Clinical trials: Fluorescence Imaging
Head and Neck Cancer, Lung Cancer
Fluorescent Light Bronchoscopy Plus White Light Bronchoscopy for Early Detection of Lung Cancer
RATIONALE: Fluorescent bronchoscopy, when used in combination with conventional white light bronchoscopy, may improve the ability to detect early lung cancer.
- Trial name
- NCT00019201
- Testing
- cytology specimen collection procedure, immunohistochemistry staining method, sputum cytology
- Where
- United States
- Sponsor
- National Cancer Institute (NCI)
Perfusion, Fluorescence Imaging
Micro-dosing Indocyanine Green (ICG) in Children
The goal of this cohort study is to identify the lowest dose of Indocyanine Green (ICG) that achieves satisfactory intra-operative fluorescence for the assessment of gastrointestinal or genitourinary tract perfusion in children.
- Conditions
- Perfusion, Fluorescence Imaging, Gastrointestinal Tract Disorders, Genitourinary Disease
- Trial name
- NCT06421103
- Testing
- Indocyanine Green (ICG)
- Where
- United Kingdom
- Volunteers
- 90 people
- Sponsor
- Great Ormond Street Hospital for Children NHS Foundation Trust
Neck Pain, Back Pain
Near-infrared Fluorescence Lymphatic Imaging Assessment of Lymphatic Response to Pneumatic Back/Neck Lymphatic Drainage Delivered by a Pneumatic Manual Lymphatic Drainage Device
The purpose of this study is to objectively assess lymphatic function before, during, and immediately after Neuroglide treatment in lower trunk and leg lymphatic vessels, torso, axillary regions, inguinal regions, upper…
- Trial name
- NCT05946837
- Testing
- Indocyanine green (ICG) dye, NIRF-LI imaging, Neuroglide pad
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- The University of Texas Health Science Center, Houston
NMIBC
Trop2-Targeted Near-Infrared Fluorescence Imaging-Guided Precise Resection of Non-Muscle Invasive Bladder Cancer
Research Objective Taking Trop2, a specific target of bladder urothelial carcinoma, as the research basis, this study adopts a Trop2-targeted near-infrared (NIR) fluorescent probe combined with an intravesical rapid incubation…
- Trial name
- NCT07800507
- Testing
- TTP-ICG NIR fluorescent diagnostic agent
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Yunnan Cancer Hospital
Peritoneal Carcinomatosis, Colorectal Cancer
Multi-modality Imaging in Peritoneal Carcinomatosis of Colorectal Origin
Intraoperative tumor localization and resection can be enhanced using intraoperative fluorescence imaging and radiodetection. Labetuzumab specifically recognizes CEA which is is expressed on > 95% of colorectal cancers..
- Conditions
- Peritoneal Carcinomatosis, Colorectal Cancer, Carcinoma, Neoplasms
- Trial name
- MMIPC (NCT03699332)
- Testing
- Indium-111-DOTA-Labetuzumab-IRDye800CW injection, SPECT/CT scan, CRS extended with dual-modality imaging
- Where
- Netherlands
- Volunteers
- 29 people
- Sponsor
- Radboud University Medical Center
Breast Cancer
A Study of Multiparametric MRI and pHLIP® ICG in Breast Cancer Imaging During Surgery
The purpose of this study is to find out whether pre-operative mpMRI using additional MRI sequences may improve surgical outcomes by providing more accurate information about the extent and acidity of the tumor than standard MRI…
- Trial name
- NCT05130801
- Testing
- pHLIP® ICG NIRF imaging
- Where
- 2 sites in United States
- Volunteers
- 55 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Bladder Cancer
Near Infrared Fluorescence Imaging for Bladder Cancer Detection
The primary outcome of this study is to determine the minimal dwell time needed for adequate detection of hexaminolevinulate HCL avid tumors using protoporphyrin IX (PpIX) near infrared fluorescence (NIRF).
- Trial name
- NCT03058705
- Testing
- Hexaminolevulinate HCL, Near Infrared Fluorescence (NIRF)
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Edward Messing
Breast Cancer
Identification of Sentinel Lymph Nodes Using Indocyanine Green in Breast Cancer Patients
This study aims to evaluate the (inter)national implementation of a new diagnostic method for sentinel lymph node (SLN) detection in breast cancer.
- Trial name
- INFLUENCE II (NCT07311278)
- Testing
- Phase I: Technetium is administered as single tracer to identify the SLN (current standard)., Phase II: SLN biopsy using double tracer technetium and ICG (learning curve), Phase III: ICG is administered as single tracer to identify the SLN (alternative method).
- Where
- 11 sites in Italy, Netherlands
- Volunteers
- 493 people
- Sponsor
- St. Antonius Hospital
Glioblastoma Multiforme, Anaplastic Astrocytoma
Loupe-Based Intraoperative Fluorescence Imaging
Glioblastoma multiforme (GBM) and anaplastic astrocytoma (AA) are the most common primary malignant brain tumors. Survival of patients with these brain tumors is directly related to the extent of resection.
- Trial name
- NCT04780009
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Guoqiang Yu
Complications of Perfusion
Real-time Quantitative Optical Perfusion Imaging in Surgery
Surgeons are nowadays unable to visualize and quantitatively evaluate microvascularisation in real-time during surgery. Complications due to vascular compromise are a major problem, especially in reconstructive surgery.
- Trial name
- NCT02902549
- Where
- Netherlands
- Volunteers
- 26 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Breast Neoplasm Female, Breast Cancer
Fluorescence Imaging of Carcinoma During Breast Conserving Surgery
Breast conserving surgery (BCS) is performed on patients with breast cancer to resect and completely remove the cancer while conserving as much of the surrounding healthy tissue as possible.
- Trial name
- NCT04815083
- Testing
- Aminolevulinic Acid Hydrochloride, Eagle V1.2 Imaging System
- Where
- 7 sites in United States
- Volunteers
- 57 people
- Sponsor
- SBI ALApharma Canada, Inc.
Leakage, Anastomotic, Colon Cancer
COLOFLOW: Laser Speckle Contrast Imaging Versus Near-infrared Fluorescence Imaging With Indocyanine Green
COLOFLOW is a prospective observational study investigating whether Laser Speckle Contrast Imaging (LSCI), a dye-free and objective perfusion imaging technique, corresponds with the currently used subjective assessment of…
- Conditions
- Leakage, Anastomotic, Colon Cancer, Colon Anastomosis, Colon and Rectal Cancer
- Trial name
- COLOFLOW (NCT07720505)
- Testing
- Laser Speckle Contrast Imaging
- Volunteers
- 30 people
- Sponsor
- Leiden University Medical Center
Lung Cancer
A Study to Evaluate Pegsitacianine, an Intraoperative Fluorescence Imaging Agent for the Detection of Lung Malignancies
This Phase 2 study is an open-label, single-arm trial where each patient is his/her own "intrapatient" control. All patients will receive a single dose of pegsitacianine prior to standard of care surgery.
- Trial name
- NCT05048082
- Testing
- pegsitacianine, Tumor resection surgery
- Where
- 2 sites in United States
- Volunteers
- 24 people
- Sponsor
- OncoNano Medicine, Inc.
Gynecologic Cancers, Ovarian Cancer
Near-Infrared Fluorescence Imaging With Indocyanine Green to Evaluate Bowel Anastomoses in Gynecologic Oncology Surgery
The goal of this study is to evaluate if indocyanine green (ICG) fluorescence imaging helps reduce complications in bowel surgery performed during gynecologic cancer operations.
- Conditions
- Gynecologic Cancers, Ovarian Cancer, Endometrial Cancers, Cervical Cancers
- Trial name
- INOCA (NCT06871787)
- Testing
- Indocyanine Green, Near-Infrared Fluorescence Imaging System
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Istanbul University
Stage III Non-small Cell Lung Cancer, Unresectable Stage III NSCLC
In Vivo Fluorescence Molecular Bronchoscopy of Durvalumab-680LT in Patients With Unresectable Stage III Non-small Cell Lung Cancer (NSCLC) After Chemoradiotherapy
PulmoPrint is a clinical study at the University Medical Center Groningen (UMCG) that investigates why some patients with unresectable stage III lung cancer don't respond to immunotherapy after chemoradiotherapy.
- Trial name
- PulmoPrint (NCT07653438)
- Testing
- Fluorescence molecular imaging during bronchoscopy with durvalumab-680LT
- Volunteers
- 20 people
- Sponsor
- University Medical Center Groningen
Pancreas Adenocarcinoma
NIR-Fluorescence Guided Surgical Resection of Neoadjuvant Treated Localized Pancreatic Cancer Using SGM-101
Pancreatic carcinoma has a dismal prognosis at time of diagnosis, due to late onset of clinical symptoms, patients present with advance disease.
- Trial name
- FLUOPANC-II (NCT05984810)
- Testing
- Fluorescence-guided surgery using CEA-targeted fluorophore SGM-101
- Where
- Netherlands
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Leiden University Medical Center
Solid Tumor, Adult
Ex Vivo Tumor Visualization and Resection Margin Assessment Using Topically Applied Fluorescent Imaging Agents
This is a proof-of-principle study, that uses freshly resected human solid tumor specimens to assess the performance of topically applied fluorescent imaging agents for the detection of tumor tissue and close / tumor-positive…
- Trial name
- SprayDye (NCT06292845)
- Testing
- Topical application of a fluorescent imaging agent
- Where
- Netherlands
- Volunteers
- 200 people
- Sponsor
- Erasmus Medical Center
Total Thyroidectomy, Bilateral Neck Exploration for Primary Hyperparathyroidism
Intra-operative Infra-red Fluorescent Imaging in Thyroid and Parathyroid Surgery
Reliable identification of parathyroid glands is critical to the success of thyroid and parathyroid surgery. In thyroid surgery, inadvertent injury to parathyroid glands may cause temporary or permanent hypoparathyroidism (low…
- Trial name
- NCT02089542
- Testing
- MB and fluorescent imaging
- Where
- United Kingdom
- Volunteers
- 41 people
- Sponsor
- Sheffield Teaching Hospitals NHS Foundation Trust
Liver Neoplasms
Assessment of Indocyanine Green as a Near-Infrared Fluorescent Contrast Agent for Image-guided Liver Surgery
This is a prospective, monocentric, non-randomized, phase I-II study. The goal is to assess the faisability and the capabilities of fluorescence imaging in hepatic surgery, and specially to help the surgeon while performing liver…
- Trial name
- HEPATOFLUO (NCT01738217)
- Testing
- Fluobeam
- Where
- France
- Volunteers
- 48 people
- Sponsor
- Centre Leon Berard
Abdominal Skin Redundancy
Laser Fluorescent Imaging of Abdominal Skin During Abdominoplasty
Abdominoplasty is a common cosmetic operation. Some investigators believe that the risk of complications is reduced by limiting the operative dissection. However, this can compromise the quality of the result.
- Trial name
- NCT02196779
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Swanson Center