Clinical trials: Fluid Therapy
Fluid Overload, Fluid Therapy
The Effect of Maintenance Fluids on Overall Fluid Balance in ICU Patients
The amount of fluids characterized as non-resuscitation fluids given to ICU patients are likely to be high and will probably have a substantial impact on the total amount of fluid administered to ICU patients daily.
- Conditions
- Fluid Overload, Fluid Therapy, Critical Care
- Trial name
- NCT03972475
- Where
- 6 sites in Sweden
- Volunteers
- 200 people
- Sponsor
- Uppsala University
Coronary Artery Bypass Grafting, Fluid Therapy
Comparison of Dynamic Fluid Responsiveness by EIT and Transpulmonary Thermodilution in Postoperative of CABG Patients
The purpose of this study is to evaluate the stroke volume variation measured by both methods: transpulmonary thermodilution and electrical impedance tomography (EIT), during fluid responsiveness maneuvers and after fluid…
- Conditions
- Coronary Artery Bypass Grafting, Fluid Therapy, Stroke Volume, Hemodynamic Monitoring
- Trial name
- NCT04362033
- Testing
- Passive Leg Raising (PLR) and PEEP increment (PEEP)
- Where
- Brazil
- Volunteers
- 28 people
- Sponsor
- Ludhmila Abrahão Hajjar
Goal-directed Fluid Therapy
Goal Directed Fluid Therapy Guided Fluid Management in Pneumoresection
Perioperative fluid management is a key component of anesthetic management during thoracic surgery. On one hand, fluid restriction could compromise perfusion of vital organs and surgical anastomosis.
- Trial name
- NCT03237351
- Testing
- Fluid therapy
- Where
- China
- Volunteers
- 60 people
- Sponsor
- ZhiHeng Liu
Fluid Therapy
The Effect of Goal-directed Therapy Guided by Stroke Volume Variation and Cardiac Index in Non-severe Surgical Patients
To evaluate the application of fluid-infusion therapy with the combination of stroke volume variation (SVV) and cardiac index (CI) as the primary judgment in non-severe patients underwent resection of gastrointestinal tumor.
- Trial name
- NCT02841046
- Testing
- cardiac index, Stroke Volume Variation
- Volunteers
- 50 people
- Sponsor
- First Affiliated Hospital, Sun Yat-Sen University
Anesthesia, General, Fluid Therapy
Management of Intraoperative Fluids in Ambulatory Surgery
This is a single-center prospective randomized control trial (RCT) to determine whether the continuous monitoring of the plethysmographic variability index (PVI) during low-risk surgeries, can be used to optimize the…
- Conditions
- Anesthesia, General, Fluid Therapy, Ambulatory Surgical Procedures
- Trial name
- MIFAS (NCT03193320)
- Testing
- Fluid therapy protocol
- Where
- Venezuela
- Volunteers
- 243 people, healthy volunteers welcome
- Sponsor
- Policlinica Metropolitana
Hemodynamic Instability, Fluid Therapy
Hemodynamic Stability During Induction of Anaesthesia
The study aim is to investigate if preoperative volume bolus based on lean body weight could preserve mean arterial pressure during target controlled infusion of anaesthesia (TCI) or rapid sequence induction of anaesthesia (RSI)…
- Conditions
- Hemodynamic Instability, Fluid Therapy, Anesthesia; Adverse Effect
- Trial name
- NCT03394833
- Testing
- gelofusine
- Where
- Sweden
- Volunteers
- 80 people
- Sponsor
- Umeå University
Hypovolemia, Sepsis
A Prospective Observational Study of the Expectations and Physiological Effects of Fluid Bolus Therapy
This prospective observational study aims to (i) asses intensive care doctors trigger for and the expected physiological response to a fluid bolus and (ii) evaluate the patient's actual physiological response to a single fluid…
- Conditions
- Hypovolemia, Sepsis, Post-operative Hypovolemia, Fluid Therapy
- Trial name
- NCT03178578
- Where
- 3 sites in Australia, Sweden
- Volunteers
- 100 people
- Sponsor
- Karolinska Institutet
Goal Directed Fluid Therapy
Assisted Fluid Management in Patients Undergoing Major Abdominal and Orthopedic Surgery
This study will compare a group of patients managed with a manual GDFT protocol (using the EV1000 monitoring device; Edwards Lifesciences, Irvine, USA) to a group of patients managed using a decision support system for GDFT…
- Trial name
- AFM (NCT03779373)
- Testing
- Use of a decision support system on the EV1000 monitor (AFM mode)
- Where
- France
- Sponsor
- Erasme University Hospital
Continuous Renal Replacement Therapy, Intensive Care Unit
Diagnosis Accuracy of Hemoconcentration to Detect Hypovolemia During CRRT
The aim of the study is to analyze if blood protein concentration variation during continuous renal replacement therapy (CRRT) with fluid removal can predict a decrease of 15 % of cardiac index in intensive care unit (ICU)…
- Conditions
- Continuous Renal Replacement Therapy, Intensive Care Unit, Hypovolemia, Fluid Overload
- Trial name
- NCT03144349
- Where
- 2 sites in France
- Volunteers
- 52 people
- Sponsor
- Hopital Louis Pradel
Goal Directed Fluid Therapy
Goal Directed Fluid Therapy
Intraoperative fluid demand will be monitored by Esophageal Doppler in lean and obese patients.
- Trial name
- FLO1 (NCT00860704)
- Testing
- fluidotherapy with ringer-lactate
- Where
- Austria
- Volunteers
- 90 people
- Sponsor
- Medical University of Vienna
Fluid Therapy
Crystalloid FLUID Choices for Resuscitation of Hospital Patients
Salt fluids are used extensively for acutely ill patients who are admitted to hospital. Two salt fluids commonly used are Normal Saline and Ringer's Lactate.
- Trial name
- FLUID (NCT02721485)
- Testing
- Ringer's Lactate, Normal Saline
- Where
- 4 sites in Canada
- Volunteers
- 30,000 people
- Sponsor
- Ottawa Hospital Research Institute
AMD (With Persistent or Recurrent Fluid Despite Monthly Intravitreal Anti-VEGF Therapy)
To Evaluate The Role of Intravitreal Aflibercept Injection (2.0 mg) in the Management of Previously Treated Patients With Exudative AMD
This is an open label study to evaluate intravitreally administered 2.0 mg intravitreal aflibercept injection in patients who have been previously treated for AMD and have persistent or recurrent fluid despite monthly…
- Trial name
- NCT01495221
- Testing
- Alfilbercept
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Vitreous -Retina- Macula Consultants of New York
Fluid Therapy
Fluid Day Spanish Observational Study
Perioperative fluid therapy has undergone a huge change in clinical practice in recent years. The patterns of replacement and / or restoration of volemia described in the classic anaesthesiology books were supported by weak…
- Trial name
- Fluid Day (NCT03630744)
- Testing
- Fluid therapy
- Where
- Spain
- Volunteers
- 3,500 people
- Sponsor
- Sociedad Española de Anestesiología, Reanimación y Terapéutica del Dolor
Fluid and Electrolyte Imbalance, Fluid Therapy
Correlation Between Duration of Fasting and Response to Fluid Replenishment, Evaluated With Repeated Measures of VTI.
The investigators will study the correlation between the lenght of the fasting before surgery and the need to replenish with intra-venous fluids in children, evaluated with 3 measures of the aortic Integral Time Velocity with…
- Trial name
- NCT03599973
- Testing
- Plasmalyte A Viaflo
- Where
- Belgium
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Erasme University Hospital
Fluid Therapy
Restrictive Versus Conservative Fluid Therapy in Colorectal Surgery
Fluid administration during and after surgery is an essential part of postoperative care to maintain the patients' fluid and biochemical balance.
- Trial name
- NCT03070080
- Testing
- restrictive fluid strategy, conservative fluid strategy
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Assiut University
Hypotension, Fluid Therapy
Phenylephrine or Norepinephrine for a Better Hemodynamic Stability
A prospective, double-blinded study. The present study consisted in applying Stroke volume variation fluid guided therapy to old patients (65 years old) undergoing radical resection of colon surgery.
- Trial name
- NCT03215797
- Testing
- phenylephrine, Norepinephrine
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- The Second Affiliated Hospital of Dalian Medical University
Goal-directed Fluid Therapy, Hemodynamics Instability
Multi-center Trial of Goal-directed Fluid Management Based on Pulse Pressure Variation Monitoring
Background: Intraoperative fluid therapy guided by mechanical ventilation-induced pulse-pressure variation (PPV) may improve outcomes after major surgery. It was tested this hypothesis in a multi-center study.
- Conditions
- Goal-directed Fluid Therapy, Hemodynamics Instability, High-risk Surgery, Pulse-pressure Variation
- Trial name
- GDTPPV (NCT03128190)
- Testing
- Pulse pressure variation monitoring
- Volunteers
- 256 people, healthy volunteers welcome
- Sponsor
- Instituto de Assistencia Medica ao Servidor Publico Estadual, Sao Paulo
Hemodynamics, Fluid Therapy
Observation of Principal Hemodynamic Variables After Spinal Anesthesia With Non Invasive Hemodynamic Monitoring
The study is aimed at observe how spinal anesthesia modifies the hemodynamic state of the patient after optimization to preload independence with a Goal Directed Therapy algorithm guided by non invasive hemodynamic monitoring…
- Conditions
- Hemodynamics, Fluid Therapy, Anesthesia, Spinal, Monitoring, Intraoperative
- Trial name
- NCT03086603
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- Istituto Ortopedico Rizzoli
Pancreatectomy, Fluid Therapy
Comparison of Fluid Requirements in Pancreatectomy: Laparotomy vs. Laparoscopy
In this retrospective cohort study, the investigators reviewed and analyzed the electronic medical records of consecutive patients who underwent distal pancreatectomy either via laparotomy or laparoscopy.
- Conditions
- Pancreatectomy, Fluid Therapy, Laparoscopy
- Trial name
- NCT03060408
- Volunteers
- 304 people
- Sponsor
- Seoul National University Bundang Hospital
Ovarian Neoplasm, Fluid Therapy
Fluid Balance During Surgery for Ovarian Cancer
Extensive tumour debulking challenges both surgeon and anaesthesiologist but promotes survival in late-stage ovarian cancer patients.
- Trial name
- NCT03006939
- Testing
- Cytoreductive surgery
- Where
- Germany
- Volunteers
- 60 people
- Sponsor
- University Hospital, Bonn