Clinical trials: Fragility
Hip Fracture, Femoral Neck Fracture
The Hip Fracture Surgical Approach Trial
The HIFSAT study will compare the standard direct lateral approach to hemiarthroplasty to a new muscle sparing approach (SPAIRE) in femoral neck fracture patients.
- Trial name
- HIFSAT (NCT06146205)
- Testing
- Direct lateral approach, SPAIRE
- Where
- Norway
- Volunteers
- 476 people
- Sponsor
- Diakonhjemmet Hospital
Fragility, Multimorbidity
Effectiveness of Integrated Care Network
This project aims to examine the effectiveness of the community-based integrated care service model , based on a multi-domain intervention program, among community-dwelling older adults.
- Trial name
- NCT03528005
- Testing
- Multi-domain intervention
- Where
- 6 sites in Taiwan
- Volunteers
- 398 people
- Sponsor
- National Yang Ming Chiao Tung University
Osteoporosis, Bone Loss
Zoledronic Acid for Osteoporosis in the Elderly
This trial will examine the safety, efficacy and feasibility of a single dose of intravenous zoledronic acid in the maintenance of skeletal integrity for frail, institutionalized women, who are most at risk for the deleterious…
- Conditions
- Osteoporosis, Bone Loss, Fragility Fractures
- Trial name
- ZEST (NCT00558012)
- Testing
- Intravenous zoledronic acid, Vitamin D 800 IU/daily, Calcium 1200 mg/daily
- Where
- United States
- Volunteers
- 181 people
- Sponsor
- University of Pittsburgh
Bone Loss, Age-related
Microbiota and Bone Fragility:Study of the Relation Between Gut Microbiota and Bone Microarchitecture
Gut microbiota regulate metabolism of their human host. Some diseases are associated with variations in gut microbiota diversity and higher fracture risk.
- Trial name
- MICROBONE (NCT04265742)
- Testing
- bone densitometry, High resolution peripheral QCT, Collection of biological samples
- Where
- France
- Volunteers
- 440 people
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Osteoporosis in Post-menopausal Women, Prevention
Development of a Wearable Device for Osteoporosis Prevention and Fracture Risk Reduction in Women
This project aims to determine the impact on bone health of: A lifestyle intervention promoting impact-based activities and physical activity for nine months. The same program enhanced with home-based strength training.
- Conditions
- Osteoporosis in Post-menopausal Women, Prevention, Exercise, Physical Activity
- Trial name
- Weapom (NCT06741956)
- Testing
- Weapom Lifestyle Intervention to measure bone impacts using a Fitbit Versa wearable device and the Weapom App.
- Where
- Spain
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Seville
Pelvic Fractures, Fragility Fractures of the Pelvis (FFP)
Assessment of Treatment Variability for Pelvic Ring Fragility Fractures
Fragility fractures of the pelvic ring are a common injury associated with poor patient outcomes and high healthcare costs. Management of these injuries is evolving with increasing frequency of operative stabilization of the…
- Trial name
- Pelvis ATV (NCT07351123)
- Testing
- Surgical stabilization of pelvic fracture, Closed treatment of pelvic fracture
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- University of Maryland, Baltimore
Porphyria Cutanea Tarda
Safety and Efficacy of Oral Deferasirox in Patients With Porphyria Cutanea Tarda
While clinical phlebotomy is current standard practice for alleviating non-transfusion iron overload in patients with PCT, it may not be suitable for all patients.
- Trial name
- NCT01284946
- Testing
- Exjade
- Where
- France
- Volunteers
- 45 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Heart Failure, Acute Decompensated Heart Failure
Reducing Readmission for Frail Elderly Patients With Decompensated Heart Failure
A randomized study designed to determine whether telephone based interventions can prevent return hospital visits for elderly and frail patients with acute symptoms of heart failure.
- Conditions
- Heart Failure, Acute Decompensated Heart Failure, Fragility, Emergencies
- Trial name
- HFF-ED (NCT03246035)
- Testing
- Intervention Group, Control Group (Standard Care)
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- Jewish General Hospital
Sacral Fracture, Osteoporotic Fracture
Sacroplasty for Sacral Insufficiency Fractures.
This study is designed to determine whether sacroplasty, a minimally invasive procedure to stabilize sacral fractures, improves quality of life and functional recovery in adults aged 50 years or older with sacral or posterior…
- Trial name
- SACRA (NCT07493564)
- Testing
- Percutaneous Sacroplasty, Standard conservative management
- Where
- United Kingdom
- Volunteers
- 110 people
- Sponsor
- Hull University Teaching Hospitals NHS Trust
75 Years Old and More, Cancer
Tool for the Detection of Oncogeriatric Fragility in Patients Aged ≥75 Years Undergoing Oncological Treatment.(D-FOG)
Many cancers are diagnosed after 75 years. Treatment in chemotherapy begins without evidence of geriatric risk factors. A new tool for screening for geriatric fragilities is used, a self-administered questionnaire carried out by…
- Conditions
- 75 Years Old and More, Cancer, Chemotherapy
- Trial name
- D-FOG (NCT03261128)
- Testing
- Self-questionnaire
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Poitiers University Hospital
Vascular, Stoke
Analysis of the Impact of the Fragility of the Over 70 Years of TIAprognosis
Fragility, geriatric concept recent identification is defined by simple physical indicators. The literature suggests that it is related to the risk of hospitalization, falls, institutionalization and death.
- Conditions
- Vascular, Stoke, Ischemic, Transient Ischemic Attack
- Trial name
- AIT70 (NCT02828488)
- Testing
- No intervention
- Where
- France
- Volunteers
- 110 people
- Sponsor
- Fondation Hôpital Saint-Joseph
Osteoporosis, Bone Mineral Density
Metabolic Determinants of DXA-Measured Bone Mineral Density
This retrospective observational study will examine bone mineral density measurements and their metabolic and clinical determinants in adults aged 40 years and older.
- Trial name
- NCT07836868
- Where
- Turkey (Türkiye)
- Volunteers
- 750 people
- Sponsor
- Mardin Artuklu University
Pelvic Fracture
Conservative or Operative Therapy in Patients With a Fragility Fracture of the Pelvis
In our society the population consists of more elderly patients. Medical treatment needs to be adjusted to this patient group. This research project focusses on patients with a fragility fracture of the pelvis.
- Trial name
- NCT04744350
- Testing
- Treatment of FFP type IIb and IIc
- Where
- Switzerland
- Volunteers
- 68 people
- Sponsor
- Björn-Christian Link
Hip Fractures
Radiologic and Clinical Outcomes of Augmentation in Fragility Intertrochanteric Hip Fracture Treatment
Randomized clinical trial to assess if the use of augmentation in the treatment of fragility intertrochanteric hip fractures improves radiologic and clinical outcomes in patients aged 65 years or older 1 year after surgery
- Trial name
- AFIF (NCT02631824)
- Testing
- open reduction and internal fixation, TFNA, Augmentation (Cement)
- Where
- 2 sites in Colombia
- Volunteers
- 90 people
- Sponsor
- Hospital Infantil Universitario de San Jose
Femoral Fracture, Fragility Fracture
Essential Amino Acid Supplementation for Femoral Fragility Fractures
This trial will evaluate the impact of 4 weeks of postoperative essential amino acid (EAA)-based supplementation on muscle morphology after femoral fragility fracture.
- Conditions
- Femoral Fracture, Fragility Fracture, Muscle Atrophy
- Trial name
- NCT06050668
- Testing
- Essential Amino Acid Supplementation
- Where
- 2 sites in United States
- Volunteers
- 60 people
- Sponsor
- Michael C Willey
Fragility, Cancer
Frailty Evaluation in Elderly Population With Cancer
The Comprehensive Geriatric Assessment (CGA) is, still today, barely established in the standard practice. Although the different scientific societies recommend a CGA in elderly population affected with cancer at first visit, the…
- Trial name
- ELDERLY (NCT03101631)
- Testing
- Comprehensive Geriatric Assessment (CGA)
- Volunteers
- 62 people
- Sponsor
- Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana
Osteoporotic Fracture
Effectiveness or Orthopedic Intervention in Osteoporosis Management After a Fracture of the Hip With Cost-Benefit Analysis
Patients who present with fragility fractures are consistently under-evaluated and under-treated for underlying osteoporosis. This point of care represents a lost opportunity to prevent future fractures.
- Trial name
- NCT02239523
- Testing
- Letter Group, Intervention Group
- Where
- Israel
- Volunteers
- 200 people
- Sponsor
- Shaare Zedek Medical Center
Frail Elderly Syndrome, Mild Cognitive Impairment
Spanish Linguistic Validation, Validity and Reliability Test of Frail´BESTest in Elderly Institutionalized Frail People
The aging of the global population presents significant social and health challenges. In Aragón, 15% of the population is between 65 and 79 years old, and the over-aging index is 16.6%, higher than the national average.
- Trial name
- NCT06438718
- Where
- Spain
- Volunteers
- 83 people, healthy volunteers welcome
- Sponsor
- Instituto de Investigación Sanitaria Aragón
Fragility
Exercise Intervention to Reverse Frailty
The objective of this study is to evaluate a multi-component exercise intervention as an effective therapy to reverse pre-frailty phenotype in females age 65 or older.
- Trial name
- ERF (NCT02952443)
- Testing
- Exercise, Control
- Where
- Canada
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Humidifier Lung, Mechanical Fragility
Evaluation of Gas Humidification Practices in Patients Under Invasive Mechanical Ventilation
When mechanical ventilation is initiated, a humidification method should be chosen. There is two methods: heat and humidity exchanger filters or heated humidity.
- Conditions
- Humidifier Lung, Mechanical Fragility, Respiratory Complication
- Trial name
- FP950 (NCT06719258)
- Testing
- MR850, FP950
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- Laval University