Clinical trials: Frailty/Sarcopenia
Cystic Fibrosis, Sarcopenia
Tele-Rehabilitation in Adults With Cystic Fibrosis
This study is a randomized controlled trial designed to evaluate the effectiveness of an 8-week tele-rehabilitation program in adults with cystic fibrosis.
- Conditions
- Cystic Fibrosis, Sarcopenia, Frailty
- Trial name
- CF-TR (NCT07500493)
- Testing
- Tele-Rehabilitation Exercise Program
- Volunteers
- 76 people
- Sponsor
- King Saud University
Frailty, Sarcopenia
PROfiles of FGF-19 Post-prandial Secretion in Older Adults With Frailty and Without Frailty
Fibroblast Growth Factor 19 (FGF-19) is an intestinal hormone secreted in the post-prandial state, whose primary role is to inhibit bile acid synthesis in the liver.
- Trial name
- PRO-FGF (NCT07893665)
- Testing
- FLEXMEAL : post-prandial blood sampling
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Hospices Civils de Lyon
Frailty, Sarcopenia
Effect of Exercise-education Program PERMANENTO in Late Life
The general aim of the present study is to create and empirically evaluate (RCT trial) an online education and exercise program (called PERMANENTO) to help older adults to understand the wider consequences of being active and…
- Trial name
- PERMANENTO (NCT06133894)
- Testing
- Exercise program PERMANENTO inspired by developmental kinesiology
- Where
- Czechia
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Charles University, Czech Republic
Sarcopenia, Muscle Loss
Counteracting Age-related Loss of Skeletal Muscle Mass (CALM)
Up to 66 healthy elderly individuals (at least 65 years old) are recruited as subjects. They will be recruited as a subgroup to protocol ID: H-4-2013-070.
- Trial name
- CALM (NCT02115698)
- Testing
- Heavy Resistance Training, Light Intensity Training, Protein Whey
- Where
- Denmark
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Bispebjerg Hospital
Balance Impairment, Sarcopenia in Elderly
Multicomponent Exercise and Frailty in Nursing Home Residents
Frailty is common among older adults living in nursing homes and increases the risk of falls, disability, and loss of independence.
- Conditions
- Balance Impairment, Sarcopenia in Elderly, Frailty at Older Adults, Functional Decline
- Trial name
- BASE-Frail (NCT07686146)
- Testing
- Multicomponent Exercise Program (BASE), Usual Care
- Where
- Spain
- Volunteers
- 66 people
- Sponsor
- Escoles Universitaries Gimbernat
Breast Cancer, Frailty
Multicomponent Prehabilitation in Older Adults With Breast Cancer
Older adults with breast cancer frequently present with frailty, decreased functional reserve, and increased risk of postoperative complications.
- Conditions
- Breast Cancer, Frailty, Sarcopenia, Aging
- Trial name
- PREHAB-BC65 (NCT07531836)
- Testing
- Home-based Multicomponent Prehabilitation (Vivifrail), Supervised Multicomponent Prehabilitation, Comprehensive Geriatric Assessment and Optimization
- Where
- Spain
- Volunteers
- 90 people
- Sponsor
- Fundacion Miguel Servet
Weak; Senile, Old Age; Debility
Comparison of the Functional Status, Psychosocial Aspects and Discharge Locations of Geriatric Patients Before and After Inpatient Geriatric Rehabilitation
Due to demographic change in Switzerland, the proportion of older people in the population is expected to increase. It is therefore important that people in old age remain in the best of health and maintain their independence for…
- Conditions
- Weak; Senile, Old Age; Debility, Movement Disorders, Quality of Life
- Trial name
- NCT07131865
- Where
- Switzerland
- Volunteers
- 753 people
- Sponsor
- University of Bern
Sarcopenia in Elderly, Sarcopenic Obesity
Comparative Analysis of Sarcopenia in Rehabilitation Outcomes Following Femoral Neck Fracture: a Study in Normal Weight and Obese Study Cohort
Impact of Obesity on Sarcopenia Prevalence and Severity in Elderly Adults Recovering from Femoral Neck Fractures: A Prospective Study Introduction Age-related muscle loss, or sarcopenia, which includes reductions in both muscle…
- Conditions
- Sarcopenia in Elderly, Sarcopenic Obesity, Frailty, Femoral Fractures
- Trial name
- NCT06705166
- Volunteers
- 300 people
- Sponsor
- Shmuel Harofeh Hospital, Geriatric Medical Center
Frailty, Fall
Validation and Application of a Multi-dimentional Frailty Assessment Tool-Cohort Intervention and Follow up
We aim to (1) use a multifaceted, frailty assessment model. (2) use randomized controlled trials to deal with and intervene with cross-field, multi-faceted and intelligent remote management strategies for the elderly with…
- Conditions
- Frailty, Fall, Sarcopenia
- Trial name
- NCT05731167
- Testing
- Multidomain frailty prevention method, Regular follow up
- Where
- Taiwan
- Volunteers
- 216 people
- Sponsor
- National Taiwan University Hospital
Sarcopenia, Frailty
Whole Grain Job's Tear, Muscle Health, Blood Glucose and Lipid Level
Background: This investigation aims to explore efficacy of Taiwanese whole grain job's tear on muscle health and blood glucose and lipid levels in community-dwelling older adults.
- Conditions
- Sarcopenia, Frailty, Hyperglycemia, Hyperlipidemia
- Trial name
- NCT06503172
- Testing
- Taiwanese whole grain job's tear (red job's tear), White job's tear
- Where
- Taiwan
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Frail Elderly Syndrome, Diabetes
Muscle Multi-parametric NMR Imaging Development in Aged People With Sarcopenia or Frailty Syndrome; CLINical Study
Frailty is a multideterminant syndrome in which muscle function appears to play a central role. Muscle function depends on brain control, nutrition and perfusion.
- Trial name
- MIDAS (NCT04238494)
- Testing
- Nuclear magnetic resonance (NMR)
- Where
- 2 sites in France
- Volunteers
- 60 people
- Sponsor
- University Hospital, Bordeaux
Cirrhosis, Liver, Liver Transplant Surgery
Online Prehabilitation for Patients Awaiting Liver Transplantation
Physical frailty is common in patients awaiting liver transplantation and has been associated with poor health outcomes. There is promising data from small studies showing that behavioural, nutrition, exercise therapy…
- Conditions
- Cirrhosis, Liver, Liver Transplant Surgery, Liver Disease
- Trial name
- OPAL (NCT05899231)
- Testing
- Prehabilitation Programming
- Where
- 6 sites in Canada
- Volunteers
- 177 people
- Sponsor
- University of Alberta
Frailty, Sarcopenia
Effect of a Multicomponent Therapeutic Exercise Program in Primary Care on Frailty and Sarcopenia in Older Adults
Background: Frailty and sarcopenia are common conditions in older adults that increase the risk of disability, dependence, and hospitalizations.
- Conditions
- Frailty, Sarcopenia, Aging, Exercises Therapy
- Trial name
- FRACTEP-65 (NCT07132632)
- Testing
- 12-week multicomponent therapeutic exercise program including supervised and home-based sessions focused on strength, balance, mobility, and aerobic capacity
- Volunteers
- 60 people
- Sponsor
- Fundacio d'Investigacio en Atencio Primaria Jordi Gol i Gurina
Sarcopenia, Frailty
Impact of Hand Grip Strength on Length of Hospital Stay After Cardiac Surgery Among Elderly Patients
Hand grip strength has been shown to be a predictor of adverse cardiovascular outcomes in the elderly population. This study aims to investigate whether measurement of hand grip strength could be used as a predictor of prolonged…
- Trial name
- NCT05546671
- Testing
- Hand grip strength measurement
- Where
- Turkey (Türkiye)
- Volunteers
- 240 people
- Sponsor
- Kartal Kosuyolu High Speciality Training and Research Hospital
Nutritional Disorder, Critical Illness
The Effect of Higher Protein Dosing in Critically Ill Patients: A Multicenter Randomized Trial
The primary research question: In critically ill patients with nutrition 'risk factors', what is the effect of providing combined EN/PN to the group prescribed a higher dose (≥2.2 grams/kg/day) of protein/amino acid…
- Conditions
- Nutritional Disorder, Critical Illness, Malnutrition, Frailty
- Trial name
- EFFORTcombo (NCT04012333)
- Testing
- OLIMEL 7,6%E / PeriOLIMEL 2,5%E
- Where
- Germany
- Sponsor
- RWTH Aachen University
Liver Diseases, End Stage Liver Disease
Prehabilitation Intervention to Maximize Early Recovery (PRIMER) in Liver Transplantation
This is a single center, 2-arm, patient-randomized study evaluating the feasibility and potential efficacy of the PRIMER intervention in improving physical function and reducing frailty in adult Liver Transplant candidates.
- Conditions
- Liver Diseases, End Stage Liver Disease, Frailty
- Trial name
- PRIMER (NCT03584646)
- Testing
- Nokia GO Wearable StepTracker, Medication Reminder, Weekly Check-in appointment with study team or provider
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Pennsylvania
Muscle Strengh, Frailty
Effectiveness of Intervention in Prevention of Sarcopenia, Frailty and Functional Decline in Pre-frail Community Elderly
Frailty is a geriatric syndrome characterized by a decrease in the function of various organs and systems that leads to a greater risk of suffering from diseases or disabilities.
- Conditions
- Muscle Strengh, Frailty, Sarcopenia
- Trial name
- ESPAI-F (NCT06280586)
- Testing
- Multidisciplinary intervention
- Where
- 2 sites in Spain
- Volunteers
- 232 people
- Sponsor
- Consorci Sanitari del Maresme
Sarcopenia, Frailty
Evaluation of Efficacy, Tolerability, and Pharmacokinetics of MYMD1 for Chronic Inflammation and Sarcopenia/Frailty
The study will be conducted to investigate the efficacy, tolerability and pharmacokinetics of MYMD1 in participants with chronic inflammation associated with sarcopenia/frailty, a condition linked to elevated levels of…
- Conditions
- Sarcopenia, Frailty, Aging
- Trial name
- NCT05283486
- Testing
- MYMD-1 600MG, MYMD-1 750mg, MYMD-1 900mg
- Where
- 3 sites in United States
- Volunteers
- 40 people
- Sponsor
- TNF Pharmaceuticals, Inc.
Frailty Syndrome
Ghrelin Plus Strength Training in Frail Elderly Study
Frailty is a geriatric syndrome leading to physical deterioration including muscle wasting (sarcopenia) and unintentional weight loss. There are currently no approved therapies for frailty.
- Trial name
- NCT01898611
- Testing
- Ghrelin
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- University of Pennsylvania
Frailty at Older Adults, Sarcopenia
A Clinical Study on the Improvement of Frailty and Sarcopenia in Elderly Community Residents Through Pulsed Electromagnetic Field Therapy
The entire clinical study will be conducted strictly following the following procedure: 1) Informed Consent If you decide to participate in this trial, we will first ensure that you fully understand the research purpose…
- Trial name
- NCT07834697
- Testing
- Standard treatment with pulsed magnetic therapy apparatus, Fake stimulation therapy with pulse magnetic therapy device
- Volunteers
- 100 people
- Sponsor
- Xuanwu Hospital, Beijing