Clinical trials: Frail Elderly
Frail Elderly Syndrome
A Machine Learning Algorithm to Predict Health Clinical Situations in Primary Healthcare for Frail Older Adults.
Introduction: We developed a machine learning algorithm to predict the risk of emergency hospitalization within the new 7 to 14 days with a good predictive performance (AUC=0.85).
- Trial name
- NCT06013709
- Testing
- PRESAE CARE
- Volunteers
- 1,478 people
- Sponsor
- Presage
Head and Neck Cancer, Head and Neck Neoplasms
Radiotherapy, Cetuximab, and Injections of TNFerade™ Biologic for Elderly or Frail Patients With Head and Neck Cancer
This study is looking at the safety and tolerability of TNFeradeä Biologic combined with conventional once daily radiation therapy in elderly or frail patients with new onset locally advanced head and neck tumors.
- Trial name
- NCT00496236
- Testing
- TNFerade biologic
- Where
- United States
- Sponsor
- GenVec
Diffuse Large B-cell Lymphoma
A Study of Loncastuximab Tesirine and Rituximab (Lonca-R) in Previously Untreated Unfit/Frail Participants With Diffuse Large B-cell Lymphoma (DLBCL)
The main objective of the trial is to assess the efficacy and tolerability of Lonca-R in unfit and frail participants with previously untreated DLBCL.
- Trial name
- LOTIS-9 (NCT05144009)
- Testing
- Loncastuximab Tesirine, Rituximab
- Where
- 41 sites in United States, Italy and 2 more
- Volunteers
- 41 people
- Sponsor
- ADC Therapeutics S.A.
Frail Elderly Syndrome, Older
eHealth for Screening Health Risks in Home-Based Older Adults: A Prospective Study
Introduction: Due to the worldwide ageing population and the increasing prevalence of chronic illnesses and cognitive deficits, appropriate instruments for frailty early screening and assessment of geriatric syndromes are…
- Trial name
- Proxi (NCT06019390)
- Testing
- Presage care
- Volunteers
- 200 people
- Sponsor
- Presage
Frail Elderly Syndrome, Aging
Autologous Stem/Stromal Cellular Stromal Vascular Fraction (cSVF) In Frailty-Aging Processes
With increasing age and health issues associated with aging, many systemic cellular and structural changes are known to occur. The intent of this trial is to determine the safety and efficacy of delivery of autologous cellular…
- Conditions
- Frail Elderly Syndrome, Aging, Degenerative Disease
- Trial name
- GARM-W (NCT03514537)
- Testing
- Microcannula harvest adipose stromal tissues, Centricyte 1000, Sterile Normal Saline IV Deployment of cSVF
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Healeon Medical Inc
Diffuse Large B-Cell Lymphoma
Study of Acalabrutinib and Rituximab in Untreated Elderly and/or Frail Patients With DLBCL
The study will measure the safety, tolerability, and efficacy with acalabrutinib in combination with rituximab in treatment-naïve elderly and/or frail patients with diffuse large B-cell lymphoma (DLBCL), who are otherwise…
- Trial name
- ACRUE (NCT05952024)
- Testing
- Acalabrutinib, Rituximab
- Where
- 57 sites in United States, Brazil and 3 more
- Volunteers
- 80 people
- Sponsor
- AstraZeneca
Elderly People
Immune Benefits of WGP in Elderly
The aim of this research is to assess the immune enhancing property of food fibers in the elderly population.
- Trial name
- NCT02262091
- Testing
- Food fibers, Maltodextrin, Influenza vaccine (incl. criterion)
- Where
- Germany
- Volunteers
- 150 people
- Sponsor
- Société des Produits Nestlé (SPN)
Elderly, Frail
Randomized Study Of Exercise And Vitamin D In Frail Elderly Subjects
The study will explore multiple mobility function tests as well as functional and neuropsychological tests in elderly subjects at risk for falls and disability, before and after 4-month exercise and/or Vitamin D intervention.
- Trial name
- NCT00249704
- Testing
- Vitamin D + Exercise
- Where
- 4 sites in United States
- Volunteers
- 64 people
- Sponsor
- Pfizer
Frail Elderly Syndrome, Heart Failure
Medical Monitoring of Older Adults Patients After Discharged From Heart Failure Hospitalization
Introduction: PRESAGE CARE has developed a solution for early detection of the risk of emergency department visits and unscheduled hospitalizations.
- Trial name
- NCT06018532
- Testing
- PRESAGE CARE
- Volunteers
- 100 people
- Sponsor
- Presage
Breast Cancer, Recurrent Breast Cancer
A Study of Diffusing Alpha Radiation Therapy for Patients With Breast Carcinoma in Frail or Elderly Patients.
A unique approach for cancer treatment employing intratumoral diffusing alpha radiation emitter device for the treatment of newly diagnosed or Recurrent Breast Carcinoma in frail or elderly patients.
- Conditions
- Breast Cancer, Recurrent Breast Cancer, Breast Carcinoma
- Trial name
- NCT06202118
- Testing
- Diffusing Alpha Radiation Emitters Therapy (DaRT)
- Where
- Israel
- Volunteers
- 10 people
- Sponsor
- Alpha Tau Medical LTD.
Aging, Frail Older Adults
Effects Of An Oral Growth Hormone Secretagogue In Older Functionally Limited Adults
A 24-month, placebo controlled, double dummy, parallel-design outpatient trial in generally healthy elderly men and women who are at risk of becoming frail.
- Trial name
- NCT00527046
- Testing
- CP-424,391
- Where
- 12 sites in United States
- Volunteers
- 396 people
- Sponsor
- Pfizer
Frailty, Sarcopenia
Impact of Urolithin A (Mitopure) on Mitochondrial Quality in Muscle of Frail Older Adults
The study is a single-center, randomized, placebo-control double-blind study in frail older adults over 65yrs. to investigate the impact of Mitopure (Urolithin A) supplementation on muscle mitochondrial quality in frail older…
- Conditions
- Frailty, Sarcopenia, Aging, Muscle Atrophy
- Trial name
- MitoEM (NCT06556706)
- Testing
- Mitopure (Urolithin A)
- Where
- Canada
- Volunteers
- 26 people
- Sponsor
- Amazentis SA
COVID, Drug Effect
Simulation of Risk of Adverse Drug Events Associated With the Initiation of Drugs Repurposed for the Treatment of COVID-19 in Frail Elderly Adults With Polypharmacy
This retrospective study aims to perform a medication risk stratification using drug claims data and to simulate the impact of the addition of various repurposed drugs on the Medication Risk Score (MRS) in elderly people enrolled…
- Conditions
- COVID, Drug Effect, Drug Interaction, Adverse Drug Event
- Trial name
- NCT04339634
- Testing
- Simulation of Repurposed Drugs for COVID-19
- Where
- United States
- Volunteers
- 12,873 people
- Sponsor
- Tabula Rasa HealthCare
Frail Elderly, Medication Errors
MD.2 Medication Dispenser Medication Adherence Study
The objective of this study is to quantify the benefits of using the MD.2 on health outcomes.
- Trial name
- NCT00560001
- Testing
- MD.2 Medication Dispenser
- Where
- United States
- Volunteers
- 600 people
- Sponsor
- Interactive Medical Developments
Aging, Frailty
Mitophagy and Autophagy in Elderly Subjects
In recent years, evidence has shown that mitochondrial dysfunction plays an important role in the development of age-related muscle decline that may lead to frailty.
- Conditions
- Aging, Frailty, Mitophagy
- Trial name
- NCT02472340
- Testing
- Muscle Biopsy
- Where
- Netherlands
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Amazentis SA
Malnutrition, Sarcopenia
Evaluation of an Oral Nutritional Supplement Containing AN777
To evaluate the effect of an experimental oral nutritional supplement containing AN777 compared to another oral nutritional supplement in a malnourished, elderly population.
- Trial name
- NCT01191125
- Testing
- medical food with AN777, oral nutritional formula
- Where
- 23 sites in United States, Belgium and 6 more
- Volunteers
- 331 people
- Sponsor
- Abbott Nutrition
Frail Elderly Syndrome, Older Adults
A Digital Home-Based Physiotherapy Program for Active Aging
This clinical trial will aim to understand the effects of the TRAK-SILVER digital platform on pre-frail and older adults living at home, assessing its impact on physical activity level, emotional variables, and overall quality of…
- Trial name
- TRAK-SILVER (NCT06381336)
- Testing
- TRAK-SILVER platform
- Where
- Spain
- Volunteers
- 72 people
- Sponsor
- Trak Health Solutions S.L.
Pre-frail Elderly, Frail Elderly
Dose Finding Study in Physically Frail Elderly to Measure 25(OH) Vitamin D Levels After Supplementation With Hy.D Calcifediol 25 SD/S and Vitamin D3
The purpose of this study is to assess the dose of Hy.D Calcifediol 25 SD/S (a metabolite of vitamin D3) which will achieve the range of mean serum 25(OH)D between 75-100nmol/L in physically frail elderly people after 24 weeks of…
- Trial name
- D-DOSE (NCT01868945)
- Testing
- 5 µg/day Hy.D Calcifediol, 10 µg/day Hy.D Calcifediol, 15 µg/day Hy.D Calcifediol
- Where
- Netherlands
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- dsm-firmenich Switzerland AG
Frail Elderly Syndrome
Management of Frailty in Older Adults With Turmeric and Tulsi Supplements
The aim of this study is to determine the efficacy of turmeric and tulsi polyherbal formulation in the management of frailty in the elderly population.
- Trial name
- NCT03365310
- Testing
- C. longa, curcuminoids , Z. officianale, O. sanctum along with 200 ml of Milk, Standard of Care
- Where
- India
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Composite Interceptive Med Science