Clinical trials: Fluorescence Imaging
Neurosurgery, Neuro-Oncology
Intraoperative Hyperspectral Imaging for Fluorescence Guided Surgery in Low Grade Gliomas
The purpose of this study is to obtain images of brain tumours during surgery using a new type of surgical camera. The study will assess how the information obtained from the images during surgery matches the removed tissue.
- Conditions
- Neurosurgery, Neuro-Oncology, Brain Tumor
- Trial name
- Neuro-qFHSI (NCT05397574)
- Where
- United Kingdom
- Volunteers
- 60 people
- Sponsor
- King's College London
Thyroid Carcinoma, Surgery
Thyroid Cancer and Central Lymph Node Metastases Detection Using Bevacizumab-IRDye800CW
Background: Papillary thyroid cancer (PTC) patients often develop central lymph node metastases (CLNM), which pose a high risk of disease recurrence.
- Trial name
- TARGET-beva (NCT06095362)
- Testing
- Bevacizumab-IRDye800CW
- Where
- Netherlands
- Volunteers
- 20 people
- Sponsor
- University Medical Center Groningen
Basal Cell Carcinoma of Skin, Squamous Cell Carcinoma
Two-photon Fluorescence Microscopy of Dermatologic Biopsies
The goal of this study is to investigate the ability of two-photon fluorescence microscopy to evaluate dermatologic biopsies. The main questions it aims to answer are: How well do two-photon fluorescence images of biopsies taken…
- Conditions
- Basal Cell Carcinoma of Skin, Squamous Cell Carcinoma, Melanocytic Lesion, Adult
- Trial name
- NCT07773688
- Testing
- Two photon microscopy imaging
- Where
- United States
- Volunteers
- 644 people
- Sponsor
- University of Rochester
Surgery, Fluorescence
ICG Indocyanine Green in Reconstructive Surgery
The success or failure of a reconstruction is largely related to the vascularization of the operated area. Near infrared fluorescence (also near infrared fluorescence angiography, NIR FA) with ICG administration is an innovative…
- Trial name
- ICG-R (NCT06129669)
- Testing
- Indocyanine green
- Where
- Netherlands
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Amsterdam UMC, location VUmc
Total Thyroidectomy, Bilateral Neck Exploration for Primary Hyperparathyroidism
Intra-operative Infra-red Fluorescent Imaging in Thyroid and Parathyroid Surgery
Reliable identification of parathyroid glands is critical to the success of thyroid and parathyroid surgery. In thyroid surgery, inadvertent injury to parathyroid glands may cause temporary or permanent hypoparathyroidism (low…
- Trial name
- NCT02089542
- Testing
- MB and fluorescent imaging
- Where
- United Kingdom
- Volunteers
- 41 people
- Sponsor
- Sheffield Teaching Hospitals NHS Foundation Trust
Thyroid Surgery
Quantitative Intra-operative Assessment of Parathyroid Perfusion Using Indocyanine Green (ICG) Fluorescence Imaging
This single-center, prospective, three-phase observational cohort quantifies the relationship between indocyanine green (ICG) fluorescence and early parathyroid function.
- Trial name
- NCT07010341
- Testing
- ntra-operative Indocyanine Green (ICG) Fluorescence Quantification
- Where
- 2 sites in China
- Volunteers
- 210 people
- Sponsor
- Fujian Medical University
To Assess the Feasibility, Visualization Capability, and Optimal Dosing of ICG Fluorescence Imaging for Intraoperative Assessment of Knee Tissue Perfusion
ICG Fluorescence in Knee Arthroscopy Study
The purpose of this study is to first evaluate whether ICG fluorescence angiography can be used to evaluate blood flow of the anterior cruciate ligament (ACL), tendons, and knee structures during an arthroscopic surgery.
- Trial name
- NCT07793266
- Testing
- Intravenous administration of indocyanine green (SPY Agent Green) 2 mL of SPY Agent Green (5.0 mg dose), Intravenous administration of indocyanine green (SPY Agent Green) 3 mL of SPY Agent Green (7.5 mg dose), Intravenous administration of indocyanine green (SPY Agent Green) 4 mL of SPY Agent Green (10 mg dose)
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Henry Ford Health System
Cancer Prostate
Assessment of a New Fluorescence Imaging Technique Using Biopsies From Prostate Resection
In this study, we aim to evaluate the feasibility of anti-PSMA labelling to detect post-operative prostatic tissues by two ex vivo fluorescence techniques.
- Trial name
- Bio-Prost (NCT03157856)
- Testing
- Fluorescence assessment
- Where
- 2 sites in France
- Volunteers
- 8 people
- Sponsor
- University Hospital, Grenoble
Cholecystolithiasis, Cholecystitis
FALCON: a Multicenter Randomized Controlled Trial
Rationale: Several clinical feasibility studies have shown the potential benefit of near-infrared fluorescence (NIRF) imaging using indocyanine green (ICG) for enhanced and earlier biliary anatomy visualization during…
- Trial name
- NCT02558556
- Testing
- Laparoscopic Fluorescence Imaging System (Karl Storz), Indocyanine Green
- Where
- Netherlands
- Volunteers
- 308 people
- Sponsor
- Maastricht University Medical Center
Leakage, Anastomotic, Colon Cancer
COLOFLOW: Laser Speckle Contrast Imaging Versus Near-infrared Fluorescence Imaging With Indocyanine Green
COLOFLOW is a prospective observational study investigating whether Laser Speckle Contrast Imaging (LSCI), a dye-free and objective perfusion imaging technique, corresponds with the currently used subjective assessment of…
- Conditions
- Leakage, Anastomotic, Colon Cancer, Colon Anastomosis, Colon and Rectal Cancer
- Trial name
- COLOFLOW (NCT07720505)
- Testing
- Laser Speckle Contrast Imaging
- Volunteers
- 30 people
- Sponsor
- Leiden University Medical Center
Glioma
IRDye800CW-BBN PET-NIRF Imaging Guiding Surgery in Patients With Lower Grade Glioma
This is an open-label positron emission tomography/near infrared (PET/NIRF) study to investigate the imaging navigation performance and evaluation efficacy of dual modality imaging probe 68Ga-BBN-IRDye800CW in patients with lower…
- Trial name
- NCT03407781
- Testing
- 68Ga-BBN-IRDye800CW
- Where
- China
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Deling Li
Glioblastoma Multiforme, Anaplastic Astrocytoma
Loupe-Based Intraoperative Fluorescence Imaging
Glioblastoma multiforme (GBM) and anaplastic astrocytoma (AA) are the most common primary malignant brain tumors. Survival of patients with these brain tumors is directly related to the extent of resection.
- Trial name
- NCT04780009
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Guoqiang Yu
Skin Lesion
Non-invasive Melanoma Assessment Using a Topical Fluorescence Reagent and Optical Imaging
The use of MDS to access the presence of melanoma in the skin.
- Trial name
- NCT02193581
- Testing
- MDS
- Where
- Israel
- Volunteers
- 50 people
- Sponsor
- Orlucent, Inc
Pancreas Adenocarcinoma, Cholangiocarcinoma
FLUOPANC-trial - Fluorescence-guided Surgery of Pancreatic and Bileduct Tumors Using cRGD-ZW800-1
Pancreas as well as Cholangiocarcinoma have a dismal prognosis at time of diagnosis, due to late onset of clinical symptoms, patients present with advance disease.
- Trial name
- FLUOPANC (NCT05518071)
- Testing
- CRGD-ZW800-1, Intraoperative near-infrared fluorescence imaging
- Where
- Netherlands
- Volunteers
- 20 people
- Sponsor
- Leiden University Medical Center
Breast Neoplasm, Lymphedema
Effectiveness of Fluoroscopy-guided MLD for Treatment of BCRL
The main scientific objective of this multicentric double-blinded randomised controlled trial entails examining the effectiveness of fluoroscopy-guided MLD versus traditional MLD versus placebo MLD, applied as part of the…
- Trial name
- EFforT-BCRL (NCT02609724)
- Testing
- Information, Skin care, Compression therapy
- Where
- 3 sites in Belgium
- Volunteers
- 194 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Prostate Cancer
ICG-based Fluorescence Imaging in Localization of Prostate Cancer and Metastatic Lymph Nodes
This study aims to evaluate the feasibility of indocyanine green (ICG)-based fluorescence imaging in the detection of prostate tumors and metastatic lymph nodes.
- Trial name
- NCT02840617
- Testing
- Indocyanine Green (ICG)
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Third Affiliated Hospital, Sun Yat-Sen University
Bone Neoplasms, Soft Tissue Neoplasms
Investigation Into the Safety and Efficacy of ICG-Labeled Fluorescence Imaging Technology in Guiding the Resection of Bone and Soft Tissue Tumors
Investigate the application protocol, feasibility, and efficacy of indocyanine green (ICG)-assisted near-infrared (NIR) fluorescence-guided resection in bone and soft tissue tumors.
- Trial name
- ICG-BST (NCT06979115)
- Testing
- Indocyanine green (ICG)
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Guangdong Provincial People's Hospital
Trauma Injury
ICG Fluorescence Imaging in Post-traumatic Infection
The focus of this prospective observational study is to (1) establish the range and variation associated with bone/soft tissue perfusion in fracture patients, using ICG fluorescence imaging; (2) examine the relationship between…
- Trial name
- NCT04403204
- Testing
- Immunofluorescence Imaging, DCE-MRI
- Where
- 4 sites in United States
- Volunteers
- 104 people
- Sponsor
- Dartmouth-Hitchcock Medical Center