Clinical trials: Fragility Fractures
Chronic Stroke, Osteoporosis
Incidence of Fragility Fractures and Osteoporosis Screening in Chronic Stroke Patients
Stroke is a known risk factor for the development of osteoporosis, leading to an increased risk of falls and fractures. Several international studies have associated stroke with hip fractures, showing an odds ratio ranging…
- Conditions
- Chronic Stroke, Osteoporosis, Fragility Fractures
- Trial name
- NCT06804252
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- University of Palermo
Femoral Fracture, Fragility Fracture
Essential Amino Acid Supplementation for Femoral Fragility Fractures
This trial will evaluate the impact of 4 weeks of postoperative essential amino acid (EAA)-based supplementation on muscle morphology after femoral fragility fracture.
- Conditions
- Femoral Fracture, Fragility Fracture, Muscle Atrophy
- Trial name
- NCT06050668
- Testing
- Essential Amino Acid Supplementation
- Where
- 2 sites in United States
- Volunteers
- 60 people
- Sponsor
- Michael C Willey
Pelvic Fracture
Fragility Fractures of the Pelvis (FFP)
Prospective data will be collected in approximately 420 patients, above the age of 65, suffering from an FFP type fracture equal to or higher than type II, according to Rommens and Hofmann.
- Trial name
- NCT04182776
- Where
- 10 sites in United States, Canada and 5 more
- Volunteers
- 420 people
- Sponsor
- AO Innovation Translation Center
Hip Fractures
The Effects of Fragility Fracture Integrated Rehabilitation Management
To determine the effects of Fragility Fracture Integrated Rehabilitation Management approach in geriatric hip fracture patients (post surgical)
- Trial name
- NCT04760756
- Testing
- Fragility Fracture Integrated Rehabilitation Management
- Where
- Pakistan
- Volunteers
- 20 people
- Sponsor
- Zohra Institute of Health Sciences
Osteoporosis, Postmenopausal Osteoporosis
Can Serum Lumican Level Identify a Hidden Fragility Phenotype Beyond Bone Mineral Density in Postmenopausal Women?
Osteoporosis is a major cause of morbidity and fragility fractures in postmenopausal women. Bone mineral density (BMD) alone may not fully reflect fracture risk and skeletal fragility.
- Conditions
- Osteoporosis, Postmenopausal Osteoporosis, Frailty, Fragility Fractures
- Trial name
- LUMINOS (NCT07677072)
- Where
- Turkey (Türkiye)
- Volunteers
- 98 people
- Sponsor
- Kanuni Sultan Suleyman Training and Research Hospital
Hip Fracture
The Comparison of Comprehensive Multi-disciplinary Program and Conventional Care Program on Fragility Fracture Elderly
Fragility fractures are one of the commonest injuries among elderly people in Hong Kong and account for 12% of the disease burden in elderly aged 65 or above.
- Trial name
- NCT01382875
- Testing
- Multi-disciplinary management program
- Where
- China
- Volunteers
- 160 people
- Sponsor
- Chinese University of Hong Kong
Osteoporosis
Study in Patients With Osteoporosis and Fragility Fractures to Estimate the Extent and Impact of Delayed Administration of Anti-fracture Therapy
Osteoporosis (OP) and fragility fractures are a significant problem that leads to morbidity, mortality, and high costs for the National Health System.
- Trial name
- OPGAP01 (NCT07512453)
- Where
- Italy
- Volunteers
- 8,000 people
- Sponsor
- Azienda Ospedaliero, Universitaria Pisana
Obesity, Bariatric Surgery Candidate
Bone Fragility Evaluation in Obese Patients
This research will study the bone fragility in obese patients, on DXA and CT-scan, in a transversal study. The investigators want also to study the specific risk factors of bone fragility in these obese patients (relationship…
- Trial name
- NCT04174495
- Testing
- DXA and CT-scan
- Where
- France
- Volunteers
- 1,500 people
- Sponsor
- Central Hospital, Nancy, France
Fragility Fractures
Application and Effect of "Internet + Nursing" in Hip Fragility Fracture Patients Based on Fracture Liaison Service
Fragility fractures, also known as osteoporotic fractures, are fractures that occur as a result of low-energy trauma or minor impact.
- Trial name
- NCT06975254
- Testing
- On the basis of routine nursing, the "Internet + nursing program" based on the FLS model is implemented
- Where
- China
- Volunteers
- 94 people
- Sponsor
- The Fourth Affiliated Hospital of Zhejiang University School of Medicine
Chronic Obstructive Pulmonary Disease (COPD), Acute Coronary Syndrome
Feasibility Study of a Digital Interactive Life-style Platform for Individuals After Rehabilitation
The goal of this clinical trial is to evaluate the feasibility and usability of a digital lifestyle platform designed to support patients after discharge from inpatient rehabilitation.
- Conditions
- Chronic Obstructive Pulmonary Disease (COPD), Acute Coronary Syndrome, Fragility Fracture, Minor Stroke
- Trial name
- Feas Platf (NCT07597031)
- Testing
- Digital Lifestyle Platform, Usual Care (Standard Post-Rehabilitation Care)
- Where
- 2 sites in Switzerland
- Volunteers
- 240 people
- Sponsor
- Matthias Wilhelm, MD
Multiple Myeloma, Vertebral Fracture
Vertebral Fat Quantitative MRI as a Marker of Bone Fragility in Multiple Myeloma (MYELOMEFRAGIQUANTI)
Multiple myeloma is a disease that causes increased bone fragility which is often revealed or complicated by vertebral fractures. Invasion of bone marrow by tumor plasma cells leads to bone destruction and reduced fat fraction.
- Trial name
- NCT04609150
- Testing
- Bone marrow fat quantification by MRI
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Osteoporosis
Osteoporosis Treatment Protocol in Patients With Fragility Fractures: Application and Efficacy
Osteoporosis and osteoporotic fractures, especially hip fractures, have a significant impact on public healthcare. Despite the fact that the patients that have suffered an osteoporotic fracture have 86% increased risk of…
- Trial name
- NCT04861142
- Testing
- Anti-osteoporotic medication( alendronate or denosumab)
- Where
- Greece
- Volunteers
- 350 people
- Sponsor
- University General Hospital of Heraklion
Sacral Fracture, Osteoporotic Fracture
Sacroplasty for Sacral Insufficiency Fractures.
This study is designed to determine whether sacroplasty, a minimally invasive procedure to stabilize sacral fractures, improves quality of life and functional recovery in adults aged 50 years or older with sacral or posterior…
- Trial name
- SACRA (NCT07493564)
- Testing
- Percutaneous Sacroplasty, Standard conservative management
- Where
- United Kingdom
- Volunteers
- 110 people
- Sponsor
- Hull University Teaching Hospitals NHS Trust
Osteoporosis, Arthroplasty Complications
Surgeon-Initiated Bone Health Referral Pathway in Patients Undergoing Lower Extremity Arthroplasty
The goal of this clinical trial is to observe the impact of a surgeon-driven bone health referral pathway following lower extremity arthroplasty.
- Conditions
- Osteoporosis, Arthroplasty Complications, Fragility Fracture
- Trial name
- NCT05845021
- Testing
- Surgeon-Initiated Bone Health Referral Pathway
- Where
- United States
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Osteoporosis Risk
Fragility Re-fractures Prediction Score
Fragility fractures increase among elderly patients worldwide, representing a global burden in terms of disability and care expenditure.
- Trial name
- RIFRA (NCT06448325)
- Testing
- Hip arthroplasty
- Where
- Italy
- Volunteers
- 800 people
- Sponsor
- I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio
Depression in Old Age, Fragility Fracture
Serotonin-norepinephrine Reuptake Inhibitor in Prophylaxis of Depression Following Fragility Fractures
The goal of this pilot study is to learn about the feasibility about prescribing anti-depressants at discharge in patients aged 50 years and older with a lower extremity fragility fracture.
- Trial name
- SNRI (NCT05851898)
- Testing
- Duloxetine 30 mg
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Wake Forest University Health Sciences
Fractures, Bone, Dementia
Function Focused Care: Fracture Care at Home
This pilot study will evaluate the feasibility of implementing an intervention in the home setting that is specifically designed to coach and mentor caregivers as they assist individuals with Alzheimer's disease and related…
- Trial name
- NCT03147222
- Testing
- Fracture Care at Home
- Where
- United States
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
Sacral Fracture
Operative vs Non-Operative Treatment of Sacral Fractures
The purpose of this study is to compare percutaneous trans-iliac trans-sacral screw fixation to non-operative management for the treatment of symptomatic, sacral fragility fractures in elderly patients.
- Trial name
- NCT04044300
- Testing
- Single screw fixation, Conservative
- Where
- United States
- Volunteers
- 104 people
- Sponsor
- More Foundation
Ankle Fractures, Pilon Fracture
FRAME Study (Frailty-Related Ankle Fracture Management and Evaluation)
This will be a multi-centre randomized controlled trial, with London Health Sciences Centre (LHSC) as the lead site. Elderly patients with complex ankle fractures who meet the inclusion criteria and provide consent will be…
- Trial name
- FRAME (NCT05131321)
- Testing
- Primary ankle arthrodesis (fusion), ORIF (open reduction and internal fixation), Intramedullary Fibular Nailing (IMFN)
- Where
- Canada
- Volunteers
- 172 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Osteoporosis
Real-World Evidence of Adherence to Denosumab Therapy and Fracture Risk Associated With Drug Withdrawal: A Cross-sectional Study
In the light of current literature data, it is not recommended to discontinue Denosumab therapy without initiating another antiresorptive therapy.
- Trial name
- NCT06414616
- Where
- Turkey (Türkiye)
- Volunteers
- 210 people
- Sponsor
- Trakya University