Clinical trials: Fluid Management
Crohn's Disease, Ulcerative Colitis
An Assessment of Goal-Directed Intraoperative Fluid Management in Hand Assisted Laparoscopic Colectomy
The purpose of this study is to find out if guided fluid administration with the esophageal monitor is superior to standard fluid administration and whether use of the hetastarch or lactated ringers offers different benefits with…
- Conditions
- Crohn's Disease, Ulcerative Colitis, Rectal Cancer, Colon Cancer
- Trial name
- NCT00467922
- Testing
- Hextend, Lactated Ringers
- Where
- United States
- Volunteers
- 69 people
- Sponsor
- Corewell Health West
Shock Hypovolemic, Shock, Septic
Management of Shock in Children With SAM or Severe Underweight and Diarrhea
Diarrhea is one of the leading causes of under-five childhood mortality and accounts for 8% of 5.4 million global under-5 deaths.
- Conditions
- Shock Hypovolemic, Shock, Septic, Blood Transfusion, Adrenaline
- Trial name
- NCT04750070
- Testing
- Blood and Dopamine, Blood and adrenaline
- Where
- Bangladesh
- Volunteers
- 135 people
- Sponsor
- International Centre for Diarrhoeal Disease Research, Bangladesh
Healthy
Lung Pharmacokinetics (PK) in Epithelial Lining Fluid (ELF)
The aim of the present study is to increase the general understanding of lung PK of selected compounds by sampling epithelial lining fluid ELF and lung tissue.
- Trial name
- NCT03524066
- Testing
- Inhalation, Systemic, Bronchoscopy
- Where
- Germany
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Fraunhofer-Institute of Toxicology and Experimental Medicine
Spinal Fusion
Thromboelastography-Guided Fluid Management in Spinal Surgery
The Researchers are trying to evaluate whether using a blood test called thromboelastogram (TEG) to manage patients undergoing multi-level spinal fusion surgery will reduce complications after surgery compared with the standard…
- Trial name
- NCT03999086
- Testing
- Intervention, Control Group
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Mayo Clinic
Critical Illness
Lithium Dilution Method in Guiding Fluid Therapy in Critically Ill Patients
Hypothesis: Fluid management guided by LiDCO doesn´t increase cumulative fluid balance and shorten organ dysfunction compared to fluid management based on CVP and clinical judgment.
- Trial name
- LIGA (NCT00626756)
- Testing
- LiDCO technology
- Where
- Czechia
- Volunteers
- 15 people
- Sponsor
- ASQA a.s.
Healthy, Psoriasis
Distribution of Secukinumab (AIN457) Into Dermal Interstitial Fluid After a Single Subcutaneous Administration of 300 mg
The proposed exploratory study aims to understand the in vivo skin distribution properties of subcutaneously (s.c.) administered AIN457 in psoriatic and healthy skin using open flow microperfusion (OFM).
- Trial name
- OFM ISF (NCT01539213)
- Testing
- secukinumab (AIN457)
- Where
- Austria
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Novartis Pharmaceuticals
Heart Arrest, Out-Of-Hospital, Brain Swelling
The Effect of Lumbar CSF Drainage on the Neurologic Outcome Improvement in OHCA Underwent TTM
Aim: The investigators aim to evaluate the effect of lumbar cerebrospinal fluid (CSF) drainage on neurologic outcome in post-cardiac arrest (CA) patients treated with target temperature management (TTM).
- Trial name
- NCT04328974
- Testing
- lumbar CSF drainage
- Where
- South Korea
- Volunteers
- 40 people
- Sponsor
- Chungnam National University Hospital
Chatbot-Based Training, Hemodialysis
DialysisBot: AI Chatbot for Hemodialysis Self-Management
End-stage kidney disease requiring hemodialysis is a chronic condition with substantial clinical, functional, and psychosocial burden.
- Conditions
- Chatbot-Based Training, Hemodialysis, Self-management
- Trial name
- NCT07830810
- Testing
- DialysisBot
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- University of Rome Tor Vergata
Fluid Retention Tissue
Comparison of Liberal and Restrictive Fluid Management on the Endothelial Glycocalyx in Radical Cystectomy
The aim of this study is to compare the effect of the liberal and restrictive fluid treatments which are routinely performed in major urological surgeries in the perioperative period on ANP release and the endothelial glycocalyx…
- Trial name
- NCT04780490
- Testing
- liberal fluid management, restrictive fluid management
- Where
- Turkey (Türkiye)
- Volunteers
- 37 people
- Sponsor
- Istanbul University
Acute Decompensated Heart Failure
Fluid Management of Acute Decompensated Heart Failure Subjects Treated With Reprieve Decongestion Management System (DMS)
The objective of this study is to prospectively compare decongestive therapy administered by the Reprieve DMS system to Optimal Diuretic Therapy (ODT) in the treatment of patients diagnosed with acute decompensated heart failure…
- Trial name
- FASTR (NCT05174312)
- Testing
- Reprieve Decongestion Management System, Diuretic
- Where
- 16 sites in United States
- Volunteers
- 100 people
- Sponsor
- Reprieve Cardiovascular, Inc
USCOM, Echocardiography
Comparison of the Ultrasonic Cardiac Output Monitor and Echocardiography for Hemodynamic Assessment in Pediatric Anesthesia
This prospective observational pilot study evaluates agreement between Ultrasound Cardiac Output Monitor (USCOM) measurements and transthoracic echocardiography-derived hemodynamic parameters in pediatric patients under…
- Conditions
- USCOM, Echocardiography, Echocardiography Guided Fluid Management
- Trial name
- NCT07342842
- Testing
- USCOM, Echocardiography
- Where
- Turkey (Türkiye)
- Volunteers
- 57 people
- Sponsor
- Sehit Prof. Dr. Ilhan Varank Sancaktepe Training and Research Hospital
Hypertension
Fluid Overload Management and Vascular Stiffness in Chronic Kidney Disease Patients With Hypertension
This study aims to reduce fluid overload in order to control blood pressure of hypertensive CKD patients using bio-impedance assessment of fluid status and using a diuretic therapy algorithm.
- Trial name
- NCT05378750
- Testing
- Diuretic algorithm
- Where
- Canada
- Volunteers
- 2 people
- Sponsor
- University of Alberta
Supratentorial Brain Tumor
Effects of Two Different Goals of Fluid Management in Patients Undergoing Supratentorial Tumour Resection
Neurosurgical operations are characterised by major fluid shift, frequent use of diuretics, and prolonged operative time. The role of fluid therapy in these patients is very critical; hypovolemia might decrease cerebral…
- Trial name
- NCT05561894
- Testing
- pulse pressure variation index guided fluid therapy
- Where
- Egypt
- Volunteers
- 150 people
- Sponsor
- Assiut University
Goal-Directed Fluid Therapy, Hemodynamic Monitoring
Comparison of Goal-directed and Liberal Fluid Management
Background: The investigators aim is to indicate that the "goal directed fluid management" is more effective for open abdominal surgeries by performing perioperative hemodynamic monitorisation using a minimal invasive pulse…
- Conditions
- Goal-Directed Fluid Therapy, Hemodynamic Monitoring, Fluid Management
- Trial name
- NCT04265014
- Testing
- Goal-directed fluid treatment, Liberal Fluid Therapy
- Where
- Turkey (Türkiye)
- Volunteers
- healthy volunteers welcome
- Sponsor
- Bakirkoy Dr. Sadi Konuk Research and Training Hospital
Premature Baby 26 to 32 Weeks, Premature Baby 33 to 36 Weeks
Fluid Responsiveness Evaluation by a Non-invasive Method in Children, Extended to PREterm Infants - FRENCH-PREMA
In this study, the investigators aim to validate a non-invasive marker of fluid-responsiveness in preterm infants (term below 37 gestational week) with acute circulatory failure based on standardized abdominal compression.
- Trial name
- FRENCH-PREMA (NCT06287710)
- Testing
- Non interventional study (study of diagnostic accuracy with an extra echocardiographic assessment).
- Where
- France
- Volunteers
- 20 people
- Sponsor
- University Hospital, Bordeaux
Liver Transplantation
Effect of Rapid Transfusion With Fluid Management System 2000® (FMS)
Rapid infusion of red blood cells is known to result in the increase of plasma potassium. The researchers are trying to investigate the change in plasma potassium during rapid infusion of mixed blood components in the reservoir…
- Trial name
- FMS (NCT01448343)
- Testing
- Fluid management system 2000 (FMS)
- Where
- South Korea
- Volunteers
- 10 people
- Sponsor
- Seoul National University Hospital
Heart Failure, Ventricular Tachycardia
Compare Remote Patient Management and Standard Care in CRT-D and ICD-patients to Assess the Effect on Heart Failure
This pilot study is to prospectively evaluate the benefit of clinicians being able to access ICD device information in a timelier manner and treat fluid overload with a pre-defined pattern using the Medtronic OptiVol, Medtronic…
- Conditions
- Heart Failure, Ventricular Tachycardia, Cardiac Desynchronization
- Trial name
- ConnectOptiVol (NCT00730548)
- Testing
- Device triggered remote telephone contact because of Care Alert
- Where
- Germany
- Volunteers
- 180 people
- Sponsor
- Medtronic Cardiac Rhythm and Heart Failure
Hypovolemia, Hypotension
Dynamic Parameters in Evaluation of Fluid Responsiveness
Intravenous infusion of fluids in patients after surgery is a very important part of treatment. However, administering too much or too little fluid can lengthen the stay in the intensive care unit or even harm the patient.
- Conditions
- Hypovolemia, Hypotension, Surgery
- Trial name
- NCT04283851
- Testing
- testing functional haemodynamic parameters for preload assessment
- Where
- Czechia
- Volunteers
- 50 people
- Sponsor
- Charles University, Czech Republic
Prehypertension
A Clinical Trial of an Herbal Liquid Supplement - 'DBPS' for Managing Blood Pressure
Prehypertension is a clinical condition characterized by systolic blood pressure (SBP) readings between 120 and 139 mmHg and/or diastolic blood pressure (DBP) readings between 80 and 89 mmHg, as per the Joint National Committee…
- Trial name
- NCT07629570
- Testing
- DBPS
- Where
- 4 sites in India
- Volunteers
- 198 people, healthy volunteers welcome
- Sponsor
- Eetho Brands, Inc
Arthroplasty, Replacement, Hip, Anesthesia, Spinal
Goal Directed Fluid Therapy Versus Liberal Fluid Regimen in Primary Elective Hip Artrhoplasty
Patients undergoing elective primary total hip replacement and spinal anesthesia may encounter significant hemodynamic instability.
- Conditions
- Arthroplasty, Replacement, Hip, Anesthesia, Spinal, Hemodynamic Monitoring, Crystalloid Solutions
- Trial name
- NCT04996420
- Testing
- Clearsight non invasive hemodynamic monitoring
- Where
- Italy
- Volunteers
- 15 people
- Sponsor
- Istituto Ortopedico Rizzoli