)
- Testing
- Mask Ventilation During Routine Anesthesia Induction
- Where
- Turkey (Türkiye)
- Volunteers
- 450 people
- Sponsor
- Ankara City Hospital Bilkent
HIV-1-infection, Frailty
Tesamorelin as an Adjunct to Exercise for Improving Physical Function in HIV
People with HIV experience earlier impairments in physical function compared to people in the general population. They also exhibit an earlier presentation and more rapid development of frailty, a multisystemic syndrome of aging…
- Conditions
- HIV-1-infection, Frailty, Impaired Physical Function, Abdominal Obesity
- Trial name
- TRIUMPH (NCT06554717)
- Testing
- Tesamorelin, Exercise
- Where
- 2 sites in United States
- Volunteers
- 100 people
- Sponsor
- Massachusetts General Hospital
Oropharynx Cancer, Frailty
Dose Adjusted Chemoradiotherapy in HPV-Associated Oropharynx Cancer of the Elderly
Previous studies of this type of head and necl cancer have shown high rates of cancer control but result in many short and long term side effects when treated with high dose radiation and chemotherapy.
- Trial name
- (DACHOC-E) (NCT06309225)
- Testing
- Modified dose and fields intensity modulated radiotherapy
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Omar Mahmoud
Frailty, Sarcopenia
PROfiles of FGF-19 Post-prandial Secretion in Older Adults With Frailty and Without Frailty
Fibroblast Growth Factor 19 (FGF-19) is an intestinal hormone secreted in the post-prandial state, whose primary role is to inhibit bile acid synthesis in the liver.
- Trial name
- PRO-FGF (NCT07893665)
- Testing
- FLEXMEAL : post-prandial blood sampling
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Hospices Civils de Lyon
Frailty in Older Adults
Safety and Tolerability Study of Mesenchymal Stem Cells, HeXell-2020, in Elderly Subjects With Mild to Moderate Frailty Syndrome
This is a phase I study to investigate the safety, and Tolerability of HeXell-2020 in Elderly Subjects with Mild to Moderate Frailty Syndrome.
- Trial name
- NCT07144072
- Testing
- HeXell-2020
- Volunteers
- 12 people
- Sponsor
- Hexun Biosciences Co., LTD.
Influenza
Systems Investigation of Vaccine Responses in Aging and Frailty
This study will compare the immune response signatures (including immunologic, transcriptomic and metabolomic) of the two influenza vaccines approved for use in adults age 65 and over (Fluad and Fluzone High-Dose).
- Trial name
- NCT05291676
- Testing
- Fluzone, Fluad
- Where
- United States
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Yale University
Multiple Myeloma (MM), Plasma Cell Leukemia (PCL)
Personalising Treatment for Myeloma Patients Based on Initial Response to NHS Treatment and Their Overall Fitness Level
iFIT is a trial for newly diagnosed transplant-ineligible patients with the bone marrow cancer myeloma. These patients are generally older and have a lower level of fitness than others.
- Trial name
- iFIT (NCT07649525)
- Testing
- Daratumumab, Lenalidomide, Dexamethasone
- Where
- 5 sites in United Kingdom
- Volunteers
- 1,226 people
- Sponsor
- University of Leeds
Age-related Muscle Decline
CALM-AF-AI: Counteracting Age-related Loss of Muscle With AAV-Follistatin Combined With Angiogenesis-Inducing VEGF Plasmid Gene Therapy
This Phase 1/2a, open-label, non-randomized study is designed to evaluate the safety and tolerability of intramuscular AAV9-Follistatin gene therapy administered either as monotherapy or in combination with a VEGF-encoding…
- Trial name
- CALM-AF-AI (NCT07443826)
- Testing
- AAV9-Follistatin gene therapy, VEGF Plasmid
- Where
- Honduras
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Unlimited Biotechnology LLC
Frailty
A Study of Human Allogeneic Bone-marrow-derived Mesenchymal Stromal Cell Product (StromaForte) in Patients With Aging Frailty
The goal of this phase I/II clinical trial is to evaluate the safety and tolerability of intravenous infusion of human allogeneic bone-marrow-derived mesenchymal stromal cell product StromaForte in patients with aging frailty.
- Trial name
- NCT06070532
- Testing
- Human Allogeneic Bone-Marrow-Derived Mesenchymal Stromal Cell Product (StromaForte)
- Where
- The Bahamas
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Cellcolabs Clinical LTD.
Frailty Syndrome
A Study to Evaluate the Safety and Tolerability of Intravenous Stemis™ in Elderly Subjects With Mild to Moderate Frailty Syndrome
This is a Phase 1 clinical study designed to evaluate the safety and tolerability of an investigational cell therapy product, Stemis™, in older adults with mild to moderate frailty.
- Trial name
- NCT07462819
- Testing
- Stemis™, Normal Saline
- Where
- Taiwan
- Volunteers
- 12 people
- Sponsor
- Ji Yan Biomedical Co., Ltd.