Clinical trials: Fragility
HIV Infections, Frail Older Adults
Spanish Cohort of Patients with HIV Infection Older Than 50 Years for the Study of Fragility and Physical Function
It's a prospective observational study to assess frailty and physical function
- Trial name
- FUNCFRAIL (NCT03558438)
- Testing
- No interventions
- Where
- 13 sites in Spain
- Volunteers
- 802 people
- Sponsor
- Fundacion SEIMC-GESIDA
Humidifier Lung, Mechanical Fragility
Evaluation of Gas Humidification Practices in Patients Under Invasive Mechanical Ventilation
When mechanical ventilation is initiated, a humidification method should be chosen. There is two methods: heat and humidity exchanger filters or heated humidity.
- Conditions
- Humidifier Lung, Mechanical Fragility, Respiratory Complication
- Trial name
- FP950 (NCT06719258)
- Testing
- MR850, FP950
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- Laval University
Severe Fragility Fracture
Outcomes of Severe Osteoporotic Fractures Hospitalized in France: the CROSS Cohort
The purpose of this study is to determine the outcomes of severe osteoporotic fractures hospitalized in France, the risk of incident severe fracture at 2 years and 5 years and the risk of mortality over 2 and 5 years.
- Trial name
- CROSS (NCT02606162)
- Where
- France
- Volunteers
- 912 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Old Age, Hip Fractures
Validity and Reliability of the Modified Delirium Diagnostic Tool - Provisional (DDT-Pro) (Thai Version) in Peri-operative Fragility Hip Fracture Patient
Nowadays, the number of hip fracture patients is increasing. As Thailand enters into an aging society, hip fractures are becoming more common. They are typically treated with surgery.
- Conditions
- Old Age, Hip Fractures, Delirium
- Trial name
- NCT06504251
- Testing
- Delirium Diagnostic Tool-Provisional ( DDT-Pro )
- Where
- Thailand
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Mahidol University
Frail in HIV Population
Search for Fragility Indicators Among People Aged 50+ With Chronic HIV Infection
The frailty and frail elderly was defined in 2001 by Fried as a physiological state of heightened vulnerability to external shocks. 5 criteria for classifying the elderly in 3 categories: frail, pre-frail and not frail.
- Trial name
- Visage 3 (NCT02874118)
- Testing
- Fried scale for frailty assessement
- Where
- France
- Volunteers
- 510 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Hypophosphatasia
Prospective, Longitudinal, Observational Registry of Adult Patients With Hypophosphatasia (REG-HYPO)
The purpose of this study is to assess medical events during follow-up of adult patients having hypophosphatasia and consulting rheumatologists.
- Trial name
- REG-HYPO (NCT05596539)
- Testing
- Data collection
- Where
- 11 sites in France
- Volunteers
- 200 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Delirium in Old Age, Fragility Fracture
Use of Anesthetic Block for the Prevention of in Hospital Delirium in Patients of the Orthogeriatric Clinical Care Center of the HUFSFB and HUSJI From 2019 - 2020
The purpose of this study is to identify the association between analgesic management with blockade of the iliac fascia versus intravenous analgesia with the presence of delirium during hospital stay in patients admitted to the…
- Conditions
- Delirium in Old Age, Fragility Fracture, Hip Fractures
- Trial name
- NCT04654962
- Testing
- Anesthetic nerve block
- Where
- Colombia
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Fundación Santa Fe de Bogota
Hip Fractures, Osteoporosis, Postmenopausal
STRONG - Study of AGN1 LOEP for the Treatment of the Contralateral Femur After Fragility Fracture
To evaluate the procedure and safety profile of the AGN1 Femoral LOEP Kit. This pilot study will be used to evaluate AGN1 Femoral LOEP treatment in a contralateral proximal femur during hip fracture repair.
- Trial name
- NCT03268356
- Testing
- AGN1 Femoral Local Osteo-Enhancement Procedure Kit
- Where
- Hong Kong
- Volunteers
- 13 people
- Sponsor
- AgNovos Healthcare, LLC
Colorectal Cancer, Fragility
MPI Predicts Outcome of CRC Elderly Patients (MPI=MULTIDIMENSIONAL PROGNOSTIC INDEX; CRC=COLORECTAL CANCER)
Patients aged ≥75 year scheduled for CRC surgery were studied (104 cases) and variables associated with major postoperative complications / mortality were evaluated.
- Conditions
- Colorectal Cancer, Fragility, Elderly
- Trial name
- MPI;CRC (NCT04594655)
- Testing
- surgery
- Where
- Italy
- Volunteers
- 104 people
- Sponsor
- Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia
Aging
Effect of Topical Sulforaphane on Skin Fragility Seen in Skin Aging and With Ultraviolet Exposure
This study aims to compare the expression of keratins before and after application of sulforaphane (SF) to determine whether this agent alters skin fragility seen in both intrinsic and extrinsic skin aging and UV light exposure.
- Trial name
- NCT03126539
- Testing
- Sulforaphane, Narrow-band Ultraviolet B exposure, 4 mm skin punch biopsy
- Where
- United States
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Cholestasis, Red Cell Membrane and Enzyme Abnormalities
Osmotic Fragility in Red Blood Cells of Pediatric Patients With Cholestatic Liver Disease
Objective: The investigators propose to perform ektacytometry on 20 pediatric patients over age one with cholestatic liver diseases and a direct bilirubin level of greater than 2 gm/dl.
- Trial name
- NCT05582447
- Testing
- ektacytometry of red blood cells
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Old Age; Debility
Effectiveness of 8 Week Multicomponent Exercise Program in Older Adults With Frailty and Cognitive Impairment
Multicomponent exercise program in a frail population. It is analyzed whether there is an improvement in different parameters of the daily life of the study subjects, analyzing the variables of: physical condition, fragility…
- Trial name
- GERYPHYSIO (NCT06440733)
- Testing
- Multicomponent exercise program focused in elderly.
- Where
- Spain
- Volunteers
- 17 people
- Sponsor
- University of Malaga
Osteoporosis With Current Fragility Fracture
Evaluation of an Osteoporosis Prevention Strategy in Women With Osteoporotic Fracture of the Upper Limb
Osteoporosis is a disease characterized by reduced bone mass and increased skeletal fragility, predisposing to an increased fracture risk.
- Trial name
- PREVOST (NCT01780012)
- Testing
- Osteoporosis prevention program
- Where
- France
- Volunteers
- 436 people
- Sponsor
- Hospices Civils de Lyon
Osteoporosis
Bone Adaptation to Impact Loading
Ageing populations have made osteoporosis and fragility fractures a major public health concern worldwide. Half of all women and 30% of all men will suffer a fracture related to osteoporosis during their lifetime.
- Trial name
- NCT00697957
- Testing
- Exercise
- Where
- Finland
- Volunteers
- 120 people
- Sponsor
- University of Oulu
Osteoporosis in Post-menopausal Women
Efficacy of Romosozumab and Denosumab Combined Treatment in Postmenopausal Osteoporosis Patients with Multiple Fragility Fractures
The aim of this clinical trial is to investigate the effectiveness of romosozumab started without stopping denosumab in patients diagnosed with postmenopausal osteoporosis with a very high risk of fragility fractures and who is…
- Trial name
- MORD (NCT06720350)
- Testing
- Romosozumab and Denosumab Combination Therapy, Romosozumab Prefilled Syringe [Evenity], Denosumab (Prolia)
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Marmara University
Osteoporosis
Exploring Efficacy, Cost Effectiveness and Experiences Related to Adherence of Different Bisphosphonate Regimens for the Prevention of Osteoporotic Fragility Fractures.
Osteoporosis is a condition where bones become weak and fragile and can easily break. Suffering from one fragility fracture doubles your chance of having another.
- Trial name
- BLASTOFF (NCT04283786)
- Testing
- Qualitative Interview
- Where
- United Kingdom
- Volunteers
- 100 people
- Sponsor
- Nottingham University Hospitals NHS Trust
Fragility Fracture, Femur; Fracture, Pertrochanteric
Role of Strontium Ranelate in Proximal Femur Fragility Fractures.
This study is being conducted with the aim of comparing the time to bone healing after surgery for fragility fractures of proximal femur between patients receiving strontium ranelate and placebo.
- Conditions
- Fragility Fracture, Femur; Fracture, Pertrochanteric, Clinical Trial
- Trial name
- STRONG (NCT05712616)
- Testing
- Strontium Ranelate, Lacto-N-Hexaose
- Where
- Pakistan
- Volunteers
- 100 people
- Sponsor
- Aga Khan University Hospital, Pakistan
Osteoporosis, Osteopenia or Osteoporosis
Assessment of Cortical Bone Mechanics Technology (CBMT) Fracture Discrimination Capability
Osteoporosis is a disease characterized by low bone mass and structural deterioration of bone tissue leading to bone fragility (i.e., weakness) and an increased risk for fracture.
- Conditions
- Osteoporosis, Osteopenia or Osteoporosis, Osteoporosis, Postmenopausal, Osteoporosis Risk
- Trial name
- STRONGER (NCT05721898)
- Testing
- Cortical Bone Mechanics Technology
- Where
- 5 sites in United States
- Volunteers
- 394 people
- Sponsor
- Ohio University
Osteoporosis, Fracture
Fragility Fracture Liaison Service Project
Aims: to Establish the FLS services at the National Taiwan University Hospital (NTUH) and its Beihu Branch (BB). Method: From Jan., 2014, two related fracture liaison services (FLSs) following the 13 'Capture the Fracture Best…
- Trial name
- NCT02194660
- Where
- Taiwan
- Volunteers
- 600 people
- Sponsor
- National Taiwan University Hospital
Femur Fracture
Combined Drug Therapy in Lateral Fragility Fractures of the Femur
It was conducted a prospective study with a series of 50 patients treated by intramedullary nail using Clodronic acid and Vitamin D (study group including 25 patients) and patients with the same fractures treated with Vitamin D…
- Trial name
- NCT05183308
- Testing
- Clodronic Acid
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- Azienda Ospedaliero-Universitaria Consorziale Policlinico di Bari