Clinical trials: Fracture Open Tibia
Open Tibia Fracture, Open Dislocation of Ankle
Accelerated Flap Coverage in Severe Lower Extremity Trauma
The goal of this randomized controlled trial is to determine if accelerated flap coverage compared to standard flap coverage timing leads to improved infection-related complications in patients with open fractures and/or…
- Conditions
- Open Tibia Fracture, Open Dislocation of Ankle, Extremity Fracture Lower, Extremity Injuries Lower
- Trial name
- FLAP ATTACK (NCT06293469)
- Testing
- Accelerated Flap Coverage Surgery, Standard of Care Flap Timing
- Where
- 11 sites in United States, Australia and 2 more
- Volunteers
- 356 people
- Sponsor
- Johns Hopkins University
Fractures, Bone, Nonunion of Fracture
Safety, Efficacy, & Use of ViviGen Cellular Bone Matrix Allograft in Orthopaedic Fracture Care
Prospective registry and retrospective data collection study to assess the efficacy and safety of Vivigen Cellular Bone Matrix (Vivigen) in orthopaedic trauma patients who require bone grafting in the acute, delayed, non-union…
- Conditions
- Fractures, Bone, Nonunion of Fracture, Fractures, Open, Fractures, Ununited
- Trial name
- NCT04299022
- Testing
- Vivigen Cellular Bone Matrix
- Where
- 4 sites in United States
- Volunteers
- 250 people
- Sponsor
- LifeNet Health
Reconstructive Surgical Procedure
Treatment of Compound Tibia Fracture With a Microvascular Latissimus Dorsi Flap and the Ilizarov Technique
This study assesses the long-term results of compound tibial reconstruction treated with a microvascular latissimus dorsi flap and bone transport technique during the last 25 year in Helsinki University central Hospital.
- Trial name
- NCT02369991
- Testing
- Reconstructive surgery
- Where
- Finland
- Volunteers
- 9 people
- Sponsor
- Helsinki University Central Hospital
Tibial Fractures
Multiregion BHA in Open Tibia Fractures
This clinical study is being conducted to demonstrate the safety and effectiveness of the Bone Healing Accelerant (BHA) product when applied to tibia (leg bone) fractures with an external wound or skin break (also called open…
- Trial name
- NCT04056429
- Testing
- BHA
- Sponsor
- Carmell Therapeutics Corporation
Pilon Fracture
Two-stage ORIF Vs Ex. Fix. in Complex Pilon Fractures
This study aims to compare the clinical, radiological, and functional outcomes of two-stage open reduction and internal fixation with single-stage external fixation in the treatment of comminuted tibial pilon fractures.
- Trial name
- NCT05141227
- Testing
- Two-stage Open reduction and internal fixation ( ORIF) using plates & screws, single-stage external fixation (EX.FIX.) with minimal internal fixation using cannulated screws if needed
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Fractures, Bone, Fractures, Closed
Post Market Evaluation of Clinical Safety and Performance of the Fitbone Transport and Lengthening System
This is an open-label, prospective, observational, post-market, uncontrolled, multi-center study intended to evaluate the safety and clinical performance of the FITBONE Transport and Lengthening Nail when used according to the…
- Conditions
- Fractures, Bone, Fractures, Closed, Fractures, Open, Fracture of Femur
- Trial name
- NCT06400732
- Testing
- Fitbone Transport and Lengthening System
- Where
- 9 sites in United States
- Volunteers
- 1 people
- Sponsor
- Orthofix Inc.
Open tíbia Fracture
Management of Open Fracture Tibia in Teenagers
The aim of this study is to study the incidence of open tibial fractures in early teenagers and evaluate the management outcomes
- Trial name
- NCT06288139
- Volunteers
- 100 people
- Sponsor
- Assiut University
Ankle Fractures, Tibia Fracture
CBD for Pain Reduction and Opioid Use After Ankle and Tibia Fracture ORIF
The purpose of this study is to evaluate the effects of administering CBD to control post-operative pain in patients undergoing ankle fracture open reduction and internal fixation, tibial plafond (pilon) open reduction and…
- Trial name
- NCT04768478
- Testing
- CBD
- Where
- United States
- Sponsor
- NYU Langone Health
Type II and IIa Open Tibia Fractures
A Study of Immediate and Delayed Closure of Type II and IIIa Open Tibia Fractures
Delayed wound closure is considered by many to be the standard of care for the treatment of an open fracture. This study was conducted to determine the feasibility of a large multi-center prospective randomized clinical trial and…
- Trial name
- NCT01315392
- Testing
- delayed closure, immediate wound closure
- Where
- United States
- Volunteers
- 451 people
- Sponsor
- Wake Forest University Health Sciences
Tibial Plateau Fracture
Clinical Efficacy of Open Reduction and Suture Bridge Fixation for PCL Tibial Avulsion Fractures
Abstract Background: Posterior cruciate ligament (PCL) tibial avulsion fractures significantly impair knee function; however, optimal surgical fixation approaches are not agreed upon.
- Trial name
- fracture (NCT06918171)
- Testing
- Clinical Efficacy of Open Reduction and Anchor Suture Bridge Fixation
- Where
- China
- Volunteers
- 17 people
- Sponsor
- Second Affiliated Hospital of Soochow University
Tibial Fractures
Prosthesis Versus Osteosynthesis in Proximal Tibia Fractures
The aim of this study is to compare knee function and pain one year after treatment of intra-articular proximal tibia fracture using either osteosynthesis with a locking plate (ORIF) or primary total knee replacement (TKR) in…
- Trial name
- POSITIF (NCT03172715)
- Testing
- Locking plate, TKR
- Where
- 8 sites in Finland
- Volunteers
- 98 people
- Sponsor
- Central Finland Hospital District
Tibial Fractures
New Bone Fixation Plate for the Repair of Tibial Avulsion Fracture of Posterior Cruciate Ligament of the Knee
To construct a self-designed plate fixation device for posterior cruciate ligament reconstruction, aim to verify its advantages on anatomical knee stability, so as to achieve fracture healing and keep tension after posterior…
- Trial name
- NCT03059368
- Testing
- new bone fixation plate with screw
- Volunteers
- 20 people
- Sponsor
- Cangzhou Central Hospital
Fracture of Calcaneus, Pilon or Tibial Plateau
Vacuum Assisted Closure as a Treatment for Soft Tissue Injuries
This project is designed as a prospective, randomized, comparative study evaluating the use of a negative pressure vacuum device in treating soft tissue injuries and the surgical incision following open reduction and internal…
- Trial name
- VAC-ST (NCT00582998)
- Testing
- Standard Wound Dressing, Vacuum Assisted Closure Device
- Where
- United States
- Volunteers
- 249 people
- Sponsor
- University of Alabama at Birmingham
Severe Open Fractures of the Tibia (Shin) Bone
Assessment of Fixation Strategies for Severe Open Tibia Fractures
The purpose of this study is to compare the use of modern ring external fixation versus internal fixation for fracture stabilization of severe open tibia fractures.
- Trial name
- FIXIT (NCT01494519)
- Testing
- Surgery with an external ring fixator, Definitive fixation with a locked IM nail or plate
- Where
- 33 sites in United States
- Volunteers
- 442 people
- Sponsor
- Major Extremity Trauma Research Consortium
Tibial Fractures
rhBMP-2 Versus Autograft in Critical Size Tibial Defects
The purpose of our study is to evaluate the use of recombinant human bone morphogenetic protein 2 (RhBMP-2) as compared to standard ICBG in the treatment of severe open tibia fractures with a critical size bone defect (at least…
- Trial name
- NCT00853489
- Testing
- recombinant bone morphogenetic protein 2, Autogenous iliac crest bone graft
- Where
- 13 sites in United States
- Volunteers
- 33 people
- Sponsor
- St. Louis University
Pain, Acute
SOFT Block Versus Spinal Anesthesia in Patientsusing Ilizarov External Fixator
Peripheral nerve block is an ideal choice for lower limb surgery because of the peripheral site of the surgical procedure and the ability to block pain pathways at multiple levels.
- Trial name
- NCT03450798
- Testing
- SOFT block group, spinal anesthesia group
- Where
- Egypt
- Volunteers
- 107 people
- Sponsor
- Ain Shams University
Tibial Fractures, Open Fractures
Safety and Performance of BonyPid-1000™ in the Treatment of Gustilo I, II, IIIA and IIIB Tibial Open Fractures
This is a prospective, multi-national, multicenter, randomized, two arms, single blind, Standard of Care (SOC) controlled, with blinded central reading center study.
- Trial name
- NCT02491047
- Testing
- BonyPid-1000, Standard of Care (SOC) treatment
- Where
- 9 sites in Israel, Philippines
- Volunteers
- 51 people
- Sponsor
- PolyPid Ltd.
Ankle Fractures
Open Reduction Syndesmosis Tightrope Versus Screw Fixation
Tibia-fibular syndesmosis injury occurs in a significant proportion of ankle injuries and is assumed to disrupt the syndesmotic ligaments.
- Trial name
- NCT02199249
- Testing
- Open reduction Tightrope fixation, open reduction screw fixation
- Where
- Canada
- Volunteers
- 103 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Open Fracture of Tibia
Role of Vacuum in Open Fracture Tibia Grade III Type B
Evaluate the role of VAC in decreasing the time needed for soft tissue coverage and definitive fixation in open IIIB tibial fractures
- Trial name
- NCT04063111
- Testing
- vacuum assistant closure, CONVENTIONAL DRESSING
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Assiut University
Tibial Fractures, Nonunion of Fracture
Intramedullary Bone Grafting for Open Tibial Shaft Fractures
This study will examine if there is a difference between the time to full union between the control group and the study group. Each group will be composed of patients who have an open fracture in the mid tibia.
- Conditions
- Tibial Fractures, Nonunion of Fracture, Delayed Union of Fracture
- Trial name
- NCT03891888
- Testing
- Intramedullary Bone Graft
- Where
- 2 sites in United States
- Volunteers
- 130 people
- Sponsor
- University of Louisville