Clinical trials: Fluid Challenge
Septic Shock
Guided Fluid-balance Optimization With Mini-fluid chALlenge During Septic Shock
Many observational studies have highlighted an independent association between fluid overload and clinical outcomes during septic shock.
- Trial name
- GOAL (NCT03461900)
- Testing
- Minifluid challenge, Usual practice
- Where
- 18 sites in France
- Volunteers
- 535 people
- Sponsor
- University Hospital, Brest
Intraoperative Monitoring, Hypovolemia
Interest of the Pleth Variability Index in Neurosurgery
This clinical trial aims to study the interest of the Pleth Variability Index (PVI) to evaluate perioperative fluid responsiveness in neurosurgery in adults.
- Conditions
- Intraoperative Monitoring, Hypovolemia, Fluid Challenge
- Trial name
- NCT06624891
- Testing
- perioperative fluid responsiveness with the Pleth variability index, perioperative fluid responsiveness with delta PP
- Where
- Tunisia
- Volunteers
- 70 people
- Sponsor
- National Institute of Neurology, Tunisia
Anesthesia, Spine Fusion
Fluid Responsiveness in Prone Position
We are planning to measure hemodynamic parameters (Heart Rate, Mean Arterial Pressure, Stroke Volume Index, Stroke Volume Variation, and Pulse Pressure Variation) and ventilatory parameters at four times (T1, T2,T3, and T4)…
- Trial name
- NCT05401526
- Where
- Turkey (Türkiye)
- Volunteers
- 53 people
- Sponsor
- Istanbul University
Acute Circulatory Failure
Peripheral Tissue Perfusion in Intensive Care
Tissue perfusion has been identified as an early prognosis factor in patients admitted to intensive care. However, little is known about the effects of different hemodynamic interventions performed in clinical routine on…
- Trial name
- INPPEREA (NCT06384287)
- Where
- France
- Volunteers
- 180 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Volume Overload
Inferior Vena Cava Diameter Dependent Colloid Challenge Versus Routine Crystalloid Strategy Transurethral Resection Prostate
Background: Intravenous fluid replacement during transurethral resection of the prostate is still unclear. Ultrasonography of the inferior vena cava (IVC) has been recently used to assess the volume status and predict fluid…
- Trial name
- NCT04131361
- Testing
- Ultrasound-guided Inferior vena cava diameter dependent colloid challenge versus routine crystalloid strategy Fluid replacement
- Where
- Egypt
- Volunteers
- 34 people
- Sponsor
- Mansoura University
Lung Diseases, Obstructive
Cigarette Smoke Nasal and Whole Blood Challenge in Patients With Chronic Obstructive Pulmonary Disease (COPD)
This is a clinical research study to assess whether after exhaling a single cigarette smoke through the nose there are changes in the inflammatory cells and proteins of nasal secretions.
- Trial name
- NCT00159341
- Testing
- Nasal lavage, Nasal filter paper, Blood sampling
- Where
- United Kingdom
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Hemodynamic Instability, Anesthesia
Mini Fluid chAlleNge and End-expiratory Occlusion Test and to Assess flUid responsiVEness in opeRating Room
End-expiratory occlusion test (EEOT) has been previously successfully tested in surgical patients, consisting of the interruption of the mechanical ventilation for 30 seconds, and in the evaluation of the changes in the SV.
- Conditions
- Hemodynamic Instability, Anesthesia, Surgery
- Trial name
- MANEUVER (NCT03808753)
- Testing
- End-expiratory occlusion test (EEOT), mini fluid challenge (mFC)
- Where
- 3 sites in Italy
- Volunteers
- 103 people
- Sponsor
- Humanitas Clinical and Research Center
Interventional Radiology, Surgery
Dynamic Estimation of Cardiac Output in the Operating Room
During major surgery, it is recommended to monitor invasive arterial blood pressure and cardiac output (CO) during hemodynamic interventions (fluid challenge or vasopressors).
- Conditions
- Interventional Radiology, Surgery, General Anesthesia, Organ Failure
- Trial name
- TRIPLEFLOW (NCT04926220)
- Testing
- Trans-esophageal Doppler monitoring, MostCareUP Haemodynamic Monitor, Argos Cardiac Output (CO) Monitor
- Where
- France
- Volunteers
- 36 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Overweight or Obese Adults
Effect of a Liquid Tonic Drink on Post-meal Glucose and Insulin Responses
A randomised, double blinded, placebo-controlled crossover design clinical trial conducted at the Mary MacKillop Institute for Health Research (MMIHR, Australian Catholic University) for individuals with overweight/ obesity.
- Trial name
- NCT07030010
- Testing
- Breakfast meal challenge with tonic drink
- Where
- Australia
- Volunteers
- 20 people
- Sponsor
- Australian Catholic University
Hemodynamic Instability, Shock
VOLume and Vasopressor Therapy in Patients With Hemodynamic instAbility
This prospective observational study will include critically ill patients with hemodynamic compromise. It will compare passive leg raising and a mini volume challenge (MVC) carried out on every patient sequentially.
- Conditions
- Hemodynamic Instability, Shock, Septic Shock
- Trial name
- VOLTA (NCT04089098)
- Testing
- passive leg raising versus mini volume challenge
- Where
- Germany
- Volunteers
- 125 people
- Sponsor
- University of Leipzig
Acute Respiratory Distress Syndrome, Septic Shock
Assessment of Preload Responsiveness in ARDS Patients During Prone Position
Evaluation of preload responsiveness in ARDS patients during prone position is difficult and only one study showed Trendelenburg manoeuvre can be used in this group of patients.
- Conditions
- Acute Respiratory Distress Syndrome, Septic Shock, Hemodynamic Instability
- Trial name
- PR-ARDS-PP (NCT04457739)
- Testing
- Tidal volume challenge, End-expiratory occlusion test, Trendelenburg maneuver
- Where
- France
- Volunteers
- 58 people
- Sponsor
- Bicetre Hospital
Anesthesia
Does the Response to a Mini-fluid Challenge of 3ml/kg in 2 Minutes Predict Fluid Responsiveness for Pediatric Patient?
To predict fluid responsiveness in anesthetized pediatric patient is not an easy task although anesthesia provider has to deal with this question on their daily practices.
- Trial name
- PEDIFLUID (NCT02894996)
- Testing
- fluid challenge
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Hospices Civils de Lyon