Clinical trials: Focus
Healthy
Investigation of the Genetic and Environmental Determinants of MP Including Response to Supplementation
This study aims to investigate genetic and environmental determinants of macular pigment (MP) and assess the effects of lutein and zeaxanthin-rich supplements on macular pigment levels.
- Trial name
- NCT01778231
- Testing
- Nutrof Total
- Where
- United Kingdom
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Queen's University, Belfast
Sarcoma
Combination Chemotherapy and Surgery With or Without G-CSF in Treating Patients With Osteosarcoma
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Colony-stimulating factors such as G-CSF may increase the number of immune cells found in bone marrow or…
- Trial name
- NCT00002539
- Testing
- filgrastim, cisplatin, doxorubicin hydrochloride
- Where
- 16 sites in Belgium, Denmark and 6 more
- Volunteers
- 214 people
- Sponsor
- European Organisation for Research and Treatment of Cancer - EORTC
Primary Focus of the Study is Cost-minimization Analysis
Cost-Minimization Analysis After a Targeted Intervention for EGD and Colonoscopy
This study performs a single intervention of informing endoscopists how much the disposable accessories cost following each procedure.
- Trial name
- NCT02328001
- Testing
- Debriefing endoscopists of the procedure accessory costs
- Where
- United States
- Volunteers
- 969 people
- Sponsor
- Sindhu R Kaitha, MD
no Condition is Studied, the Focus of the Study is the Impact of Mental Imagery on Non Technical Skills of Medical Students
Impact of Mental Imagery on the Non-technical Skills of Anaesthesia Residents
The goal of this randomized trial is to learn if mental imagery works to improve non technical skills in residents. It will also learn about knowledge and technical skills.
- Trial name
- NCT06954519
- Testing
- Mental imagery, Cognitive aid reading
- Where
- 2 sites in France
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Reims University hospital
Sickle Cell Disease, Sickle Cell Anemia in Children
Development of a Provider-Focused Intervention to Improve Health Outcomes in Pediatric Sickle Cell Disease
The goal of this interventional study is to learn about the impact of an intervention for health care providers that teaches individuation and perspective-taking (IPT) skills to enhance patient-centered communication in pediatric…
- Conditions
- Sickle Cell Disease, Sickle Cell Anemia in Children, Sickle Cell Disease (SCD), Sickle Cell
- Trial name
- NCT07540767
- Testing
- Individuation and Perspective-Taking (IPT), pediatric SCD pain management education session
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Connecticut Children's Medical Center
Organ Protection
Effects of Dexmedetomidine on Respiratory Function and Inflammatory Responses in Patient With Sepsis Undergoing Cleaning Focus of Infection
The purpose of this study is to assess the efficacy of dexmedetomidine on lung protection in patient with sepsis undergoing cleaning focus of infection.
- Trial name
- NCT02842437
- Testing
- dexmedetomidine, normal saline
- Where
- China
- Volunteers
- 50 people
- Sponsor
- General Hospital of Ningxia Medical University
Bladder Cancer
S1314, Co-expression Extrapolation (COXEN) Program to Predict Chemotherapy Response in Patients With Bladder Cancer
The primary focus of this study is to see if looking at tumor biomarkers using a program called coexpression extrapolation or "COXEN" may predict a patient's response to chemotherapy before surgery.
- Trial name
- COXEN (NCT02177695)
- Testing
- Gemcitabine, Cisplatin, Methotrexate
- Where
- 566 sites in United States
- Volunteers
- 237 people
- Sponsor
- SWOG Cancer Research Network
Diabetes Mellitus, Type 2
A Family Dyad-focused Diabetes Self-Management Intervention for African American Adults
A family dyad-focused diabetes self-management for African American adults with type 2 diabetes is a randomized controlled trial (RCT) that aims to test the feasibility, acceptability, and efficacy of a family-dyad focused…
- Trial name
- NCT05905575
- Testing
- Family dyad diabetes intervention
- Where
- United States
- Volunteers
- 208 people, healthy volunteers welcome
- Sponsor
- Ohio State University
Allodynic Symptoms, Localized Neuropathic Pain
Impact of 5% Lidocaine Medicated Plaster on Allodynic Symptoms of Localized Neuropathic Pain After Knee Surgery
The aim of this study is to evaluate the impact of 5% lidocaine medicated plaster on allodynic symptoms of localized neuropathic pain after knee surgery.
- Trial name
- LiNe (NCT02763592)
- Testing
- Lidocaine
- Where
- France
- Volunteers
- 37 people
- Sponsor
- University Hospital, Clermont-Ferrand
Accidental Falls, Rehabilitation
The Role of Attention Focus Walking Training in Older Adults.
This study aims to examine the effect of external, internal and no attention focus walking training during gait rehabilitation on real-time conscious motor processing (reinvestment), balance, walking ability and fear of falling…
- Conditions
- Accidental Falls, Rehabilitation, Walking, Aged
- Trial name
- NCT04419753
- Testing
- attention focus walking training
- Where
- Hong Kong
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- Dr. Thomson Wai-Lung Wong
Breast Cancer Female
Mind Programme for Women With Breast Cancer (Nationwide Coverage)
The purpose of this research project is to optimize the Mind programme for women with breast cancer, taking into consideration the results from its pilot study, and to testits efficacy and cost-effectiveness through a 3-arm…
- Trial name
- MIND(n) (NCT06212414)
- Testing
- Mind Programme, Support Group
- Where
- Portugal
- Volunteers
- 153 people
- Sponsor
- University of Coimbra
Kidney Diseases
China Kidney Patient Trials Network
This is a prospective multi-centre, observational cohort study of incident and prevalent patients diagnosed with a kidney disease in China.
- Trial name
- CKPTN (NCT05036850)
- Where
- China
- Volunteers
- 1,200 people
- Sponsor
- George (Beijing) Clinical Research Co. Ltd.
Intermediate Risk Prostate Cancer (Diagnosis), Prostate Cancer
Dose-dEscalated MR-Guided Radiotherapy for Localized Prostate Cancer
DESTINATION 2 is a multi-centre randomised trial treating intermediate risk localised prostate cancer with 2 fraction Stereotactic Body Radiotherapy (SBRT).
- Trial name
- DESTINATION 2 (NCT07674225)
- Testing
- Prostate radical radiotherapy
- Where
- Canada
- Volunteers
- 24 people
- Sponsor
- Sunnybrook Health Sciences Centre
Public Speaking Fear
Optimizing Exposure Therapy Via Reward-focused Interventions in Individuals With Public Speaking Anxiety
The present study aims to examine whether the efficacy of an exposure treatment in individuals with public speaking anxiety can be enhanced by implementing interventions that target reward processes.
- Trial name
- EXOPAT (NCT06258889)
- Testing
- reward-focused intervention, cognitive flexibility intervention, exposure
- Where
- Germany
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Philipps University Marburg
Epilepsy
Impact of Thermocoagulation During Invasive EEG Monitoring in Children With Focal Drug-resistant Epilepsies
When focal epilepsies become drug-resistant, it could be eligible for cortical surgical resection. Therefore, an invasive EEG monitoring with depth electrodes is often needed during presurgical evaluation.
- Trial name
- COAG (NCT02886650)
- Testing
- Thermocoagulation
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
The Study Focus on no Specific Condition
Interpretation of Health News Items Reporting Results of Phase I/II (Non-randomized) Trials With or Without Spin by English-speaking Population*
The main objective of this study is to compare the interpretation of health news items reporting results of phase I/II (non-randomized) trials with or without spin (i.e., distortion of research results).
- Trial name
- NCT03094091
- Testing
- News items with spin, News items without spin
- Where
- France
- Volunteers
- healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Vulvar Pain, Vulvodynia
Vestibulectomy Surgical Techniques Comparison Study
Vestibulectomy Surgical Techniques Comparison Study
- Trial name
- NCT05343182
- Testing
- Modified Technique, Traditional Technique
- Where
- United States
- Volunteers
- 118 people
- Sponsor
- Oregon Health and Science University
Breast Cancer, Leukemia
Phase I/II Study of Escalating-Dose Melphalan w/Autologous SCS & Amifostine Cytoprotect
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining chemotherapy with peripheral stem cell transplantation may allow the doctor to give higher doses of…
- Conditions
- Breast Cancer, Leukemia, Lymphoma, Neuroblastoma
- Trial name
- NCT00003425
- Testing
- filgrastim, amifostine trihydrate, cyclophosphamide
- Where
- 4 sites in United States
- Volunteers
- 25 people
- Sponsor
- University of Kentucky
Cataract Senile
Performance of Two Intraocular Lenses With Extended Depth of Vision
Comparison of the capsular bag performance of two extended depth of vision (EDOF) intraocular lenses (IOLs), the Rayone EMV and the Alcon Acrysof IQ Vivity, in a mini-monovision setting
- Trial name
- NCT05194150
- Testing
- non-diffractive monofocal IOL, standard EDOF IOL
- Where
- Austria
- Volunteers
- 48 people
- Sponsor
- Vienna Institute for Research in Ocular Surgery
Atrial Fibrillation (AF), Cardiovascular Diseases
Low-Intensity Focused Ultrasound Targeting the Stellate Ganglion for Regulating Autonomic Nerve Function and Sleep Quality in Perioperative Patients With Cardiovascular Diseases
The goal of this multicenter, double-blind, randomized controlled trial is to evaluate the efficacy and safety of low-intensity focused ultrasound (LIFU) stellate ganglion modulation for improving autonomic function and sleep…
- Trial name
- US-REST (NCT07595068)
- Testing
- Low-intensity focused ultrasound (LIFU) targeting the left stellate ganglion
- Where
- 7 sites in China
- Volunteers
- 200 people
- Sponsor
- Renmin Hospital of Wuhan University