Clinical trials: Fragility
Osteoporosis, Arthroplasty Complications
Surgeon-Initiated Bone Health Referral Pathway in Patients Undergoing Lower Extremity Arthroplasty
The goal of this clinical trial is to observe the impact of a surgeon-driven bone health referral pathway following lower extremity arthroplasty.
- Conditions
- Osteoporosis, Arthroplasty Complications, Fragility Fracture
- Trial name
- NCT05845021
- Testing
- Surgeon-Initiated Bone Health Referral Pathway
- Where
- United States
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Fragility
Determinants of Frailty Among of Informal Caregivers of Demented Patient
Frailty, a transitional state between successful and pathological aging, may be benefit from early multi-interventional intervention. Fried's criteria are the more commonly used criteria to diagnose frailty.
- Trial name
- DELFAF (NCT03994562)
- Where
- 2 sites in France
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Gérond'if
Living Kidney Donor, Living Kidney Donation
Fracture Risk in Living Kidney Donors
This study will be a population-based, matched retrospective cohort study using linked administrative healthcare databases from Ontario, Alberta, and British Columbia to evaluate the long-term risk of fractures among living…
- Conditions
- Living Kidney Donor, Living Kidney Donation, Fractures, Nephrectomy,Kidney Donation
- Trial name
- NCT07401953
- Testing
- Nephrectomy
- Volunteers
- 50,000 people, healthy volunteers welcome
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Fragility
Mobility Assessment & Follow-up in Frail Elderly: Clinic-technical Validation of a Smart Insole in Real Life
The investigators aim is to evaluate an instrument for supporting physical activity and monitors multiple parameters of frailty (a pre-disability condition) in frail elderly persons.
- Trial name
- RESPECT (NCT02316600)
- Testing
- smart insole
- Where
- France
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- University Hospital, Toulouse
Fragility
Fragility and Adapted Physical Activity
Older people are a very heterogeneous population characterized by a high interindividual variability. Functional abilities (walking, transfers ...) used to classify individuals aged (Lalive d'épinay et al., 1999) in three…
- Trial name
- NCT02690402
- Testing
- adapted physical activity
- Where
- France
- Volunteers
- 970 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Nice
Aging, Fragility
Ischemic Conditioning to Promote Microvascular Resiliency in Frail Individuals
The goal of this clinical trial is to see how small blood vessels respond to the stress of high intensity exercise, and if a safe and simple intervention called ischemic conditioning can protect blood vessels from the stress of…
- Conditions
- Aging, Fragility, Endothelial Dysfunction
- Trial name
- NCT05808686
- Testing
- Ischemic Conditioning
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Medical College of Wisconsin
Fragility Ankle Fractures and Complex Distal Tibial Fractures
Tibio-talo-calcaneal Fusion by Hindfoot Nail Versus Open Reduction and Internal Fixation in Treatment of Complex Fractures Distal Tibial and Fragility Ankle Fractures in Elderly
Tibiotalar calcaneal fusion by hindfoot nail Vs open reduction and internal fixation in treatment of complex distal tibial fractures and ankle fragility ankle fractures in elderly
- Trial name
- NCT06709365
- Testing
- Tibiotalar calcaneal fusion by hindfoot
- Where
- Egypt
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Sohag University
Skin Condition, Hair Fragility
Assessment of Anti-aging Efficacy of Marine Collagen Peptides
To assess the anti-aging efficacy of Marine Collagen Peptides on skin, hair and finger nails for human
- Conditions
- Skin Condition, Hair Fragility, Nails, Ingrown
- Trial name
- NCT06306105
- Testing
- Marine Collagen Peptides
- Where
- Taiwan
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- TCI Co., Ltd.
Osteoporosis Risk, Fracture of Femur
Prediction Model of Hip Fragility Fracture Realistic Data From a Traumatology Department and Orthogeriatric Ward.
The aim of the project is to build a prediction model of hip fragility fracture using hospital data routinely collected in the traumatology department from the last 12 years and up to date Explainable Artificial Intelligence…
- Conditions
- Osteoporosis Risk, Fracture of Femur, Fragility
- Trial name
- NCT06545487
- Testing
- BLOOD SAMPLE
- Where
- Chile
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Universidad de Valparaiso
Multimodal Intervention, Fragility
Effectiveness of a Multi-component Physical Training in Hyper-fragile Elders: A Randomized Clinical Trial
Objective: To compare short-term and medium-term effectiveness of a multimodal program that integrates a program of therapeutic exercise, medication review, adequacy of diet and health education, compared with standard medical…
- Conditions
- Multimodal Intervention, Fragility, Other Metabolic Diseases, Physical Activity
- Trial name
- PowerA-01 (NCT02772952)
- Testing
- Control Intervention, Multimodal Intervention
- Where
- Spain
- Volunteers
- 114 people, healthy volunteers welcome
- Sponsor
- University of Malaga
Fragility
Biological Markers of Functional Effects of Physical Activity in an Elderly Population
Circulating biomarkers are promising tools for the early diagnosis of aging-associated pathologies. Inflammation and immunity are associated with the risk of sarcopenia and frailty in elderly patients.
- Trial name
- BIO-APAS (NCT04080063)
- Testing
- adapted physical activity
- Where
- France
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Nice
Fragility Fracture
Hip Fracture Prevention Follow-up of Elderly Women in Primary Health Care
Researchers plan a 2022 follow-up of medical records data to investigate fracture incidence and survival for 1248 women, born 1902-1931, in a comparative fracture prevention study with 435 participants from an intervention area…
- Trial name
- HIP22 (NCT05269979)
- Testing
- Prevention of hip fractures
- Volunteers
- 1,248 people, healthy volunteers welcome
- Sponsor
- Kronoberg County Council
Delirium in Old Age, Fragility Fracture
Use of Anesthetic Block for the Prevention of in Hospital Delirium in Patients of the Orthogeriatric Clinical Care Center of the HUFSFB and HUSJI From 2019 - 2020
The purpose of this study is to identify the association between analgesic management with blockade of the iliac fascia versus intravenous analgesia with the presence of delirium during hospital stay in patients admitted to the…
- Conditions
- Delirium in Old Age, Fragility Fracture, Hip Fractures
- Trial name
- NCT04654962
- Testing
- Anesthetic nerve block
- Where
- Colombia
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Fundación Santa Fe de Bogota
Fractures, Bone, Fragility
Factors Associated With Future Fractures in Middle-aged Men and Women
From prospectively collected health and life-style data and anthropometric data in the Malmo Diet and Cancer (MDC) cohort identify factors that predicts or are associated with forthcoming fracture in middle-aged men and women.
- Conditions
- Fractures, Bone, Fragility, Life Style
- Trial name
- MDCFract (NCT04151732)
- Testing
- Physical activity, alcohol, tobacco, Hormonal factors, Cardiovascular disease
- Where
- Sweden
- Volunteers
- 30,351 people, healthy volunteers welcome
- Sponsor
- Lund University
Frailty, Frailty Syndrome
Prevalence, Determinants and Natural History of Frailty and Pre-frailty in Elderly People
Frailty syndrome (i.e. frailty) is a geriatric syndrome which relies on the reduction of multisystem reserve capacity. Frail people have a lower potential to respond to external stressors and various life incidents as well as…
- Conditions
- Frailty, Frailty Syndrome, Frail Elderly Syndrome, Fragility
- Trial name
- FRAILPOL (NCT04518423)
- Where
- Poland
- Volunteers
- 1,093 people, healthy volunteers welcome
- Sponsor
- The Opole University of Technology
Fragility, Intensive Care Unit Syndrome
Fragility and Programmed Cardiovascular Surgery (EcoSarco)
Objectives: To characterize textural ultrasonographic biomarkers of the brachial biceps musculature, wrist flexors, quadriceps and anterior tibial muscle that allow the recognition of the muscular and functional status of…
- Trial name
- EcoSarco (NCT04110509)
- Where
- Spain
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Universidad Antonio de Nebrija
Fragility
Investigation of a Link Between Heart Rate Variability and Frailty in Geriatric Patients
The aim of this study is the evaluation of differences in heart rate variability (both time- and frequency-domain) [a]: between frail and non-frail patients and [b] at the beginning and end of a geriatric therapy which included…
- Trial name
- NCT03585985
- Testing
- Standard patient monitor, Photoplethysmographie-Imaging (PPGI) + Infrared thermography (IRT)
- Where
- Germany
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- RWTH Aachen University
Fragility
Testing the Effectiveness of an Occupation-based Cultural Intervention in Long-term Care
The goals of the proposed research were to: 1. describe the person and environment characteristics and activity patterns of residents in long-term care (LTC) facilities; 2.
- Trial name
- OBCHI (NCT03009851)
- Testing
- OBCHI
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Texas Woman's University
Fragility
Exercise Intervention to Reverse Frailty
The objective of this study is to evaluate a multi-component exercise intervention as an effective therapy to reverse pre-frailty phenotype in females age 65 or older.
- Trial name
- ERF (NCT02952443)
- Testing
- Exercise, Control
- Where
- Canada
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Osteoporosis, Osteopenia
Wiser Choices in Osteoporosis Choice II: A Decision Aid for Patients and Clinicians
Emphasis in treating osteoporosis has been on T-scores rather than overall fracture risk. Fracture Risk Assessment Tool (FRAX) supports a risk sensitive approach to osteoporosis treatment by providing an absolute fracture risk.
- Conditions
- Osteoporosis, Osteopenia, Fragility Fractures
- Trial name
- NCT00949611
- Testing
- FRAX + Decision Aid, FRAX estimated fracture risk
- Where
- 2 sites in United States
- Volunteers
- 79 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic