Clinical trials: Fluid Resuscitation
Sepsis, Intra-Abdominal Infections
Gelaspan vs Crystalloid Therapy in Sepsis
The goal of this randomized clinical trial is to evaluate whether balanced gelatin solution is more effective and safe than balanced crystalloid solution for perioperative fluid management in adults with sepsis undergoing…
- Trial name
- SPACES (NCT07172451)
- Testing
- Balanced Gelatin Solution, Acetate Ringer's Solution
- Where
- 9 sites in China
- Volunteers
- 318 people
- Sponsor
- Shanghai Zhongshan Hospital
Burn, War-Related Injuries
ASV and Targeted Fluid Resuscitation in Severe Burns
This prospective cohort study will evaluate the use of Adaptive Support Ventilation (ASV) together with targeted fluid resuscitation in adult patients with severe burn injuries requiring mechanical ventilation in the intensive…
- Conditions
- Burn, War-Related Injuries, Mechanical Ventilation, Infusion Fluid
- Trial name
- BURN-ASV/TFR (NCT07689097)
- Where
- Ukraine
- Volunteers
- 100 people
- Sponsor
- Ukrainian Society of Regional Anesthesia and Pain Therapy
Wounds and Injuries, Multiple Trauma
Normal Saline Versus Plasmalyte in Initial Resuscitation of Trauma Patients
The purpose of this study is to determine whether an intravenous salt solution called "Plasmalyte" causes less abnormality of the body's acid levels than a solution called "Normal Saline."
- Conditions
- Wounds and Injuries, Multiple Trauma, Disorder of Fluid Balance
- Trial name
- NCT01270854
- Testing
- Plasmalyte A, Normal Saline
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- University of California, Davis
Fluid and Electrolyte Imbalance
Volume Kinetics of Fluid Resuscitation in Early Sepsis
The recommended volume resuscitation for patients with early sepsis-induced hypoperfusion is at least 30 ml/kg of crystalloid administered within the first three hours.
- Trial name
- NCT06499701
- Testing
- Ringer's Lactate
- Where
- 2 sites in Romania
- Volunteers
- 13 people
- Sponsor
- Institutul de Urgenţă pentru Boli Cardiovasculare Prof.Dr. C.C. Iliescu
Shock
Fluid Resuscitation In Trauma: What Are The Best Strategies And Fluids?
Illustration of the differential effects of commonly used resuscitation fluids, including isotonic crystalloids, natural and artificial colloids, hypertonic and hyperoncotic solutions to prevent the cellular injury through wiser…
- Trial name
- NCT05738265
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Assiut University
Septic Shock
Lung Ultrasound-guided Fluid Resuscitation in Neonatal Septic Shock
object name: Lung ultrasound-guided fluid resuscitation in neonatal septic shock. type of study: prospective observational study.
- Trial name
- LUGFRINSS (NCT06144463)
- Testing
- lung ultrasound-guided fluid resuscitation
- Where
- China
- Volunteers
- 72 people
- Sponsor
- Guangdong Second Provincial General Hospital
Critical Illness, Fluid Therapy
Intravenous Fluid Practices in Turkish Intensive Care Units (TR-FLUID)
Intravenous (IV) fluids-fluids given directly into a vein-are among the most common treatments used in intensive care units (ICUs).
- Conditions
- Critical Illness, Fluid Therapy, Practices
- Trial name
- NCT07649694
- Where
- Turkey (Türkiye)
- Volunteers
- 400 people
- Sponsor
- Ondokuz Mayıs University
Dengue Shock Syndrome
Effect of Hypertonic Sodium Lactate on sVCAM-1 Level as Surrogate Marker of Endothelial Capillary Leakage in Pediatric Dengue Shock Syndrome Patients (DSS)
Dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS) are among the leading causes of pediatric hospitalization in Asia.Mortality rates range from 1% at centres experienced in fluid resuscitation, to upto 44% in…
- Trial name
- NCT00966628
- Testing
- Hypertonic sodium lactate, Ringer's lactate
- Where
- Indonesia
- Volunteers
- 50 people
- Sponsor
- Innogene Kalbiotech Pte. Ltd
Cirrhosis With Sepsis
Comparison of Colloid (20% Albumin) Versus Crystalloid (Plasmalyte) for Fluid Resuscitation in Cirrhotics With Sepsis Induced Hypotension.
Consecutive cirrhotics who present to emergency department of Institute of Liver \& Biliary Sciences with documented or suspected sepsis induced hypotension will be randomized to receive either human albumin infusion over 3 hours…
- Trial name
- NCT02721238
- Testing
- 20% Albumin, Plasmalyte
- Where
- India
- Volunteers
- 100 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Fluid Resuscitation
Effect of Fluid Resuscitation on Lactate in Traumatic Injury Patients
The study aims to investigate the effect of 3% hypertonic saline resuscitation on lactate clearance in comparison to ringer's lactated solution and 0.9% normal saline in traumatic injury patients.
- Trial name
- NCT06370975
- Testing
- 3% hypertonic Saline, Ringer's lactated solution, 0.9% Normal saline
- Volunteers
- 150 people
- Sponsor
- Assiut University
Fluid Overload, Critical Illness
Role of Active Deresuscitation After Resuscitation:
The RADAR-Canada trial is a pilot RCT undertaken to assess the acceptability of, compliance with, and biologic consequences of a deresuscitation protocol designed to expedite the removal of excess interstitial fluid in patients…
- Conditions
- Fluid Overload, Critical Illness, Sepsis, ARDS
- Trial name
- RADAR-Canada (NCT06326112)
- Testing
- Furosemide Injection, Metolazone Tablets
- Where
- Canada
- Volunteers
- 120 people
- Sponsor
- Unity Health Toronto
Septic Shock
Pilot Study for the SQUEEZE Trial
The purpose of the SQUEEZE Trial is to determine which fluid resuscitation strategy results in the best outcomes for children treated for suspected or confirmed septic shock.
- Trial name
- SQUEEZE (NCT01973907)
- Testing
- Fluid Sparing Resuscitation Strategy
- Where
- Canada
- Volunteers
- 53 people
- Sponsor
- McMaster Children's Hospital
Microcirculation, Intensive Care
Direct Assessment of Microcirculation In Shock (DAMIS)
Maintaining organ perfusion is the key to successful intensive care medicine. Shock is the most dangerous microcirculatory disorder and one of the most hazardous and lethal conditions of critically ill patients still showing high…
- Conditions
- Microcirculation, Intensive Care, Shock
- Trial name
- NCT04173221
- Testing
- Sublingual SDF-Measurement with communication and interpreting checklist to the treating physician, Sublingual SDF-Measurement without communication and interpreting checklist to the treating physician
- Where
- 5 sites in Germany
- Volunteers
- 141 people
- Sponsor
- Heinrich-Heine University, Duesseldorf
Septic Shock
The Conservative vs. Liberal Approach to Fluid Therapy of Septic Shock in Intensive Care Trial
The purpose of this trial is to assess patient important benefits and harms of IV fluid restriction vs. standard care fluid therapy in patients with septic shock.
- Trial name
- CLASSIC (NCT03668236)
- Testing
- Isotonic crystalloids
- Where
- 31 sites in Belgium, Czechia and 6 more
- Volunteers
- 1,554 people
- Sponsor
- Anders Perner, MD, PhD
Large Volume Resuscitation, Acute Kidney Injury
Resuscitation Fluid Choice and Clinical Outcomes
This observational study evaluates the potential benefits, costs and clinical outcomes of albumin over saline and other non-saline fluids in patients receiving large volume resuscitation.
- Conditions
- Large Volume Resuscitation, Acute Kidney Injury, Hyperchloremic Metabolic Acidosis
- Trial name
- NCT02641119
- Volunteers
- 65,800 people
- Sponsor
- University of Pittsburgh
Septic Shock, Sepsis
Conservative vs. Liberal Approach to Fluid Therapy of Septic Shock in Intensive Care
The purpose of this trial is to o assess feasibility of a protocol comparing conservative (trigger guided) vs. liberal (target guided) approach to fluid resuscitation in patients with septic shock after initial fluid…
- Trial name
- CLASSIC (NCT02079402)
- Testing
- Isotonic crystalloids
- Where
- 9 sites in Denmark, Finland
- Volunteers
- 153 people
- Sponsor
- Anders Perner
Critical Illness, Fluid Over-load
Effect of Dynamic Arterial Elastance and Assisted Fluid Management Software Guided Resuscitation in Septic Shock: Pilot Study
To investigate the benefit of using the AFM and Eadyn-guided fluid and vasopressor therapy in septic shock resuscitation for mechanically ventilated patients compared with the standard of care.
- Conditions
- Critical Illness, Fluid Over-load, Dynamic Arterial Elastance, Septic Shock
- Trial name
- DAFM shock (NCT06937918)
- Testing
- The AFM and Eadyn - guided resuscitation group, The standard care for septic shock
- Where
- 3 sites in Thailand
- Volunteers
- 60 people
- Sponsor
- Mahidol University
Shock, Critical Illness
Chloride High Level Of Resuscitation Infusion Chloride High Level Of Resuscitation Infusion Delivered Evaluation
The purpose of this study is to determine whether intravenous fluid management using lower chloride solutions (Hartmann's solutions and Plasmalyte®) will result in better outcome when compared to management using high chloride…
- Trial name
- CHLORIDE (NCT00885404)
- Testing
- Lower chloride fluids (Hartmann's solution and Plasmalyte®)
- Where
- Australia
- Volunteers
- 7,000 people
- Sponsor
- Austin Health
Acute Kidney Injury, Critical Illness
Definition of Acute Kidney Injury by Urine Output in Critically Ill Patients
The goal of this observational study is to explore the association between urine output and acute kidney injury in severely ill patients admitted to intensive care units.
- Conditions
- Acute Kidney Injury, Critical Illness, Critical Care, Intensive Care, Critical Care, Fluid Resuscitation
- Trial name
- NCT06722924
- Volunteers
- 15,000 people
- Sponsor
- Uppsala University
Cirrhosis, Liver, Cirrhotic Cardiomyopathy
Echocardiography-guided Cirrhosis and Liver Failure-Intensive Care Protocol Sepsis
Point-of-care echocardiography is used to guide septic shock resuscitation in patients with severe sepsis in the intensive care unit (ICU), but without systematic evidence for efficacy in critically patients with Cirrhosis and…
- Conditions
- Cirrhosis, Liver, Cirrhotic Cardiomyopathy, Septic Shock
- Trial name
- ECLIPSE-I (NCT07286643)
- Testing
- POCUS, Fixed Resuscitation Strategy based on Target MAP
- Where
- India
- Volunteers
- 140 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh