Clinical trials: Focus
Hope, Nursing
The Effect of the Solution-Focused Approach on Social Participation Skills and Hope in Children Living in Residential Care Objective: This Study Aimed to Evaluate the Effect of a Solution-focused Approach Program on the Hope Levels and Social Participation Skills of Children Living in Institutional
his study examined whether a solution-focused approach program could improve hope and social participation skills in children living in institutional care.
- Conditions
- Hope, Nursing, Social Acceptance
- Trial name
- NCT07135908
- Testing
- solution-oriented approach
- Where
- Turkey (Türkiye)
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- Muş Alparslan University
Focus: Hospitalized Patients
Hospital to Home Outcomes
Home Nurse Visit post discharge.
- Trial name
- NCT02081846
- Testing
- Nurse Home Visit, Standard of Care
- Where
- United States
- Volunteers
- 1,500 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Depression
Low Intensity Focused Ultrasound: a New Paradigm for Depression and Anxiety
Objective: Preliminary studies show that low intensity focused ultrasound (LIFU), a new type of non invasive brain stimulation, may be able to reach deep structures of the brain involved with depression and anxiety, that remain…
- Trial name
- LIFU (NCT05147142)
- Testing
- Low Intensity Focused Ultrasound
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Ocean State Research Institute, Inc.
Extrahepatic Bile Duct Cancer, Gallbladder Cancer
Liposomal Doxorubicin in Treating Patients With Liver or Bile Duct Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. PURPOSE: Phase II trial to study the effectiveness of liposomal doxorubicin in treating patients with liver…
- Conditions
- Extrahepatic Bile Duct Cancer, Gallbladder Cancer, Liver Cancer
- Trial name
- NCT00003296
- Testing
- filgrastim, pegylated liposomal doxorubicin hydrochloride
- Where
- 2 sites in United States
- Volunteers
- 26 people
- Sponsor
- Brown University
Relapsed or Refractory Acute Myeloid Leukemia, Relapsed or Refractory B-Cell Acute Lymphoblastic Leukemia
Dose Escalation Study in Acute Myeloid or B-Cell Acute Lymphoblastic Leukemia
The main purpose of this study is to test the safety and efficacy of VS-4718 in two types of leukemia patients and to find the right dose of VS-4718 for future clinical trials.
- Trial name
- NCT02215629
- Testing
- VS-4718
- Sponsor
- Verastem, Inc.
Postoperative Cognitive Dysfunction, Coronary Artery Disease
Neuroinflammation in Cognitive Decline Post-cardiac Surgery
Major cardiovascular surgery is associated with postoperative cognitive decline (POCD), with a deterioration in memory, attention and speed of information processing.
- Conditions
- Postoperative Cognitive Dysfunction, Coronary Artery Disease, Pathophysiology
- Trial name
- FOCUS (NCT04520802)
- Testing
- 18F-DPA-714 PET/CT neuroimaging
- Where
- Netherlands
- Volunteers
- 15 people
- Sponsor
- Radboud University Medical Center
Prostate Cancer
Preoperative Docetaxel for Localized Progressive Castration-resistant Prostate Cancer (CRPC)
Objectives: Primary: To evaluate the association of the probability of increase in phosphorylation of platelet-derived growth factor receptor (PDGFR) of > 0.5 in peripheral blood leucocytes following pre-operative docetaxel…
- Trial name
- NCT00811031
- Testing
- Taxotere, Prednisone
- Sponsor
- M.D. Anderson Cancer Center
Parent-Child Relations, Parenting
Examine the Feasibility and Acceptability of Project Support
In this study, the investigators will conduct a proof-of-concept pilot trial of delivering the Project Support Positive Parenting Module (Project Support) to n = 30 families waiting for trauma-focused services.
- Conditions
- Parent-Child Relations, Parenting, Child Mental Disorder
- Trial name
- NCT06391229
- Testing
- Project Support
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Medical University of South Carolina
Cataract
To Compare Early Rotation of Two Extended Depth of Focus Intraocular Lenses
To demonstrate that the Carl Zeiss Meditec (CZM) Extended depth of focus (EDOF) Intraocular lens (IOL) is superior to the competitor EDOF IOL with respect to Rotational Stability.
- Trial name
- VENUStoric (NCT03839420)
- Testing
- CZM IOL, Competitor IOL
- Where
- Germany
- Volunteers
- 250 people
- Sponsor
- Carl Zeiss Meditec AG
Central Auditory Processing Disorder, Hearing Impaired (Partially)
A Treatment for a Form of Age-Related Central Auditory Processing Disorder Consisting of Clemastine Fumarate Plus Engineered Sound
The goal of this clinical trial is to determine the efficacy of Clemastine Fumarate in the presence of engineered sound to treat age-related central auditory processing disorder (CAPD).
- Conditions
- Central Auditory Processing Disorder, Hearing Impaired (Partially), Hearing, Hearing Abnormality
- Trial name
- CAPD-LOOT (NCT07304024)
- Testing
- Clemastine Fumarate Combined With Engineered Sound, Clemastine Fumarate Combined With Pink Noise
- Where
- United States
- Volunteers
- 344 people
- Sponsor
- University of Colorado, Denver
Focal Segmental Glomerulosclerosis
Safety and Pharmacokinetics of FG-3019 in Adolescents and Adults With Focal Segmental Glomerulosclerosis (FSGS)
The purpose of this study is to evaluate the safety and tolerability of FG-3019 administered over 8 weeks to adolescent and adult subjects with steroid-resistant focal segmental glomerulosclerosis (FSGS).
- Trial name
- NCT00782561
- Testing
- FG-3019
- Where
- 3 sites in United States
- Volunteers
- 2 people
- Sponsor
- Kyntra Bio
Hypertrophy
High Intensity Resistance Training Combined With Blood Flow Restricted Exercise in Elite Handball Players
Purpose of the study is: to investigate the effects of 8 weeks intervention of high intensity resistance training(HIRT) combined with Blood Flow Restricted Exercise (BFRE) compared to high intensity resistance training alone.
- Trial name
- NCT04750694
- Testing
- Resistance training
- Where
- Denmark
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Department of Public Health, Denmark
Resectable Pancreatic Ductal Adenocarcinoma (PDAC), Pancreatic Ductal Adenocarcinoma
Study of Pembrolizumab With or Without Defactinib Following Chemotherapy as a Neoadjuvant and Adjuvant Treatment for Resectable Pancreatic Ductal Adenocarcinoma
This study will test the effectiveness (anti-tumor activity), safety, and ability to increase the body's immune system to fight pancreatic cancer by combining standard chemotherapy before and after surgery, with study drug PD-1…
- Trial name
- NCT03727880
- Testing
- Pembrolizumab, Defactinib
- Where
- 3 sites in United States
- Volunteers
- 28 people
- Sponsor
- Lei Zheng
Adult Acute Lymphoblastic Leukemia in Remission, Adult B Acute Lymphoblastic Leukemia
Dasatinib in Treating Patients With Solid Tumors or Lymphomas That Are Metastatic or Cannot Be Removed By Surgery
This phase I trial studies the side effects and best dose of dasatinib in treating patients with solid tumors or lymphomas that are metastatic or cannot be removed by surgery.
- Conditions
- Adult Acute Lymphoblastic Leukemia in Remission, Adult B Acute Lymphoblastic Leukemia, Adult Hepatocellular Carcinoma, Adult Nasal Type Extranodal NK/T-Cell Lymphoma
- Trial name
- NCT00608361
- Testing
- Dasatinib, Pharmacological Study
- Where
- 23 sites in United States
- Volunteers
- 80 people
- Sponsor
- National Cancer Institute (NCI)
Thyroid Papillary Carcinoma
Radiofrequency Ablation for Curative Treatment of Small Low-Risk Papillary Thyroid Cancer: Pilot Study
This pilot, single-arm clinical study evaluates the feasibility, safety, and effectiveness of radiofrequency ablation (RFA) as a curative treatment for small, low-risk papillary thyroid cancer (PTC).
- Trial name
- PTC-RFA (NCT07376837)
- Testing
- Radiofrequency Ablation of Papillary Thyroid Cancer, VIVA combo RF Generator with Coagulation Electrode
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- University Health Network, Toronto
Brain Injuries, Focal
VR Versus Task-Oriented Circuit Training on UL Sensorimotor in Children With Immature Brain Injury
To investigate and compare the effect of virtual reality and task-oriented circuit training on pinch grip and quality of life in children with with immature brain injury.
- Trial name
- NCT07827365
- Testing
- Virtual reality, Task-oriented circuit training
- Volunteers
- 44 people
- Sponsor
- October 6 University
Fear of Cancer Recurrence
Fear-focused Self-Compassion Therapy for Young Breast Cancer Patients' Fear of Cancer Recurrence
Few studies have tailored psychological intervention for fear of cancer recurrence (FCR) in young breast cancer patients, and the long-term efficacy of psychological intervention and its underlying mechanism are still unknown.
- Trial name
- NCT04965428
- Testing
- Fear-focused Self-Compassion Therapy
- Where
- China
- Volunteers
- 160 people
- Sponsor
- Shaanxi Normal University
PROSTATE CANCER
Two-fraction Versus Five-fraction Stereotactic Radiotherapy for Localized Prostate Cancer
The goal of this clinical trial is to compare two dose schedules of stereotactic radiation therapy in patients with localized prostate cancer.
- Trial name
- SABR-Dual (NCT06027892)
- Testing
- Two-fraction stereotactic radiotherapy, Five-fraction stereotactic radiotherapy
- Where
- Israel
- Volunteers
- 562 people
- Sponsor
- Rabin Medical Center
Prostate Adenocarcinoma
Perioperative Atezolizumab With MVA-BN-Brachyury and PROSTVAC For Intermediate-Risk And High-Risk Localized Prostate Cancer
This study is a prospective, open label, single arm phase II trial. A total of 22 patients will be treated with atezolizumab, PROSTVAC, and pre-operative MVA-BN-Brachyury to confirm the efficacy of prostatic combination…
- Trial name
- AtezoVax (NCT04020094)
- Testing
- MVA-BN-Brachyury
- Where
- United States
- Sponsor
- University of Utah
Left Branch Bundle Block, RV - Right Ventricular Abnormality
Functional Outcomes in CondUction System Pacing and Right Ventricular Synchrony (FOCUS-Right)
The goal of this prospective single center clinical trial is to evaluate the safety and feasibility of performing simultaneous exercise stress cardiac magnetic resonance (CPET-CMR) and cardiopulmonary exercise testing in patients…
- Trial name
- FOCUS-Right (NCT06601322)
- Testing
- Pacemaker Interrogation and Electrocardiogram (ECG):, Cardiopulmonary Exercise Test (CPET) and Exercise Stress Cardiac Magnetic Resonance (ExeCMR, Continuous pacemaker telemetry (CPT)
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Virginia Commonwealth University