Clinical trials: Fluid Responsiveness
Intravenous Fluids, Pharmacodynamics
Effect of Oral Water in Healthy Volunteers on Cardiac Output, Regional Flow and Microcirculation in Healthy Volunteers
Human digestive system physiologically ensures the absorption of oral water and hydration of the human body. Water is quickly absorbed by the digestive tract with a peak between 15 and 20 minutes.
- Conditions
- Intravenous Fluids, Pharmacodynamics, Fluid Therapy, Fluid Responsiveness
- Trial name
- WATERNAL (NCT05153837)
- Testing
- saline intravenous administration, oral water
- Where
- France
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Fluid Responsiveness
Plethysmographic Perfusion Index and Fluid Responsiveness
The objective of this study is to assess the reliability of the perfusion index to predict fluid responsiveness in patients with acute circulatory failure in intensive care.
- Trial name
- PPI-FR (NCT06313671)
- Testing
- Perfusion index
- Where
- Morocco
- Volunteers
- 50 people
- Sponsor
- Avicenna Military Hospital
Fluid Responsiveness, Hemodynamic Monitoring
Internal Jugular Venous Distensibility Index and Innominate Venous Flow Patterns As Predictors of Fluid Responsiveness
The measurement of internal jugular vein distensibility index corresponds to the measurement of stroke volume using trans-thoracic Doppler echocardiography in assessing the response to fluid administration in elective surgical…
- Trial name
- NCT05930600
- Testing
- Ultrasonography of Internal Jugular Vein, Doppler Echocardiograhy
- Where
- Indonesia
- Volunteers
- 79 people, healthy volunteers welcome
- Sponsor
- Universitas Indonesia
Fluid Responsiveness in Early Post-kidney Transplantation Period
Collapsibility Index of the Inferior Vena Cava and Kidney Transplantation
Delayed graft function following renal transplantation is common occurrence and is associated with an increased risk of acute rejection and chronic allograft nephropathy.
- Trial name
- CIVC-KT (NCT06799299)
- Testing
- No Intervention
- Where
- France
- Volunteers
- 150 people
- Sponsor
- CHU de Reims
Hemodynamic, Fluid Responsiveness
Fluid Responsiveness and Venous Congestion Evolution During Volume Expansion
Fluid responsiveness is a critical determinant guiding fluid therapy in critically ill patients. However, excessive fluid administration can result in fluid overload, leading to venous congestion and worse clinical outcomes.
- Conditions
- Hemodynamic, Fluid Responsiveness, Venous Congestion, Fluid Challenge
- Trial name
- FREVO (NCT06772038)
- Where
- 3 sites in China, France
- Volunteers
- 64 people
- Sponsor
- Bicetre Hospital
Fluid Responsiveness Predictability
Hemodynamic Response to the End-expiratory Occlusion Test to Titrate Fluid Challenge in Operating Room.
Personalzing intraoperative anesthetic fluid management may help in preventing fluid accumulation and related complications. Fluids are gine as boluses in operating room (the so-called FC).
- Trial name
- FC_EEOT (NCT06627907)
- Testing
- fluid challenge, end-expiratory occlusion test
- Volunteers
- 300 people
- Sponsor
- Humanitas Clinical and Research Center
Fluid Responsiveness
Passive Leg Raise and Mini-fluid Challenge Effect on Various Cardiac Output Surrogates for Fluid Responsiveness
In the critically ill population, fluid administration in an unstable patient is perhaps the most common intervention that is performed.
- Trial name
- PHOENIX (NCT06390423)
- Testing
- Passive leg raise, SVI via bioreactance, Echo based VTI
- Where
- United States
- Volunteers
- 64 people
- Sponsor
- CentraCare
Fluid Responsiveness, Common Carotid Artery
Carotid Artery Corrected Flow Time and Fluid Responsiveness in Geriatric Patients
Carotid blood flow and corrected carotid flow time (Carotid Flow Time (FTc)) provide information about left ventricular preload and inversely correlate with systemic vascular resistance.
- Trial name
- NCT06087250
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Marmara University
Fluid Responsiveness
Fluid Responsiveness in Prone Patients
To assess fluid responsiveness in prone patient
- Trial name
- NCT06254456
- Testing
- End expiratory occlusion test
- Volunteers
- 84 people
- Sponsor
- Bhumibol Adulyadej Hospital
Stroke Volume Variation, SVV-FloTrac
A Comparison of Stroke Volume Variation for Prediction of Fluid Responsiveness
Stroke volume variation (SVV) is an indicator used to assess the patient's volume status. The FloTrac system (Edwards Lifesciences, Irvine, CA) continuously monitors cardiac output (CO) and SVV (SVV-FloTrac) by analyzing the…
- Conditions
- Stroke Volume Variation, SVV-FloTrac, Thoracic Electrical Bioimpedance, Fluid Responsiveness
- Trial name
- NCT06215157
- Testing
- Flotrac Group, BioZ Group
- Where
- China
- Volunteers
- 120 people
- Sponsor
- RenJi Hospital
Stroke Volume Variation, SVV-FloTrac
A Comparison of Thoracic Electrical Bioimpedance and FloTrac/Vigileo
Stroke volume variation (SVV) is an indicator used to assess the patient's volume status. The FloTrac system (Edwards Lifesciences, Irvine, CA) continuously monitors cardiac output (CO) and SVV (SVV-FloTrac) by analyzing the…
- Conditions
- Stroke Volume Variation, SVV-FloTrac, Thoracic Electrical Bioimpedance, Fluid Responsiveness
- Trial name
- NCT06143111
- Testing
- Flotrac Group, BioZ Group
- Where
- China
- Volunteers
- 100 people
- Sponsor
- RenJi Hospital
Haemodynamics, Fluid Responsiveness
Factors Influencing of Pulse Pressure Variation (PPV)
The investigators studied the predictive value of PPV in the patients with different influencing factors;and the method to improve the predictive value,which can improve the application of PPV in ICU.
- Conditions
- Haemodynamics, Fluid Responsiveness, Pulse Pressure Variation
- Trial name
- FacPPV (NCT04802668)
- Testing
- Patients were ventilated with assist-control ventilation（A/C） mode at different tidal volume, spontaneous breathing and no spontaneous breathing
- Where
- China
- Volunteers
- 189 people
- Sponsor
- Southeast University, China
Septic Shock, Fluid Responsiveness
Timing of Preload Responsiveness in Sepsis
During acute circulatory failure, volume expansion does not always lead to a significant increase in cardiac output (fluid responsiveness).
- Trial name
- TIPRES (NCT05627817)
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Bicetre Hospital
Inotropy, Fluid Management
RESIPI for Reducing Perioperative Major Adverse Cardiac Events
This study aims to evaluate the effect of a novel hemodynamic management and monitoring strategy for reducing cardiac bio marker elevations and major adverse cardiac events.
- Conditions
- Inotropy, Fluid Management, Cardiac Event, Perioperative Cardiac Risk
- Trial name
- RESIPI (NCT03208023)
- Testing
- RESIPI Management Strategy, No intervention
- Where
- United States
- Volunteers
- 155 people
- Sponsor
- Vanderbilt University Medical Center
Anesthesia, Fluid Responsiveness
RPVI for Fluid Responsiveness in Children
The purpose of this study is to validate Rainbow pleth variability index for prediction of fluid responsiveness in children.
- Trial name
- NCT05601622
- Testing
- Fluid loading, Transthoracic echocardiography, PVI, RPVI
- Volunteers
- 45 people
- Sponsor
- Seoul National University Hospital
Intraoperative Care, Fluid Responsiveness
Short Time Low PEEP Challenge and Mini Fluid Challenge
Optimizing fluid therapy is one of the main concerns for anesthesiologists during the intraoperative period. It becomes even more important in high-risk long lasting surgeries as pancreaticoduodenectomy.
- Trial name
- NCT05419570
- Testing
- Fluid Loading
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 35 people
- Sponsor
- Istanbul Saglik Bilimleri University
VCO2 Variation in Intensive Care as a Marker of Fluid Responsiveness, Cardiac Index Variation Transpulmonary Thermodilution in Patients on Controlled Ventilation With Shock
Cardiac Responsiveness Assessment by CO2
The increase of cardiac output resulting from increased blood volume (systolic ejection volume) during intravenous fluid administration defines a state of fluid responsiveness.
- Trial name
- CRAC (NCT05430880)
- Testing
- impact of fluid challenge on the cardiac index and CO2 respiratory parameters analysis (VCO2, EtCO2)
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Hospices Civils de Lyon
Electrical Cardiometry, Transthoracic Echocardiography
Electrical Cardiometry Compared to Transthoracic Echocardiography in Fluid Responsiveness in Sepsis
The aim of this study is to evaluate the diagnostic accuracy of electrical cardiometry (EC) for the noninvasive determination of fluid responsiveness in sepsis and agreement of (EC) compared to transthoracic echocardiography…
- Conditions
- Electrical Cardiometry, Transthoracic Echocardiography, Fluid Responsiveness, Sepsis
- Trial name
- NCT03938220
- Testing
- Electrical Cardiometry
- Where
- Egypt
- Volunteers
- 25 people
- Sponsor
- Tanta University
Fluid Responsiveness
Peripheral Venous Pressure Variation and Fluid Responsiveness
The decision to give fluids or not should not be taken lightly. Indeed, excessive or insufficient fluid administration is associated with increased morbidity and mortality.
- Trial name
- NCT05131516
- Testing
- Alveolar recrutment maneuver
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Erasme University Hospital
Fluid Responsiveness, Modified Prone Position
Pleth Variability Index in Modified Prone Position or Knee-chest Position (Concord Position)
To investigate whether PVI predicts the fluid responsiveness in modified prone position undergoing posterior approach cervical operation.
- Trial name
- NCT04002193
- Testing
- volume expansion
- Where
- South Korea
- Volunteers
- 44 people
- Sponsor
- Asan Medical Center