Clinical trials: Focus
Alcohol Consumption
Testing Brief Personalized Feedback Integrating Lab-based Alcohol Cue Information
This study aims to develop a brief intervention that uses information from a lab-based cue reactivity protocol to create personalized feedback targeting high-risk alcohol use among young adults who drink alcohol.
- Trial name
- Project ACE (NCT05873556)
- Testing
- Lab-based Cue Reactivity Personalized Feedback Intervention (PFI)
- Where
- United States
- Volunteers
- 93 people, healthy volunteers welcome
- Sponsor
- University of Washington
Anxiety, Burn Out
A Study to Assess Virtual Reality by Healthcare Providers: A Pilot Study
The purpose of this study is to evaluate the acceptability of using Virtual Reality intervention to help reduce anxiety and burnout symptoms and improve focus in the workplace.
- Trial name
- NCT04622527
- Testing
- Random assigned paradigm viewing order
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Other Conditions That May Be A Focus of Clinical Attention
Genetic Basis for Variation in the Renal Elimination of Metformin
The current study is part of a large multi-investigator grant to look at the pharmacogenetics of a number of membrane transporters.
- Trial name
- NCT00187720
- Testing
- Metformin
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Healthy
Endophenotype for Alcohol Misuse in Healthy Minority Populations
The purpose of the study is to understand the relationship between what an individual inherited from their family (genetics), how they respond and feel after drinking alcohol, and how they respond to pre-treatment with…
- Trial name
- DEFINE (NCT00256451)
- Testing
- Naltrexone, alcohol
- Where
- United States
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Cellulite
CONtrolled Focal Fibrous Band Release Method Study
Study to evaluate the safety and effectiveness of the Avéli medical device to reduce the appearance of cellulite.
- Trial name
- CONFFIRM (NCT04743635)
- Testing
- Avéli device
- Where
- 9 sites in United States, Australia
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- Revelle Aesthetics, Inc
Moderate to Severe Convexity of Submental Fat, Safety
Safety Study of Deoxycholic Acid for the Reduction of Localized Subcutaneous Fat in the Submental Area in Subjects 65 to 75 Years of Age
The objectives of this study are to explore the safety and efficacy of subcutaneous injections of Deoxycholic Acid relative to placebo, in the submental area of participants who are 65 to 75 years old.
- Conditions
- Moderate to Severe Convexity of Submental Fat, Safety, Efficacy
- Trial name
- NCT02123134
- Testing
- ATX-101
- Where
- 6 sites in United States
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Kythera Biopharmaceuticals
Healthy
Transcranial Focused Ultrasound (tFUS) Modulation of Reward Network
Aim: Evaluate whether sonicating the Nucleus Accumbens (NAc) with transcranial focused ultrasound modifies functional connectivity between the NAc and the prefrontal cortex (PFC).
- Trial name
- NCT05986019
- Testing
- transcranial focused ultrasound (tFUS)
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Development of LIFU for Clinical Purposes
Investigation of Low-intensity Focused Ultrasound Parameters
This project examines the effects of different brain stimulation settings on muscle contractions. The investigators believe this study will help to better understand noninvasive brain stimulation techniques that may have the…
- Trial name
- NCT05134233
- Testing
- Low-intensity Focused Ultrasound
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Virginia Polytechnic Institute and State University
Obesity
Promoting The Self-Regulation Of Energy Intake
The goal of this study is to develop and test the efficacy of a scientifically-based, culturally competent seven-session parent directed, obesity prevention program focused on parental feeding strategies that support young…
- Trial name
- SEEDs (NCT01513343)
- Testing
- Parent and child groups focused on self-regulation of eating
- Where
- 2 sites in United States
- Volunteers
- 255 people, healthy volunteers welcome
- Sponsor
- Baylor College of Medicine
Evidence-Based Practices, CBT
A Hybrid Type 2 Trial of Trauma-Focused Cognitive Behavioral Therapy and a Pragmatic Individual-Level Implementation Strategy
This research project is a hybrid type 2 effectiveness-implementation trial that simultaneously examines (1) the effectiveness of a trauma-focused intervention for youth in the education sector and (2) the impact of a…
- Conditions
- Evidence-Based Practices, CBT, School Health Services, Trauma, Psychological
- Trial name
- NCT04451161
- Testing
- Beliefs and Attitudes for Successful Implementation in Schools (BASIS), Trauma-Focused Cognitive-Behavioral Therapy, Treatment as Usual
- Where
- United States
- Volunteers
- 292 people, healthy volunteers welcome
- Sponsor
- University of Washington
Keloid, Alopecia Areata
Pain Outcomes Following Intralesional Corticosteroid Injections
Corticosteroid therapy, including intralesional and topical applications, has many indications within the fields of Dermatology, Plastic Surgery, and Orthopedics.
- Conditions
- Keloid, Alopecia Areata, Acne, Hypertrophic Scar
- Trial name
- NCT03630198
- Testing
- Corticosteroid with lidocaine, Corticosteroid with normal saline
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Hyperhidrosis
Image Guided Targeted Photoablation for the Treatment of Localized Hyperhidrosis
Hyperhidrosis is a condition in which sweating is in excess of that required for normal regulation of body temperature. Commonly affected areas in primary hyperhidrosis include axillae, palms and soles.
- Trial name
- NCT04178161
- Testing
- Laser treatment
- Where
- United States
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Presbyopia Condition
A Randomized, Active-Controlled, Double-Masked, Crossover Study to Evaluate the Clinical Performance of Deseyne (Vifilcon C) Daily Disposable Soft Contact Lens for Presbyopia Extended Depth of Focus (EDOF)
The goal of this clinical trial is to learn if the contact lens we are testing will work to extend the range of clear focus at distance to provide an increase in clear vision at closer ranges without the additional need for…
- Trial name
- EDOF (NCT06698731)
- Testing
- Test lens, Control lens
- Where
- 3 sites in United States
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Bruno Vision Care
Chronic Kidney Disease, Hypertension
Alpha-Adrenoceptor Vascular Function In Chronic Kidney Disease Focus On The Role Of Endothelial Nitric Oxide
The purpose of this study is to learn more about why most patients with early stages of kidney disease have high blood pressure.
- Trial name
- NCT00356265
- Testing
- Procedure: Regional phenylephrine arterial infusion
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Focus Groups
Effect of, OAT3, on the Renal Secretion of Cefotaxime
In the proposed study, we plan to use a genotype to phenotype strategy to study the role of the organic anion transporter, OAT3, in drug response.
- Trial name
- NCT00187655
- Testing
- Cefotaxime
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Moderate or Severe Submental Fullness
Phase 3 Study of Deoxycholic Acid Injection (ATX-101) Versus Placebo for the Reduction of Localized Subcutaneous Fat in the Submental Area
To evaluate the safety and efficacy of deoxycholic acid injection in the reduction of submental fat (fat below the chin).
- Trial name
- NCT01546142
- Testing
- Deoxycholic acid injection
- Where
- 35 sites in United States, Canada
- Volunteers
- 516 people, healthy volunteers welcome
- Sponsor
- Kythera Biopharmaceuticals
Alcoholism
Health Focused Motivational Treatment for Alcohol Dependent Veterans
The purpose of this study is to determine whether a health focused motivational intervention will reduce alcohol use for dependent veterans who are receiving outpatient alcohol and drug treatment.
- Trial name
- NCT00252590
- Testing
- Health Motivational Feedback, Health Education, Control - treatment as usual
- Where
- United States
- Volunteers
- 99 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Submental Fat, Healthy
Long-term Follow-up Study on Safety and Maintenance of Efficacy of ATX-101
The investigation of the long-term safety and maintenance of efficacy of ATX-101 in reduction of submental fat.
- Trial name
- NCT02163902
- Testing
- ATX-101
- Where
- 15 sites in United States, Canada
- Volunteers
- 224 people, healthy volunteers welcome
- Sponsor
- Kythera Biopharmaceuticals
Focal Segmental Glomerulosclerosis
Permeability Factor in Focal Segmental Glomerulosclerosis
Focal segmental glomerulosclerosis (FSGS) is a renal syndrome characterized by proteinuria (usually nephrotic range), limited response to conventional therapy, and a poor renal prognosis, with progression to end stage renal…
- Trial name
- NCT00007475
- Testing
- Plasma exchange, Cyclophosphamide
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Focus of Study: Radiolabel Recovery and Survival of RBCs
Inactivation of Whole Blood With Mirasol
The purpose of this study is to evaluate radiolabeled recovery and survival of autologous red blood cells (RBC), derived from Mirasol-treated fresh whole blood (WB), stored as leukoreduced packed RBC (LR-pRBC), and re-infused in…
- Trial name
- IMPROVEII (NCT01907906)
- Testing
- Mirasol System for Whole Blood
- Where
- 2 sites in United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Terumo BCTbio