Clinical trials: Frailty/Sarcopenia
Frailty, Muscle Loss
A Randomized-Control Study of Gym Tonic's Community Based Strength Training Intervention.
Launched in April 2015 , Gym Tonic is the first of its kind cross-border exercise-as-medicine partnership between research institutions, business enterprises and service providers from Singapore and Finland.
- Conditions
- Frailty, Muscle Loss, Sarcopenia
- Trial name
- NCT04661618
- Testing
- Gym Tonic programme and Gym equipment
- Where
- Singapore
- Volunteers
- 318 people, healthy volunteers welcome
- Sponsor
- PulseSync Pte Ltd
Preventing Age-Related Muscle Loss: the Role of Exercise in Improving Strength, Function, and Well-being
Muscle Aging Evaluation
This study aims to assess the effects of physical activity in counteracting muscle aging. The increasing life expectancy worldwide has led to a rise in age-related muscle decline, which negatively impacts strength, function, and…
- Trial name
- NCT06845748
- Testing
- Physical activity Group
- Where
- Italy
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Milan
Ageing, Frailty
Physiotherapy Interventions on Functional Capacity, Balance and Mental Domains in Community-Dwelling Older Adults: A Randomized Clinical Trial With Two Parallel Groups
This study will investigate whether two different physiotherapy exercise programs can improve physical function, balance and mental well-being in older adults living in the community in Angola.
- Conditions
- Ageing, Frailty, Sarcopenia, Decline, Cognitive
- Trial name
- NCT07424274
- Testing
- Multicomponent Physiotherapy Exercise Program, Reduced Functional Physiotherapy Exercise Program
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- Aveiro University
Metabolic Disease
Effectiveness of Technology for Metabolic Diseases Combined Sarcopenia
The lifestyle program intervention program focusing on healthy dietary habit and exercise effectively prevents metabolic syndrome, sarcopenia or frailty.
- Trial name
- NCT05476536
- Testing
- self-management skills and healthy technology APP
- Where
- Taiwan
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Chang Gung University of Science and Technology
Sarcopenia, Chronic Kidney Disease
The Effects of Frailty on Chronic Kidney Disease
Frailty is a syndrome characterized by decreased reserve and diminished resistance to stressors. The proposed research will evaluate the association of frailty with chronic kidney disease (CKD).
- Trial name
- NCT02775305
- Testing
- Frail
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- San Francisco Veterans Affairs Medical Center
Sarcopenia, Frailty
Protein and Skeletal Muscle in Older Twins: Role of the Gut Microbiome
Research Question: Does the gut microbiome contribute to muscle anabolic resistance to protein supplementation in older adults? Background: Loss of muscle occurs with age and skeletal muscle in older adults can display anabolic…
- Conditions
- Sarcopenia, Frailty, Age-Related Sarcopenia
- Trial name
- PROMOTe (NCT04309292)
- Testing
- Prebiotic food supplement, Protein supplement
- Where
- United Kingdom
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- King's College London
Nutritional Disorder, Critical Illness
The Effect of Higher Protein Dosing in Critically Ill Patients: A Multicenter Randomized Trial
The primary research question: In critically ill patients with nutrition 'risk factors', what is the effect of providing combined EN/PN to the group prescribed a higher dose (≥2.2 grams/kg/day) of protein/amino acid…
- Conditions
- Nutritional Disorder, Critical Illness, Malnutrition, Frailty
- Trial name
- EFFORTcombo (NCT04012333)
- Testing
- OLIMEL 7,6%E / PeriOLIMEL 2,5%E
- Where
- Germany
- Sponsor
- RWTH Aachen University
Heart Failure
Comparison of Different Frailty Assessment Tools
Feasibility and Comparison of the Impact of different Frailty Assessment Tools on the Outcome of Ventricular Assist Device Implantation and Heart Transplantation in advanced heart failure patients
- Trial name
- NCT04222400
- Testing
- Frailty Assessment
- Where
- Germany
- Volunteers
- 150 people
- Sponsor
- German Heart Institute
End-stage Liver Disease, Liver Cirrhosis
Nutrition and Exercise Prehabilitation in Patients Awaiting Liver Transplantation
This study aims to evaluate the effects of a diet with even protein distribution plus exercise (Group A) versus a diet with skewed protein distribution plus exercise (Group B) versus standard dietary and physical activity advice…
- Conditions
- End-stage Liver Disease, Liver Cirrhosis, Liver Transplantation, Malnutrition
- Trial name
- POWER-LT (NCT07561138)
- Testing
- Diet with even protein distribution plus exercise program, Diet with skewed protein distribution plus exercise program, Standard dietary and physical activity advice
- Where
- 2 sites in Greece
- Volunteers
- 90 people
- Sponsor
- Kalliopi Anna Poulia
Heart Failure, Sarcopenia
Multivariate Biomarker Study for Sarcopenia in Heart Failure
In the United Kingdom, heart failure (HF) affects about 900,000 people with 60,000 new cases annually. Up to 60% of people living with HF also experience sarcopenia, known as loss of muscle mass and strength.
- Conditions
- Heart Failure, Sarcopenia, Muscle Weakness, Body Weight
- Trial name
- NCT06217640
- Testing
- Dual X Ray Absorptiometry
- Where
- United Kingdom
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Liverpool
Aging, Rehabilitation
Physical Function of Older Citizens During Municipality-based Rehabilitation
When choosing outcomes to assess rehabilitation's effect or progress, it is essential to consider the constructs being measured and their value to the patient and the psychometric properties.
- Conditions
- Aging, Rehabilitation, Frailty, Sarcopenia
- Trial name
- NCT04862481
- Where
- Denmark
- Volunteers
- 115 people
- Sponsor
- University College Absalon
Frailty, Sarcopenia
Effect of Exercise-education Program PERMANENTO in Late Life
The general aim of the present study is to create and empirically evaluate (RCT trial) an online education and exercise program (called PERMANENTO) to help older adults to understand the wider consequences of being active and…
- Trial name
- PERMANENTO (NCT06133894)
- Testing
- Exercise program PERMANENTO inspired by developmental kinesiology
- Where
- Czechia
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Charles University, Czech Republic
Cognition Disorders in Old Age, Cognitive Function
Impact of Nutrition, Sleep, and Physical Activity on Intellectual Function and Muscle Mass in Older Adults
The goal of this prospective, single site, interventional randomized control trial is to treat age related health conditions in adults older than 65 years and functional independence.
- Conditions
- Cognition Disorders in Old Age, Cognitive Function, Frailty/Sarcopenia, MCI
- Trial name
- INSPIOR (NCT06135740)
- Testing
- Fitbit wearing, with notification for sleep, activity and nutrition based fitbit data, Routine care
- Where
- Japan
- Volunteers
- 355 people, healthy volunteers welcome
- Sponsor
- Tokyo University
Liver Diseases, End Stage Liver Disease
Prehabilitation Intervention to Maximize Early Recovery (PRIMER) in Liver Transplantation
This is a single center, 2-arm, patient-randomized study evaluating the feasibility and potential efficacy of the PRIMER intervention in improving physical function and reducing frailty in adult Liver Transplant candidates.
- Conditions
- Liver Diseases, End Stage Liver Disease, Frailty
- Trial name
- PRIMER (NCT03584646)
- Testing
- Nokia GO Wearable StepTracker, Medication Reminder, Weekly Check-in appointment with study team or provider
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Pennsylvania
Muscle Strengh, Frailty
Effectiveness of Intervention in Prevention of Sarcopenia, Frailty and Functional Decline in Pre-frail Community Elderly
Frailty is a geriatric syndrome characterized by a decrease in the function of various organs and systems that leads to a greater risk of suffering from diseases or disabilities.
- Conditions
- Muscle Strengh, Frailty, Sarcopenia
- Trial name
- ESPAI-F (NCT06280586)
- Testing
- Multidisciplinary intervention
- Where
- 2 sites in Spain
- Volunteers
- 232 people
- Sponsor
- Consorci Sanitari del Maresme
Cirrhosis, Ascites
The BRAINFOOD Trial to Prevent Recurrent Hepatic Encephalopathy.
This study is being completed for patients with cirrhosis, including patients with a prior history of hepatic encephalopathy (HE) to evaluate the feasibility and benefits of medically-tailored meals as an intervention.
- Conditions
- Cirrhosis, Ascites, Liver Diseases, Frailty
- Trial name
- NCT04675775
- Testing
- Medically-tailored meals (MTM), Protein supplements, Nutrition education handout
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- University of Michigan
Frailty, Stroke
Body Composition, Frailty, and Function in Rehabilitation
The investigators are investigating if body composition measures - in particular muscle mass, body fat, and something called the phase angle - are able to reliably predict functional outcomes for patients who are in an acute…
- Conditions
- Frailty, Stroke, Debility Due to Disease
- Trial name
- NCT06527742
- Where
- Singapore
- Volunteers
- 345 people
- Sponsor
- Changi General Hospital
Aging, Cognitive Decline
Blood Flow Restriction and High-intense Resistance Training in Aging: Interactions Between Neuroplasticity and Muscle
BRAIN-M is a randomized controlled trial designed to examine the effects of a single bout or 12 weeks of blood-flow restriction training or high-intensity resistance training on cognitive function, brain health, muscular…
- Conditions
- Aging, Cognitive Decline, Sarcopenia, Frailty
- Trial name
- BRAIN-M (NCT05744167)
- Testing
- BFRT, MDRT
- Where
- Lithuania
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Lithuanian Sports University
Sarcopenia, Frailty
Using Exergame-based Program in Elders of Rural LTCF
Background: Sarcopenia is the progressive loss of skeletal muscle mass and decline of muscle function associated with aging. Frailty is defined as a clinically recognizable state of increased vulnerability resulting from…
- Conditions
- Sarcopenia, Frailty, Long Term Care Facility
- Trial name
- NCT05360667
- Testing
- Standard care plus plus Exergame-based multicomponent training program, Standard care
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- Cishan Hospital, Ministry of Health and Welfare
Malnutrition, Sarcopenia
Nutritional Status in Hospitalized Patients Over 65 Years of Age With Mental Disorders
The objective of of this observational study is to evaluate the nutritional status and the prevalence of nutrition-related conditions, as well as dysphagia, among patients aged 65 years and older with mental disorders.
- Conditions
- Malnutrition, Sarcopenia, Obesity, Sarcopenic Obesity
- Trial name
- NutriP-SI65 (NCT07710456)
- Volunteers
- 450 people
- Sponsor
- University Psychiatric Clinic Ljubljana