Clinical trials: Focus
Liver Cancer
Positron Emission Tomography Using Carbon-11 Acetate and Fludeoxyglucose F 18 in Detecting Hepatocellular Carcinoma (Liver Cancer) in Patients With Known or Suspected Liver Cancer
RATIONALE: Imaging procedures, such as carbon-11 acetate positron emission tomography (PET) and fludeoxyglucose F 18 PET, may improve the ability to detect hepatocellular carcinoma (liver cancer) and allow doctors to plan the…
- Trial name
- NCT00081094
- Testing
- 18F-Fluorodeoxyglucose-PET (FDG-PET), 11Carbon-Acetate-PET
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- Washington University School of Medicine
Nephrotic Syndrome
INSIGHT (Insight Into Nephrotic Syndrome)
INSIGHT is a longitudinal study of childhood nephrotic syndrome to determine genetic, serologic and environmental factors contributing to nephrotic syndrome and disease progression.
- Trial name
- INSIGHT (NCT01605266)
- Where
- 4 sites in Canada
- Volunteers
- 1,000 people
- Sponsor
- The Hospital for Sick Children
Gastric Adenocarcinoma or Gastroesophageal Junction Adenocarcinoma or Esophageal Carcinoma, Non Metastatic Disease
Evaluation of Efficacy and Safety De-escalation Versus Standard Adjuvant Chemotherapy in Patients With Low Risk Localized Gastroesophageal Adenocarcinoma
The ATTENUATION study targets patients with gastric adenocarcinoma (GA), esophageal adenocarcinoma (EAC) or gastro-esophageal junction (GEJ) who have received 4 cycles of FLOT chemotherapy before the surgery.
- Trial name
- ATTENUATION (NCT06933966)
- Testing
- observation alone
- Where
- 3 sites in France
- Volunteers
- 120 people
- Sponsor
- Centre Leon Berard
Anxiety, Medication-refractory Focal-onset Epilepsy
The Impact of Focused Ultrasound Thalamotomy of the Anterior Nucleus for Focal-Onset Epilepsy on Anxiety
The purpose of this study is to evaluate the feasibility, safety, and effects on anxiety of high intensity focused ultrasound ablation (FUSA) in patients suffering from treatment-refractory focal epilepsy and anxiety.
- Trial name
- NCT05032105
- Testing
- Magnetic Resonance Imaging-guided Focused Ultrasound Ablation (MRgFUSA)
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Ohio State University
Diabetes Mellitus, Depression
Conexion: A Localized Information Resource on Diabetes and Depression for a Low-income Hispanic Community
The proposed Conexion resource combines best publicly available evidence-based information and local community resources in one place. The information is curated and contextualized to meet local needs of consumers and providers.
- Trial name
- NCT03984929
- Testing
- Conexion Localized, Conexion Generic
- Where
- 2 sites in United States
- Volunteers
- 136 people, healthy volunteers welcome
- Sponsor
- Columbia University
Prostate Cancer
Preoperative Docetaxel for Localized Progressive Castration-resistant Prostate Cancer (CRPC)
Objectives: Primary: To evaluate the association of the probability of increase in phosphorylation of platelet-derived growth factor receptor (PDGFR) of > 0.5 in peripheral blood leucocytes following pre-operative docetaxel…
- Trial name
- NCT00811031
- Testing
- Taxotere, Prednisone
- Sponsor
- M.D. Anderson Cancer Center
Bone Neoplasms
Localized Osteosarcoma in Upper Egypt: A Clinical Prediction Model
To assess survival outcome of pediatric patients with localized osteosarcoma of the extremities in Upper Egypt, identify factors of prognostic significance for survival, and to determine factors predictive of surgical methods…
- Trial name
- NCT03839095
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Assiut University
Focus of the Study is on Gut Health
Effects of a Dietary Fiber on Fecal Microbiota and Metabolism
The purpose of the study is to examine how a dietary fiber affects metabolism in healthy overweight and obese adults. The fiber will be added to foods that participants will consume for two, three-week periods.
- Trial name
- NCT01518088
- Testing
- Dietary Fiber
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Ingredion Incorporated
Patellar Tendinitis
Comparative Effects of Focused and Unfocused (Radial) ESWT in the Treatment of Patellar Tendinopathy.
There is no scientific study in the literature regarding the use of different extracorporeal shock wave therapies (ESWT) in the treatment of patellar tendinopathy.
- Trial name
- NCT05423366
- Testing
- Extracorporeal Shock Wave Therapy (ESWT)
- Where
- Turkey (Türkiye)
- Volunteers
- 75 people
- Sponsor
- Yuzuncu Yil University
Uterine Fibroids
Magnetic Resonance Guided Focused Ultrasound for Uterine Fibroids
This is a pilot randomized, blinded, placebo-controlled trial of a noninvasive, FDA approved treatment for uterine fibroids called MR Guided Focused Ultrasound (MRgFUS).
- Trial name
- PROMISe (NCT01377519)
- Testing
- MR Guided Focused Ultrasound
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of California, San Francisco
Shortness of Breath, Acute Respiratory Failure
Enhanced FoCUS in Patients With Shortness of Breath
Retrospective observational study performed in a internal medicine ward of a French university hospital. Included patients were hospitalized for acute shortness of breath who have benefited from a eFOCUS which was defined as a…
- Trial name
- eFOCUS (NCT05403619)
- Testing
- Diagnostic test
- Where
- France
- Volunteers
- 119 people
- Sponsor
- Nantes University Hospital
Prostate Adenocarcinoma
A Phase I-II Dose Escalation Study of Stereotactic Body Radiation Therapy in Patients With Localized Prostate Cancer
The aim of this study is to test the safety and efficacy of Stereotactic Body Radiation Therapy (SBRT) in localized prostate carcinoma in patients for whom the standard treatment is the irradiation of the entire prostate gland…
- Trial name
- NCT02254746
- Testing
- Stereotactic Body Radiation Therapy (SBRT)
- Where
- Switzerland
- Volunteers
- 27 people
- Sponsor
- Centre Hospitalier Universitaire Vaudois
Atopic Dermatitis, Artificial Intelligence
AI App for Management of Atopic Dermatitis
Background: Atopic dermatitis (AD) is a chronic inflammatory skin disease characterized by recurrent rashes and itching, which seriously affects the quality of life of patients and brings heavy economic burden to society.
- Trial name
- NCT06362629
- Testing
- Artificial Intelligence assistant decision-making system (AIADMS) App
- Where
- China
- Volunteers
- 232 people
- Sponsor
- West China Hospital
Pharmacokinetics
Pharmacokinetic Study With Repeated Doses of Stalevo
The purpose of this study is to show that higher minimum concentration values are obtained following repeated doses of Stalevo 4 times daily compared to lecodopa/carbidopa treatment with corresponding dosing regimen.
- Trial name
- NCT00693862
- Testing
- levodopa, carbidopa, entacapone, levodopa, carbidopa
- Where
- 3 sites in Finland
- Volunteers
- 19 people
- Sponsor
- Orion Corporation, Orion Pharma
Diabetic Retinopathy, Macular Edema
Triple Therapy of Pars Plana Vitrectomy and Grid/Focal Laser for Diabetic Macular Edema (DME)
This study is designed to report 3-year result of triple therapy of vitrectomy, intravitreal triamcinolone and macular laser photocoagulation for intractable diabetic macular edema.
- Trial name
- NCT01202461
- Testing
- Triple therapy of vitrectomy, IVTA and grid/focal laser photocoagulation
- Where
- South Korea
- Volunteers
- 41 people
- Sponsor
- Samsung Medical Center
Gingival Recession, Localized
Impact of Microneedling on Coverage of RT1 Gingival Recession in Thin Phenotype.
Gingival Recession (GR) is a common finding among adults, regardless of the oral hygiene levels. When it is associated with esthetic impairment, dentin hypersensitivity, root caries, surgical treatment is indicated.
- Trial name
- NCT06432439
- Testing
- microneedling followed by CAF procedures, CAF procedure
- Where
- India
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Postgraduate Institute of Dental Sciences Rohtak
Posttraumatic Stress Disorder
CBITS - Treat Trauma in Child Welfare
The goal of this randomized controlled trial is to evaluate the effectiveness of the trauma-focused group intervention CBITS compared with enhanced treatment as usual (TAU+) in child welfare programs in Germany.
- Trial name
- CBITS (NCT06038357)
- Testing
- CBITS, TAU+
- Volunteers
- 90 people
- Sponsor
- University Hospital Ulm
Intimate Partner Violence, Post Traumatic Stress Disorder
Vedic Counselling for Women Victims of Domestic Abuse
The Vedic Counselling is the whole person approach, system of total life style counselling based on 'Vedic Laws of right living, right actions, right relationship and right awareness'.Vedic Counselling was developed as trauma…
- Trial name
- NCT05261230
- Testing
- Vedic Counselling, Standard Care
- Where
- India
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Active Natural Limited
NK-T-Cell Lymphoma, Extranodal
PET and EBV DNA-directed Therapy for Localized Nasal Extranodal NK/T Cell Lymphoma
A prospective, open-abel, phase 2 clinical study to investigate whether interim Positron Emission Tomography (PET) and Epstein-Barr virus (EBV) DNA-directed therapy can improve the prognosis of localized nasal extranodal NK/T…
- Trial name
- ENKTL (NCT06069830)
- Testing
- 4 cycles of ESA regimen with sandwiched radiotherapy, 2 cycles of ESA regimen sequential radiotherapy and 2 cycles of PD-1 monoclonal antibody combined with pegaspargase, 2 cycles of ESA regimen, 2 cycles of PD-1 monoclonal antibody and concurrent radiotherapy, 2 cycles of PD-1 monoclonal antibody combined with pegaspargase
- Where
- China
- Volunteers
- 89 people
- Sponsor
- Ruijin Hospital
Postoperative Bile Leak, Focal Liver Lesions
Prevention of Bile Leakage After Liver Resection in Children
Bile leakage is a clinically important complication after liver resection in children and may require prolonged drainage, additional radiological or endoscopic procedures, or repeat surgery.
- Trial name
- NCT07867522
- Testing
- prophylactic extrahepatic biliary drainage during liver resection
- Where
- Russia
- Volunteers
- 12 people
- Sponsor
- Federal Research Institute of Pediatric Hematology, Oncology and Immunology